Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dorsal root ganglia homeobox protein

Gene

DRGX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 92HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Dorsal root ganglia homeobox protein
Alternative name(s):
Paired-related homeobox protein-like 1
Gene namesi
Name:DRGX
Synonyms:PRRXL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000165606.8
HGNCiHGNC:21536 DRGX
MIMi606701 gene
neXtProtiNX_A6NNA5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165606

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003008141 – 263Dorsal root ganglia homeobox proteinAdd BLAST263

Proteomic databases

EPDiA6NNA5
PaxDbiA6NNA5
PRIDEiA6NNA5

PTM databases

iPTMnetiA6NNA5
PhosphoSitePlusiA6NNA5

Expressioni

Gene expression databases

BgeeiENSG00000165606
CleanExiHS_DRGX

Organism-specific databases

HPAiHPA043978

Interactioni

Subunit structurei

Interacts with RGMB.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000401653

Structurei

3D structure databases

ProteinModelPortaliA6NNA5
SMRiA6NNA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi204 – 217OARPROSITE-ProRule annotationAdd BLAST14

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490 Eukaryota
ENOG410YIJ3 LUCA
GeneTreeiENSGT00900000140809
HOGENOMiHOG000231518
HOVERGENiHBG106743
InParanoidiA6NNA5
OMAiKGSPLCS
OrthoDBiEOG091G0YX9
PhylomeDBiA6NNA5

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR003654 OAR_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF03826 OAR, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
PS50803 OAR, 1 hit

Sequencei

Sequence statusi: Complete.

A6NNA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYFHCPPQL EGTATFGNHS SGDFDDGFLR RKQRRNRTTF TLQQLEALEA
60 70 80 90 100
VFAQTHYPDV FTREELAMKI NLTEARVQVW FQNRRAKWRK TERGASDQEP
110 120 130 140 150
GAKEPMAEVT PPPVRNINSP PPGDQARSKK EALEAQQSLG RTVGPAGPFF
160 170 180 190 200
PSCLPGTLLN TATYAQALSH VASLKGGPLC SCCVPDPMGL SFLPTYGCQS
210 220 230 240 250
NRTASVATLR MKAREHSEAV LQSANLLPST SSSPGPVAKP APPDGSQEKT
260
SPTKEQSEAE KSV
Length:263
Mass (Da):28,672
Last modified:July 24, 2007 - v1
Checksum:i7FF77B9C4763EDE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027674 Genomic DNA No translation available.
CH471187 Genomic DNA Translation: EAW93100.1
CCDSiCCDS44388.2
RefSeqiNP_001263380.1, NM_001276451.1
UniGeneiHs.534530

Genome annotation databases

EnsembliENST00000374139; ENSP00000363254; ENSG00000165606
ENST00000434016; ENSP00000401653; ENSG00000165606
GeneIDi644168
KEGGihsa:644168
UCSCiuc021pqd.2 human

Similar proteinsi

Entry informationi

Entry nameiDRGX_HUMAN
AccessioniPrimary (citable) accession number: A6NNA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health