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A6Q2C1

- PYRF_NITSB

UniProt

A6Q2C1 - PYRF_NITSB

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Nitratiruptor sp. (strain SB155-2)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 48 (01 Oct 2014)
      Sequence version 1 (21 Aug 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei8 – 81SubstrateUniRule annotation
    Binding sitei30 – 301SubstrateUniRule annotation
    Active sitei61 – 611Proton donorUniRule annotation
    Binding sitei118 – 1181SubstrateUniRule annotation
    Binding sitei178 – 1781SubstrateUniRule annotation
    Binding sitei187 – 1871SubstrateUniRule annotation
    Binding sitei207 – 2071Substrate; via amide nitrogenUniRule annotation
    Binding sitei208 – 2081SubstrateUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesis

    Enzyme and pathway databases

    BioCyciNSP387092:GHA5-544-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Short name:
    OMPDCaseUniRule annotation
    Short name:
    OMPdecaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:NIS_0516
    OrganismiNitratiruptor sp. (strain SB155-2)
    Taxonomic identifieri387092 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaNitratiruptor
    ProteomesiUP000001118: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 227227Orotidine 5'-phosphate decarboxylasePRO_1000065923Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi387092.NIS_0516.

    Structurei

    3D structure databases

    ProteinModelPortaliA6Q2C1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni59 – 6810Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000226071.
    KOiK01591.
    OMAiRPITQSA.
    OrthoDBiEOG6N6815.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_B. OMPdecase_type1_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6Q2C1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLCVALDLP SIEENLSLAK SLKNYDIWLK VGLRSYIRDG KEFLKQIKQI    50
    NPNFHIFLDL KLYDIPNTMA DAAEEIAKLG VEMFNIHASA GKEAMQSVMQ 100
    RVQKFQNPPL VLAVTVLTSF NEEQFRSIYN DSIENKAKQF AKEAYEAGLD 150
    GVVCSVYESD LIKNITSDTF ITLTPGIRPF GESAGDQKRV ADINLAKEKK 200
    VDFIVVGRPI YQANNPAEVV EKILTNL 227
    Length:227
    Mass (Da):25,503
    Last modified:August 21, 2007 - v1
    Checksum:i12DA729F1FD13C58
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009178 Genomic DNA. Translation: BAF69630.1.
    RefSeqiWP_012081893.1. NC_009662.1.
    YP_001355987.1. NC_009662.1.

    Genome annotation databases

    EnsemblBacteriaiBAF69630; BAF69630; NIS_0516.
    GeneIDi5360934.
    KEGGinis:NIS_0516.
    PATRICi22683066. VBINitSp82229_0547.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009178 Genomic DNA. Translation: BAF69630.1 .
    RefSeqi WP_012081893.1. NC_009662.1.
    YP_001355987.1. NC_009662.1.

    3D structure databases

    ProteinModelPortali A6Q2C1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 387092.NIS_0516.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF69630 ; BAF69630 ; NIS_0516 .
    GeneIDi 5360934.
    KEGGi nis:NIS_0516.
    PATRICi 22683066. VBINitSp82229_0547.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000226071.
    KOi K01591.
    OMAi RPITQSA.
    OrthoDBi EOG6N6815.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci NSP387092:GHA5-544-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_B. OMPdecase_type1_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Deep-sea vent epsilon-proteobacterial genomes provide insights into emergence of pathogens."
      Nakagawa S., Takaki Y., Shimamura S., Reysenbach A.-L., Takai K., Horikoshi K.
      Proc. Natl. Acad. Sci. U.S.A. 104:12146-12150(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SB155-2.

    Entry informationi

    Entry nameiPYRF_NITSB
    AccessioniPrimary (citable) accession number: A6Q2C1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: August 21, 2007
    Last modified: October 1, 2014
    This is version 48 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3