A6NNW6 (ENO4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Enolase-like protein ENO4

Gene names

Name:	ENO4
Synonyms:	C10orf134

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	628 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the enolase family.
Caution	Although it is highly related to enolase enzyme family, lacks the conserved Glu active site at position 353, which is replaced by a Gln residue. It is therefore unsure whether it has enolase activity.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: InterPro
Cellular component	phosphopyruvate hydratase complex Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphopyruvate hydratase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6NNW6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A6NNW6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     56-333: Missing.
     409-450: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 628	628	Enolase-like protein ENO4		PRO_0000348454
Regions
	Compositional bias	189 – 231	43	Pro-rich
Natural variations
	Alternative sequence	56 – 333	278	Missing in isoform 2.		VSP_038263
	Alternative sequence	409 – 450	42	Missing in isoform 2.		VSP_038264
Experimental info
	Sequence conflict	32	1	V → I in BX647301. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: B18C91E2B81A19DA	FASTA	628	68,821
	10 20 30 40 50 60 MEEEGGGRSC GTTRELQKLK QQAMEYYREN DVPRRLEELL NSTFYLQPAD VYGHLKANCF 70 80 90 100 110 120 SKLAKPPTIC KIVGKDVLDG LGLPTLQVDI FCTIQNFPKN VCSVVISTHF EVHENALPEL 130 140 150 160 170 180 AKAEEAERAS AVSTAVQWVN STITHELQGM APSDQAEVDH LLRIFFASKV QEDKGRKELE 190 200 210 220 230 240 KSLEYSTVPT PLPPVPPPPP PPPPTKKKGQ KPGRKDTITE KPIAPAEPVE PVLSGSMAIG 250 260 270 280 290 300 AVSLAVAKAC AMLLNKPLYL NIALLKHNQE QPTTLSMPLL MVSLVSCGKS SSGKLNLMKE 310 320 330 340 350 360 VICIPHPELT TKQGVEMLME MQKHINKIIE MMPPSPPKAE TKKGHDGSKR GQQQITGKMS 370 380 390 400 410 420 HLGCLTINCD SIEQPLLLIQ EICANLGLEL GTNLHLAINC AGHELMDYNK GKYEVIMGTY 430 440 450 460 470 480 KNAAEMVDLY VDLINKYPSI IALIDPFRKE DSEQWDSIYH ALGSRCYIIA GTASKSISKL 490 500 510 520 530 540 LEQGNISIPK SNGLIIKHTN QTTMSDLVEI TNLIDSKKHI TVFGSTEGES SDDSLVDLAV 550 560 570 580 590 600 GLGVRFIKLG GLSRGERVTK YNRLLTIEEE LVQNGTLGFK EEHTFFYFNE EAEKAAEALE 610 620 AAAAREPLVP TFPTQGVEES AETGASSG
	Isoform 2 [UniParc]. Checksum: 454F89A2A13D18AC	FASTA	308	33,793
	10 20 30 40 50 60 MEEEGGGRSC GTTRELQKLK QQAMEYYREN DVPRRLEELL NSTFYLQPAD VYGHLPSPPK 70 80 90 100 110 120 AETKKGHDGS KRGQQQITGK MSHLGCLTIN CDSIEQPLLL IQEICANLGL ELGTNLHLAI 130 140 150 160 170 180 NCAGHELMDY DSEQWDSIYH ALGSRCYIIA GTASKSISKL LEQGNISIPK SNGLIIKHTN 190 200 210 220 230 240 QTTMSDLVEI TNLIDSKKHI TVFGSTEGES SDDSLVDLAV GLGVRFIKLG GLSRGERVTK 250 260 270 280 290 300 YNRLLTIEEE LVQNGTLGFK EEHTFFYFNE EAEKAAEALE AAAAREPLVP TFPTQGVEES AETGASSG

References

[1]

"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

[2]

"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX647301 mRNA. No translation available. AC023283 Genomic DNA. No translation available.
IPI	IPI00888542. IPI00953311.
UniGene	Hs.696001.
3D structure databases
ProteinModelPortal	A6NNW6.
SMR	A6NNW6. Positions 67-577.
ModBase	Search...
Proteomic databases
PRIDE	A6NNW6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341276; ENSP00000345555; ENSG00000188316. ENST00000409522; ENSP00000387194; ENSG00000188316.
Organism-specific databases
GeneCards	GC10P118599.
HGNC	HGNC:31670. ENO4.
HPA	HPA037937.
neXtProt	NX_A6NNW6.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00550000074560.
HOGENOM	HBG505206.
HOVERGEN	HBG107850.
InParanoid	A6NNW6.
OrthoDB	EOG4ZCT45.
PhylomeDB	A6NNW6.
Gene expression databases
Bgee	A6NNW6.
Genevestigator	A6NNW6.
Family and domain databases
InterPro	IPR000941. Enolase. IPR020810. Enolase_C. IPR020811. Enolase_N. [Graphical view]
PANTHER	PTHR11902. Enolase. 1 hit.
Pfam	PF00113. Enolase_C. 1 hit. PF03952. Enolase_N. 1 hit. [Graphical view]
PROSITE	PS00164. ENOLASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ENO4_HUMAN

Accession

Primary (citable) accession number: A6NNW6
Secondary accession number(s): B8ZZN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 38 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.