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A6NNN8

- S38A8_HUMAN

UniProt

A6NNN8 - S38A8_HUMAN

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Protein

Putative sodium-coupled neutral amino acid transporter 8

Gene
SLC38A8
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Putative sodium-dependent amino acid/proton antiporter By similarity.

GO - Biological processi

  1. amino acid transport Source: UniProtKB-KW
  2. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Protein family/group databases

TCDBi2.A.18.6.12. the amino acid/auxin permease (aaap) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative sodium-coupled neutral amino acid transporter 8
Alternative name(s):
Solute carrier family 38 member 8
Gene namesi
Name:SLC38A8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:32434. SLC38A8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4921Helical; Reviewed predictionAdd
BLAST
Transmembranei55 – 7521Helical; Reviewed predictionAdd
BLAST
Transmembranei100 – 12021Helical; Reviewed predictionAdd
BLAST
Transmembranei151 – 17121Helical; Reviewed predictionAdd
BLAST
Transmembranei178 – 19821Helical; Reviewed predictionAdd
BLAST
Transmembranei218 – 24023Helical; Reviewed predictionAdd
BLAST
Transmembranei250 – 27021Helical; Reviewed predictionAdd
BLAST
Transmembranei295 – 31521Helical; Reviewed predictionAdd
BLAST
Transmembranei348 – 36821Helical; Reviewed predictionAdd
BLAST
Transmembranei374 – 39421Helical; Reviewed predictionAdd
BLAST
Transmembranei410 – 43021Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162403773.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Putative sodium-coupled neutral amino acid transporter 8PRO_0000319593Add
BLAST

Proteomic databases

PaxDbiA6NNN8.
PRIDEiA6NNN8.

PTM databases

PhosphoSiteiA6NNN8.

Expressioni

Gene expression databases

BgeeiA6NNN8.
CleanExiHS_SLC38A8.
GenevestigatoriA6NNN8.

Structurei

3D structure databases

ProteinModelPortaliA6NNN8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0814.
HOGENOMiHOG000008036.
HOVERGENiHBG055999.
InParanoidiA6NNN8.
KOiK14994.
OMAiIFGQSTV.
OrthoDBiEOG769ZJG.
PhylomeDBiA6NNN8.
TreeFamiTF328787.

Family and domain databases

InterProiIPR013057. AA_transpt_TM.
[Graphical view]
PfamiPF01490. Aa_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NNN8-1 [UniParc]FASTAAdd to Basket

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MEGQTPGSRG LPEKPHPATA AATLSSMGAV FILMKSALGA GLLNFPWAFS    50
KAGGVVPAFL VELVSLVFLI SGLVILGYAA AVSGQATYQG VVRGLCGPAI 100
GKLCEACFLL NLLMISVAFL RVIGDQLEKL CDSLLSGTPP APQPWYADQR 150
FTLPLLSVLV ILPLSAPREI AFQKYTSILG TLAACYLALV ITVQYYLWPQ 200
GLVRESHPSL SPASWTSVFS VFPTICFGFQ CHEAAVSIYC SMRKRSLSHW 250
ALVSVLSLLA CCLIYSLTGV YGFLTFGTEV SADVLMSYPG NDMVIIVARV 300
LFAVSIVTVY PIVLFLGRSV MQDFWRRSCL GGWGPSALAD PSGLWVRMPL 350
TILWVTVTLA MALFMPDLSE IVSIIGGISS FFIFIFPGLC LICAMGVEPI 400
GPRVKCCLEV WGVVSVLVGT FIFGQSTAAA VWEMF 435
Length:435
Mass (Da):46,731
Last modified:July 24, 2007 - v1
Checksum:iBFB558790F654F9F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti220 – 2201S → T.
Corresponds to variant rs11862366 [ dbSNP | Ensembl ].
VAR_048125

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC040169 Genomic DNA. No translation available.
CCDSiCCDS32495.1.
RefSeqiNP_001073911.1. NM_001080442.2.
XP_006721198.1. XM_006721135.1.
UniGeneiHs.461575.

Genome annotation databases

EnsembliENST00000299709; ENSP00000299709; ENSG00000166558.
GeneIDi146167.
KEGGihsa:146167.
UCSCiuc002fhg.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC040169 Genomic DNA. No translation available.
CCDSi CCDS32495.1.
RefSeqi NP_001073911.1. NM_001080442.2.
XP_006721198.1. XM_006721135.1.
UniGenei Hs.461575.

3D structure databases

ProteinModelPortali A6NNN8.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 2.A.18.6.12. the amino acid/auxin permease (aaap) family.

PTM databases

PhosphoSitei A6NNN8.

Proteomic databases

PaxDbi A6NNN8.
PRIDEi A6NNN8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000299709 ; ENSP00000299709 ; ENSG00000166558 .
GeneIDi 146167.
KEGGi hsa:146167.
UCSCi uc002fhg.1. human.

Organism-specific databases

CTDi 146167.
GeneCardsi GC16M084043.
HGNCi HGNC:32434. SLC38A8.
neXtProti NX_A6NNN8.
PharmGKBi PA162403773.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0814.
HOGENOMi HOG000008036.
HOVERGENi HBG055999.
InParanoidi A6NNN8.
KOi K14994.
OMAi IFGQSTV.
OrthoDBi EOG769ZJG.
PhylomeDBi A6NNN8.
TreeFami TF328787.

Miscellaneous databases

GenomeRNAii 146167.
NextBioi 85262.
PROi A6NNN8.

Gene expression databases

Bgeei A6NNN8.
CleanExi HS_SLC38A8.
Genevestigatori A6NNN8.

Family and domain databases

InterProi IPR013057. AA_transpt_TM.
[Graphical view ]
Pfami PF01490. Aa_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiS38A8_HUMAN
AccessioniPrimary (citable) accession number: A6NNN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 24, 2007
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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