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Protein
Submitted name:

Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Gene

PIP5K1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinasePROSITE-ProRule annotation, Transferase
LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphatidylinositol 4-phosphate 5-kinase type-1 alphaImported
Gene namesi
Name:PIP5K1AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143398.19.
HGNCiHGNC:8994. PIP5K1A.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143398.

PTM / Processingi

Proteomic databases

MaxQBiA6PW57.
PaxDbiA6PW57.
PeptideAtlasiA6PW57.
PRIDEiA6PW57.

Expressioni

Gene expression databases

BgeeiENSG00000143398.
ExpressionAtlasiA6PW57. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliA6PW57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 437PIPKInterPro annotationAdd BLAST369

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG5253. LUCA.
GeneTreeiENSGT00760000119184.
HOGENOMiHOG000193876.
HOVERGENiHBG052818.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
InterProiView protein in InterPro
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiView protein in Pfam
PF01504. PIP5K. 1 hit.
SMARTiView protein in SMART
SM00330. PIPKc. 1 hit.
PROSITEiView protein in PROSITE
PS51455. PIPK. 1 hit.

Sequencei

Sequence statusi: Complete.

A6PW57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASASSGPSS SVGFSSFDPA VPSCTLSSAA SGIKRPMASE VPYASGMPIK
60 70 80 90 100
KIGHRSVDSS GETTYKKTTS SALKGAIQLG ITHTVGSLST KPERDVLMQD
110 120 130 140 150
FYVVESIFFP SEGSNLTPAH HYNDFRFKTY APVAFRYFRE LFGIRPDDYL
160 170 180 190 200
YSLCSEPLIE LCSSGASGSL FYVSSDDEFI IKTVQHKEAE FLQKLLPGYY
210 220 230 240 250
MNLNQNPRTL LPKFYGLYCV QAGGKNIRIV VMNNLLPRSV KMHIKYDLKG
260 270 280 290 300
STYKRRASQK EREKPLPTFK DLDFLQDIPD GLFLDADMYN ALCKTLQRDC
310 320 330 340 350
LVLQSFKIMD YSLLMSIHNI DHAQREPLSS ETQYSVDTRR PAPQKALYST
360 370 380 390 400
AMESIQGEAR RGGTMETDDH MGGIPARNSK GERLLLYIGI IDILQSYRFV
410 420 430 440 450
KKLEHSWKAL VHDGDTVSVH RPGFYAERFQ RFMCNTVFKK IPLKPSPSKK
460 470 480 490 500
FRSGSSFSRR AGSSGNSCIT YQPSVSGEHK AQVTTKAEVE PGVHLGRPDV
510 520 530 540 550
LPQTPPLEEI SEGSPIPDPS FSPLVGETLQ MLTTSTTLEK LEVAESEFTH
Length:550
Mass (Da):61,258
Last modified:March 3, 2009 - v2
Checksum:i169439AD1F8AE6D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL592424 Genomic DNA. No translation available.
RefSeqiNP_001317618.1. NM_001330689.1.
UniGeneiHs.655131.
Hs.661888.

Genome annotation databases

EnsembliENST00000409426; ENSP00000386432; ENSG00000143398.
GeneIDi8394.
UCSCiuc057ktg.1. human.

Similar proteinsi

Entry informationi

Entry nameiA6PW57_HUMAN
AccessioniPrimary (citable) accession number: A6PW57
Entry historyiIntegrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: March 3, 2009
Last modified: September 27, 2017
This is version 81 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported