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A6NN92 (CXE1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Gap junction epsilon-1 protein
Alternative name(s):
Connexin-23
Short name=Cx23
Gene names
Name:GJE1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Subunit structure

A connexon is composed of a hexamer of connexins By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein. Cell junctiongap junction By similarity.

Sequence similarities

Belongs to the connexin family. Beta-type (group I) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 205205Gap junction epsilon-1 protein
PRO_0000317611

Regions

Topological domain1 – 3232Cytoplasmic Potential
Transmembrane33 – 5321Helical; Potential
Topological domain54 – 7623Extracellular Potential
Transmembrane77 – 9721Helical; Potential
Topological domain98 – 11215Cytoplasmic Potential
Transmembrane113 – 13321Helical; Potential
Topological domain134 – 17037Extracellular Potential
Transmembrane171 – 19121Helical; Potential
Topological domain192 – 20514Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
A6NN92 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 494389B01BCB07D2

FASTA20523,755
        10         20         30         40         50         60 
MSLNYIKNFY EGCVKPPTVI GQFHTLFFGS IRIFFLGVLG FAVYGNEALH FICDPDKREV 

        70         80         90        100        110        120 
NLFCYNQFRP ITPQVSFSAL QLVIVLVPGA LFHLYAACKS INQECILQKP IYTIIYILSV 

       130        140        150        160        170        180 
LLRISLAAIA FWLQIYLFGF QVKSLYLCDA RSLGENMIIR CMVPEHFEKT IFLIAINTFT 

       190        200 
TITILLFVAE IFEIIFRRLY FPFRQ 

« Hide

References

[1]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL033522 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalA6NN92.
SMRA6NN92. Positions 12-197.
ModBaseSearch...
MobiDBSearch...

Chemistry

GuidetoPHARMACOLOGY714.

Proteomic databases

PRIDEA6NN92.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000450456; ENSP00000455469; ENSG00000203733.

Organism-specific databases

GeneCardsGC06P142454.
HGNCHGNC:33251. GJE1.
HPAHPA014916.
neXtProtNX_A6NN92.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG094838.
InParanoidA6NN92.
OMAYNQFRPI.
OrthoDBEOG7Z95N8.
PhylomeDBA6NN92.

Gene expression databases

GenevestigatorA6NN92.

Family and domain databases

InterProIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR013092. Connexin_N.
[Graphical view]
PANTHERPTHR11984. PTHR11984. 1 hit.
PfamPF00029. Connexin. 1 hit.
PF10582. Connexin_CCC. 1 hit.
[Graphical view]
SMARTSM01089. Connexin_CCC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROA6NN92.

Entry information

Entry nameCXE1_HUMAN
AccessionPrimary (citable) accession number: A6NN92
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM