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A6NN92

- CXE1_HUMAN

UniProt

A6NN92 - CXE1_HUMAN

Protein

Gap junction epsilon-1 protein

Gene

GJE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cell communication Source: InterPro
    2. cell morphogenesis Source: Ensembl
    3. lens development in camera-type eye Source: Ensembl
    4. organ growth Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gap junction epsilon-1 protein
    Alternative name(s):
    Connexin-23
    Short name:
    Cx23
    Gene namesi
    Name:GJE1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:33251. GJE1.

    Subcellular locationi

    GO - Cellular componenti

    1. connexon complex Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Gap junction, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 205205Gap junction epsilon-1 proteinPRO_0000317611Add
    BLAST

    Proteomic databases

    PRIDEiA6NN92.

    Expressioni

    Gene expression databases

    GenevestigatoriA6NN92.

    Organism-specific databases

    HPAiHPA014916.

    Interactioni

    Subunit structurei

    A connexon is composed of a hexamer of connexins.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliA6NN92.
    SMRiA6NN92. Positions 12-197.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3232CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini54 – 7623ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini98 – 11215CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini134 – 17037ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini192 – 20514CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei33 – 5321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei113 – 13321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG094838.
    InParanoidiA6NN92.
    OMAiYNQFRPI.
    OrthoDBiEOG7Z95N8.
    PhylomeDBiA6NN92.

    Family and domain databases

    InterProiIPR000500. Connexin.
    IPR019570. Connexin_CCC.
    IPR013092. Connexin_N.
    [Graphical view]
    PANTHERiPTHR11984. PTHR11984. 1 hit.
    PfamiPF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view]
    SMARTiSM01089. Connexin_CCC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NN92-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLNYIKNFY EGCVKPPTVI GQFHTLFFGS IRIFFLGVLG FAVYGNEALH    50
    FICDPDKREV NLFCYNQFRP ITPQVSFSAL QLVIVLVPGA LFHLYAACKS 100
    INQECILQKP IYTIIYILSV LLRISLAAIA FWLQIYLFGF QVKSLYLCDA 150
    RSLGENMIIR CMVPEHFEKT IFLIAINTFT TITILLFVAE IFEIIFRRLY 200
    FPFRQ 205
    Length:205
    Mass (Da):23,755
    Last modified:July 24, 2007 - v1
    Checksum:i494389B01BCB07D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL033522 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENST00000450456; ENSP00000455469; ENSG00000203733.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL033522 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali A6NN92.
    SMRi A6NN92. Positions 12-197.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 714.

    Proteomic databases

    PRIDEi A6NN92.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000450456 ; ENSP00000455469 ; ENSG00000203733 .

    Organism-specific databases

    GeneCardsi GC06P142454.
    HGNCi HGNC:33251. GJE1.
    HPAi HPA014916.
    neXtProti NX_A6NN92.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG094838.
    InParanoidi A6NN92.
    OMAi YNQFRPI.
    OrthoDBi EOG7Z95N8.
    PhylomeDBi A6NN92.

    Miscellaneous databases

    PROi A6NN92.

    Gene expression databases

    Genevestigatori A6NN92.

    Family and domain databases

    InterProi IPR000500. Connexin.
    IPR019570. Connexin_CCC.
    IPR013092. Connexin_N.
    [Graphical view ]
    PANTHERi PTHR11984. PTHR11984. 1 hit.
    Pfami PF00029. Connexin. 1 hit.
    PF10582. Connexin_CCC. 1 hit.
    [Graphical view ]
    SMARTi SM01089. Connexin_CCC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCXE1_HUMAN
    AccessioniPrimary (citable) accession number: A6NN92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3