A6NNL0 (FA22B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM22B

Gene names

Name:

FAM22B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	878 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the FAM22 family.
Sequence caution	The sequence CAQ08562.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAQ08563.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6NNL0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A6NNL0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     617-653: Missing.
     657-672: ERDVPDPQQGVGMETC → PSDAPGTDRC
     673-878: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 878	878	Protein FAM22B		PRO_0000337992
Regions
	Compositional bias	278 – 285	8	Poly-Pro
	Compositional bias	425 – 514	90	Pro-rich
Natural variations
	Alternative sequence	617 – 653	37	Missing in isoform 2.		VSP_034025
	Alternative sequence	657 – 672	16	ERDVP…GMETC → PSDAPGTDRC in isoform 2.		VSP_034026
	Alternative sequence	673 – 878	206	Missing in isoform 2.		VSP_034027

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 10, 2008. Version 2. Checksum: AE5AC5B8AA17750D	FASTA	878	93,984
	10 20 30 40 50 60 MEVKGPSGRS FCCESEGQFK SCLKRHTPSL LLPSSWKGNS GSCLMAEALH RTSPTPNSCP 70 80 90 100 110 120 LPLPLCRMSG VLCSRNLFTF KFSLFQLDSG ASGEPGHSLG LTLGFSYCGN CQTAVVSAQP 130 140 150 160 170 180 EGMASNGAYP VLGPGVTANP GTSLSVFTAL PFTTPAPGPA HGPLLVTAGA PPGGPLVLST 190 200 210 220 230 240 FPSTPLVTEQ DGCGPSGAGA SNVFVQMRTE VGPVKAAQAQ TLVLTQAPLV WQAPGALCGG 250 260 270 280 290 300 VVCPPPLLLA AAPVVPVMAA QVVGGTQACE GGWSQGLPLP PPPPPAAQLP PIVSQGNAGP 310 320 330 340 350 360 WPQGAHGESS LASSQAKAPP DDSCNPRSVY ENFRLWQHYK PLARRHLPQS PDTEALSCFL 370 380 390 400 410 420 IPVLRSLARR KPTMTLEEGL WRAMREWQHT SNFDRMIFYE MAEKFLEFEA EEEMQIQKSQ 430 440 450 460 470 480 WMKGPQCLPP PATPRLEPRG PPAPEVVKQP VYLPSKAGPK APTACLPPPR PQRPVTKARR 490 500 510 520 530 540 PPPRPHRRAE TKARLPPPRP QRPAETKVPE EIPPEVVQEY VDIMEELLGP SLGATGEPEK 550 560 570 580 590 600 QREEGKVKQP QEEDWTPPDP GLLSYIDKLC SQKDFVTKVE AVIHPQFLEE LLSPDPQMDF 610 620 630 640 650 660 LALSQDLEQE EGLTLAQLVE KRLPPLKEKQ HARAAPSRGT ARLDSSSSKF AAGQGAERDV 670 680 690 700 710 720 PDPQQGVGME TCPPQMTARD SQGRGRAHTG MARSEDSVVL LGCQDSPGLR AAWPTSPPQD 730 740 750 760 770 780 HRPTCPGVGT KDALDLPGGS PVRESHGLAQ GSSEEEELPS LAFLLGSQHK LLPWWLPQSP 790 800 810 820 830 840 VPASGLLSPE KWGPQGTHQS PSAERRGLNL APSPANKAKK RPLFGSLSPA EKTPYPGPGL 850 860 870 RVSGEQSLTW GLGGPSQSQK RKGDPLVSRK EKKQHCSQ
	Isoform 2 [UniParc]. Checksum: 9A3E39648983D8E8	FASTA	629	67,401
	10 20 30 40 50 60 MEVKGPSGRS FCCESEGQFK SCLKRHTPSL LLPSSWKGNS GSCLMAEALH RTSPTPNSCP 70 80 90 100 110 120 LPLPLCRMSG VLCSRNLFTF KFSLFQLDSG ASGEPGHSLG LTLGFSYCGN CQTAVVSAQP 130 140 150 160 170 180 EGMASNGAYP VLGPGVTANP GTSLSVFTAL PFTTPAPGPA HGPLLVTAGA PPGGPLVLST 190 200 210 220 230 240 FPSTPLVTEQ DGCGPSGAGA SNVFVQMRTE VGPVKAAQAQ TLVLTQAPLV WQAPGALCGG 250 260 270 280 290 300 VVCPPPLLLA AAPVVPVMAA QVVGGTQACE GGWSQGLPLP PPPPPAAQLP PIVSQGNAGP 310 320 330 340 350 360 WPQGAHGESS LASSQAKAPP DDSCNPRSVY ENFRLWQHYK PLARRHLPQS PDTEALSCFL 370 380 390 400 410 420 IPVLRSLARR KPTMTLEEGL WRAMREWQHT SNFDRMIFYE MAEKFLEFEA EEEMQIQKSQ 430 440 450 460 470 480 WMKGPQCLPP PATPRLEPRG PPAPEVVKQP VYLPSKAGPK APTACLPPPR PQRPVTKARR 490 500 510 520 530 540 PPPRPHRRAE TKARLPPPRP QRPAETKVPE EIPPEVVQEY VDIMEELLGP SLGATGEPEK 550 560 570 580 590 600 QREEGKVKQP QEEDWTPPDP GLLSYIDKLC SQKDFVTKVE AVIHPQFLEE LLSPDPQMDF 610 620 LALSQDLEQE EGLTLAQGAP SDAPGTDRC

References

[1]

"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL132656 Genomic DNA. Translation: CAQ08562.1. Sequence problems. AL132656 Genomic DNA. Translation: CAQ08563.1. Sequence problems.
IPI	IPI00785017. IPI00854814.
3D structure databases
ProteinModelPortal	A6NNL0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000394623.
PTM databases
PhosphoSite	A6NNL0.
Proteomic databases
PaxDb	A6NNL0.
PRIDE	A6NNL0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342531; ENSP00000344811; ENSG00000188199. ENST00000372321; ENSP00000361396; ENSG00000188199. ENST00000429828; ENSP00000394623; ENSG00000188199. ENST00000448135; ENSP00000391631; ENSG00000188199.
Organism-specific databases
GeneCards	GC10P081462.
HGNC	HGNC:23445. FAM22B.
neXtProt	NX_A6NNL0.
PharmGKB	PA134908712.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG252751.
HOGENOM	HOG000112470.
HOVERGEN	HBG107898.
InParanoid	A6NNL0.
OMA	SAESKSH.
Gene expression databases
Bgee	A6NNL0.
CleanEx	HS_FAM22B.
Genevestigator	A6NNL0.
Family and domain databases
InterPro	IPR024310. NUT/FAM22. IPR024313. NUT_C. IPR024309. NUT_N. [Graphical view]
PANTHER	PTHR22879. PTHR22879. 1 hit.
Pfam	PF12882. NUT_C. 2 hits. PF12881. NUT_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	21548359.

Entry information

Entry name

FA22B_HUMAN

Accession

Primary (citable) accession number: A6NNL0
Secondary accession number(s): A6NM73

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	April 3, 2013
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.