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A6NNN8

- S38A8_HUMAN

UniProt

A6NNN8 - S38A8_HUMAN

Protein

Putative sodium-coupled neutral amino acid transporter 8

Gene

SLC38A8

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Putative sodium-dependent amino acid/proton antiporter.By similarity

    GO - Biological processi

    1. amino acid transport Source: UniProtKB-KW
    2. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Amino-acid transport, Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Protein family/group databases

    TCDBi2.A.18.6.12. the amino acid/auxin permease (aaap) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative sodium-coupled neutral amino acid transporter 8
    Alternative name(s):
    Solute carrier family 38 member 8
    Gene namesi
    Name:SLC38A8
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:32434. SLC38A8.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162403773.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435Putative sodium-coupled neutral amino acid transporter 8PRO_0000319593Add
    BLAST

    Proteomic databases

    PaxDbiA6NNN8.
    PRIDEiA6NNN8.

    PTM databases

    PhosphoSiteiA6NNN8.

    Expressioni

    Gene expression databases

    BgeeiA6NNN8.
    CleanExiHS_SLC38A8.
    GenevestigatoriA6NNN8.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NNN8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei151 – 17121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei218 – 24023HelicalSequence AnalysisAdd
    BLAST
    Transmembranei250 – 27021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei348 – 36821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei374 – 39421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei410 – 43021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0814.
    HOGENOMiHOG000008036.
    HOVERGENiHBG055999.
    InParanoidiA6NNN8.
    KOiK14994.
    OMAiIFGQSTV.
    OrthoDBiEOG769ZJG.
    PhylomeDBiA6NNN8.
    TreeFamiTF328787.

    Family and domain databases

    InterProiIPR013057. AA_transpt_TM.
    [Graphical view]
    PfamiPF01490. Aa_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NNN8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEGQTPGSRG LPEKPHPATA AATLSSMGAV FILMKSALGA GLLNFPWAFS    50
    KAGGVVPAFL VELVSLVFLI SGLVILGYAA AVSGQATYQG VVRGLCGPAI 100
    GKLCEACFLL NLLMISVAFL RVIGDQLEKL CDSLLSGTPP APQPWYADQR 150
    FTLPLLSVLV ILPLSAPREI AFQKYTSILG TLAACYLALV ITVQYYLWPQ 200
    GLVRESHPSL SPASWTSVFS VFPTICFGFQ CHEAAVSIYC SMRKRSLSHW 250
    ALVSVLSLLA CCLIYSLTGV YGFLTFGTEV SADVLMSYPG NDMVIIVARV 300
    LFAVSIVTVY PIVLFLGRSV MQDFWRRSCL GGWGPSALAD PSGLWVRMPL 350
    TILWVTVTLA MALFMPDLSE IVSIIGGISS FFIFIFPGLC LICAMGVEPI 400
    GPRVKCCLEV WGVVSVLVGT FIFGQSTAAA VWEMF 435
    Length:435
    Mass (Da):46,731
    Last modified:July 24, 2007 - v1
    Checksum:iBFB558790F654F9F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti220 – 2201S → T.
    Corresponds to variant rs11862366 [ dbSNP | Ensembl ].
    VAR_048125

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC040169 Genomic DNA. No translation available.
    CCDSiCCDS32495.1.
    RefSeqiNP_001073911.1. NM_001080442.2.
    XP_006721198.1. XM_006721135.1.
    UniGeneiHs.461575.

    Genome annotation databases

    EnsembliENST00000299709; ENSP00000299709; ENSG00000166558.
    GeneIDi146167.
    KEGGihsa:146167.
    UCSCiuc002fhg.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC040169 Genomic DNA. No translation available.
    CCDSi CCDS32495.1.
    RefSeqi NP_001073911.1. NM_001080442.2.
    XP_006721198.1. XM_006721135.1.
    UniGenei Hs.461575.

    3D structure databases

    ProteinModelPortali A6NNN8.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.18.6.12. the amino acid/auxin permease (aaap) family.

    PTM databases

    PhosphoSitei A6NNN8.

    Proteomic databases

    PaxDbi A6NNN8.
    PRIDEi A6NNN8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000299709 ; ENSP00000299709 ; ENSG00000166558 .
    GeneIDi 146167.
    KEGGi hsa:146167.
    UCSCi uc002fhg.1. human.

    Organism-specific databases

    CTDi 146167.
    GeneCardsi GC16M084043.
    HGNCi HGNC:32434. SLC38A8.
    neXtProti NX_A6NNN8.
    PharmGKBi PA162403773.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0814.
    HOGENOMi HOG000008036.
    HOVERGENi HBG055999.
    InParanoidi A6NNN8.
    KOi K14994.
    OMAi IFGQSTV.
    OrthoDBi EOG769ZJG.
    PhylomeDBi A6NNN8.
    TreeFami TF328787.

    Miscellaneous databases

    GenomeRNAii 146167.
    NextBioi 85262.
    PROi A6NNN8.

    Gene expression databases

    Bgeei A6NNN8.
    CleanExi HS_SLC38A8.
    Genevestigatori A6NNN8.

    Family and domain databases

    InterProi IPR013057. AA_transpt_TM.
    [Graphical view ]
    Pfami PF01490. Aa_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
      , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
      Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiS38A8_HUMAN
    AccessioniPrimary (citable) accession number: A6NNN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3