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A6Q512

- SYL_NITSB

UniProt

A6Q512 - SYL_NITSB

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nitratiruptor sp. (strain SB155-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei586 – 5861ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. arginine-tRNA ligase activity Source: InterPro
    3. ATP binding Source: UniProtKB-HAMAP
    4. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginyl-tRNA aminoacylation Source: InterPro
    2. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNSP387092:GHA5-1509-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:NIS_1464
    OrganismiNitratiruptor sp. (strain SB155-2)
    Taxonomic identifieri387092 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaNitratiruptor
    ProteomesiUP000001118: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 815815Leucine--tRNA ligasePRO_1000009382Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi387092.NIS_1464.

    Structurei

    3D structure databases

    ProteinModelPortaliA6Q512.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5011"HIGH" regionAdd
    BLAST
    Motifi583 – 5875"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiHISHELW.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR001278. Arg-tRNA-ligase.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6Q512-1 [UniParc]FASTAAdd to Basket

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    MQYDPKAIEQ KWQNEWKEKN AFEPQENYSK EKMYVLSMFP YPSGRIHMGH    50
    VRNYTIGDAI ARYYRKTGAN VLHPIGWDAF GMPAENAAIK HKVHPKKWTY 100
    ENIDYMRKEL DALGLSFSHD REFATCDPLY SKWEQSFIID MWNRGLLYRK 150
    KAAVNWCPHD KTVLANEQVI EGRCWRCDTE VVQKEIEQYF LKITDYAQEL 200
    LEDLKKLEGN WPNQVIAMQR NWIGRSEGLE FRLHFDETSA KKAGIDGFEV 250
    FTTRPDTIYG VTYTALAPEH PVVKHLIETK QLSDEAVQKI CTMQNQNART 300
    RQQAEKEGLF LDLYVIHPLT KQKIPVWVAN FVLAEYGSGA VMAVPAHDER 350
    DFEFAHKYNL PIKYIIKPKE GELDTTKAYT EPGILFDSGE FSGFESSEAK 400
    QKIIEYFEEN GIGKRSVNYK LKDWLVSRQR YWGTPIPLIK CPKCGIVPEK 450
    KENLPVTLPE DVEITGEGNP LELHPTWKKT TCPKCGGEAE RETDTLDTFV 500
    ESSWYFLRYT TPRKYWEEVP FRKEDTDYWM PVDQYIGGIE HAILHLLYAR 550
    FFTKVLRDLG YVNLDEPFKR LLTQGMVLKD GAKMSKSKGN TVDPDEIVAK 600
    FGADTARLFI LFAAPPAKEL EWSDSAVEGA YRFIKRFFER SQNAYKTKSL 650
    PKIDQKSLSK EEKEARKKVY EALQKSTDVY TKSFSFNTLI AASMEALNAL 700
    NGQNNPDIWT EGYWVLTNIL EPIIPHTCWE ISHNLFERNN FTRLQLDPAA 750
    LEEDSVTLAV TVNGKRRAEI EVPKDASKEE ILAKAKEIAK KWIDGKTIVK 800
    EIVVPGRLVN IVVKG 815
    Length:815
    Mass (Da):94,146
    Last modified:August 21, 2007 - v1
    Checksum:i48FB5009F2996E89
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009178 Genomic DNA. Translation: BAF70571.1.
    RefSeqiWP_012082834.1. NC_009662.1.
    YP_001356928.1. NC_009662.1.

    Genome annotation databases

    EnsemblBacteriaiBAF70571; BAF70571; NIS_1464.
    GeneIDi5360666.
    KEGGinis:NIS_1464.
    PATRICi22685078. VBINitSp82229_1536.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009178 Genomic DNA. Translation: BAF70571.1 .
    RefSeqi WP_012082834.1. NC_009662.1.
    YP_001356928.1. NC_009662.1.

    3D structure databases

    ProteinModelPortali A6Q512.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 387092.NIS_1464.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF70571 ; BAF70571 ; NIS_1464 .
    GeneIDi 5360666.
    KEGGi nis:NIS_1464.
    PATRICi 22685078. VBINitSp82229_1536.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi HISHELW.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci NSP387092:GHA5-1509-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 2 hits.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR001278. Arg-tRNA-ligase.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF00750. tRNA-synt_1d. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
      Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
      Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SB155-2.

    Entry informationi

    Entry nameiSYL_NITSB
    AccessioniPrimary (citable) accession number: A6Q512
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3