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A6Q367

- RTPR_NITSB

UniProt

A6Q367 - RTPR_NITSB

Protein

Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Nitratiruptor sp. (strain SB155-2)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

    Cofactori

    Adenosylcobalamin.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei355 – 3551By similarity
    Active sitei357 – 3571By similarity

    GO - Molecular functioni

    1. cobalamin binding Source: UniProtKB-KW
    2. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Cobalamin, Cobalt

    Enzyme and pathway databases

    BioCyciNSP387092:GHA5-851-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
    Short name:
    RTPR
    Gene namesi
    Name:rtpR
    Ordered Locus Names:NIS_0814
    OrganismiNitratiruptor sp. (strain SB155-2)
    Taxonomic identifieri387092 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaNitratiruptor
    ProteomesiUP000001118: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 650650Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326543Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi123 ↔ 366Redox-activeBy similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi387092.NIS_0814.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG0209.
    HOGENOMiHOG000154224.
    KOiK00525.
    OMAiDSLNNCW.
    OrthoDBiEOG68DCVH.

    Family and domain databases

    InterProiIPR000788. RNR_lg_C.
    [Graphical view]
    PfamiPF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6Q367-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYVEHFFKLP SQTKELLQNT PYRFGFGLLS EVTFYRSYSR LKEDGTNEHW    50
    PDTVIRVTEG IFSIRKNHAL NYHLPWDEEQ AQIFAKEFAL SMLQLRWLPP 100
    GRGLWMMGTR YMYERGSAGL YNCAAVDTSN LAHAAEWAMD MLMVGAGVGF 150
    NTAWSGKATK PDKKHPKIYV IDDSKEGWVK SVRLLIQSYT DNGPFYRFDY 200
    SKIRPAGSPL KTFGGIAPGP EPLKRLHKKI EQILDDYLDK KIDKTRCVVD 250
    LFNNIGLCVV SGNIRRSAEI AIGRPGDKTF LHLKDYEKFP ERKEYGWISN 300
    NSVVIENLDD FHYIDAITSL IASNGEPGVL HLENMQKYGR FGEIVPDRAW 350
    LSNPCGEIAL ESYELCNLSE IFISKCSNEE DFQKLIEYAT FYASTVNLLP 400
    THRPETNEII ARNRRIGVSV SGVADAIEKF GLETIIKWLR KGYEKVRTVN 450
    ERLAKEAGIP VSLKVTCVKP SGTISILAGT SPGMHYPLAT YALRRIRIGK 500
    TSKLAKLLID SGLSFEEDIY DKNSYVFAFP IHYDNPRSIK EVDIYEQMLV 550
    LTMLQREWAD NMVSNTIQFD PTRYDAKDLS QIVKHFLPMI KSLTLLPEKE 600
    TIYPQMPFES IKKEEFEKRV TQLPKVEWNT LSGHHADSER FCSTQSCQID 650
    Length:650
    Mass (Da):74,398
    Last modified:August 21, 2007 - v1
    Checksum:i55ED17318FE61465
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009178 Genomic DNA. Translation: BAF69926.1.
    RefSeqiWP_012082189.1. NC_009662.1.
    YP_001356283.1. NC_009662.1.

    Genome annotation databases

    EnsemblBacteriaiBAF69926; BAF69926; NIS_0814.
    GeneIDi5360169.
    KEGGinis:NIS_0814.
    PATRICi22683696. VBINitSp82229_0854.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009178 Genomic DNA. Translation: BAF69926.1 .
    RefSeqi WP_012082189.1. NC_009662.1.
    YP_001356283.1. NC_009662.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 387092.NIS_0814.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF69926 ; BAF69926 ; NIS_0814 .
    GeneIDi 5360169.
    KEGGi nis:NIS_0814.
    PATRICi 22683696. VBINitSp82229_0854.

    Phylogenomic databases

    eggNOGi COG0209.
    HOGENOMi HOG000154224.
    KOi K00525.
    OMAi DSLNNCW.
    OrthoDBi EOG68DCVH.

    Enzyme and pathway databases

    BioCyci NSP387092:GHA5-851-MONOMER.

    Family and domain databases

    InterProi IPR000788. RNR_lg_C.
    [Graphical view ]
    Pfami PF02867. Ribonuc_red_lgC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
      Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
      Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SB155-2.

    Entry informationi

    Entry nameiRTPR_NITSB
    AccessioniPrimary (citable) accession number: A6Q367
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3