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Protein

E3 ubiquitin-protein ligase MARCH11

Gene

MARCH11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri162 – 22261RING-CH-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase MARCH11 (EC:6.3.2.-)
Alternative name(s):
Membrane-associated RING finger protein 11
Membrane-associated RING-CH protein XI
Short name:
MARCH-XI
Gene namesi
Name:MARCH11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:33609. MARCH11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei245 – 26521HelicalSequence analysisAdd
BLAST
Transmembranei278 – 29821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162395055.

Polymorphism and mutation databases

BioMutaiMARCH11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402E3 ubiquitin-protein ligase MARCH11PRO_0000339344Add
BLAST

Proteomic databases

PaxDbiA6NNE9.
PRIDEiA6NNE9.

PTM databases

PhosphoSiteiA6NNE9.

Expressioni

Gene expression databases

BgeeiA6NNE9.
CleanExiHS_MARCH11.
ExpressionAtlasiA6NNE9. baseline and differential.
GenevisibleiA6NNE9. HS.

Interactioni

Subunit structurei

Interacts (YXXL motif) with AP1M1. Interacts (via PDZ-binding motif) with LIN7A. Interacts with unidentified fucose glycoproteins (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000333181.

Structurei

3D structure databases

ProteinModelPortaliA6NNE9.
SMRiA6NNE9. Positions 167-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi371 – 3744YXXL motif
Motifi399 – 4024PDZ-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi22 – 9170Pro-richAdd
BLAST
Compositional biasi146 – 1527Poly-Ser

Domaini

The RING-CH-type zinc finger domain is required for E3 ligase activity.PROSITE-ProRule annotation

Sequence similaritiesi

Contains 1 RING-CH-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri162 – 22261RING-CH-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1609. Eukaryota.
COG5183. LUCA.
GeneTreeiENSGT00730000110738.
HOGENOMiHOG000113484.
HOVERGENiHBG052412.
InParanoidiA6NNE9.
KOiK10659.
OMAiDQRAGHQ.
OrthoDBiEOG7Q8CNM.
PhylomeDBiA6NNE9.
TreeFamiTF319557.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR033275. MARCH-like.
IPR011016. Znf_RING-CH.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR23012. PTHR23012. 2 hits.
PfamiPF12906. RINGv. 1 hit.
[Graphical view]
SMARTiSM00744. RINGv. 1 hit.
[Graphical view]
PROSITEiPS51292. ZF_RING_CH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NNE9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFEGGHGGS RCRGAESGDA EPPPQPPPPP PPTPPPGEPA PVPAAPRYLP
60 70 80 90 100
PLPASPETPE RAAGPSEPLG EVAPRCRGAD ELPPPPLPLQ PAGQEVAAAG
110 120 130 140 150
DSGEGPRRLP EAAAAKGGPG ESEAGAGGER ERRGAGDQPE TRSVCSSRSS
160 170 180 190 200
SSGGGDQRAG HQHQHHQPIC KICFQGAEQG ELLNPCRCDG SVRYTHQLCL
210 220 230 240 250
LKWISERGSW TCELCCYRYH VIAIKMKQPC QWQSISITLV EKVQMIAVIL
260 270 280 290 300
GSLFLIASVT WLLWSAFSPY AVWQRKDILF QICYGMYGFM DLVCIGLIVH
310 320 330 340 350
EGAAVYRVFK RWRAVNLHWD VLNYDKATDI EESSRGESST SRTLWLPLTA
360 370 380 390 400
LRNRNLVHPT QLTSPRFQCG YVLLHLFNRM RPHEDLSEDN SSGEVVMRVT

SV
Length:402
Mass (Da):43,878
Last modified:June 10, 2008 - v3
Checksum:i8040B7DCE9277601
GO
Isoform 2 (identifier: A6NNE9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-244: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):18,226
Checksum:i705BD4B109EC84A1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 244244Missing in isoform 2. 1 PublicationVSP_034147Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092335 Genomic DNA. No translation available.
AC016650 Genomic DNA. No translation available.
BC150513 mRNA. Translation: AAI50514.1.
BC150514 mRNA. Translation: AAI50515.1.
CR590337 mRNA. No translation available.
CCDSiCCDS47192.1. [A6NNE9-1]
RefSeqiNP_001096032.1. NM_001102562.1. [A6NNE9-1]
UniGeneiHs.662216.

Genome annotation databases

EnsembliENST00000332432; ENSP00000333181; ENSG00000183654. [A6NNE9-1]
GeneIDi441061.
KEGGihsa:441061.
UCSCiuc003jfo.3. human. [A6NNE9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092335 Genomic DNA. No translation available.
AC016650 Genomic DNA. No translation available.
BC150513 mRNA. Translation: AAI50514.1.
BC150514 mRNA. Translation: AAI50515.1.
CR590337 mRNA. No translation available.
CCDSiCCDS47192.1. [A6NNE9-1]
RefSeqiNP_001096032.1. NM_001102562.1. [A6NNE9-1]
UniGeneiHs.662216.

3D structure databases

ProteinModelPortaliA6NNE9.
SMRiA6NNE9. Positions 167-229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333181.

PTM databases

PhosphoSiteiA6NNE9.

Polymorphism and mutation databases

BioMutaiMARCH11.

Proteomic databases

PaxDbiA6NNE9.
PRIDEiA6NNE9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332432; ENSP00000333181; ENSG00000183654. [A6NNE9-1]
GeneIDi441061.
KEGGihsa:441061.
UCSCiuc003jfo.3. human. [A6NNE9-1]

Organism-specific databases

CTDi441061.
GeneCardsiMARCH11.
HGNCiHGNC:33609. MARCH11.
MIMi613338. gene.
neXtProtiNX_A6NNE9.
PharmGKBiPA162395055.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1609. Eukaryota.
COG5183. LUCA.
GeneTreeiENSGT00730000110738.
HOGENOMiHOG000113484.
HOVERGENiHBG052412.
InParanoidiA6NNE9.
KOiK10659.
OMAiDQRAGHQ.
OrthoDBiEOG7Q8CNM.
PhylomeDBiA6NNE9.
TreeFamiTF319557.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

GenomeRNAii441061.
NextBioi109733.
PROiA6NNE9.
SOURCEiSearch...

Gene expression databases

BgeeiA6NNE9.
CleanExiHS_MARCH11.
ExpressionAtlasiA6NNE9. baseline and differential.
GenevisibleiA6NNE9. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR033275. MARCH-like.
IPR011016. Znf_RING-CH.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR23012. PTHR23012. 2 hits.
PfamiPF12906. RINGv. 1 hit.
[Graphical view]
SMARTiSM00744. RINGv. 1 hit.
[Graphical view]
PROSITEiPS51292. ZF_RING_CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  3. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 40-402 (ISOFORM 1).
    Tissue: Neuroblastoma.

Entry informationi

Entry nameiMARHB_HUMAN
AccessioniPrimary (citable) accession number: A6NNE9
Secondary accession number(s): A7E2S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 10, 2008
Last modified: May 11, 2016
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.