A6NNN8 (S38A8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative sodium-coupled neutral amino acid transporter 8

Gene names

Name:

SLC38A8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	435 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Putative sodium-dependent amino acid/proton antiporter By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the amino acid/polyamine transporter 2 family.

Ontologies

Keywords
Biological process	Amino-acid transport Ion transport Sodium transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	amino acid transport Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 435	435	Putative sodium-coupled neutral amino acid transporter 8		PRO_0000319593
Regions
	Transmembrane	29 – 49	21	Helical; Potential
	Transmembrane	55 – 75	21	Helical; Potential
	Transmembrane	100 – 120	21	Helical; Potential
	Transmembrane	151 – 171	21	Helical; Potential
	Transmembrane	178 – 198	21	Helical; Potential
	Transmembrane	218 – 240	23	Helical; Potential
	Transmembrane	250 – 270	21	Helical; Potential
	Transmembrane	295 – 315	21	Helical; Potential
	Transmembrane	348 – 368	21	Helical; Potential
	Transmembrane	374 – 394	21	Helical; Potential
	Transmembrane	410 – 430	21	Helical; Potential
Natural variations
	Natural variant	220	1	S → T. Corresponds to variant rs11862366 [ dbSNP | Ensembl ].		VAR_048125

Sequences

	Sequence		Length	Mass (Da)
	A6NNN8 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: BFB558790F654F9F	FASTA	435	46,731
	10 20 30 40 50 60 MEGQTPGSRG LPEKPHPATA AATLSSMGAV FILMKSALGA GLLNFPWAFS KAGGVVPAFL 70 80 90 100 110 120 VELVSLVFLI SGLVILGYAA AVSGQATYQG VVRGLCGPAI GKLCEACFLL NLLMISVAFL 130 140 150 160 170 180 RVIGDQLEKL CDSLLSGTPP APQPWYADQR FTLPLLSVLV ILPLSAPREI AFQKYTSILG 190 200 210 220 230 240 TLAACYLALV ITVQYYLWPQ GLVRESHPSL SPASWTSVFS VFPTICFGFQ CHEAAVSIYC 250 260 270 280 290 300 SMRKRSLSHW ALVSVLSLLA CCLIYSLTGV YGFLTFGTEV SADVLMSYPG NDMVIIVARV 310 320 330 340 350 360 LFAVSIVTVY PIVLFLGRSV MQDFWRRSCL GGWGPSALAD PSGLWVRMPL TILWVTVTLA 370 380 390 400 410 420 MALFMPDLSE IVSIIGGISS FFIFIFPGLC LICAMGVEPI GPRVKCCLEV WGVVSVLVGT 430 FIFGQSTAAA VWEMF

References

[1]

"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC040169 Genomic DNA. No translation available.
IPI	IPI00094624.
RefSeq	NP_001073911.1. NM_001080442.1.
UniGene	Hs.461575.
3D structure databases
ProteinModelPortal	A6NNN8.
ModBase	Search...
PTM databases
PhosphoSite	A6NNN8.
Proteomic databases
PaxDb	A6NNN8.
PRIDE	A6NNN8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000299709; ENSP00000299709; ENSG00000166558.
GeneID	146167.
KEGG	hsa:146167.
UCSC	uc002fhg.1. human.
Organism-specific databases
CTD	146167.
GeneCards	GC16M084043.
HGNC	HGNC:32434. SLC38A8.
neXtProt	NX_A6NNN8.
PharmGKB	PA162403773.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0814.
HOGENOM	HOG000008036.
HOVERGEN	HBG055999.
InParanoid	A6NNN8.
KO	K14994.
OMA	IFGQSTV.
OrthoDB	EOG490798.
Gene expression databases
ArrayExpress	A6NNN8.
Bgee	A6NNN8.
CleanEx	HS_SLC38A8.
Genevestigator	A6NNN8.
Family and domain databases
InterPro	IPR013057. AA_transpt_TM. [Graphical view]
Pfam	PF01490. Aa_trans. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	146167.
NextBio	85262.

Entry information

Entry name

S38A8_HUMAN

Accession

Primary (citable) accession number: A6NNN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 24, 2007
Last modified:	April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.