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Protein

Zinc finger protein 726

Gene

ZNF726

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 645C2H2-type 17; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri651 – 673C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri707 – 729C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-33838-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 726
Gene namesi
Name:ZNF726
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32462. ZNF726.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213967.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003406821 – 738Zinc finger protein 726Add BLAST738

Proteomic databases

PaxDbiA6NNF4.
PRIDEiA6NNF4.

PTM databases

iPTMnetiA6NNF4.
PhosphoSitePlusiA6NNF4.

Expressioni

Gene expression databases

BgeeiENSG00000213967.
ExpressionAtlasiA6NNF4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000317125.

Structurei

3D structure databases

ProteinModelPortaliA6NNF4.
SMRiA6NNF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 20 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 645C2H2-type 17; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri651 – 673C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri679 – 701C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri707 – 729C2H2-type 20; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
InParanoidiA6NNF4.
KOiK09228.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 21 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NNF4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLLTFRDVA IEFSLEEWQC LDTAQKNLYR NVMLENYRNL AFLGIAVSKP
60 70 80 90 100
DLIICLEKEK EPWNMKRDEM VDEPPGICPH FAQDIWPEQG VEDSFQKVIL
110 120 130 140 150
RRFEKCGHEN LQLRKGCKSV DECKVHKEGY NGLNQCFTTT QGKASQCGKY
160 170 180 190 200
LKVFYKFINL NRYKIRHTRK KPFKCKNCVK SFCMFSHKTQ HKSIYTTEKS
210 220 230 240 250
YKCKECGKTF NWSSTLTNHK KTHTEEKPYK CEEYGKAFNQ SSNYTTHKVT
260 270 280 290 300
HTGEKPYKCE ECGKAFSQSS TLTIHKRIHT GEKPCKCEEC GKAFSQPSAL
310 320 330 340 350
TIHKRMHIGE KPYKCEECGK AFVWSSTLTR HKRLHSGEKP YKCEECAKAF
360 370 380 390 400
SQFGHLTTHR IIHTGEKPYK CEECGKAFIW PSTLTKHKRI HTGEKPYKCE
410 420 430 440 450
ECGKAFHRSS NLTKHKIIHT GEKPYKCEEC GKAFIWSSNL TEHKKIHTRE
460 470 480 490 500
KPYKCEECSK AFSRSSALTT HKRMHTGEKP YKCEECGKAF SQSSTLTAHK
510 520 530 540 550
IIHTGEKPYK CEECGKAFIL SSTLSKHKRI HTGEKPYKCE ECGKTFNQSS
560 570 580 590 600
NLSTHKIIHT GEKPYKCEEC GKAFNRSSNL STHKIIHTGE KPYKCDECGK
610 620 630 640 650
SFIWSSTLFK HKRIHTGEKP YKCEECGKAF NHSQILLHIR HKRMHTGEKP
660 670 680 690 700
YKCEECGKSF NLSSTFIKHK VIHTGVKLYK CEECGKVFFW SSALTRHKKI
710 720 730
HAGQQPYKWE KIGKAFNQSS HLTTDKITHI GEKSYKCE
Length:738
Mass (Da):85,539
Last modified:May 14, 2014 - v4
Checksum:iAB6F0803DAC4FA22
GO
Isoform 2 (identifier: A6NNF4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-77: I → R
     78-738: Missing.

Show »
Length:77
Mass (Da):9,077
Checksum:i2DDCCB4AFC94C2BA
GO
Isoform 3 (identifier: A6NNF4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     617-738: Missing.

Show »
Length:616
Mass (Da):71,359
Checksum:iF93DB0E02A2C04DA
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03421677I → R in isoform 2. 1 Publication1
Alternative sequenceiVSP_03421778 – 738Missing in isoform 2. 1 PublicationAdd BLAST661
Alternative sequenceiVSP_054850617 – 738Missing in isoform 3. CuratedAdd BLAST122

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011503 Genomic DNA. No translation available.
BC046415 mRNA. Translation: AAH46415.2.
CCDSiCCDS59372.1. [A6NNF4-3]
RefSeqiNP_001230967.1. NM_001244038.1. [A6NNF4-3]
UniGeneiHs.655305.

Genome annotation databases

EnsembliENST00000531821; ENSP00000432583; ENSG00000213967. [A6NNF4-2]
ENST00000594466; ENSP00000471516; ENSG00000213967. [A6NNF4-3]
GeneIDi730087.
KEGGihsa:730087.
UCSCiuc021urw.2. human. [A6NNF4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011503 Genomic DNA. No translation available.
BC046415 mRNA. Translation: AAH46415.2.
CCDSiCCDS59372.1. [A6NNF4-3]
RefSeqiNP_001230967.1. NM_001244038.1. [A6NNF4-3]
UniGeneiHs.655305.

3D structure databases

ProteinModelPortaliA6NNF4.
SMRiA6NNF4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000317125.

PTM databases

iPTMnetiA6NNF4.
PhosphoSitePlusiA6NNF4.

Proteomic databases

PaxDbiA6NNF4.
PRIDEiA6NNF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000531821; ENSP00000432583; ENSG00000213967. [A6NNF4-2]
ENST00000594466; ENSP00000471516; ENSG00000213967. [A6NNF4-3]
GeneIDi730087.
KEGGihsa:730087.
UCSCiuc021urw.2. human. [A6NNF4-1]

Organism-specific databases

CTDi730087.
GeneCardsiZNF726.
HGNCiHGNC:32462. ZNF726.
neXtProtiNX_A6NNF4.
OpenTargetsiENSG00000213967.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
InParanoidiA6NNF4.
KOiK09228.

Enzyme and pathway databases

BioCyciZFISH:G66-33838-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii730087.
PROiA6NNF4.

Gene expression databases

BgeeiENSG00000213967.
ExpressionAtlasiA6NNF4. baseline and differential.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 21 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 18 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 16 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN726_HUMAN
AccessioniPrimary (citable) accession number: A6NNF4
Secondary accession number(s): M0R0X8, Q86Y87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: May 14, 2014
Last modified: November 30, 2016
This is version 87 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.