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Protein
Submitted name:

Tumor suppressor p53-binding protein 1

Gene

TP53BP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Tumor suppressor p53-binding protein 1Imported
Gene namesi
Name:TP53BP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:11999. TP53BP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000067369.

PTM / Processingi

Proteomic databases

EPDiA6NNK5.
MaxQBiA6NNK5.
PaxDbiA6NNK5.
PeptideAtlasiA6NNK5.
PRIDEiA6NNK5.

Expressioni

Gene expression databases

BgeeiENSG00000067369.
ExpressionAtlasiA6NNK5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371475.

Structurei

3D structure databases

ProteinModelPortaliA6NNK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1679 – 1803BRCTInterPro annotationAdd BLAST125
Domaini1819 – 1919BRCTInterPro annotationAdd BLAST101

Phylogenomic databases

eggNOGiKOG3548. Eukaryota.
ENOG411075K. LUCA.
GeneTreeiENSGT00390000011891.
HOGENOMiHOG000231961.
HOVERGENiHBG060882.

Family and domain databases

CDDicd00027. BRCT. 2 hits.
Gene3Di2.30.30.30. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR015125. 53-BP1_Tudor.
IPR001357. BRCT_dom.
IPR014722. Rib_L2_dom2.
[Graphical view]
PfamiPF09038. 53-BP1_Tudor. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 2 hits.
PROSITEiPS50172. BRCT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NNK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGEQMDPTG SQLDSDFSQQ DTPCLIIEDS QPESQVLEDD SGSHFSMLSR
60 70 80 90 100
HLPNLQTHKE NPVLDVVSNP EQTAGEERGD GNSGFNEHLK ENKVADPVDS
110 120 130 140 150
SNLDTCGSIS QVIEQLPQPN RTSSVLGMSV ESAPAVEEEK GEELEQKEKE
160 170 180 190 200
KEEDTSGNTT HSLGAEDTAS SQLGFGVLEL SQSQDVEENT VPYEVDKEQL
210 220 230 240 250
QSVTTNSGYT RLSDVDANTA IKHEEQSNED IPIAEQSSKD IPVTAQPSKD
260 270 280 290 300
VHVVKEQNPP PARSEDMPFS PKASVAAMEA KEQLSAQELM ESGLQIQKSP
310 320 330 340 350
EPEVLSTQED LFDQSNKTVS SDGCSTPSRE EGGCSLASTP ATTLHLLQLS
360 370 380 390 400
GQRSLVQDSL STNSSDLVAP SPDAFRSTPF IVPSSPTEQE GRQDKPMDTS
410 420 430 440 450
VLSEEGGEPF QKKLQSGEPV ELENPPLLPE STVSPQASTP ISQSTPVFPP
460 470 480 490 500
GSLPIPSQPQ FSHDIFIPSP SLEEQSNDGK KDGDMHSSSL TVECSKTSEI
510 520 530 540 550
EPKNSPEDLG LSLTGDSCKL MLSTSEYSQS PKMESLSSHR IDEDGENTQI
560 570 580 590 600
EDTEPMSPVL NSKFVPAEND SILMNPAQDG EVQLSQNDDK TKGDDTDTRD
610 620 630 640 650
DISILATGCK GREETVAEDV CIDLTCDSGS QAVPSPATRS EALSSVLDQE
660 670 680 690 700
EAMEIKEHHP EEGSSGSEVE EIPETPCESQ GEELKEENME SVPLHLSLTE
710 720 730 740 750
TQSQGLCLQK EMPKKECSEA MEVETSVISI DSPQKLAILD QELEHKEQEA
760 770 780 790 800
WEEATSEDSS VVIVDVKEPS PRVDVSCEPL EGVEKCSDSQ SWEDIAPEIE
810 820 830 840 850
PCAENRLDTK EEKSVEYEGD LKSGTAETEP VEQDSSQPSL PLVRADDPLR
860 870 880 890 900
LDQELQQPQT QEKTSNSLTE DSKMANAKQL SSDAEAQKLG KPSAHASQSF
910 920 930 940 950
CESSSETPFH FTLPKEGDII PPLTGATPPL IGHLKLEPKR HSTPIGISNY
960 970 980 990 1000
PESTIATSDV MSESMVETHD PILGSGKGDS GAAPDVDDKL CLRMKLVSPE
1010 1020 1030 1040 1050
TEASEESLQF NLEKPATGER KNGSTAVAES VASPQKTMSV LSCICEARQE
1060 1070 1080 1090 1100
NEARSEDPPT TPIRGNLLHF PSSQGEEEKE KLEGDHTIRQ SQQPMKPISP
1110 1120 1130 1140 1150
VKDPVSPASQ KMVIQGPSSP QGEAMVTDVL EDQKEGRSTN KENPSKALIE
1160 1170 1180 1190 1200
RPSQNNIGIQ TMECSLRVPE TVSAATQTIK NVCEQGTSTV DQNFGKQDAT
1210 1220 1230 1240 1250
VQTERGSGEK PVSAPGDDTE SLHSQGEEEF DMPQPPHGHV LHRHMRTIRE
1260 1270 1280 1290 1300
VRTLVTRVIT DVYYVDGTEV ERKVTEETEE PIVECQECET EVSPSQTGGS
1310 1320 1330 1340 1350
SGDLGDISSF SSKASSLHRT SSGTSLSAMH SSGSSGKGAG PLRGKTSGTE
1360 1370 1380 1390 1400
PADFALPSSR GGPGKLRETA VPGPLGIEDI SPNLSPDDKS FSRVVPRVPD
1410 1420 1430 1440 1450
STRRTDVGAG ALRRSDSPEI PFQAAAGPSD GLDASSPGNS FVGLRVVAKW
1460 1470 1480 1490 1500
SSNGYFYSGK ITRDVGAGKY KLLFDDGYEC DVLGKDILLC DPIPLDTEVT
1510 1520 1530 1540 1550
ALSEDEYFSA GVVKGHRKES GELYYSIEKE GQRKWYKRMA VILSLEQGNR
1560 1570 1580 1590 1600
LREQYGLGPY EAVTPLTKAA DISLDNLVEG KRKRRSNVSS PATPTASSSS
1610 1620 1630 1640 1650
STTPTRKITE SPRASMGVLS GKRKLITSEE ERSPAKRGRK SATVKPGAVG
1660 1670 1680 1690 1700
AGEFVSPCES GDNTGEPSAL EEQRGPLPLN KTLFLGYAFL LTMATTSDKL
1710 1720 1730 1740 1750
ASRSKLPDGP TGSSEEEEEF LEIPPFNKQY TESQLRAGAG YILEDFNEAQ
1760 1770 1780 1790 1800
CNTAYQCLLI ADQHCRTRKY FLCLASGIPC VSHVWVHDSC HANQLQNYRN
1810 1820 1830 1840 1850
YLLPAGYSLE EQRILDWQPR ENPFQNLKVL LVSDQQQNFL ELWSEILMTG
1860 1870 1880 1890 1900
GAASVKQHHS SAHNKDIALG VFDVVVTDPS CPASVLKCAE ALQLPVVSQE
1910 1920
WVIQCLIVGE RIGFKQHPKY KHDYVSH
Length:1,927
Mass (Da):209,019
Last modified:January 15, 2008 - v2
Checksum:i325E21C18C6627A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018924 Genomic DNA. No translation available.
RefSeqiXP_011520287.1. XM_011521985.1.
UniGeneiHs.440968.
Hs.584887.

Genome annotation databases

EnsembliENST00000382039; ENSP00000371470; ENSG00000067369.
GeneIDi7158.
UCSCiuc059ijn.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018924 Genomic DNA. No translation available.
RefSeqiXP_011520287.1. XM_011521985.1.
UniGeneiHs.440968.
Hs.584887.

3D structure databases

ProteinModelPortaliA6NNK5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371475.

Proteomic databases

EPDiA6NNK5.
MaxQBiA6NNK5.
PaxDbiA6NNK5.
PeptideAtlasiA6NNK5.
PRIDEiA6NNK5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382039; ENSP00000371470; ENSG00000067369.
GeneIDi7158.
UCSCiuc059ijn.1. human.

Organism-specific databases

CTDi7158.
HGNCiHGNC:11999. TP53BP1.
OpenTargetsiENSG00000067369.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3548. Eukaryota.
ENOG411075K. LUCA.
GeneTreeiENSGT00390000011891.
HOGENOMiHOG000231961.
HOVERGENiHBG060882.

Miscellaneous databases

ChiTaRSiTP53BP1. human.
GenomeRNAii7158.

Gene expression databases

BgeeiENSG00000067369.
ExpressionAtlasiA6NNK5. baseline and differential.

Family and domain databases

CDDicd00027. BRCT. 2 hits.
Gene3Di2.30.30.30. 1 hit.
3.40.50.10190. 2 hits.
InterProiIPR015125. 53-BP1_Tudor.
IPR001357. BRCT_dom.
IPR014722. Rib_L2_dom2.
[Graphical view]
PfamiPF09038. 53-BP1_Tudor. 1 hit.
[Graphical view]
SMARTiSM00292. BRCT. 2 hits.
[Graphical view]
SUPFAMiSSF52113. SSF52113. 2 hits.
PROSITEiPS50172. BRCT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA6NNK5_HUMAN
AccessioniPrimary (citable) accession number: A6NNK5
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: January 15, 2008
Last modified: November 30, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.