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A6Q3K8 (MURA_NITSB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
EC=2.5.1.7
Alternative name(s):
Enoylpyruvate transferase
UDP-N-acetylglucosamine enolpyruvyl transferase
Short name=EPT
Gene names
Name:murA
Ordered Locus Names:NIS_0957
OrganismNitratiruptor sp. (strain SB155-2) [Complete proteome] [HAMAP]
Taxonomic identifier387092 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Epsilonproteobacteria › Nitratiruptor

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP-Rule MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine. HAMAP-Rule MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00111

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 420420UDP-N-acetylglucosamine 1-carboxyvinyltransferase HAMAP-Rule MF_00111
PRO_1000023061

Sites

Active site1161Proton donor By similarity

Amino acid modifications

Modified residue11612-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

Sequence LengthMass (Da)Tools
A6Q3K8 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 24E42AF7F37DBFC1

FASTA42045,097
        10         20         30         40         50         60 
MDFLRIEGGK TLNGSVPISG AKNAALPLIA STILSKQSVQ IDNLPDVQDI KTLLRLLQNL 

        70         80         90        100        110        120 
GASYQYEDGL ATIDASKLTS TVATYDIVRT MRASILVLGP ILAKYGRCEV SLPGGCAIGQ 

       130        140        150        160        170        180 
RPIDLHLQAL EQMGAKITIK AGYVVAEAPN GLKGSTIIFD KITVTGTENI VMAAALAKGT 

       190        200        210        220        230        240 
TTIINAAKEP EVVQLCEVLK DAGVQIDGIG SDELIIEGTD REPIEMRAIH VIPDRIEAGT 

       250        260        270        280        290        300 
YLCAGAITNS TLSIENVIPH HLDSVLVKLK QMGFPLDVNE SNITIHPART IEPVEIVTSE 

       310        320        330        340        350        360 
YPGFPTDMQA QFMALALLAN GASIIEERLF ENRFMHVSEL KRFGANIQLK GNIATVIGPT 

       370        380        390        400        410        420 
ELWGADVMAT DLRASSALVL AGLAAKGTTN VHRIYHLDRG YEKLEEKLNA LGANIQRLSE

« Hide

References

[1]"Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SB155-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP009178 Genomic DNA. Translation: BAF70067.1.
RefSeqYP_001356424.1. NC_009662.1.

3D structure databases

ProteinModelPortalA6Q3K8.
ModBaseSearch...

Protein-protein interaction databases

STRING387092.NIS_0957.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAF70067; BAF70067; NIS_0957.
GeneID5361176.
KEGGnis:NIS_0957.
PATRIC22683990. VBINitSp82229_0999.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0766.
HOGENOMHOG000075602.
KOK00790.
OMASIWALAP.
ProtClustDBPRK09369.

Enzyme and pathway databases

BioCycNSP387092:GHA5-963-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.65.10.10. 2 hits.
HAMAPMF_00111. MurA.
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01072. murA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURA_NITSB
AccessionPrimary (citable) accession number: A6Q3K8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 1, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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