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A6Q388 (MDH_NITSB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase

EC=1.1.1.37
Gene names
Name:mdh
Ordered Locus Names:NIS_0835
OrganismNitratiruptor sp. (strain SB155-2) [Complete proteome] [HAMAP]
Taxonomic identifier387092 [NCBI]
Taxonomic lineageBacteriaProteobacteriaEpsilonproteobacteriaNitratiruptor

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

malate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionL-malate dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Malate dehydrogenase HAMAP-Rule MF_00487
PRO_1000026480

Regions

Nucleotide binding11 – 177NAD By similarity
Nucleotide binding122 – 1243NAD By similarity

Sites

Active site1791Proton acceptor By similarity
Binding site371NAD By similarity
Binding site861Substrate By similarity
Binding site921Substrate By similarity
Binding site991NAD By similarity
Binding site1241Substrate By similarity
Binding site1551Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
A6Q388 [UniParc].

Last modified August 21, 2007. Version 1.
Checksum: 043747D19C29D188

FASTA31834,071
        10         20         30         40         50         60 
MAKSSKVSIV GAGGNVGSIV AYSVAMQGLA HEVILVDRDK DRAQGKALDM NQAAAAMRTH 

        70         80         90        100        110        120 
SIVRAANDYT DIEGSKVVVI TAGFPRKPGM SRDDLLFANA DIVSEVVENV VKHAPDSIII 

       130        140        150        160        170        180 
VVTNPLDTMT YVALKKSGFP KNRVIGMAGI LDGARMTHFI YEKLGFGAGQ IRATVIGGHG 

       190        200        210        220        230        240 
DYMVPLPRYS TVAGIPITDL LTPQELQEVV EATKNGGAQI VKLMGTSAYF APGKATAIMV 

       250        260        270        280        290        300 
EAILQDSKKI YPCSTLLEGE YGVHGIPNGV PVTLGANGVE EIIELQLTPR EREEFQRSVD 

       310 
SVKELIDVLE NQNYFGEK 

« Hide

References

[1]"Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SB155-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP009178 Genomic DNA. Translation: BAF69947.1.
RefSeqYP_001356304.1. NC_009662.1.

3D structure databases

ProteinModelPortalA6Q388.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING387092.NIS_0835.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAF69947; BAF69947; NIS_0835.
GeneID5360099.
KEGGnis:NIS_0835.
PATRIC22683742. VBINitSp82229_0875.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0039.
HOGENOMHOG000213794.
KOK00024.
OMAYGQNDIC.
OrthoDBEOG6091FG.

Enzyme and pathway databases

BioCycNSP387092:GHA5-874-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01763. MalateDH_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMDH_NITSB
AccessionPrimary (citable) accession number: A6Q388
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: August 21, 2007
Last modified: May 14, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families