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Protein

Zinc finger protein 716

Gene

ZNF716

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri157 – 179C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri185 – 207C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri213 – 235C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 290C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-30757-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 716
Gene namesi
Name:ZNF716
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:32458. ZNF716.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182111.

Polymorphism and mutation databases

BioMutaiZNF716.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003188551 – 495Zinc finger protein 716Add BLAST495

Proteomic databases

MaxQBiA6NP11.
PaxDbiA6NP11.
PRIDEiA6NP11.

PTM databases

iPTMnetiA6NP11.
PhosphoSitePlusiA6NP11.

Expressioni

Gene expression databases

CleanExiHS_ZNF716.

Interactioni

Protein-protein interaction databases

BioGridi137285. 1 interactor.
STRINGi9606.ENSP00000394248.

Structurei

3D structure databases

ProteinModelPortaliA6NP11.
SMRiA6NP11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 87KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri157 – 179C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri185 – 207C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri213 – 235C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri241 – 263C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri269 – 290C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri296 – 318C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA6NP11.
KOiK09228.
OMAiVKKCCKS.
OrthoDBiEOG091G02KC.
PhylomeDBiA6NP11.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NP11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRPGPPGS REMGLLTFRD IAIEFSLAEW QCLDHAQQNL YRDVMLENYR
60 70 80 90 100
NLVSLGIAVS KPDLITCLEQ NKEPQNIKRN EMVAKHPVTC SHFTQDLQSE
110 120 130 140 150
QGIKDSLQKV ILRRYGKCGQ EDLQVKKCCK SVGECEVHKG GYNYVNQCLS
160 170 180 190 200
ATQNKTFQTH KCVKVFGKFS NSNRHKTRHT GKKHFKCKND GKSFCMLSRL
210 220 230 240 250
NQHQIIHTRE KSYKCEECGK SFNCSSTLTR HKRIHTGEKP YRCEECGKAF
260 270 280 290 300
SWSASLTKHK RIHTGEKPYT CEERGKVFSR STLTNYKRIH TGEKPYTCEE
310 320 330 340 350
CGKAFSRSST LTNHKRIHTG ERPYKCEECG KAFSLSSTLK KHKIVHTGEK
360 370 380 390 400
LYTCEECGKA FTFSSTLNTH KRIHTGEKPY TCEECGKAFS LPSTFTYHKR
410 420 430 440 450
THTGEKPYKC EECGKAFNCS STLKKHKIIH TGEKLYKCKE CGKAFTFSST
460 470 480 490
LNTHKRIHTG EKPYKCEECD QTFKWHSSLA NHKNMHTGEK PYKYE
Length:495
Mass (Da):57,006
Last modified:March 21, 2012 - v4
Checksum:i0EDE6E44362C630A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131575 mRNA. No translation available.
AC092175 Genomic DNA. No translation available.
CCDSiCCDS55112.1.
RefSeqiNP_001152751.1. NM_001159279.1.
UniGeneiHs.533121.

Genome annotation databases

EnsembliENST00000420713; ENSP00000394248; ENSG00000182111.
GeneIDi441234.
KEGGihsa:441234.
UCSCiuc011kdi.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131575 mRNA. No translation available.
AC092175 Genomic DNA. No translation available.
CCDSiCCDS55112.1.
RefSeqiNP_001152751.1. NM_001159279.1.
UniGeneiHs.533121.

3D structure databases

ProteinModelPortaliA6NP11.
SMRiA6NP11.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi137285. 1 interactor.
STRINGi9606.ENSP00000394248.

PTM databases

iPTMnetiA6NP11.
PhosphoSitePlusiA6NP11.

Polymorphism and mutation databases

BioMutaiZNF716.

Proteomic databases

MaxQBiA6NP11.
PaxDbiA6NP11.
PRIDEiA6NP11.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000420713; ENSP00000394248; ENSG00000182111.
GeneIDi441234.
KEGGihsa:441234.
UCSCiuc011kdi.2. human.

Organism-specific databases

CTDi441234.
GeneCardsiZNF716.
HGNCiHGNC:32458. ZNF716.
neXtProtiNX_A6NP11.
OpenTargetsiENSG00000182111.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiA6NP11.
KOiK09228.
OMAiVKKCCKS.
OrthoDBiEOG091G02KC.
PhylomeDBiA6NP11.
TreeFamiTF342117.

Enzyme and pathway databases

BioCyciZFISH:G66-30757-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii441234.
PROiA6NP11.

Gene expression databases

CleanExiHS_ZNF716.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 11 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN716_HUMAN
AccessioniPrimary (citable) accession number: A6NP11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 21, 2012
Last modified: November 2, 2016
This is version 81 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.