Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 729

Gene

ZNF729

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri180 – 202C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri208 – 230C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri236 – 258C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri264 – 286C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri292 – 314C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri600 – 622C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri628 – 650C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri656 – 678C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri684 – 706C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri712 – 734C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri740 – 762C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri768 – 790C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri796 – 818C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri824 – 846C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri852 – 874C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri880 – 902C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri908 – 930C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri936 – 958C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri964 – 986C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri992 – 1014C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1020 – 1042C2H2-type 31PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1048 – 1070C2H2-type 32PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1076 – 1098C2H2-type 33PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1104 – 1126C2H2-type 34PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1132 – 1154C2H2-type 35PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1160 – 1182C2H2-type 36PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1188 – 1210C2H2-type 37PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-32283-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 729
Gene namesi
Name:ZNF729
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32464. ZNF729.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196350.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003323141 – 1252Zinc finger protein 729Add BLAST1252

Proteomic databases

PaxDbiA6NN14.
PRIDEiA6NN14.

PTM databases

iPTMnetiA6NN14.
PhosphoSitePlusiA6NN14.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000469582.

Structurei

3D structure databases

ProteinModelPortaliA6NN14.
SMRiA6NN14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 84KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 37 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri180 – 202C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri208 – 230C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri236 – 258C2H2-type 3; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri264 – 286C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri292 – 314C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 7; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri376 – 398C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri404 – 426C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri432 – 454C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri460 – 482C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri488 – 510C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri516 – 538C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri544 – 566C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri572 – 594C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri600 – 622C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri628 – 650C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri656 – 678C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri684 – 706C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri712 – 734C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri740 – 762C2H2-type 21PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri768 – 790C2H2-type 22PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri796 – 818C2H2-type 23PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri824 – 846C2H2-type 24PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri852 – 874C2H2-type 25PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri880 – 902C2H2-type 26PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri908 – 930C2H2-type 27PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri936 – 958C2H2-type 28PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri964 – 986C2H2-type 29PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri992 – 1014C2H2-type 30PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1020 – 1042C2H2-type 31PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1048 – 1070C2H2-type 32PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1076 – 1098C2H2-type 33PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1104 – 1126C2H2-type 34PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1132 – 1154C2H2-type 35PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1160 – 1182C2H2-type 36PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1188 – 1210C2H2-type 37PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
InParanoidiA6NN14.
KOiK09228.
OMAiFSALMKH.
OrthoDBiEOG091G02KC.
TreeFamiTF343410.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 38 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 10 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 37 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 34 hits.
PS50157. ZINC_FINGER_C2H2_2. 37 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NN14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGAPGSLEM GPLTFRDVTI EFSLEEWQCL DTVQQNLYRD VMLENYRNLV
60 70 80 90 100
FLGMAVFKPD LITCLKQGKE PWNMKRHEMV TKPPVMRSHF TQDLWPDQST
110 120 130 140 150
KDSFQEVILR TYARCGHKNL RLRKDCKSAN EGKMHKEGYN KLNQCRTATQ
160 170 180 190 200
RKIFQCNKHM KVFHKYSNRN KVRHTKKKTF KCIKCSKSFF MLSCLIRHKR
210 220 230 240 250
IHIRQNIYKC EERGKAFKSF STLTKHKIIH TEDKPYKYKK CGNAFKFSST
260 270 280 290 300
FTKHKRIHTG ETPFRCEECG KAFNQSSNLT DHKRIHTGEK TYKCEECGKA
310 320 330 340 350
FKGSSNFNAH KVIHTAEKPY KCEDCGKTFN HFSALRKHKI IHTGKKPYKR
360 370 380 390 400
EECGKAFSQS STLRKHEIIH TGEKPYKCEE CGKAFKWSSK LTVHKVVHTG
410 420 430 440 450
EKPYKCEECG KAFSQFSTLK KHKIIHTGKK PYKCEECGKA FNSSSTLMKH
460 470 480 490 500
KIIHTGEKPY KCEECGKAFR QSSHLTRHKA IHTGEKPYKC EECGKAFNHF
510 520 530 540 550
SDLRRHKIIH TGKKPYKCEE CGKAFSQSST LRNHQIIHTG EKPYKCEECG
560 570 580 590 600
KAFKWSSKLT VHKVIHTGEK PCKCEECGKA FKHFSALRKH KVIHTREKLY
610 620 630 640 650
KCEECGKAFN NSSILAKHKI IHTGKKPYKC EECGKAFRQS SHLTRHKAIH
660 670 680 690 700
TGEKPYKCEE CGKAFSHFSA LRRHKIIHTG KKPYKCEECG KAFSHFSALR
710 720 730 740 750
RHKIIHTGEK PYKCEECGKA FKWSSKLTVH KVIHTAEKPC KCEECGKSFK
760 770 780 790 800
HFSALRKHKV IHTREKLYKC EECVKAFNSF SALMKHKVIH TGEKPYKCEE
810 820 830 840 850
CGKAFKWSSK LTVHKVIHTG EKPCKCEECG KAFKHFSALR KHKVIHTGKK
860 870 880 890 900
PYKCEECGKA FSQSSSLRKH EIIHSGEKPY KCEECGKAFK WLSKLTVHKV
910 920 930 940 950
IHTAEKPCKC EECGKAFKHF SALRKHKIIH TGKKPYKCEE CGKAFNDSST
960 970 980 990 1000
LMKHKIIHTG KKPYKCAECG KAFKQSSHLT RHKAIHTGEK PYKCEECGKD
1010 1020 1030 1040 1050
FNNSSTLKKH KLIHTREKLY KCEECVKAFN NFSALMKHKI IHTGEKPYKC
1060 1070 1080 1090 1100
EECGKAFKWS SKLTEHKVIH TGEKPCKCEE CDKAFKHFSA LRKHKVIHTG
1110 1120 1130 1140 1150
KKPYQCDECG KAFNNSSTLT KHKIIHTGEK PYKCEECGKA FSQSSILTKH
1160 1170 1180 1190 1200
KIIHSVEKPY KCEECGKAFN QSSHLTRHKT IHTGEKPYKC EECGKAFIQC
1210 1220 1230 1240 1250
SYLIRHKTIH TREKPTNVKK VPKLLSNPHT LLDKTIHTGE KPYKCEECAK

AF
Length:1,252
Mass (Da):145,022
Last modified:May 14, 2014 - v4
Checksum:iDA92ED8A0114DE8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011494 Genomic DNA. No translation available.
AC073539 Genomic DNA. No translation available.
BX956721 mRNA. No translation available.
CCDSiCCDS59368.1.
RefSeqiNP_001229609.1. NM_001242680.1.
UniGeneiHs.531629.

Genome annotation databases

EnsembliENST00000601693; ENSP00000469582; ENSG00000196350.
GeneIDi100287226.
KEGGihsa:100287226.
UCSCiuc021urs.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011494 Genomic DNA. No translation available.
AC073539 Genomic DNA. No translation available.
BX956721 mRNA. No translation available.
CCDSiCCDS59368.1.
RefSeqiNP_001229609.1. NM_001242680.1.
UniGeneiHs.531629.

3D structure databases

ProteinModelPortaliA6NN14.
SMRiA6NN14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000469582.

PTM databases

iPTMnetiA6NN14.
PhosphoSitePlusiA6NN14.

Proteomic databases

PaxDbiA6NN14.
PRIDEiA6NN14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000601693; ENSP00000469582; ENSG00000196350.
GeneIDi100287226.
KEGGihsa:100287226.
UCSCiuc021urs.2. human.

Organism-specific databases

CTDi100287226.
GeneCardsiZNF729.
HGNCiHGNC:32464. ZNF729.
neXtProtiNX_A6NN14.
OpenTargetsiENSG00000196350.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
InParanoidiA6NN14.
KOiK09228.
OMAiFSALMKH.
OrthoDBiEOG091G02KC.
TreeFamiTF343410.

Enzyme and pathway databases

BioCyciZFISH:G66-32283-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii100287226.
PROiA6NN14.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 38 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 7 hits.
PF13912. zf-C2H2_6. 10 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 37 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 34 hits.
PS50157. ZINC_FINGER_C2H2_2. 37 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN729_HUMAN
AccessioniPrimary (citable) accession number: A6NN14
Secondary accession number(s): M0QY45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 14, 2014
Last modified: November 2, 2016
This is version 83 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.