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Protein

Enolase-like protein ENO4

Gene

ENO4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Enolase-like protein ENO4
Gene namesi
Name:ENO4
Synonyms:C10orf134
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:31670. ENO4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 628628Enolase-like protein ENO4PRO_0000348454Add
BLAST

Proteomic databases

PaxDbiA6NNW6.
PRIDEiA6NNW6.

Expressioni

Gene expression databases

BgeeiA6NNW6.
ExpressionAtlasiA6NNW6. baseline.

Organism-specific databases

HPAiHPA037938.
HPA061509.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345555.

Structurei

3D structure databases

ProteinModelPortaliA6NNW6.
SMRiA6NNW6. Positions 235-571.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi189 – 23143Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the enolase family.Curated

Phylogenomic databases

eggNOGiCOG0148.
GeneTreeiENSGT00550000074560.
HOGENOMiHOG000168691.
HOVERGENiHBG107850.
InParanoidiA6NNW6.
PhylomeDBiA6NNW6.
TreeFamiTF354238.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 2 hits.
InterProiIPR000941. Enolase.
IPR020810. Enolase_C.
IPR029065. Enolase_C-like.
IPR020811. Enolase_N.
IPR029017. Enolase_N_like.
[Graphical view]
PANTHERiPTHR11902. PTHR11902. 1 hit.
PfamiPF00113. Enolase_C. 1 hit.
PF03952. Enolase_N. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NNW6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEEGGGRSC GTTRELQKLK QQAMEYYREN DVPRRLEELL NSTFYLQPAD
60 70 80 90 100
VYGHLKANCF SKLAKPPTIC KIVGKDVLDG LGLPTLQVDI FCTIQNFPKN
110 120 130 140 150
VCSVVISTHF EVHENALPEL AKAEEAERAS AVSTAVQWVN STITHELQGM
160 170 180 190 200
APSDQAEVDH LLRIFFASKV QEDKGRKELE KSLEYSTVPT PLPPVPPPPP
210 220 230 240 250
PPPPTKKKGQ KPGRKDTITE KPIAPAEPVE PVLSGSMAIG AVSLAVAKAC
260 270 280 290 300
AMLLNKPLYL NIALLKHNQE QPTTLSMPLL MVSLVSCGKS SSGKLNLMKE
310 320 330 340 350
VICIPHPELT TKQGVEMLME MQKHINKIIE MMPPSPPKAE TKKGHDGSKR
360 370 380 390 400
GQQQITGKMS HLGCLTINCD SIEQPLLLIQ EICANLGLEL GTNLHLAINC
410 420 430 440 450
AGHELMDYNK GKYEVIMGTY KNAAEMVDLY VDLINKYPSI IALIDPFRKE
460 470 480 490 500
DSEQWDSIYH ALGSRCYIIA GTASKSISKL LEQGNISIPK SNGLIIKHTN
510 520 530 540 550
QTTMSDLVEI TNLIDSKKHI TVFGSTEGES SDDSLVDLAV GLGVRFIKLG
560 570 580 590 600
GLSRGERVTK YNRLLTIEEE LVQNGTLGFK EEHTFFYFNE EAEKAAEALE
610 620
AAAAREPLVP TFPTQGVEES AETGASSG
Length:628
Mass (Da):68,821
Last modified:January 15, 2008 - v2
Checksum:iB18C91E2B81A19DA
GO
Isoform 2 (identifier: A6NNW6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     56-333: Missing.
     409-450: Missing.

Show »
Length:308
Mass (Da):33,793
Checksum:i454F89A2A13D18AC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321V → I in BX647301 (PubMed:17974005).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei56 – 333278Missing in isoform 2. 1 PublicationVSP_038263Add
BLAST
Alternative sequencei409 – 45042Missing in isoform 2. 1 PublicationVSP_038264Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX647301 mRNA. No translation available.
AC023283 Genomic DNA. No translation available.
UniGeneiHs.693248.

Genome annotation databases

EnsembliENST00000409522; ENSP00000387194; ENSG00000188316. [A6NNW6-2]
UCSCiuc001lcw.3. human. [A6NNW6-2]
uc021pzj.1. human. [A6NNW6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX647301 mRNA. No translation available.
AC023283 Genomic DNA. No translation available.
UniGeneiHs.693248.

3D structure databases

ProteinModelPortaliA6NNW6.
SMRiA6NNW6. Positions 235-571.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000345555.

Proteomic databases

PaxDbiA6NNW6.
PRIDEiA6NNW6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409522; ENSP00000387194; ENSG00000188316. [A6NNW6-2]
UCSCiuc001lcw.3. human. [A6NNW6-2]
uc021pzj.1. human. [A6NNW6-1]

Organism-specific databases

GeneCardsiGC10P118599.
H-InvDBHIX0026101.
HGNCiHGNC:31670. ENO4.
HPAiHPA037938.
HPA061509.
neXtProtiNX_A6NNW6.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0148.
GeneTreeiENSGT00550000074560.
HOGENOMiHOG000168691.
HOVERGENiHBG107850.
InParanoidiA6NNW6.
PhylomeDBiA6NNW6.
TreeFamiTF354238.

Miscellaneous databases

PROiA6NNW6.

Gene expression databases

BgeeiA6NNW6.
ExpressionAtlasiA6NNW6. baseline.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 2 hits.
InterProiIPR000941. Enolase.
IPR020810. Enolase_C.
IPR029065. Enolase_C-like.
IPR020811. Enolase_N.
IPR029017. Enolase_N_like.
[Graphical view]
PANTHERiPTHR11902. PTHR11902. 1 hit.
PfamiPF00113. Enolase_C. 1 hit.
PF03952. Enolase_N. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiENO4_HUMAN
AccessioniPrimary (citable) accession number: A6NNW6
Secondary accession number(s): B8ZZN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: January 15, 2008
Last modified: June 24, 2015
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Although it belongs to the enolase family, Leu-362 is present instead of the conserved Glu which is expected to be an active site residue. It is therefore unsure whether this protein has enolase activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.