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A6PW57

- A6PW57_HUMAN

UniProt

A6PW57 - A6PW57_HUMAN

Protein
Submitted name:

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Gene

PIP5K1A

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 2 (03 Mar 2009)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. phosphatidylinositol phosphate kinase activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Phosphatidylinositol 4-phosphate 5-kinase type-1 alphaImported
    Gene namesi
    Name:PIP5K1AImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8994. PIP5K1A.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA
    3. plasma membrane Source: HPA

    PTM / Processingi

    Proteomic databases

    MaxQBiA6PW57.

    Expressioni

    Gene expression databases

    ArrayExpressiA6PW57.

    Structurei

    3D structure databases

    ProteinModelPortaliA6PW57.
    SMRiA6PW57. Positions 70-355.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains PIPK domain.SAAS annotation

    Phylogenomic databases

    HOGENOMiHOG000193876.
    HOVERGENiHBG052818.
    KOiK00889.

    Family and domain databases

    Gene3Di3.30.800.10. 1 hit.
    3.30.810.10. 1 hit.
    InterProiIPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view]
    PANTHERiPTHR23086. PTHR23086. 1 hit.
    PfamiPF01504. PIP5K. 1 hit.
    [Graphical view]
    SMARTiSM00330. PIPKc. 1 hit.
    [Graphical view]
    PROSITEiPS51455. PIPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6PW57-1 [UniParc]FASTAAdd to Basket

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    MASASSGPSS SVGFSSFDPA VPSCTLSSAA SGIKRPMASE VPYASGMPIK    50
    KIGHRSVDSS GETTYKKTTS SALKGAIQLG ITHTVGSLST KPERDVLMQD 100
    FYVVESIFFP SEGSNLTPAH HYNDFRFKTY APVAFRYFRE LFGIRPDDYL 150
    YSLCSEPLIE LCSSGASGSL FYVSSDDEFI IKTVQHKEAE FLQKLLPGYY 200
    MNLNQNPRTL LPKFYGLYCV QAGGKNIRIV VMNNLLPRSV KMHIKYDLKG 250
    STYKRRASQK EREKPLPTFK DLDFLQDIPD GLFLDADMYN ALCKTLQRDC 300
    LVLQSFKIMD YSLLMSIHNI DHAQREPLSS ETQYSVDTRR PAPQKALYST 350
    AMESIQGEAR RGGTMETDDH MGGIPARNSK GERLLLYIGI IDILQSYRFV 400
    KKLEHSWKAL VHDGDTVSVH RPGFYAERFQ RFMCNTVFKK IPLKPSPSKK 450
    FRSGSSFSRR AGSSGNSCIT YQPSVSGEHK AQVTTKAEVE PGVHLGRPDV 500
    LPQTPPLEEI SEGSPIPDPS FSPLVGETLQ MLTTSTTLEK LEVAESEFTH 550
    Length:550
    Mass (Da):61,258
    Last modified:March 3, 2009 - v2
    Checksum:i169439AD1F8AE6D5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL592424 Genomic DNA. No translation available.
    RefSeqiXP_005245588.1. XM_005245531.1.
    UniGeneiHs.655131.
    Hs.661888.

    Genome annotation databases

    EnsembliENST00000409426; ENSP00000386432; ENSG00000143398.
    GeneIDi8394.
    KEGGihsa:8394.
    UCSCiuc021oyo.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL592424 Genomic DNA. No translation available.
    RefSeqi XP_005245588.1. XM_005245531.1.
    UniGenei Hs.655131.
    Hs.661888.

    3D structure databases

    ProteinModelPortali A6PW57.
    SMRi A6PW57. Positions 70-355.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    MaxQBi A6PW57.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000409426 ; ENSP00000386432 ; ENSG00000143398 .
    GeneIDi 8394.
    KEGGi hsa:8394.
    UCSCi uc021oyo.1. human.

    Organism-specific databases

    CTDi 8394.
    HGNCi HGNC:8994. PIP5K1A.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000193876.
    HOVERGENi HBG052818.
    KOi K00889.

    Miscellaneous databases

    ChiTaRSi PIP5K1A. human.
    GenomeRNAii 8394.
    NextBioi 35462821.

    Gene expression databases

    ArrayExpressi A6PW57.

    Family and domain databases

    Gene3Di 3.30.800.10. 1 hit.
    3.30.810.10. 1 hit.
    InterProi IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view ]
    PANTHERi PTHR23086. PTHR23086. 1 hit.
    Pfami PF01504. PIP5K. 1 hit.
    [Graphical view ]
    SMARTi SM00330. PIPKc. 1 hit.
    [Graphical view ]
    PROSITEi PS51455. PIPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D., Porter K.M., Prigmore E.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiA6PW57_HUMAN
    AccessioniPrimary (citable) accession number: A6PW57
    Entry historyi
    Integrated into UniProtKB/TrEMBL: August 21, 2007
    Last sequence update: March 3, 2009
    Last modified: October 1, 2014
    This is version 51 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3