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A6NNW6

- ENO4_HUMAN

UniProt

A6NNW6 - ENO4_HUMAN

Protein

Enolase-like protein ENO4

Gene

ENO4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. magnesium ion binding Source: InterPro
    2. phosphopyruvate hydratase activity Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enolase-like protein ENO4
    Gene namesi
    Name:ENO4
    Synonyms:C10orf134
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:31670. ENO4.

    Subcellular locationi

    GO - Cellular componenti

    1. phosphopyruvate hydratase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 628628Enolase-like protein ENO4PRO_0000348454Add
    BLAST

    Proteomic databases

    PaxDbiA6NNW6.
    PRIDEiA6NNW6.

    Expressioni

    Gene expression databases

    ArrayExpressiA6NNW6.
    BgeeiA6NNW6.
    GenevestigatoriA6NNW6.

    Organism-specific databases

    HPAiHPA037937.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NNW6.
    SMRiA6NNW6. Positions 67-588.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi189 – 23143Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the enolase family.Curated

    Phylogenomic databases

    eggNOGiCOG0148.
    HOGENOMiHOG000168691.
    HOVERGENiHBG107850.
    InParanoidiA6NNW6.
    PhylomeDBiA6NNW6.
    TreeFamiTF354238.

    Family and domain databases

    Gene3Di3.20.20.120. 1 hit.
    3.30.390.10. 2 hits.
    InterProiIPR000941. Enolase.
    IPR020810. Enolase_C.
    IPR029065. Enolase_C-like.
    IPR020811. Enolase_N.
    IPR029017. Enolase_N_like.
    [Graphical view]
    PANTHERiPTHR11902. PTHR11902. 1 hit.
    PfamiPF00113. Enolase_C. 1 hit.
    PF03952. Enolase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 2 hits.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A6NNW6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEEGGGRSC GTTRELQKLK QQAMEYYREN DVPRRLEELL NSTFYLQPAD    50
    VYGHLKANCF SKLAKPPTIC KIVGKDVLDG LGLPTLQVDI FCTIQNFPKN 100
    VCSVVISTHF EVHENALPEL AKAEEAERAS AVSTAVQWVN STITHELQGM 150
    APSDQAEVDH LLRIFFASKV QEDKGRKELE KSLEYSTVPT PLPPVPPPPP 200
    PPPPTKKKGQ KPGRKDTITE KPIAPAEPVE PVLSGSMAIG AVSLAVAKAC 250
    AMLLNKPLYL NIALLKHNQE QPTTLSMPLL MVSLVSCGKS SSGKLNLMKE 300
    VICIPHPELT TKQGVEMLME MQKHINKIIE MMPPSPPKAE TKKGHDGSKR 350
    GQQQITGKMS HLGCLTINCD SIEQPLLLIQ EICANLGLEL GTNLHLAINC 400
    AGHELMDYNK GKYEVIMGTY KNAAEMVDLY VDLINKYPSI IALIDPFRKE 450
    DSEQWDSIYH ALGSRCYIIA GTASKSISKL LEQGNISIPK SNGLIIKHTN 500
    QTTMSDLVEI TNLIDSKKHI TVFGSTEGES SDDSLVDLAV GLGVRFIKLG 550
    GLSRGERVTK YNRLLTIEEE LVQNGTLGFK EEHTFFYFNE EAEKAAEALE 600
    AAAAREPLVP TFPTQGVEES AETGASSG 628
    Length:628
    Mass (Da):68,821
    Last modified:January 15, 2008 - v2
    Checksum:iB18C91E2B81A19DA
    GO
    Isoform 2 (identifier: A6NNW6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         56-333: Missing.
         409-450: Missing.

    Show »
    Length:308
    Mass (Da):33,793
    Checksum:i454F89A2A13D18AC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321V → I in BX647301. (PubMed:17974005)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei56 – 333278Missing in isoform 2. 1 PublicationVSP_038263Add
    BLAST
    Alternative sequencei409 – 45042Missing in isoform 2. 1 PublicationVSP_038264Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX647301 mRNA. No translation available.
    AC023283 Genomic DNA. No translation available.
    UniGeneiHs.693248.

    Genome annotation databases

    EnsembliENST00000409522; ENSP00000387194; ENSG00000188316. [A6NNW6-2]
    UCSCiuc001lcw.3. human. [A6NNW6-2]
    uc021pzj.1. human. [A6NNW6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX647301 mRNA. No translation available.
    AC023283 Genomic DNA. No translation available.
    UniGenei Hs.693248.

    3D structure databases

    ProteinModelPortali A6NNW6.
    SMRi A6NNW6. Positions 67-588.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi A6NNW6.
    PRIDEi A6NNW6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000409522 ; ENSP00000387194 ; ENSG00000188316 . [A6NNW6-2 ]
    UCSCi uc001lcw.3. human. [A6NNW6-2 ]
    uc021pzj.1. human. [A6NNW6-1 ]

    Organism-specific databases

    GeneCardsi GC10P118599.
    H-InvDB HIX0026101.
    HGNCi HGNC:31670. ENO4.
    HPAi HPA037937.
    neXtProti NX_A6NNW6.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0148.
    HOGENOMi HOG000168691.
    HOVERGENi HBG107850.
    InParanoidi A6NNW6.
    PhylomeDBi A6NNW6.
    TreeFami TF354238.

    Miscellaneous databases

    PROi A6NNW6.

    Gene expression databases

    ArrayExpressi A6NNW6.
    Bgeei A6NNW6.
    Genevestigatori A6NNW6.

    Family and domain databases

    Gene3Di 3.20.20.120. 1 hit.
    3.30.390.10. 2 hits.
    InterProi IPR000941. Enolase.
    IPR020810. Enolase_C.
    IPR029065. Enolase_C-like.
    IPR020811. Enolase_N.
    IPR029017. Enolase_N_like.
    [Graphical view ]
    PANTHERi PTHR11902. PTHR11902. 1 hit.
    Pfami PF00113. Enolase_C. 1 hit.
    PF03952. Enolase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51604. SSF51604. 1 hit.
    SSF54826. SSF54826. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiENO4_HUMAN
    AccessioniPrimary (citable) accession number: A6NNW6
    Secondary accession number(s): B8ZZN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 59 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Although it belongs to the enolase family, Leu-362 is present instead of the conserved Glu which is expected to be an active site residue. It is therefore unsure whether this protein has enolase activity.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3