Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Collagen alpha-6(VI) chain

Gene

COL6A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Collagen VI acts as a cell-binding protein.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

BioCyciZFISH:G66-31115-MONOMER.
ReactomeiR-HSA-1442490. Collagen degradation.
R-HSA-1650814. Collagen biosynthesis and modifying enzymes.
R-HSA-186797. Signaling by PDGF.
R-HSA-2022090. Assembly of collagen fibrils and other multimeric structures.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-3000178. ECM proteoglycans.
R-HSA-419037. NCAM1 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-6(VI) chain
Gene namesi
Name:COL6A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:27023. COL6A6.

Subcellular locationi

GO - Cellular componenti

  • collagen trimer Source: UniProtKB-KW
  • extracellular region Source: Reactome
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000206384.
PharmGKBiPA165697087.

Chemistry databases

ChEMBLiCHEMBL2364188.

Polymorphism and mutation databases

BioMutaiCOL6A6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500026630620 – 2263Collagen alpha-6(VI) chainAdd BLAST2244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi198N-linked (GlcNAc...)1 Publication1
Glycosylationi275N-linked (GlcNAc...)1 Publication1
Glycosylationi288N-linked (GlcNAc...)1 Publication1
Glycosylationi298N-linked (GlcNAc...)1 Publication1
Glycosylationi347N-linked (GlcNAc...)Sequence analysis1
Glycosylationi520N-linked (GlcNAc...)Sequence analysis1
Glycosylationi930N-linked (GlcNAc...)1 Publication1
Glycosylationi988N-linked (GlcNAc...)1 Publication1
Glycosylationi1290N-linked (GlcNAc...)1 Publication1

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.By similarity

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiA6NMZ7.
PaxDbiA6NMZ7.
PRIDEiA6NMZ7.

PTM databases

iPTMnetiA6NMZ7.
PhosphoSitePlusiA6NMZ7.

Expressioni

Gene expression databases

BgeeiENSG00000206384.
ExpressionAtlasiA6NMZ7. baseline and differential.
GenevisibleiA6NMZ7. HS.

Organism-specific databases

HPAiHPA045239.

Interactioni

Subunit structurei

Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-5(VI) or alpha-6(VI).Curated

Protein-protein interaction databases

STRINGi9606.ENSP00000351310.

Structurei

3D structure databases

ProteinModelPortaliA6NMZ7.
SMRiA6NMZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 206VWFA 1PROSITE-ProRule annotationAdd BLAST180
Domaini229 – 411VWFA 2PROSITE-ProRule annotationAdd BLAST183
Domaini436 – 606VWFA 3PROSITE-ProRule annotationAdd BLAST171
Domaini622 – 791VWFA 4PROSITE-ProRule annotationAdd BLAST170
Domaini809 – 982VWFA 5PROSITE-ProRule annotationAdd BLAST174
Domaini1000 – 1171VWFA 6PROSITE-ProRule annotationAdd BLAST172
Domaini1187 – 1371VWFA 7PROSITE-ProRule annotationAdd BLAST185
Domaini1757 – 1937VWFA 8PROSITE-ProRule annotationAdd BLAST181
Domaini1965 – 2166VWFA 9PROSITE-ProRule annotationAdd BLAST202

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 1391Nonhelical regionAdd BLAST1372
Regioni1392 – 1725Triple-helical regionAdd BLAST334
Regioni1726 – 2263Nonhelical regionAdd BLAST538

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1508 – 1510Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the type VI collagen family.Curated
Contains 9 VWFA domains.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3544. Eukaryota.
ENOG410Y0KT. LUCA.
GeneTreeiENSGT00760000119000.
HOGENOMiHOG000111864.
HOVERGENiHBG107743.
InParanoidiA6NMZ7.
KOiK06238.
OMAiFQVTNAM.
OrthoDBiEOG091G006Y.
PhylomeDBiA6NMZ7.
TreeFamiTF318242.

Family and domain databases

Gene3Di3.40.50.410. 9 hits.
InterProiIPR008160. Collagen.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00092. VWA. 8 hits.
[Graphical view]
SMARTiSM00327. VWA. 9 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 9 hits.
PROSITEiPS50234. VWFA. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NMZ7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLLILFLVI ICSHISVNQD SGPEYADVVF LVDSSDRLGS KSFPFVKMFI
60 70 80 90 100
TKMISSLPIE ADKYRVALAQ YSDKLHSEFH LSTFKGRSPM LNHLRKNFGF
110 120 130 140 150
IGGSLQIGKA LQEAHRTYFS APANGRDKKQ FPPILVVLAS SESEDNVEEA
160 170 180 190 200
SKALRKDGVK IISVGVQKAS EENLKAMATS QFHFNLRTVR DLSMFSQNMT
210 220 230 240 250
HIIKDVIKYK EGAVDDIFVE ACQGPSMADV VFLLDMSING SEENFDYLKG
260 270 280 290 300
FLEESVSALD IKENCMRVGL VAYSNETKVI NSLSMGINKS EVLQHIQNLS
310 320 330 340 350
PRTGKAYTGA AIKKLRKEVF SARNGSRKNQ GVPQIAVLVT HRDSEDNVTK
360 370 380 390 400
AAVNLRREGV TIFTLGIEGA SDTQLEKIAS HPAEQYVSKL KTFADLAAHN
410 420 430 440 450
QTFLKKLRNQ ITHTVSVFSE RTETLKSGCV DTEEADIYLL IDGSGSTQAT
460 470 480 490 500
DFHEMKTFLS EVVGMFNIAP HKVRVGAVQY ADSWDLEFEI NKYSNKQDLG
510 520 530 540 550
KAIENIRQMG GNTNTGAALN FTLSLLQKAK KQRGNKVPCH LVVLTNGMSK
560 570 580 590 600
DSILEPANRL REEHIRVYAI GIKEANQTQL REIAGEEKRV YYVHDFDALK
610 620 630 640 650
DIRNQVVQEI CTEEACKEMK ADIMFLVDSS GSIGPENFSK MKTFMKNLVS
660 670 680 690 700
KSQIGPDRVQ IGVVQFSDIN KEEFQLNRFM SQSDISNAID QMAHIGQTTL
710 720 730 740 750
TGSALSFVSQ YFSPTKGARP NIRKFLILIT DGEAQDIVKE PAVVLRQEGV
760 770 780 790 800
IIYSVGVFGS NVTQLEEISG RPEMVFYVEN FDILQRIEDD LVFGICSPRE
810 820 830 840 850
ECKRIEVLDV VFVIDSSGSI DYDEYNIMKD FMIGLVKKAD VGKNQVRFGA
860 870 880 890 900
LKYADDPEVL FYLDDFGTKL EVISVLQNDQ AMGGSTYTAE ALGFSDHMFT
910 920 930 940 950
EARGSRLNKG VPQVLIVITD GESHDADKLN ATAKALRDKG ILVLAVGIDG
960 970 980 990 1000
ANPVELLAMA GSSDKYFFVE TFGGLKGIFS DVTASVCNSS KVDCEIDKVD
1010 1020 1030 1040 1050
LVFLMDGSTS IQPNDFKKMK EFLASVVQDF DVSLNRVRIG AAQFSDTYHP
1060 1070 1080 1090 1100
EFPLGTFIGE KEISFQIENI KQIFGNTHIG AALREVEHYF RPDMGSRINT
1110 1120 1130 1140 1150
GTPQVLLVLT DGQSQDEVAQ AAEALRHRGI DIYSVGIGDV DDQQLIQITG
1160 1170 1180 1190 1200
TAEKKLTVHN FDELKKVNKR IVRNICTTAG ESNCFVDVVV GFDVSTQEKG
1210 1220 1230 1240 1250
QTLLEGQPWM ETYLQDILRA ISSLNGVSCE VGTETQVSVA FQVTNAMEKY
1260 1270 1280 1290 1300
SPKFEIYSEN ILNSLKDITV KGPSLLNANL LDSLWDTFQN KSAARGKVVL
1310 1320 1330 1340 1350
LFSDGLDDDV EKLEQKSDEL RKEGLNALIT VALDGPADSS DLADLPYIEF
1360 1370 1380 1390 1400
GKGFEYRTQL SIGMRELGSR LSKQLVNVAE RTCCCLFCKC IGGDGTMGDP
1410 1420 1430 1440 1450
GPPGKRGPPG FKGSEGYLGE EGIAGERGAP GPVGEQGTKG CYGTKGPKGN
1460 1470 1480 1490 1500
RGLNGQEGEV GENGIDGLNG EQGDNGLPGR KGEKGDEGSQ GSPGKRGTPG
1510 1520 1530 1540 1550
DRGAKGLRGD PGAPGVDSSI EGPTGLKGER GRQGRRGWPG PPGTPGSRRK
1560 1570 1580 1590 1600
TAAHGRRGHT GPQGTAGIPG PDGLEGSLGL KGPQGPRGEA GVKGEKGGVG
1610 1620 1630 1640 1650
SKGPQGPPGP GGEAGNQGRL GSQGNKGEPG DLGEKGAVGF PGPRGLQGND
1660 1670 1680 1690 1700
GSPGYGSVGR KGAKGQEGFP GESGPKGEIG DPGGPGETGL KGARGKMISA
1710 1720 1730 1740 1750
GLPGEMGSPG EPGPPGRKGV KGAKGLASFS TCELIQYVRD RSPGRHGKPE
1760 1770 1780 1790 1800
CPVHPTELVF ALDHSRDVTE QEFERMKEMM AFLVRDIKVR ENSCPVGAHI
1810 1820 1830 1840 1850
AILSYNSHAR HLVRFSDAYK KSQLLREIET IPYERSSASR EIGRAMRFIS
1860 1870 1880 1890 1900
RNVFKRTLPG AHTRKIATFF SSGQSADAHS ITTAAMEFGA LEIIPVVITF
1910 1920 1930 1940 1950
SNVPSVRRAF AIDDTGTFQV IVVPSGADYI PALERLQRCT FCYDVCKPDA
1960 1970 1980 1990 2000
SCDQARPPPV QSYMDAAFLL DASRNMGSAE FEDIRAFLGA LLDHFEITPE
2010 2020 2030 2040 2050
PETSVTGDRV ALLSHAPPDF LPNTQKSPVR AEFNLTTYRS KRLMKRHVHE
2060 2070 2080 2090 2100
SVKQLNGDAF IGHALQWTLD NVFLSTPNLR RNKVIFVISA GETSHLDGEI
2110 2120 2130 2140 2150
LKKESLRAKC QGYALFVFSL GPIWDDKELE DLASHPLDHH LVQLGRIHKP
2160 2170 2180 2190 2200
DHSYGVKFVK SFINSIRRAI NKYPPINLKI KCNRLNSIDP KQPPRPFRSF
2210 2220 2230 2240 2250
VPGPLKATLK EDVLQKAKFF QDKKYLSRVA RSGRDDAIQN FMRSTSHTFK
2260
NGRMIESAPK QHD
Length:2,263
Mass (Da):247,173
Last modified:May 20, 2008 - v2
Checksum:iEED4F30ABAED7F30
GO
Isoform 2 (identifier: A6NMZ7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1512-1520: GAPGVDSSI → VSARAANWS
     1521-2263: Missing.

Note: No experimental confirmation available.
Show »
Length:1,520
Mass (Da):166,865
Checksum:i227C6A3808F5FA5F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1429A → V in CAH10639 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043609345E → K.Corresponds to variant rs4613427dbSNPEnsembl.1
Natural variantiVAR_043610370A → T.Corresponds to variant rs9830253dbSNPEnsembl.1
Natural variantiVAR_043611461E → A.Corresponds to variant rs11921769dbSNPEnsembl.1
Natural variantiVAR_061120556P → S.Corresponds to variant rs59021909dbSNPEnsembl.1
Natural variantiVAR_0436121739R → Q.Corresponds to variant rs16830494dbSNPEnsembl.1
Natural variantiVAR_0436131799H → R.Corresponds to variant rs7614116dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0339141512 – 1520GAPGVDSSI → VSARAANWS in isoform 2. 1 Publication9
Alternative sequenceiVSP_0339151521 – 2263Missing in isoform 2. 1 PublicationAdd BLAST743

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM774225 mRNA. Translation: CAO81741.1.
AM774226 mRNA. Translation: CAO81739.1.
AM774227 mRNA. Translation: CAO81740.1.
AC093006 Genomic DNA. No translation available.
AC128683 Genomic DNA. No translation available.
AL713792 mRNA. Translation: CAH10639.2.
CCDSiCCDS46911.1. [A6NMZ7-1]
RefSeqiNP_001096078.1. NM_001102608.1. [A6NMZ7-1]
XP_005247178.1. XM_005247121.4. [A6NMZ7-1]
XP_011510727.1. XM_011512425.2. [A6NMZ7-1]
XP_011510728.1. XM_011512426.2. [A6NMZ7-1]
XP_011510730.1. XM_011512428.2. [A6NMZ7-1]
XP_016861200.1. XM_017005711.1. [A6NMZ7-1]
XP_016861201.1. XM_017005712.1. [A6NMZ7-1]
XP_016861202.1. XM_017005713.1. [A6NMZ7-1]
XP_016861203.1. XM_017005714.1. [A6NMZ7-1]
XP_016861204.1. XM_017005715.1. [A6NMZ7-1]
UniGeneiHs.591282.
Hs.596805.

Genome annotation databases

EnsembliENST00000358511; ENSP00000351310; ENSG00000206384. [A6NMZ7-1]
GeneIDi131873.
KEGGihsa:131873.
UCSCiuc010htl.4. human. [A6NMZ7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM774225 mRNA. Translation: CAO81741.1.
AM774226 mRNA. Translation: CAO81739.1.
AM774227 mRNA. Translation: CAO81740.1.
AC093006 Genomic DNA. No translation available.
AC128683 Genomic DNA. No translation available.
AL713792 mRNA. Translation: CAH10639.2.
CCDSiCCDS46911.1. [A6NMZ7-1]
RefSeqiNP_001096078.1. NM_001102608.1. [A6NMZ7-1]
XP_005247178.1. XM_005247121.4. [A6NMZ7-1]
XP_011510727.1. XM_011512425.2. [A6NMZ7-1]
XP_011510728.1. XM_011512426.2. [A6NMZ7-1]
XP_011510730.1. XM_011512428.2. [A6NMZ7-1]
XP_016861200.1. XM_017005711.1. [A6NMZ7-1]
XP_016861201.1. XM_017005712.1. [A6NMZ7-1]
XP_016861202.1. XM_017005713.1. [A6NMZ7-1]
XP_016861203.1. XM_017005714.1. [A6NMZ7-1]
XP_016861204.1. XM_017005715.1. [A6NMZ7-1]
UniGeneiHs.591282.
Hs.596805.

3D structure databases

ProteinModelPortaliA6NMZ7.
SMRiA6NMZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000351310.

Chemistry databases

ChEMBLiCHEMBL2364188.

PTM databases

iPTMnetiA6NMZ7.
PhosphoSitePlusiA6NMZ7.

Polymorphism and mutation databases

BioMutaiCOL6A6.

Proteomic databases

MaxQBiA6NMZ7.
PaxDbiA6NMZ7.
PRIDEiA6NMZ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358511; ENSP00000351310; ENSG00000206384. [A6NMZ7-1]
GeneIDi131873.
KEGGihsa:131873.
UCSCiuc010htl.4. human. [A6NMZ7-1]

Organism-specific databases

CTDi131873.
GeneCardsiCOL6A6.
H-InvDBHIX0003677.
HGNCiHGNC:27023. COL6A6.
HPAiHPA045239.
MIMi616613. gene.
neXtProtiNX_A6NMZ7.
OpenTargetsiENSG00000206384.
PharmGKBiPA165697087.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3544. Eukaryota.
ENOG410Y0KT. LUCA.
GeneTreeiENSGT00760000119000.
HOGENOMiHOG000111864.
HOVERGENiHBG107743.
InParanoidiA6NMZ7.
KOiK06238.
OMAiFQVTNAM.
OrthoDBiEOG091G006Y.
PhylomeDBiA6NMZ7.
TreeFamiTF318242.

Enzyme and pathway databases

BioCyciZFISH:G66-31115-MONOMER.
ReactomeiR-HSA-1442490. Collagen degradation.
R-HSA-1650814. Collagen biosynthesis and modifying enzymes.
R-HSA-186797. Signaling by PDGF.
R-HSA-2022090. Assembly of collagen fibrils and other multimeric structures.
R-HSA-216083. Integrin cell surface interactions.
R-HSA-3000178. ECM proteoglycans.
R-HSA-419037. NCAM1 interactions.

Miscellaneous databases

ChiTaRSiCOL6A6. human.
GenomeRNAii131873.
PROiA6NMZ7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000206384.
ExpressionAtlasiA6NMZ7. baseline and differential.
GenevisibleiA6NMZ7. HS.

Family and domain databases

Gene3Di3.40.50.410. 9 hits.
InterProiIPR008160. Collagen.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00092. VWA. 8 hits.
[Graphical view]
SMARTiSM00327. VWA. 9 hits.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 9 hits.
PROSITEiPS50234. VWFA. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCO6A6_HUMAN
AccessioniPrimary (citable) accession number: A6NMZ7
Secondary accession number(s): A7DZQ0
, A7DZQ1, A7DZQ2, Q69YT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 30, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.