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A6NNW6 (ENO4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Enolase-like protein ENO4
Gene names
Name:ENO4
Synonyms:C10orf134
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the enolase family.

Caution

Although it belongs to the enolase family, Leu-362 is present instead of the conserved Glu which is expected to be an active site residue. It is therefore unsure whether this protein has enolase activity.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentphosphopyruvate hydratase complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: InterPro

phosphopyruvate hydratase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A6NNW6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A6NNW6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     56-333: Missing.
     409-450: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 628628Enolase-like protein ENO4
PRO_0000348454

Regions

Compositional bias189 – 23143Pro-rich

Natural variations

Alternative sequence56 – 333278Missing in isoform 2.
VSP_038263
Alternative sequence409 – 45042Missing in isoform 2.
VSP_038264

Experimental info

Sequence conflict321V → I in BX647301. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: B18C91E2B81A19DA

FASTA62868,821
        10         20         30         40         50         60 
MEEEGGGRSC GTTRELQKLK QQAMEYYREN DVPRRLEELL NSTFYLQPAD VYGHLKANCF 

        70         80         90        100        110        120 
SKLAKPPTIC KIVGKDVLDG LGLPTLQVDI FCTIQNFPKN VCSVVISTHF EVHENALPEL 

       130        140        150        160        170        180 
AKAEEAERAS AVSTAVQWVN STITHELQGM APSDQAEVDH LLRIFFASKV QEDKGRKELE 

       190        200        210        220        230        240 
KSLEYSTVPT PLPPVPPPPP PPPPTKKKGQ KPGRKDTITE KPIAPAEPVE PVLSGSMAIG 

       250        260        270        280        290        300 
AVSLAVAKAC AMLLNKPLYL NIALLKHNQE QPTTLSMPLL MVSLVSCGKS SSGKLNLMKE 

       310        320        330        340        350        360 
VICIPHPELT TKQGVEMLME MQKHINKIIE MMPPSPPKAE TKKGHDGSKR GQQQITGKMS 

       370        380        390        400        410        420 
HLGCLTINCD SIEQPLLLIQ EICANLGLEL GTNLHLAINC AGHELMDYNK GKYEVIMGTY 

       430        440        450        460        470        480 
KNAAEMVDLY VDLINKYPSI IALIDPFRKE DSEQWDSIYH ALGSRCYIIA GTASKSISKL 

       490        500        510        520        530        540 
LEQGNISIPK SNGLIIKHTN QTTMSDLVEI TNLIDSKKHI TVFGSTEGES SDDSLVDLAV 

       550        560        570        580        590        600 
GLGVRFIKLG GLSRGERVTK YNRLLTIEEE LVQNGTLGFK EEHTFFYFNE EAEKAAEALE 

       610        620 
AAAAREPLVP TFPTQGVEES AETGASSG 

« Hide

Isoform 2 [UniParc].

Checksum: 454F89A2A13D18AC
Show »

FASTA30833,793

References

[1]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX647301 mRNA. No translation available.
AC023283 Genomic DNA. No translation available.
UniGeneHs.693248.

3D structure databases

ProteinModelPortalA6NNW6.
SMRA6NNW6. Positions 67-577.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbA6NNW6.
PRIDEA6NNW6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000409522; ENSP00000387194; ENSG00000188316. [A6NNW6-2]
UCSCuc001lcw.3. human. [A6NNW6-2]
uc021pzj.1. human. [A6NNW6-1]

Organism-specific databases

GeneCardsGC10P118599.
H-InvDBHIX0026101.
HGNCHGNC:31670. ENO4.
HPAHPA037937.
neXtProtNX_A6NNW6.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0148.
HOGENOMHOG000168691.
HOVERGENHBG107850.
InParanoidA6NNW6.
PhylomeDBA6NNW6.
TreeFamTF354238.

Gene expression databases

ArrayExpressA6NNW6.
BgeeA6NNW6.
GenevestigatorA6NNW6.

Family and domain databases

InterProIPR000941. Enolase.
IPR020810. Enolase_C.
IPR020811. Enolase_N.
[Graphical view]
PANTHERPTHR11902. PTHR11902. 1 hit.
PfamPF00113. Enolase_C. 1 hit.
PF03952. Enolase_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROA6NNW6.

Entry information

Entry nameENO4_HUMAN
AccessionPrimary (citable) accession number: A6NNW6
Secondary accession number(s): B8ZZN9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 15, 2008
Last modified: April 16, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM