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Protein

Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductase

Gene

rtpR

Organism
Nitratiruptor sp. (strain SB155-2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei355 – 3551By similarity
Active sitei357 – 3571By similarity

GO - Molecular functioni

  1. cobalamin binding Source: UniProtKB-KW
  2. ribonucleoside-triphosphate reductase activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Cobalamin, Cobalt

Enzyme and pathway databases

BioCyciNSP387092:GHA5-851-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductase (EC:1.17.4.2)
Short name:
RTPR
Gene namesi
Name:rtpR
Ordered Locus Names:NIS_0814
OrganismiNitratiruptor sp. (strain SB155-2)
Taxonomic identifieri387092 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaNitratiruptor
ProteomesiUP000001118: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 650650Probable adenosylcobalamin-dependent ribonucleoside-triphosphate reductasePRO_0000326543Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi123 ↔ 366Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi387092.NIS_0814.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0209.
HOGENOMiHOG000154224.
KOiK00525.
OMAiDSLNNCW.
OrthoDBiEOG68DCVH.

Family and domain databases

InterProiIPR000788. RNR_lg_C.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6Q367-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYVEHFFKLP SQTKELLQNT PYRFGFGLLS EVTFYRSYSR LKEDGTNEHW
60 70 80 90 100
PDTVIRVTEG IFSIRKNHAL NYHLPWDEEQ AQIFAKEFAL SMLQLRWLPP
110 120 130 140 150
GRGLWMMGTR YMYERGSAGL YNCAAVDTSN LAHAAEWAMD MLMVGAGVGF
160 170 180 190 200
NTAWSGKATK PDKKHPKIYV IDDSKEGWVK SVRLLIQSYT DNGPFYRFDY
210 220 230 240 250
SKIRPAGSPL KTFGGIAPGP EPLKRLHKKI EQILDDYLDK KIDKTRCVVD
260 270 280 290 300
LFNNIGLCVV SGNIRRSAEI AIGRPGDKTF LHLKDYEKFP ERKEYGWISN
310 320 330 340 350
NSVVIENLDD FHYIDAITSL IASNGEPGVL HLENMQKYGR FGEIVPDRAW
360 370 380 390 400
LSNPCGEIAL ESYELCNLSE IFISKCSNEE DFQKLIEYAT FYASTVNLLP
410 420 430 440 450
THRPETNEII ARNRRIGVSV SGVADAIEKF GLETIIKWLR KGYEKVRTVN
460 470 480 490 500
ERLAKEAGIP VSLKVTCVKP SGTISILAGT SPGMHYPLAT YALRRIRIGK
510 520 530 540 550
TSKLAKLLID SGLSFEEDIY DKNSYVFAFP IHYDNPRSIK EVDIYEQMLV
560 570 580 590 600
LTMLQREWAD NMVSNTIQFD PTRYDAKDLS QIVKHFLPMI KSLTLLPEKE
610 620 630 640 650
TIYPQMPFES IKKEEFEKRV TQLPKVEWNT LSGHHADSER FCSTQSCQID
Length:650
Mass (Da):74,398
Last modified:August 21, 2007 - v1
Checksum:i55ED17318FE61465
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009178 Genomic DNA. Translation: BAF69926.1.
RefSeqiWP_012082189.1. NC_009662.1.
YP_001356283.1. NC_009662.1.

Genome annotation databases

EnsemblBacteriaiBAF69926; BAF69926; NIS_0814.
GeneIDi5360169.
KEGGinis:NIS_0814.
PATRICi22683696. VBINitSp82229_0854.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP009178 Genomic DNA. Translation: BAF69926.1.
RefSeqiWP_012082189.1. NC_009662.1.
YP_001356283.1. NC_009662.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi387092.NIS_0814.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAF69926; BAF69926; NIS_0814.
GeneIDi5360169.
KEGGinis:NIS_0814.
PATRICi22683696. VBINitSp82229_0854.

Phylogenomic databases

eggNOGiCOG0209.
HOGENOMiHOG000154224.
KOiK00525.
OMAiDSLNNCW.
OrthoDBiEOG68DCVH.

Enzyme and pathway databases

BioCyciNSP387092:GHA5-851-MONOMER.

Family and domain databases

InterProiIPR000788. RNR_lg_C.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
    Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
    Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SB155-2.

Entry informationi

Entry nameiRTPR_NITSB
AccessioniPrimary (citable) accession number: A6Q367
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: August 21, 2007
Last modified: January 7, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.