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A6NNN8 (S38A8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative sodium-coupled neutral amino acid transporter 8
Alternative name(s):
Solute carrier family 38 member 8
Gene names
Name:SLC38A8
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Putative sodium-dependent amino acid/proton antiporter By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the amino acid/polyamine transporter 2 family.

Ontologies

Keywords
   Biological processAmino-acid transport
Ion transport
Sodium transport
Transport
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processamino acid transport

Inferred from electronic annotation. Source: UniProtKB-KW

sodium ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 435435Putative sodium-coupled neutral amino acid transporter 8
PRO_0000319593

Regions

Transmembrane29 – 4921Helical; Potential
Transmembrane55 – 7521Helical; Potential
Transmembrane100 – 12021Helical; Potential
Transmembrane151 – 17121Helical; Potential
Transmembrane178 – 19821Helical; Potential
Transmembrane218 – 24023Helical; Potential
Transmembrane250 – 27021Helical; Potential
Transmembrane295 – 31521Helical; Potential
Transmembrane348 – 36821Helical; Potential
Transmembrane374 – 39421Helical; Potential
Transmembrane410 – 43021Helical; Potential

Natural variations

Natural variant2201S → T.
Corresponds to variant rs11862366 [ dbSNP | Ensembl ].
VAR_048125

Sequences

Sequence LengthMass (Da)Tools
A6NNN8 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: BFB558790F654F9F

FASTA43546,731
        10         20         30         40         50         60 
MEGQTPGSRG LPEKPHPATA AATLSSMGAV FILMKSALGA GLLNFPWAFS KAGGVVPAFL 

        70         80         90        100        110        120 
VELVSLVFLI SGLVILGYAA AVSGQATYQG VVRGLCGPAI GKLCEACFLL NLLMISVAFL 

       130        140        150        160        170        180 
RVIGDQLEKL CDSLLSGTPP APQPWYADQR FTLPLLSVLV ILPLSAPREI AFQKYTSILG 

       190        200        210        220        230        240 
TLAACYLALV ITVQYYLWPQ GLVRESHPSL SPASWTSVFS VFPTICFGFQ CHEAAVSIYC 

       250        260        270        280        290        300 
SMRKRSLSHW ALVSVLSLLA CCLIYSLTGV YGFLTFGTEV SADVLMSYPG NDMVIIVARV 

       310        320        330        340        350        360 
LFAVSIVTVY PIVLFLGRSV MQDFWRRSCL GGWGPSALAD PSGLWVRMPL TILWVTVTLA 

       370        380        390        400        410        420 
MALFMPDLSE IVSIIGGISS FFIFIFPGLC LICAMGVEPI GPRVKCCLEV WGVVSVLVGT 

       430 
FIFGQSTAAA VWEMF 

« Hide

References

[1]"The sequence and analysis of duplication-rich human chromosome 16."
Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. expand/collapse author list , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC040169 Genomic DNA. No translation available.
CCDSCCDS32495.1.
RefSeqNP_001073911.1. NM_001080442.1.
XP_006721198.1. XM_006721135.1.
UniGeneHs.461575.

3D structure databases

ProteinModelPortalA6NNN8.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB2.A.18.6.12. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSiteA6NNN8.

Proteomic databases

PaxDbA6NNN8.
PRIDEA6NNN8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000299709; ENSP00000299709; ENSG00000166558.
GeneID146167.
KEGGhsa:146167.
UCSCuc002fhg.1. human.

Organism-specific databases

CTD146167.
GeneCardsGC16M084043.
HGNCHGNC:32434. SLC38A8.
neXtProtNX_A6NNN8.
PharmGKBPA162403773.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0814.
HOGENOMHOG000008036.
HOVERGENHBG055999.
InParanoidA6NNN8.
KOK14994.
OMAIFGQSTV.
OrthoDBEOG769ZJG.
PhylomeDBA6NNN8.
TreeFamTF328787.

Gene expression databases

BgeeA6NNN8.
CleanExHS_SLC38A8.
GenevestigatorA6NNN8.

Family and domain databases

InterProIPR013057. AA_transpt_TM.
[Graphical view]
PfamPF01490. Aa_trans. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi146167.
NextBio85262.
PROA6NNN8.

Entry information

Entry nameS38A8_HUMAN
AccessionPrimary (citable) accession number: A6NNN8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM