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Protein
Submitted name:

Plasminogen

Gene

PLG

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • protein domain specific binding Source: AgBase
  • receptor binding Source: AgBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
PlasminogenImported
Gene namesi
Name:PLGImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:9071. PLG.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 166147Sequence analysisPRO_5002700586Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiA6PVI2.

Expressioni

Gene expression databases

BgeeiA6PVI2.
ExpressionAtlasiA6PVI2. baseline and differential.

Interactioni

GO - Molecular functioni

  • protein domain specific binding Source: AgBase
  • receptor binding Source: AgBase

Structurei

3D structure databases

ProteinModelPortaliA6PVI2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini119 – 16648KringleInterPro annotationAdd
BLAST

Keywords - Domaini

KringleSAAS annotation, SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00760000119133.
HOGENOMiHOG000115578.
HOVERGENiHBG003051.

Family and domain databases

InterProiIPR000001. Kringle.
IPR013806. Kringle-like.
IPR003609. Pan_app.
[Graphical view]
PfamiPF00051. Kringle. 1 hit.
PF00024. PAN_1. 1 hit.
[Graphical view]
SMARTiSM00130. KR. 1 hit.
SM00473. PAN_AP. 1 hit.
[Graphical view]
SUPFAMiSSF57440. SSF57440. 1 hit.
PROSITEiPS50070. KRINGLE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A6PVI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEHKEVVLLL LLFLKSGQGE PLDDYVNTQG ASLFSVTKKQ LGAGSIEECA
60 70 80 90 100
AKCEEDEEFT CRYFHCRCTY AGICNSDGKA FQYHSKEQQC VIMAENRKSS
110 120 130 140 150
IIIRMRDVVL FEKKVYLSEC KTGNGKNYRG TMSKTKNGIT CQKWSSTSPH
160
RPRFSPATHP SEGLEE
Length:166
Mass (Da):18,746
Last modified:August 21, 2007 - v1
Checksum:i770E0B6C22E1A86E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei166 – 1661Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109933 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000418964; ENSP00000389424; ENSG00000122194.
UCSCiuc063srd.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109933 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA6PVI2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA6PVI2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000418964; ENSP00000389424; ENSG00000122194.
UCSCiuc063srd.1. human.

Organism-specific databases

HGNCiHGNC:9071. PLG.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119133.
HOGENOMiHOG000115578.
HOVERGENiHBG003051.

Miscellaneous databases

ChiTaRSiPLG. human.

Gene expression databases

BgeeiA6PVI2.
ExpressionAtlasiA6PVI2. baseline and differential.

Family and domain databases

InterProiIPR000001. Kringle.
IPR013806. Kringle-like.
IPR003609. Pan_app.
[Graphical view]
PfamiPF00051. Kringle. 1 hit.
PF00024. PAN_1. 1 hit.
[Graphical view]
SMARTiSM00130. KR. 1 hit.
SM00473. PAN_AP. 1 hit.
[Graphical view]
SUPFAMiSSF57440. SSF57440. 1 hit.
PROSITEiPS50070. KRINGLE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  3. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiA6PVI2_HUMAN
AccessioniPrimary (citable) accession number: A6PVI2
Entry historyi
Integrated into UniProtKB/TrEMBL: August 21, 2007
Last sequence update: August 21, 2007
Last modified: June 8, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.