TP53BP1

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: TP53-binding protein 1Imported
Gene namesⁱ	Name:TP53BP1Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000067369.13.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11999. TP53BP1.

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000067369.

OpenTargetsⁱ

ENSG00000067369.

PTM / Processingⁱ

Proteomic databases

EPDⁱ	A6NNK5.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A6NNK5.
PeptideAtlas More...PeptideAtlasⁱ	A6NNK5.
PRIDEⁱ	A6NNK5.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000067369.
ExpressionAtlasⁱ	A6NNK5. baseline and differential.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	A6NNK5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1679 – 1803	BRCTInterPro annotationAdd BLAST		125
Domainⁱ	1819 – 1919	BRCTInterPro annotationAdd BLAST		101

Phylogenomic databases

eggNOGⁱ	KOG3548. Eukaryota. ENOG411075K. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011891.
HOGENOMⁱ	HOG000231961.
HOVERGENⁱ	HBG060882.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00027. BRCT. 2 hits.
Gene3Dⁱ	2.30.30.30. 1 hit. 3.40.50.10190. 2 hits.
InterProⁱ	View protein in InterPro IPR015125. 53-BP1_Tudor. IPR001357. BRCT_dom. IPR036420. BRCT_dom_sf. IPR014722. Rib_L2_dom2.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09038. 53-BP1_Tudor. 1 hit.
SMARTⁱ	View protein in SMART SM00292. BRCT. 2 hits.
SUPFAMⁱ	SSF52113. SSF52113. 2 hits.
PROSITEⁱ	View protein in PROSITE PS50172. BRCT. 2 hits.

Sequenceⁱ

Sequence statusⁱ: Complete.

A6NNK5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPGEQMDPTG SQLDSDFSQQ DTPCLIIEDS QPESQVLEDD SGSHFSMLSR 
        60         70         80         90        100
HLPNLQTHKE NPVLDVVSNP EQTAGEERGD GNSGFNEHLK ENKVADPVDS 
       110        120        130        140        150
SNLDTCGSIS QVIEQLPQPN RTSSVLGMSV ESAPAVEEEK GEELEQKEKE 
       160        170        180        190        200
KEEDTSGNTT HSLGAEDTAS SQLGFGVLEL SQSQDVEENT VPYEVDKEQL 
       210        220        230        240        250
QSVTTNSGYT RLSDVDANTA IKHEEQSNED IPIAEQSSKD IPVTAQPSKD 
       260        270        280        290        300
VHVVKEQNPP PARSEDMPFS PKASVAAMEA KEQLSAQELM ESGLQIQKSP 
       310        320        330        340        350
EPEVLSTQED LFDQSNKTVS SDGCSTPSRE EGGCSLASTP ATTLHLLQLS 
       360        370        380        390        400
GQRSLVQDSL STNSSDLVAP SPDAFRSTPF IVPSSPTEQE GRQDKPMDTS 
       410        420        430        440        450
VLSEEGGEPF QKKLQSGEPV ELENPPLLPE STVSPQASTP ISQSTPVFPP 
       460        470        480        490        500
GSLPIPSQPQ FSHDIFIPSP SLEEQSNDGK KDGDMHSSSL TVECSKTSEI 
       510        520        530        540        550
EPKNSPEDLG LSLTGDSCKL MLSTSEYSQS PKMESLSSHR IDEDGENTQI 
       560        570        580        590        600
EDTEPMSPVL NSKFVPAEND SILMNPAQDG EVQLSQNDDK TKGDDTDTRD 
       610        620        630        640        650
DISILATGCK GREETVAEDV CIDLTCDSGS QAVPSPATRS EALSSVLDQE 
       660        670        680        690        700
EAMEIKEHHP EEGSSGSEVE EIPETPCESQ GEELKEENME SVPLHLSLTE 
       710        720        730        740        750
TQSQGLCLQK EMPKKECSEA MEVETSVISI DSPQKLAILD QELEHKEQEA 
       760        770        780        790        800
WEEATSEDSS VVIVDVKEPS PRVDVSCEPL EGVEKCSDSQ SWEDIAPEIE 
       810        820        830        840        850
PCAENRLDTK EEKSVEYEGD LKSGTAETEP VEQDSSQPSL PLVRADDPLR 
       860        870        880        890        900
LDQELQQPQT QEKTSNSLTE DSKMANAKQL SSDAEAQKLG KPSAHASQSF 
       910        920        930        940        950
CESSSETPFH FTLPKEGDII PPLTGATPPL IGHLKLEPKR HSTPIGISNY 
       960        970        980        990       1000
PESTIATSDV MSESMVETHD PILGSGKGDS GAAPDVDDKL CLRMKLVSPE 
      1010       1020       1030       1040       1050
TEASEESLQF NLEKPATGER KNGSTAVAES VASPQKTMSV LSCICEARQE 
      1060       1070       1080       1090       1100
NEARSEDPPT TPIRGNLLHF PSSQGEEEKE KLEGDHTIRQ SQQPMKPISP 
      1110       1120       1130       1140       1150
VKDPVSPASQ KMVIQGPSSP QGEAMVTDVL EDQKEGRSTN KENPSKALIE 
      1160       1170       1180       1190       1200
RPSQNNIGIQ TMECSLRVPE TVSAATQTIK NVCEQGTSTV DQNFGKQDAT 
      1210       1220       1230       1240       1250
VQTERGSGEK PVSAPGDDTE SLHSQGEEEF DMPQPPHGHV LHRHMRTIRE 
      1260       1270       1280       1290       1300
VRTLVTRVIT DVYYVDGTEV ERKVTEETEE PIVECQECET EVSPSQTGGS 
      1310       1320       1330       1340       1350
SGDLGDISSF SSKASSLHRT SSGTSLSAMH SSGSSGKGAG PLRGKTSGTE 
      1360       1370       1380       1390       1400
PADFALPSSR GGPGKLRETA VPGPLGIEDI SPNLSPDDKS FSRVVPRVPD 
      1410       1420       1430       1440       1450
STRRTDVGAG ALRRSDSPEI PFQAAAGPSD GLDASSPGNS FVGLRVVAKW 
      1460       1470       1480       1490       1500
SSNGYFYSGK ITRDVGAGKY KLLFDDGYEC DVLGKDILLC DPIPLDTEVT 
      1510       1520       1530       1540       1550
ALSEDEYFSA GVVKGHRKES GELYYSIEKE GQRKWYKRMA VILSLEQGNR 
      1560       1570       1580       1590       1600
LREQYGLGPY EAVTPLTKAA DISLDNLVEG KRKRRSNVSS PATPTASSSS 
      1610       1620       1630       1640       1650
STTPTRKITE SPRASMGVLS GKRKLITSEE ERSPAKRGRK SATVKPGAVG 
      1660       1670       1680       1690       1700
AGEFVSPCES GDNTGEPSAL EEQRGPLPLN KTLFLGYAFL LTMATTSDKL 
      1710       1720       1730       1740       1750
ASRSKLPDGP TGSSEEEEEF LEIPPFNKQY TESQLRAGAG YILEDFNEAQ 
      1760       1770       1780       1790       1800
CNTAYQCLLI ADQHCRTRKY FLCLASGIPC VSHVWVHDSC HANQLQNYRN 
      1810       1820       1830       1840       1850
YLLPAGYSLE EQRILDWQPR ENPFQNLKVL LVSDQQQNFL ELWSEILMTG 
      1860       1870       1880       1890       1900
GAASVKQHHS SAHNKDIALG VFDVVVTDPS CPASVLKCAE ALQLPVVSQE 
      1910       1920 
WVIQCLIVGE RIGFKQHPKY KHDYVSH

Length:1,927

Mass (Da):209,019

Last modified:January 15, 2008 - v2

Checksum:ⁱ325E21C18C6627A6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC018924 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_011520287.1. XM_011521985.1.
UniGeneⁱ	Hs.440968. Hs.584887. Hs.718479.

Genome annotation databases

Ensemblⁱ	ENST00000382039; ENSP00000371470; ENSG00000067369.
GeneIDⁱ	7158.
UCSC genome browser More...UCSCⁱ	uc059ijn.1. human.

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A6NNK5	F7HJA9 A0A2K6NCL1 A0A2K6KZ34 A0A2K5W7P6 A0A2J8S5A5 A0A2J8QEE2 A0A2I3SU67 A0A2K5LZ54 A0A2K5HKT4 A0A2K6AIX7 +1	Macaca mulatta (Rhesus macaque) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan troglodytes (Chimpanzee) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Colobus angolensis palliatus (Peters' Angolan colobus) Mandrillus leucophaeus (Drill) (Papio leucophaeus)	1,927	UniRef90_F7HJA9	Cluster: Tumor protein p53 binding protein 1	12

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
A6NNK5	Q12888 Q12888-2 UPI00024CE295 A0A2J8QEE9 UPI00001122AF B3KVT9 A0A0R9RRX7 UPI0000111A5E UPI00045DF7FC UPI00045D65C2 +105	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Microcebus murinus (Lesser mouse lemur) (Gray Mouse Lemur) Macaca mulatta (Rhesus macaque) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Pan paniscus (Pygmy chimpanzee) (Bonobo) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Piliocolobus tephrosceles (Ugandan red Colobus) And more	1,972	UniRef50_Q12888	Cluster: TP53-binding protein 1	116

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC018924 Genomic DNA. No translation available.
NCBI Reference Sequences More...RefSeqⁱ	XP_011520287.1. XM_011521985.1.
UniGeneⁱ	Hs.440968. Hs.584887. Hs.718479.

3D structure databases

ProteinModelPortalⁱ	A6NNK5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

EPDⁱ	A6NNK5.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	A6NNK5.
PeptideAtlas More...PeptideAtlasⁱ	A6NNK5.
PRIDEⁱ	A6NNK5.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000382039; ENSP00000371470; ENSG00000067369.
GeneIDⁱ	7158.
UCSC genome browser More...UCSCⁱ	uc059ijn.1. human.

Organism-specific databases

CTDⁱ	7158.
EuPathDBⁱ	HostDB:ENSG00000067369.13.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11999. TP53BP1.
Open Targets More...OpenTargetsⁱ	ENSG00000067369.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3548. Eukaryota. ENOG411075K. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011891.
HOGENOMⁱ	HOG000231961.
HOVERGENⁱ	HBG060882.

Miscellaneous databases

ChiTaRSⁱ	TP53BP1. human.
GenomeRNAiⁱ	7158.

Gene expression databases

Bgeeⁱ	ENSG00000067369.
ExpressionAtlasⁱ	A6NNK5. baseline and differential.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00027. BRCT. 2 hits.
Gene3Dⁱ	2.30.30.30. 1 hit. 3.40.50.10190. 2 hits.
InterProⁱ	View protein in InterPro IPR015125. 53-BP1_Tudor. IPR001357. BRCT_dom. IPR036420. BRCT_dom_sf. IPR014722. Rib_L2_dom2.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF09038. 53-BP1_Tudor. 1 hit.
SMARTⁱ	View protein in SMART SM00292. BRCT. 2 hits.
SUPFAMⁱ	SSF52113. SSF52113. 2 hits.
PROSITEⁱ	View protein in PROSITE PS50172. BRCT. 2 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A6NNK5_HUMAN
Accessionⁱ	A6NNK5Primary (citable) accession number: A6NNK5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	July 24, 2007
	Last sequence update:	January 15, 2008
	Last modified:	March 28, 2018
	This is version 75 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB - A6NNK5 (A6NNK5_HUMAN)

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TP53-binding protein 1

Select a section on the left to see content.

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A6NNK5 (A6NNK5_HUMAN)

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TP53-binding protein 1

TP53BP1

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ