A6NNB3 (IFM5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interferon-induced transmembrane protein 5

Alternative name(s):
Bone-restricted interferon-induced transmembrane protein-like protein
Short name=BRIL

Gene names

Name:

IFITM5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	132 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a role in bone mineralization By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CD225 family.

Ontologies

Keywords
Biological process	Mineral balance
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	Developmental protein
PTM	Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of bone mineralization Inferred from electronic annotation. Source: UniProtKB-KW response to biotic stimulus Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 132	132	Interferon-induced transmembrane protein 5		PRO_0000305103
Regions
	Topological domain	1 – 36	36	Extracellular Potential
	Transmembrane	37 – 57	21	Helical; Potential
	Topological domain	58 – 86	29	Cytoplasmic Potential
	Transmembrane	87 – 107	21	Helical; Potential
	Topological domain	108 – 132	25	Extracellular Potential
Amino acid modifications
	Lipidation	50	1	S-palmitoyl cysteine By similarity
	Lipidation	51	1	S-palmitoyl cysteine By similarity
	Lipidation	84	1	S-palmitoyl cysteine By similarity
Natural variations
	Natural variant	27	1	G → A. Corresponds to variant rs57285449 [ dbSNP | Ensembl ].		VAR_062170

Sequences

	Sequence		Length	Mass (Da)
	A6NNB3 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 4AB8089B88507024	FASTA	132	14,378
	10 20 30 40 50 60 MDTAYPREDT RAPTPSKAGA HTALTLGAPH PPPRDHLIWS VFSTLYLNLC CLGFLALAYS 70 80 90 100 110 120 IKARDQKVVG DLEAARRFGS KAKCYNILAA MWTLVPPLLL LGLVVTGALH LARLAKDSAA 130 FFSTKFDDAD YD

References

[1]

Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH471278 Genomic DNA. Translation: EAW61222.1. BC150562 mRNA. Translation: AAI50563.1. BC150563 mRNA. Translation: AAI50564.1.
IPI	IPI00375820.
RefSeq	NP_001020466.1. NM_001025295.1.
UniGene	Hs.443469.
3D structure databases
ProteinModelPortal	A6NNB3.
ModBase	Search...
Protein-protein interaction databases
STRING	A6NNB3.
Proteomic databases
PRIDE	A6NNB3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382614; ENSP00000372059; ENSG00000206013.
GeneID	387733.
KEGG	hsa:387733.
UCSC	uc001low.1. human.
Organism-specific databases
CTD	387733.
GeneCards	GC11M000298.
HGNC	HGNC:16644. IFITM5.
HPA	HPA039258.
neXtProt	NX_A6NNB3.
PharmGKB	PA162391894.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG20307.
GeneTree	ENSGT00390000003476.
HOGENOM	HBG717582.
HOVERGEN	HBG053217.
InParanoid	A6NNB3.
OMA	MDTSYPR.
OrthoDB	EOG4PG62H.
Gene expression databases
Bgee	A6NNB3.
CleanEx	HS_IFITM5.
Genevestigator	A6NNB3.
Family and domain databases
InterPro	IPR007593. Interferon-induced_TM_protein. [Graphical view]
KO	K06566.
Pfam	PF04505. CD225. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	101561.

Entry information

Entry name

IFM5_HUMAN

Accession

Primary (citable) accession number: A6NNB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	July 24, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.