A6Q418 (MSRA_NITSB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	NIS_1118

Organism

Nitratiruptor sp. (strain SB155-2) [Complete proteome] [HAMAP]

Taxonomic identifier

387092 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Nitratiruptor

Protein attributes

Sequence length	174 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 174	174	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_1000073500
Sites
	Active site	11	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A6Q418 [UniParc]. Last modified August 21, 2007. Version 1. Checksum: 2FD265D0D29F418E	FASTA	174	20,042
	10 20 30 40 50 60 MSESAIVGGG CFWCLEAIFQ RVKGVHRVTS GYAGCRRQNP TYEQVCTGTT KCAEVVKIDF 70 80 90 100 110 120 DPHIINYEEL LHIFFAVHDP TQLNRQGADI GTQYRSVIFP LNEEQKAIAQ KVIQKLNPYF 130 140 150 160 170 ENKIVTTIEN PGTFYEAESY HQNYYNTHPD QGYCQVVIAP KLKKFMNMFQ EYLQ

References

[1]

"Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens." Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K. Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed: 17615243] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SB155-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009178 Genomic DNA. Translation: BAF70227.1.
RefSeq	YP_001356584.1. NC_009662.1.
3D structure databases
ProteinModelPortal	A6Q418.
ModBase	Search...
Protein-protein interaction databases
STRING	A6Q418.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5361291.
GenomeReviews	Gene locus NIS_1118 in contig AP009178_GR.
KEGG	nis:NIS_1118.
PATRIC	22684332. VBINitSp82229_1170.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	GYCAAVI.
Enzyme and pathway databases
BioCyc	NSP387092:NIS_1118-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_NITSB

Accession

Primary (citable) accession number: A6Q418

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	August 21, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program