A6Q4L3 (A6Q4L3_NITSB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid A disaccharide synthetase EMBL BAF70422.1
EC=2.4.1.182 EMBL BAF70422.1

Gene names

Name:	lpxB EMBL BAF70422.1
Ordered Locus Names:	NIS_1314

Organism

Nitratiruptor sp. (strain SB155-2) [Complete proteome] [HAMAP]

Taxonomic identifier

387092 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Nitratiruptor

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL BAF70422.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A6Q4L3 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: A17F35ED54D1F4A6	FASTA	347	39,223
	10 20 30 40 50 60 MKLLVSVLER SANVHLASLL THLEGVEIQG VFDKQLGSPI MDLQSLAVMG FVDAVKKISL 70 80 90 100 110 120 FMKLQNELVK MAEEADKVLL MDSSGFNIPL AKKIKKAYPD KPIIYYILPQ VWAWRPKRAK 130 140 150 160 170 180 ILEENIDHLC AIWPFESTFY SPSAPIHYVG HPLLDQIKEF KKEPIQSDTI AFLPGSRRSE 190 200 210 220 230 240 IKRLMPVFQE VRKKLNDKKA LLVVPRHFSQ ENLRTIYGDV SSFAIVHNTH QALMQAEFAF 250 260 270 280 290 300 ICSGTATLES TLTGTPFILS YIANTIDYAI AKRFVNLQYA GIANILAESI HIDPIHPEFL 310 320 330 340 QNEVTPQNLL KAYNEYNTKN FYEKSTQIRS LLGHGSAKNV AGIIQKV

References

[1]

"Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens." Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K. Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed: 17615243] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009178 Genomic DNA. Translation: BAF70422.1.
RefSeq	YP_001356779.1. NC_009662.1.
3D structure databases
ProteinModelPortal	A6Q4L3.
ModBase	Search...
Protein-protein interaction databases
STRING	A6Q4L3.
Protein family/group databases
CAZy	GT19. Glycosyltransferase Family 19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5360026.
GenomeReviews	Gene locus NIS_1314 in contig AP009178_GR.
KEGG	nis:NIS_1314.
PATRIC	22684760. VBINitSp82229_1378.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0763.
HOGENOM	HBG584837.
OMA	AEFAFIC.
ProtClustDB	PRK14089.
Enzyme and pathway databases
BioCyc	NSP387092:NIS_1314-MONOMER.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A6Q4L3_NITSB

Accession

Primary (citable) accession number: A6Q4L3

Entry history

Integrated into UniProtKB/TrEMBL:	August 21, 2007
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)