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Protein

Dorsal root ganglia homeobox protein

Gene

DRGX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi33 – 9260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dorsal root ganglia homeobox protein
Alternative name(s):
Paired-related homeobox protein-like 1
Gene namesi
Name:DRGX
Synonyms:PRRXL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:21536. DRGX.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 263263Dorsal root ganglia homeobox proteinPRO_0000300814Add
BLAST

Proteomic databases

PaxDbiA6NNA5.
PRIDEiA6NNA5.

PTM databases

PhosphoSiteiA6NNA5.

Expressioni

Gene expression databases

BgeeiA6NNA5.
CleanExiHS_DRGX.

Organism-specific databases

HPAiHPA043978.

Interactioni

Subunit structurei

Interacts with RGMB.By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000401653.

Structurei

3D structure databases

ProteinModelPortaliA6NNA5.
SMRiA6NNA5. Positions 39-89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi204 – 21714OARPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000231518.
HOVERGENiHBG106743.
InParanoidiA6NNA5.
OMAiKGSPLCS.
OrthoDBiEOG7C2R1F.
PhylomeDBiA6NNA5.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NNA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFYFHCPPQL EGTATFGNHS SGDFDDGFLR RKQRRNRTTF TLQQLEALEA
60 70 80 90 100
VFAQTHYPDV FTREELAMKI NLTEARVQVW FQNRRAKWRK TERGASDQEP
110 120 130 140 150
GAKEPMAEVT PPPVRNINSP PPGDQARSKK EALEAQQSLG RTVGPAGPFF
160 170 180 190 200
PSCLPGTLLN TATYAQALSH VASLKGGPLC SCCVPDPMGL SFLPTYGCQS
210 220 230 240 250
NRTASVATLR MKAREHSEAV LQSANLLPST SSSPGPVAKP APPDGSQEKT
260
SPTKEQSEAE KSV
Length:263
Mass (Da):28,672
Last modified:July 24, 2007 - v1
Checksum:i7FF77B9C4763EDE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027674 Genomic DNA. No translation available.
CH471187 Genomic DNA. Translation: EAW93100.1.
CCDSiCCDS44388.2.
RefSeqiNP_001263380.1. NM_001276451.1.
UniGeneiHs.534530.

Genome annotation databases

EnsembliENST00000374139; ENSP00000363254; ENSG00000165606.
ENST00000434016; ENSP00000401653; ENSG00000165606.
GeneIDi644168.
KEGGihsa:644168.
UCSCiuc021pqd.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC027674 Genomic DNA. No translation available.
CH471187 Genomic DNA. Translation: EAW93100.1.
CCDSiCCDS44388.2.
RefSeqiNP_001263380.1. NM_001276451.1.
UniGeneiHs.534530.

3D structure databases

ProteinModelPortaliA6NNA5.
SMRiA6NNA5. Positions 39-89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000401653.

PTM databases

PhosphoSiteiA6NNA5.

Proteomic databases

PaxDbiA6NNA5.
PRIDEiA6NNA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374139; ENSP00000363254; ENSG00000165606.
ENST00000434016; ENSP00000401653; ENSG00000165606.
GeneIDi644168.
KEGGihsa:644168.
UCSCiuc021pqd.2. human.

Organism-specific databases

CTDi644168.
GeneCardsiDRGX.
HGNCiHGNC:21536. DRGX.
HPAiHPA043978.
MIMi606701. gene.
neXtProtiNX_A6NNA5.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0490. Eukaryota.
ENOG410YIJ3. LUCA.
GeneTreeiENSGT00760000118958.
HOGENOMiHOG000231518.
HOVERGENiHBG106743.
InParanoidiA6NNA5.
OMAiKGSPLCS.
OrthoDBiEOG7C2R1F.
PhylomeDBiA6NNA5.

Miscellaneous databases

GenomeRNAii644168.
PROiA6NNA5.
SOURCEiSearch...

Gene expression databases

BgeeiA6NNA5.
CleanExiHS_DRGX.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003654. OAR_dom.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03826. OAR. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS50803. OAR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDRGX_HUMAN
AccessioniPrimary (citable) accession number: A6NNA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 24, 2007
Last modified: November 11, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.