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UniProtKB - A6NNK5 (A6NNK5_HUMAN)

UniProt

A6NNK5 - A6NNK5_HUMAN

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Protein
Submitted name:

Tumor suppressor p53-binding protein 1

Gene

TP53BP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor suppressor p53-binding protein 1Imported
Gene namesi
Name:TP53BP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:11999. TP53BP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiA6NNK5.
PaxDbiA6NNK5.
PeptideAtlasiA6NNK5.
PRIDEiA6NNK5.

Expressioni

Gene expression databases

BgeeiENSG00000067369.
ExpressionAtlasiA6NNK5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371475.

Structurei

3D structure databases

ProteinModelPortaliA6NNK5.
SMRiA6NNK5. Positions 1438-1557, 1679-1926.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1679 – 1803125BRCTInterPro annotationAdd
BLAST
Domaini1819 – 1919101BRCTInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG3548. Eukaryota.
ENOG411075K. LUCA.
GeneTreeiENSGT00390000011891.
HOGENOMiHOG000231961.
HOVERGENiHBG060882.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR015125. 53-BP1_Tudor.
IPR001357. BRCT_dom.
IPR014722. Rib_L2_dom2.
[Graphical view]
PfamiPF09038. 53-BP1_Tudor. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 2 hits.
PROSITEiPS50172. BRCT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NNK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGEQMDPTG SQLDSDFSQQ DTPCLIIEDS QPESQVLEDD SGSHFSMLSR 
        60         70         80         90        100
HLPNLQTHKE NPVLDVVSNP EQTAGEERGD GNSGFNEHLK ENKVADPVDS 
       110        120        130        140        150
SNLDTCGSIS QVIEQLPQPN RTSSVLGMSV ESAPAVEEEK GEELEQKEKE 
       160        170        180        190        200
KEEDTSGNTT HSLGAEDTAS SQLGFGVLEL SQSQDVEENT VPYEVDKEQL 
       210        220        230        240        250
QSVTTNSGYT RLSDVDANTA IKHEEQSNED IPIAEQSSKD IPVTAQPSKD 
       260        270        280        290        300
VHVVKEQNPP PARSEDMPFS PKASVAAMEA KEQLSAQELM ESGLQIQKSP 
       310        320        330        340        350
EPEVLSTQED LFDQSNKTVS SDGCSTPSRE EGGCSLASTP ATTLHLLQLS 
       360        370        380        390        400
GQRSLVQDSL STNSSDLVAP SPDAFRSTPF IVPSSPTEQE GRQDKPMDTS 
       410        420        430        440        450
VLSEEGGEPF QKKLQSGEPV ELENPPLLPE STVSPQASTP ISQSTPVFPP 
       460        470        480        490        500
GSLPIPSQPQ FSHDIFIPSP SLEEQSNDGK KDGDMHSSSL TVECSKTSEI 
       510        520        530        540        550
EPKNSPEDLG LSLTGDSCKL MLSTSEYSQS PKMESLSSHR IDEDGENTQI 
       560        570        580        590        600
EDTEPMSPVL NSKFVPAEND SILMNPAQDG EVQLSQNDDK TKGDDTDTRD 
       610        620        630        640        650
DISILATGCK GREETVAEDV CIDLTCDSGS QAVPSPATRS EALSSVLDQE 
       660        670        680        690        700
EAMEIKEHHP EEGSSGSEVE EIPETPCESQ GEELKEENME SVPLHLSLTE 
       710        720        730        740        750
TQSQGLCLQK EMPKKECSEA MEVETSVISI DSPQKLAILD QELEHKEQEA 
       760        770        780        790        800
WEEATSEDSS VVIVDVKEPS PRVDVSCEPL EGVEKCSDSQ SWEDIAPEIE 
       810        820        830        840        850
PCAENRLDTK EEKSVEYEGD LKSGTAETEP VEQDSSQPSL PLVRADDPLR 
       860        870        880        890        900
LDQELQQPQT QEKTSNSLTE DSKMANAKQL SSDAEAQKLG KPSAHASQSF 
       910        920        930        940        950
CESSSETPFH FTLPKEGDII PPLTGATPPL IGHLKLEPKR HSTPIGISNY 
       960        970        980        990       1000
PESTIATSDV MSESMVETHD PILGSGKGDS GAAPDVDDKL CLRMKLVSPE 
      1010       1020       1030       1040       1050
TEASEESLQF NLEKPATGER KNGSTAVAES VASPQKTMSV LSCICEARQE 
      1060       1070       1080       1090       1100
NEARSEDPPT TPIRGNLLHF PSSQGEEEKE KLEGDHTIRQ SQQPMKPISP 
      1110       1120       1130       1140       1150
VKDPVSPASQ KMVIQGPSSP QGEAMVTDVL EDQKEGRSTN KENPSKALIE 
      1160       1170       1180       1190       1200
RPSQNNIGIQ TMECSLRVPE TVSAATQTIK NVCEQGTSTV DQNFGKQDAT 
      1210       1220       1230       1240       1250
VQTERGSGEK PVSAPGDDTE SLHSQGEEEF DMPQPPHGHV LHRHMRTIRE 
      1260       1270       1280       1290       1300
VRTLVTRVIT DVYYVDGTEV ERKVTEETEE PIVECQECET EVSPSQTGGS 
      1310       1320       1330       1340       1350
SGDLGDISSF SSKASSLHRT SSGTSLSAMH SSGSSGKGAG PLRGKTSGTE 
      1360       1370       1380       1390       1400
PADFALPSSR GGPGKLRETA VPGPLGIEDI SPNLSPDDKS FSRVVPRVPD 
      1410       1420       1430       1440       1450
STRRTDVGAG ALRRSDSPEI PFQAAAGPSD GLDASSPGNS FVGLRVVAKW 
      1460       1470       1480       1490       1500
SSNGYFYSGK ITRDVGAGKY KLLFDDGYEC DVLGKDILLC DPIPLDTEVT 
      1510       1520       1530       1540       1550
ALSEDEYFSA GVVKGHRKES GELYYSIEKE GQRKWYKRMA VILSLEQGNR 
      1560       1570       1580       1590       1600
LREQYGLGPY EAVTPLTKAA DISLDNLVEG KRKRRSNVSS PATPTASSSS 
      1610       1620       1630       1640       1650
STTPTRKITE SPRASMGVLS GKRKLITSEE ERSPAKRGRK SATVKPGAVG 
      1660       1670       1680       1690       1700
AGEFVSPCES GDNTGEPSAL EEQRGPLPLN KTLFLGYAFL LTMATTSDKL 
      1710       1720       1730       1740       1750
ASRSKLPDGP TGSSEEEEEF LEIPPFNKQY TESQLRAGAG YILEDFNEAQ 
      1760       1770       1780       1790       1800
CNTAYQCLLI ADQHCRTRKY FLCLASGIPC VSHVWVHDSC HANQLQNYRN 
      1810       1820       1830       1840       1850
YLLPAGYSLE EQRILDWQPR ENPFQNLKVL LVSDQQQNFL ELWSEILMTG 
      1860       1870       1880       1890       1900
GAASVKQHHS SAHNKDIALG VFDVVVTDPS CPASVLKCAE ALQLPVVSQE 
      1910       1920 
WVIQCLIVGE RIGFKQHPKY KHDYVSH
Length:1,927
Mass (Da):209,019
Last modified:January 15, 2008 - v2
Checksum:i325E21C18C6627A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018924 Genomic DNA. No translation available.
RefSeqiXP_011520287.1. XM_011521985.1.
UniGeneiHs.440968.
Hs.584887.

Genome annotation databases

EnsembliENST00000382039; ENSP00000371470; ENSG00000067369.
GeneIDi7158.
UCSCiuc059ijn.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018924 Genomic DNA. No translation available.
RefSeqiXP_011520287.1. XM_011521985.1.
UniGeneiHs.440968.
Hs.584887.

3D structure databases

ProteinModelPortaliA6NNK5.
SMRiA6NNK5. Positions 1438-1557, 1679-1926.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371475.

Proteomic databases

EPDiA6NNK5.
PaxDbiA6NNK5.
PeptideAtlasiA6NNK5.
PRIDEiA6NNK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382039; ENSP00000371470; ENSG00000067369.
GeneIDi7158.
UCSCiuc059ijn.1. human.

Organism-specific databases

CTDi7158.
HGNCiHGNC:11999. TP53BP1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3548. Eukaryota.
ENOG411075K. LUCA.
GeneTreeiENSGT00390000011891.
HOGENOMiHOG000231961.
HOVERGENiHBG060882.

Miscellaneous databases

ChiTaRSiTP53BP1. human.
GenomeRNAii7158.

Gene expression databases

BgeeiENSG00000067369.
ExpressionAtlasiA6NNK5. baseline and differential.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR015125. 53-BP1_Tudor.
IPR001357. BRCT_dom.
IPR014722. Rib_L2_dom2.
[Graphical view]
PfamiPF09038. 53-BP1_Tudor. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 2 hits.
PROSITEiPS50172. BRCT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA6NNK5_HUMAN
AccessioniPrimary (citable) accession number: A6NNK5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: January 15, 2008
Last modified: September 7, 2016
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.