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Protein

Deoxycytidine triphosphate deaminase

Gene

dcd

Organism
Nitratiruptor sp. (strain SB155-2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

dCTP + H2O = dUTP + NH3.UniRule annotation

Pathway: dUMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dUMP from dCTP (dUTP route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Deoxycytidine triphosphate deaminase (dcd)
  2. no protein annotated in this organism
This subpathway is part of the pathway dUMP biosynthesis, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dUMP from dCTP (dUTP route), the pathway dUMP biosynthesis and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Enzyme and pathway databases

BioCyciNSP387092:GHA5-1691-MONOMER.
UniPathwayiUPA00610; UER00665.

Names & Taxonomyi

Protein namesi
Recommended name:
Deoxycytidine triphosphate deaminaseUniRule annotation (EC:3.5.4.13UniRule annotation)
Short name:
dCTP deaminaseUniRule annotation
Gene namesi
Name:dcdUniRule annotation
Ordered Locus Names:NIS_1646
OrganismiNitratiruptor sp. (strain SB155-2)
Taxonomic identifieri387092 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaNitratiruptor
ProteomesiUP000001118 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Deoxycytidine triphosphate deaminasePRO_1000009773Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi387092.NIS_1646.

Structurei

3D structure databases

ProteinModelPortaliA6Q5J3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the dCTP deaminase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0717.
HOGENOMiHOG000228600.
KOiK01494.
OMAiMEYFRIP.
OrthoDBiEOG67DPKR.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.

Sequencei

Sequence statusi: Complete.

A6Q5J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLKADCWIR QKAVEDGMIE PFCEDQIGKG VVSYGLSSYG YDIRVSDEFK
60 70 80 90 100
IFTNVNAEVV DPKHFDERNV VDFKGDVCIV PPNSFALART VEYFRIPRNV
110 120 130 140 150
LAICVGKSTY ARCGIIVNVT PFEPEFEGHI TIEISNTTPL PAKIYANEGI
160 170 180
AQVLFFEGDE DCEVSYKDKR GKYQHQRGIT LPKIL
Length:185
Mass (Da):20,836
Last modified:August 21, 2007 - v1
Checksum:i50969EA62BB2BA5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009178 Genomic DNA. Translation: BAF70752.1.
RefSeqiWP_012083015.1. NC_009662.1.
YP_001357109.1. NC_009662.1.

Genome annotation databases

EnsemblBacteriaiBAF70752; BAF70752; NIS_1646.
KEGGinis:NIS_1646.
PATRICi22685452. VBINitSp82229_1723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009178 Genomic DNA. Translation: BAF70752.1.
RefSeqiWP_012083015.1. NC_009662.1.
YP_001357109.1. NC_009662.1.

3D structure databases

ProteinModelPortaliA6Q5J3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi387092.NIS_1646.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF70752; BAF70752; NIS_1646.
KEGGinis:NIS_1646.
PATRICi22685452. VBINitSp82229_1723.

Phylogenomic databases

eggNOGiCOG0717.
HOGENOMiHOG000228600.
KOiK01494.
OMAiMEYFRIP.
OrthoDBiEOG67DPKR.

Enzyme and pathway databases

UniPathwayiUPA00610; UER00665.
BioCyciNSP387092:GHA5-1691-MONOMER.

Family and domain databases

Gene3Di2.70.40.10. 1 hit.
HAMAPiMF_00146. dCTP_deaminase.
InterProiIPR011962. dCTP_deam.
IPR029054. dUTPase-like.
IPR008180. dUTPase/dCTP_deaminase.
[Graphical view]
PfamiPF00692. dUTPase. 1 hit.
[Graphical view]
SUPFAMiSSF51283. SSF51283. 1 hit.
TIGRFAMsiTIGR02274. dCTP_deam. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
    Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
    Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB155-2.

Entry informationi

Entry nameiDCD_NITSB
AccessioniPrimary (citable) accession number: A6Q5J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: April 1, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.