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A6Q3K8

- MURA_NITSB

UniProt

A6Q3K8 - MURA_NITSB

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Protein
UDP-N-acetylglucosamine 1-carboxyvinyltransferase
Gene
murA, NIS_0957
Organism
Nitratiruptor sp. (strain SB155-2)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity.UniRule annotation

Catalytic activityi

Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei116 – 1161Proton donor By similarity

GO - Molecular functioni

  1. UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. UDP-N-acetylgalactosamine biosynthetic process Source: InterPro
  2. cell cycle Source: UniProtKB-KW
  3. cell division Source: UniProtKB-KW
  4. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  5. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

BioCyciNSP387092:GHA5-996-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC:2.5.1.7)
Alternative name(s):
Enoylpyruvate transferase
UDP-N-acetylglucosamine enolpyruvyl transferase
Short name:
EPT
Gene namesi
Name:murA
Ordered Locus Names:NIS_0957
OrganismiNitratiruptor sp. (strain SB155-2)
Taxonomic identifieri387092 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaNitratiruptor
ProteomesiUP000001118: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420UDP-N-acetylglucosamine 1-carboxyvinyltransferaseUniRule annotation
PRO_1000023061Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei116 – 11612-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Interactioni

Protein-protein interaction databases

STRINGi387092.NIS_0957.

Structurei

3D structure databases

ProteinModelPortaliA6Q3K8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0766.
HOGENOMiHOG000075602.
KOiK00790.
OMAiHGLEQMG.
OrthoDBiEOG68M4GK.

Family and domain databases

Gene3Di3.65.10.10. 2 hits.
HAMAPiMF_00111. MurA.
InterProiIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
PANTHERiPTHR21090:SF4. PTHR21090:SF4. 1 hit.
PfamiPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF55205. SSF55205. 1 hit.
TIGRFAMsiTIGR01072. murA. 1 hit.

Sequencei

Sequence statusi: Complete.

A6Q3K8-1 [UniParc]FASTAAdd to Basket

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MDFLRIEGGK TLNGSVPISG AKNAALPLIA STILSKQSVQ IDNLPDVQDI    50
KTLLRLLQNL GASYQYEDGL ATIDASKLTS TVATYDIVRT MRASILVLGP 100
ILAKYGRCEV SLPGGCAIGQ RPIDLHLQAL EQMGAKITIK AGYVVAEAPN 150
GLKGSTIIFD KITVTGTENI VMAAALAKGT TTIINAAKEP EVVQLCEVLK 200
DAGVQIDGIG SDELIIEGTD REPIEMRAIH VIPDRIEAGT YLCAGAITNS 250
TLSIENVIPH HLDSVLVKLK QMGFPLDVNE SNITIHPART IEPVEIVTSE 300
YPGFPTDMQA QFMALALLAN GASIIEERLF ENRFMHVSEL KRFGANIQLK 350
GNIATVIGPT ELWGADVMAT DLRASSALVL AGLAAKGTTN VHRIYHLDRG 400
YEKLEEKLNA LGANIQRLSE 420
Length:420
Mass (Da):45,097
Last modified:August 21, 2007 - v1
Checksum:i24E42AF7F37DBFC1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009178 Genomic DNA. Translation: BAF70067.1.
RefSeqiWP_012082330.1. NC_009662.1.
YP_001356424.1. NC_009662.1.

Genome annotation databases

EnsemblBacteriaiBAF70067; BAF70067; NIS_0957.
GeneIDi5361176.
KEGGinis:NIS_0957.
PATRICi22683990. VBINitSp82229_0999.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009178 Genomic DNA. Translation: BAF70067.1 .
RefSeqi WP_012082330.1. NC_009662.1.
YP_001356424.1. NC_009662.1.

3D structure databases

ProteinModelPortali A6Q3K8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 387092.NIS_0957.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF70067 ; BAF70067 ; NIS_0957 .
GeneIDi 5361176.
KEGGi nis:NIS_0957.
PATRICi 22683990. VBINitSp82229_0999.

Phylogenomic databases

eggNOGi COG0766.
HOGENOMi HOG000075602.
KOi K00790.
OMAi HGLEQMG.
OrthoDBi EOG68M4GK.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci NSP387092:GHA5-996-MONOMER.

Family and domain databases

Gene3Di 3.65.10.10. 2 hits.
HAMAPi MF_00111. MurA.
InterProi IPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view ]
PANTHERi PTHR21090:SF4. PTHR21090:SF4. 1 hit.
Pfami PF00275. EPSP_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF55205. SSF55205. 1 hit.
TIGRFAMsi TIGR01072. murA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
    Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
    Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB155-2.

Entry informationi

Entry nameiMURA_NITSB
AccessioniPrimary (citable) accession number: A6Q3K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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