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A6Q4N2

- PNP_NITSB

UniProt

A6Q4N2 - PNP_NITSB

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Nitratiruptor sp. (strain SB155-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi516 – 5161MagnesiumUniRule annotation
Metal bindingi522 – 5221MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciNSP387092:GHA5-1378-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:NIS_1333
OrganismiNitratiruptor sp. (strain SB155-2)
Taxonomic identifieri387092 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaNitratiruptor
ProteomesiUP000001118: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Polyribonucleotide nucleotidyltransferasePRO_0000329733Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi387092.NIS_1333.

Structurei

3D structure databases

ProteinModelPortaliA6Q4N2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini582 – 64261KHUniRule annotationAdd
BLAST
Domaini659 – 72668S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6Q4N2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKCRFEFEMN NLKEIYEFGE VAKQTNGSVL LKSGKTVMLA TVVMEKEMVD
60 70 80 90 100
EDFLPLTVQY IEKSYAAGKI PGGFVKREQK PGDFETLTAR IVDRALRPLF
110 120 130 140 150
PKGYLYPTVI TVMVLSADPE SDLQVLALNA ASAALFVSDI PVRKAVSGLR
160 170 180 190 200
VAKVDGEVLF NPPLSKLKES TLDLYLAGTK EELLMIEMAA IGSYKTEVVP
210 220 230 240 250
TTVDPLMDPT LAEEVITIKE PNAMKEEELA SIIAQGKDVI QIACNEYEKY
260 270 280 290 300
FIESAKEQLE LELLPQTIDE DIWTYVEEIY AADIKEAVQA MAKSERNELL
310 320 330 340 350
KEIAKKISED DVAKEQGWEY ETIYKVVEKY KRKIVREMIL NEGKRADGRG
360 370 380 390 400
LKDVRPIDIK TNILPSAHGS CLFTRGETQA LVVCTIGEKT DAQMYEMLTS
410 420 430 440 450
KGPEYEHFMV HYNFPPFSVG EAKPISAPGR RELGHGNLAR RALEPVVDVP
460 470 480 490 500
EDKTYRLVSE ILESNGSSSM ATVCGGALAL KAANIDLADL VAGVAMGLIV
510 520 530 540 550
EDDKYAILTD IMGLEDHDGD MDFKVAGTHD GVTAMQMDIK LGGVQQEILE
560 570 580 590 600
QALQQAREAR LHILKIMEEA AEKIEINEEN LPSSHTITVH PSKIVDIIGQ
610 620 630 640 650
AGKTIKEIIE KFEVSIDIDR DKGKVKVTGK NRPKVIAACD YIQEITNKPK
660 670 680 690 700
PEPVKFQEGD ILKGKIKRTT NFGAFVELPG GVDGLLHISK LSSGRVERVE
710 720 730
DVVNIGDEVE VEVLSQKGHK IELGLRQVLK KA
Length:732
Mass (Da):81,125
Last modified:August 21, 2007 - v1
Checksum:i15A5660875F92DF4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009178 Genomic DNA. Translation: BAF70441.1.
RefSeqiWP_012082704.1. NC_009662.1.
YP_001356798.1. NC_009662.1.

Genome annotation databases

EnsemblBacteriaiBAF70441; BAF70441; NIS_1333.
GeneIDi5361531.
KEGGinis:NIS_1333.
PATRICi22684810. VBINitSp82229_1402.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009178 Genomic DNA. Translation: BAF70441.1 .
RefSeqi WP_012082704.1. NC_009662.1.
YP_001356798.1. NC_009662.1.

3D structure databases

ProteinModelPortali A6Q4N2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 387092.NIS_1333.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF70441 ; BAF70441 ; NIS_1333 .
GeneIDi 5361531.
KEGGi nis:NIS_1333.
PATRICi 22684810. VBINitSp82229_1402.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci NSP387092:GHA5-1378-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
    Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
    Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB155-2.

Entry informationi

Entry nameiPNP_NITSB
AccessioniPrimary (citable) accession number: A6Q4N2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: August 21, 2007
Last modified: October 29, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3