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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Nitratiruptor sp. (strain SB155-2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (NIS_1773)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei8Tele-phosphohistidine intermediateUniRule annotation1
Binding sitei59SubstrateUniRule annotation1
Active sitei86Proton donor/acceptorUniRule annotation1
Binding sitei97SubstrateUniRule annotation1
Sitei182Transition state stabilizerUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processGluconeogenesisUniRule annotation, GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciNSP387092:G1G2O-1002-MONOMER
UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotationImported
Ordered Locus Names:NIS_0920Imported
OrganismiNitratiruptor sp. (strain SB155-2)Imported
Taxonomic identifieri387092 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaNitratiruptor
Proteomesi
  • UP000001118 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi387092.NIS_0920

Structurei

3D structure databases

ProteinModelPortaliA6Q3H2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 14Substrate bindingUniRule annotation8
Regioni20 – 21Substrate bindingUniRule annotation2
Regioni86 – 89Substrate bindingUniRule annotation4
Regioni113 – 114Substrate bindingUniRule annotation2
Regioni183 – 184Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DKJ Bacteria
COG0588 LUCA
HOGENOMiHOG000221682
KOiK01834
OMAiRMLPYWY
OrthoDBiPOG091H03E2

Family and domain databases

CDDicd07067 HP_PGM_like, 1 hit
Gene3Di3.40.50.1240, 1 hit
HAMAPiMF_01039 PGAM_GpmA, 1 hit
InterProiView protein in InterPro
IPR013078 His_Pase_superF_clade-1
IPR029033 His_PPase_superfam
IPR001345 PG/BPGM_mutase_AS
IPR005952 Phosphogly_mut1
PANTHERiPTHR11931 PTHR11931, 1 hit
PfamiView protein in Pfam
PF00300 His_Phos_1, 2 hits
SMARTiView protein in SMART
SM00855 PGAM, 1 hit
SUPFAMiSSF53254 SSF53254, 1 hit
TIGRFAMsiTIGR01258 pgm_1, 1 hit
PROSITEiView protein in PROSITE
PS00175 PG_MUTASE, 1 hit

Sequencei

Sequence statusi: Complete.

A6Q3H2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVLIRHGQ SVWNAKNLFT GWIDVELSEK GKAEAKKAGE LLKEANIYPN
60 70 80 90 100
ICYTSYLKRA IHTAQIALNE LGWEHIDVIR SWKLNERHYG DWQGKNKEEV
110 120 130 140 150
KAKYGEELFM AVRRGYDTPP PPIEESEPDY AKRYPLDPKY EDIGYHPKSE
160 170 180 190 200
SLKDTRERVV EYFYEEIVPA LLAYDTVMIA AHGNSLRALI MYLESIAPEN
210 220 230
VSKIEIPTGT PIVYDLTKEL VIYNKTTYNH
Length:230
Mass (Da):26,623
Last modified:August 21, 2007 - v1
Checksum:i120E7CB8462E76DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009178 Genomic DNA Translation: BAF70031.1
RefSeqiWP_012082294.1, NC_009662.1

Genome annotation databases

EnsemblBacteriaiBAF70031; BAF70031; NIS_0920
KEGGinis:NIS_0920

Entry informationi

Entry nameiA6Q3H2_NITSB
AccessioniPrimary (citable) accession number: A6Q3H2
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: March 28, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health