Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dehydrogenase/reductase SDR family member 7C

Gene

DHRS7C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Putative oxidoreductase.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei192 – 1921Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 6525NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7C (EC:1.1.-.-)
Alternative name(s):
Short-chain dehydrogenase/reductase family 32C member 21 Publication
Gene namesi
Name:DHRS7C
Synonyms:SDR32C21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:32423. DHRS7C.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiDHRS7C.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 312294Dehydrogenase/reductase SDR family member 7CPRO_0000333755Add
BLAST

Proteomic databases

PaxDbiA6NNS2.
PRIDEiA6NNS2.

PTM databases

iPTMnetiA6NNS2.
PhosphoSiteiA6NNS2.

Expressioni

Gene expression databases

BgeeiA6NNS2.
CleanExiHS_DHRS7C.
ExpressionAtlasiA6NNS2. baseline and differential.
GenevisibleiA6NNS2. HS.

Organism-specific databases

HPAiHPA027113.
HPA029558.

Interactioni

Protein-protein interaction databases

BioGridi128363. 1 interaction.
STRINGi9606.ENSP00000327975.

Structurei

3D structure databases

ProteinModelPortaliA6NNS2.
SMRiA6NNS2. Positions 31-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00840000129712.
HOVERGENiHBG107825.
InParanoidiA6NNS2.
KOiK11167.
OMAiDISCVQD.
PhylomeDBiA6NNS2.
TreeFamiTF313474.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NNS2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVMAMLMLP LLLLGISGLL FIYQEVSRLW SKSAVQNKVV VITDAISGLG
60 70 80 90 100
KECARVFHTG GARLVLCGKN WERLENLYDA LISVADPSKQ TFTPKLVLLD
110 120 130 140 150
LSDISCVPDV AKEVLDCYGC VDILINNASV KVKGPAHKIS LELDKKIMDA
160 170 180 190 200
NYFGPITLTK ALLPNMISRR TGQIVLVNNI QGKFGIPFRT TYAASKHAAL
210 220 230 240 250
GFFDCLRAEV EEYDVVISTV SPTFIRSYHV YPEQGNWEAS IWKFFFRKLT
260 270 280 290 300
YGVHPVEVAE EVMRTVRRKK QEVFMANPIP KAAVYVRTFF PEFFFAVVAC
310
GVKEKLNVPE EG
Length:312
Mass (Da):34,878
Last modified:July 22, 2008 - v3
Checksum:iADCE06D480B40E00
GO
Isoform 2 (identifier: A6NNS2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-90: Missing.

Show »
Length:311
Mass (Da):34,750
Checksum:i209D0412BB9524F6
GO

Sequence cautioni

The sequence AAI47025.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI47026.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti227 – 2271S → L.
Corresponds to variant rs2280490 [ dbSNP | Ensembl ].
VAR_043150

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei90 – 901Missing in isoform 2. 1 PublicationVSP_054852

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027045 Genomic DNA. No translation available.
BC147024 mRNA. Translation: AAI47025.1. Different initiation.
BC147025 mRNA. Translation: AAI47026.1. Different initiation.
BC171909 mRNA. Translation: AAI71909.1.
CCDSiCCDS56020.1. [A6NNS2-1]
CCDS58517.1. [A6NNS2-2]
RefSeqiNP_001099041.1. NM_001105571.2. [A6NNS2-2]
NP_001207422.1. NM_001220493.1. [A6NNS2-1]
XP_005256567.1. XM_005256510.2. [A6NNS2-1]
XP_005256568.1. XM_005256511.2. [A6NNS2-2]
UniGeneiHs.61684.

Genome annotation databases

EnsembliENST00000330255; ENSP00000327975; ENSG00000184544. [A6NNS2-1]
ENST00000571134; ENSP00000459579; ENSG00000184544. [A6NNS2-2]
GeneIDi201140.
KEGGihsa:201140.
UCSCiuc010cof.4. human. [A6NNS2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027045 Genomic DNA. No translation available.
BC147024 mRNA. Translation: AAI47025.1. Different initiation.
BC147025 mRNA. Translation: AAI47026.1. Different initiation.
BC171909 mRNA. Translation: AAI71909.1.
CCDSiCCDS56020.1. [A6NNS2-1]
CCDS58517.1. [A6NNS2-2]
RefSeqiNP_001099041.1. NM_001105571.2. [A6NNS2-2]
NP_001207422.1. NM_001220493.1. [A6NNS2-1]
XP_005256567.1. XM_005256510.2. [A6NNS2-1]
XP_005256568.1. XM_005256511.2. [A6NNS2-2]
UniGeneiHs.61684.

3D structure databases

ProteinModelPortaliA6NNS2.
SMRiA6NNS2. Positions 31-262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128363. 1 interaction.
STRINGi9606.ENSP00000327975.

PTM databases

iPTMnetiA6NNS2.
PhosphoSiteiA6NNS2.

Polymorphism and mutation databases

BioMutaiDHRS7C.

Proteomic databases

PaxDbiA6NNS2.
PRIDEiA6NNS2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330255; ENSP00000327975; ENSG00000184544. [A6NNS2-1]
ENST00000571134; ENSP00000459579; ENSG00000184544. [A6NNS2-2]
GeneIDi201140.
KEGGihsa:201140.
UCSCiuc010cof.4. human. [A6NNS2-1]

Organism-specific databases

CTDi201140.
GeneCardsiDHRS7C.
HGNCiHGNC:32423. DHRS7C.
HPAiHPA027113.
HPA029558.
MIMi616161. gene.
neXtProtiNX_A6NNS2.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1205. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00840000129712.
HOVERGENiHBG107825.
InParanoidiA6NNS2.
KOiK11167.
OMAiDISCVQD.
PhylomeDBiA6NNS2.
TreeFamiTF313474.

Miscellaneous databases

GenomeRNAii201140.
PROiA6NNS2.
SOURCEiSearch...

Gene expression databases

BgeeiA6NNS2.
CleanExiHS_DHRS7C.
ExpressionAtlasiA6NNS2. baseline and differential.
GenevisibleiA6NNS2. HS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  3. Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiDRS7C_HUMAN
AccessioniPrimary (citable) accession number: A6NNS2
Secondary accession number(s): B7ZW74, B9EJH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 22, 2008
Last modified: June 8, 2016
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.