Reviewed,
UniProtKB/Swiss-Prot A6NMY6 (AXA2L_HUMAN)
Last modified
November 24, 2009.
Version 22.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Putative annexin A2-like protein Alternative name(s): Annexin A2 pseudogene 2 Lipocortin II pseudogene | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 339 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Uncertain. |
General annotation (Comments)
| Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids By similarity. It binds two calcium ions with high affinity By similarity. May be involved in heat-stress response By similarity. |
| Subunit structure | Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2P2/p36 By similarity. |
| Subcellular location | Secreted › extracellular space › extracellular matrix › basement membrane By similarity. Melanosome By similarity. Note: In the lamina beneath the plasma membrane By similarity. In melanosome fractions from stage I to stage IV By similarity. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism By similarity. |
| Domain | A pair of annexin repeats may form one binding site for calcium and phospholipid By similarity. |
| Miscellaneous | It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis By similarity. |
| Sequence similarities | Belongs to the annexin family. Contains 4 annexin repeats. |
| Caution | Could be the product of a pseudogene. The existence of a transcript at this locus is supported by only one sequence submission (Ref.1). |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Basement membrane Extracellular matrix Secreted |
| Domain | Annexin Repeat |
| Ligand | Calcium Calcium/phospholipid-binding |
| PTM | Acetylation Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | basement membrane Inferred from electronic annotation. Source: UniProtKB-SubCell melanosomeInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW calcium-dependent phospholipid bindingInferred from electronic annotation. Source: UniProtKB-KW cytoskeletal protein bindingInferred from electronic annotation. Source: InterPro phospholipase inhibitor activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 2 – 339 | 338 | Putative annexin A2-like protein | PRO_0000343940 | |||||
Regions | |||||||||
| Repeat | 37 – 102 | 66 | Annexin 1 | ||||||
| Repeat | 109 – 174 | 66 | Annexin 2 | ||||||
| Repeat | 193 – 259 | 67 | Annexin 3 | ||||||
| Repeat | 269 – 334 | 66 | Annexin 4 | ||||||
| Region | 2 – 24 | 23 | S100A10-binding site Potential | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylserine By similarity | ||||||
| Modified residue | 18 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 19 | 1 | Phosphothreonine Ref.3 | ||||||
| Modified residue | 24 | 1 | Phosphotyrosine; by SRC Ref.4 | ||||||
| Modified residue | 26 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 30 | 1 | Phosphotyrosine Ref.4 | ||||||
| Modified residue | 127 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 188 | 1 | Phosphotyrosine Ref.4 | ||||||
| Modified residue | 238 | 1 | Phosphotyrosine Ref.4 | ||||||
| Modified residue | 316 | 1 | Phosphotyrosine Ref.4 | ||||||
| Modified residue | 317 | 1 | Phosphotyrosine Ref.4 | ||||||
| Modified residue | 318 | 1 | Phosphotyrosine Ref.4 | ||||||
Experimental info | |||||||||
| Sequence conflict | 72 | 1 | V → S in M62898. Ref.1 | ||||||
| Sequence conflict | 338 | 1 | D → A in M62898. Ref.1 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication." Spano F., Raugei G., Palla E., Colella C., Melli M. Gene 95:243-251(1990) [PubMed: 2174397] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. Dunham I.Nature 429:369-374(2004) [PubMed: 15164053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-19; SER-26 AND SER-127, MASS SPECTROMETRY. |
| [4] | "An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells." Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A., Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D., Wiley H.S., Qian W.-J. J. Proteome Res. 8:3852-3861(2009) [PubMed: 19534553] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-24; TYR-30; TYR-188; TYR-238; TYR-316; TYR-317 AND TYR-318, MASS SPECTROMETRY. Tissue: Mammary epithelium. |
Cross-references
Sequence databases | |
|---|---|
| M62898 mRNA. No translation available. AL139008 Genomic DNA. No translation available. | |
| IPI | IPI00334627. |
| UniGene | Hs.534301 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | A6NMY6. |
Genome annotation databases | |
| Ensembl | ENST00000332680; ENSP00000346032; ENSG00000182718; Homo sapiens. [Genome view] ENST00000396024; ENSP00000379342; ENSG00000182718; Homo sapiens. [Genome view] ENST00000421017; ENSP00000411352; ENSG00000182718; Homo sapiens. [Genome view] ENST00000451270; ENSP00000387545; ENSG00000182718; Homo sapiens. [Genome view] |
| UCSC | uc010mjx.1. human. |
Organism-specific databases | |
| GeneCards | GC09P033614. |
| HGNC | HGNC:539. ANXA2P2. |
| GenAtlas | Search... |
Gene expression databases | |
| Bgee | A6NMY6. |
| Genevestigator | A6NMY6. |
Family and domain databases | |
| InterPro | IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR002389. AnnexinII. [Graphical view] |
| Gene3D | G3DSA:1.10.220.10. Annexin. 4 hits. |
| PANTHER | PTHR10502. Annexin. 1 hit. PTHR10502:SF18. AnnexinII. 1 hit. |
| Pfam | PF00191. Annexin. 4 hits. [Graphical view] |
| PRINTS | PR00196. ANNEXIN. PR00198. ANNEXINII. |
| SMART | SM00335. ANX. 4 hits. [Graphical view] |
| PROSITE | PS00223. ANNEXIN. 4 hits. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AXA2L_HUMAN | ||||||||
| Accession | Primary (citable) accession number: A6NMY6 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 9 Human chromosome 9: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

Clusters with


