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A6NMY6

- AXA2L_HUMAN

UniProt

A6NMY6 - AXA2L_HUMAN

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Protein
Putative annexin A2-like protein
Gene
ANXA2P2, ANX2L2, ANX2P2, LPC2B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Protein uncertaini

Functioni

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids By similarity. It binds two calcium ions with high affinity By similarity. May be involved in heat-stress response By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. calcium-dependent phospholipid binding Source: UniProtKB-KW
  3. phospholipase inhibitor activity Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative annexin A2-like protein
Alternative name(s):
Annexin A2 pseudogene 2
Lipocortin II pseudogene
Gene namesi
Name:ANXA2P2
Synonyms:ANX2L2, ANX2P2, LPC2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:539. ANXA2P2.

Subcellular locationi

Secretedextracellular spaceextracellular matrixbasement membrane By similarity. Melanosome By similarity
Note: In the lamina beneath the plasma membrane By similarity. In melanosome fractions from stage I to stage IV By similarity. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism By similarity.

GO - Cellular componenti

  1. basement membrane Source: UniProtKB-SubCell
  2. melanosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 339338Putative annexin A2-like protein
PRO_0000343940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei24 – 241Phosphotyrosine; by SRC By similarity
Modified residuei26 – 261Phosphoserine By similarity
Modified residuei49 – 491N6-acetyllysine By similarity
Modified residuei152 – 1521N6-acetyllysine By similarity
Modified residuei199 – 1991Phosphotyrosine By similarity
Modified residuei227 – 2271N6-acetyllysine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiA6NMY6.
PRIDEiA6NMY6.

Expressioni

Gene expression databases

GenevestigatoriA6NMY6.

Organism-specific databases

HPAiCAB004311.

Interactioni

Subunit structurei

Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2P2/p36 By similarity.

Protein-protein interaction databases

IntActiA6NMY6. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliA6NMY6.
SMRiA6NMY6. Positions 2-339.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati37 – 10266Annexin 1
Add
BLAST
Repeati109 – 17466Annexin 2
Add
BLAST
Repeati193 – 25967Annexin 3
Add
BLAST
Repeati269 – 33466Annexin 4
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 2423S100A10-binding site Reviewed prediction
Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid By similarity.

Sequence similaritiesi

Belongs to the annexin family.
Contains 4 annexin repeats.

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

HOVERGENiHBG061815.
InParanoidiA6NMY6.
PhylomeDBiA6NMY6.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view]
PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NMY6-1 [UniParc]FASTAAdd to Basket

« Hide

MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG    50
VDEVTIVNIV TNRDNAQRQD IVFSYQRRTK KELASALKSA LSGHLETVIL 100
GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM 150
YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDAQDLYD 200
AGVKRKGTDV PKWISIMTER SVPHLQKVFD RYKSYSPYDM LESIRKEVKG 250
DLENAFLNLV QRIQNKPLYF ADQLYDSMKG KGTRDKVLIR IMVSRSEVDM 300
LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD 339
Length:339
Mass (Da):38,659
Last modified:January 15, 2008 - v2
Checksum:i6A05AB3E19392A15
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti72 – 721V → S in M62898. 1 Publication
Sequence conflicti338 – 3381D → A in M62898. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62898 mRNA. No translation available.
AL139008 Genomic DNA. No translation available.
UniGeneiHs.534301.

Genome annotation databases

UCSCiuc010mjx.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M62898 mRNA. No translation available.
AL139008 Genomic DNA. No translation available.
UniGenei Hs.534301.

3D structure databases

ProteinModelPortali A6NMY6.
SMRi A6NMY6. Positions 2-339.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi A6NMY6. 5 interactions.

Proteomic databases

MaxQBi A6NMY6.
PRIDEi A6NMY6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi uc010mjx.3. human.

Organism-specific databases

GeneCardsi GC09P033780.
HGNCi HGNC:539. ANXA2P2.
HPAi CAB004311.
neXtProti NX_A6NMY6.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG061815.
InParanoidi A6NMY6.
PhylomeDBi A6NMY6.

Gene expression databases

Genevestigatori A6NMY6.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002389. AnnexinII.
[Graphical view ]
PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00198. ANNEXINII.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication."
    Spano F., Raugei G., Palla E., Colella C., Melli M.
    Gene 95:243-251(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiAXA2L_HUMAN
AccessioniPrimary (citable) accession number: A6NMY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: January 15, 2008
Last modified: May 14, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis By similarity.

Caution

Could be the product of a pseudogene. The existence of a transcript at this locus is supported by only one sequence submission (1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi