Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 2AT4

Gene

OR2AT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2AT4
Alternative name(s):
Olfactory receptor OR11-265
Gene namesi
Name:OR2AT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19620. OR2AT4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 62CytoplasmicSequence analysis10
Transmembranei63 – 83Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini84 – 102ExtracellularSequence analysisAdd BLAST19
Transmembranei103 – 123Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini124 – 145CytoplasmicSequence analysisAdd BLAST22
Transmembranei146 – 166Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini167 – 200ExtracellularSequence analysisAdd BLAST34
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 245CytoplasmicSequence analysisAdd BLAST24
Transmembranei246 – 266Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini267 – 276ExtracellularSequence analysis10
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 320CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi341152.
OpenTargetsiENSG00000171561.
PharmGKBiPA134941860.

Polymorphism and mutation databases

BioMutaiOR2AT4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003108661 – 320Olfactory receptor 2AT4Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi102 ↔ 184PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NND4.
PRIDEiA6NND4.

PTM databases

PhosphoSitePlusiA6NND4.

Expressioni

Gene expression databases

CleanExiHS_OR2AT4.
ExpressionAtlasiA6NND4. baseline and differential.

Organism-specific databases

HPAiHPA060357.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304846.

Structurei

3D structure databases

ProteinModelPortaliA6NND4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II7E. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00840000129747.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiA6NND4.
KOiK04257.
OMAiCNESVDG.
OrthoDBiEOG091G0GLT.
PhylomeDBiA6NND4.
TreeFamiTF337194.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NND4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDATACNESV DGSPVFYLLG IPSLPETFFL PVFFIFLLFY LLILMGNALI
60 70 80 90 100
LVAVVAEPSL HKPMYFFLIN LSTLDILFTT TTVPKMLSLF LLGDRFLSFS
110 120 130 140 150
SCLLQMYLFQ SFTCSEAFIL VVMAYDRYVA ICHPLHYPVL MNPQTNATLA
160 170 180 190 200
ASAWLTALLL PIPAVVRTSQ MAYNSIAYIY HCFCDHLAVV QASCSDTTPQ
210 220 230 240 250
TLMGFCIAMV VSFLPLLLVL LSYVHILASV LRISSLEGRA KAFSTCSSHL
260 270 280 290 300
LVVGTYYSSI AIAYVAYRAD LPLDFHIMGN VVYAILTPIL NPLIYTLRNR
310 320
DVKAAITKIM SQDPGCDRSI
Length:320
Mass (Da):35,503
Last modified:July 24, 2007 - v1
Checksum:i62E0FB03CCB8EADB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003175 Genomic DNA. No translation available.
BC136958 mRNA. Translation: AAI36959.1.
BC136959 mRNA. Translation: AAI36960.1.
BK004820 Genomic DNA. No translation available.
CCDSiCCDS31639.1.
RefSeqiNP_001005285.1. NM_001005285.1.
XP_016873144.1. XM_017017655.1.
XP_016873145.1. XM_017017656.1.
XP_016873146.1. XM_017017657.1.
XP_016873147.1. XM_017017658.1.
UniGeneiHs.554515.

Genome annotation databases

EnsembliENST00000305159; ENSP00000304846; ENSG00000171561.
GeneIDi341152.
KEGGihsa:341152.
UCSCiuc010rro.3. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003175 Genomic DNA. No translation available.
BC136958 mRNA. Translation: AAI36959.1.
BC136959 mRNA. Translation: AAI36960.1.
BK004820 Genomic DNA. No translation available.
CCDSiCCDS31639.1.
RefSeqiNP_001005285.1. NM_001005285.1.
XP_016873144.1. XM_017017655.1.
XP_016873145.1. XM_017017656.1.
XP_016873146.1. XM_017017657.1.
XP_016873147.1. XM_017017658.1.
UniGeneiHs.554515.

3D structure databases

ProteinModelPortaliA6NND4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000304846.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiA6NND4.

Polymorphism and mutation databases

BioMutaiOR2AT4.

Proteomic databases

PaxDbiA6NND4.
PRIDEiA6NND4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305159; ENSP00000304846; ENSG00000171561.
GeneIDi341152.
KEGGihsa:341152.
UCSCiuc010rro.3. human.

Organism-specific databases

CTDi341152.
DisGeNETi341152.
GeneCardsiOR2AT4.
HGNCiHGNC:19620. OR2AT4.
HPAiHPA060357.
neXtProtiNX_A6NND4.
OpenTargetsiENSG00000171561.
PharmGKBiPA134941860.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II7E. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00840000129747.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiA6NND4.
KOiK04257.
OMAiCNESVDG.
OrthoDBiEOG091G0GLT.
PhylomeDBiA6NND4.
TreeFamiTF337194.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii341152.
PROiA6NND4.

Gene expression databases

CleanExiHS_OR2AT4.
ExpressionAtlasiA6NND4. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO2AT4_HUMAN
AccessioniPrimary (citable) accession number: A6NND4
Secondary accession number(s): B9EGZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.