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A6NMY6

- AXA2L_HUMAN

UniProt

A6NMY6 - AXA2L_HUMAN

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Protein
Putative annexin A2-like protein
Gene
ANXA2P2, ANX2L2, ANX2P2, LPC2B
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Protein uncertaini

Functioni

Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids By similarity. It binds two calcium ions with high affinity By similarity. May be involved in heat-stress response By similarity.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. calcium-dependent phospholipid binding Source: UniProtKB-KW
  3. phospholipase inhibitor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative annexin A2-like protein
    Alternative name(s):
    Annexin A2 pseudogene 2
    Lipocortin II pseudogene
    Gene namesi
    Name:ANXA2P2
    Synonyms:ANX2L2, ANX2P2, LPC2B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:539. ANXA2P2.

    Subcellular locationi

    Secretedextracellular spaceextracellular matrixbasement membrane By similarity. Melanosome By similarity
    Note: In the lamina beneath the plasma membrane By similarity. In melanosome fractions from stage I to stage IV By similarity. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism By similarity.

    GO - Cellular componenti

    1. basement membrane Source: UniProtKB-SubCell
    2. melanosome Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Basement membrane, Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed By similarity
    Chaini2 – 339338Putative annexin A2-like protein
    PRO_0000343940Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine By similarity
    Modified residuei24 – 241Phosphotyrosine; by SRC By similarity
    Modified residuei26 – 261Phosphoserine By similarity
    Modified residuei49 – 491N6-acetyllysine By similarity
    Modified residuei152 – 1521N6-acetyllysine By similarity
    Modified residuei199 – 1991Phosphotyrosine By similarity
    Modified residuei227 – 2271N6-acetyllysine By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiA6NMY6.
    PRIDEiA6NMY6.

    Expressioni

    Gene expression databases

    GenevestigatoriA6NMY6.

    Organism-specific databases

    HPAiCAB004311.

    Interactioni

    Subunit structurei

    Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2P2/p36 By similarity.

    Protein-protein interaction databases

    IntActiA6NMY6. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NMY6.
    SMRiA6NMY6. Positions 2-339.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati37 – 10266Annexin 1
    Add
    BLAST
    Repeati109 – 17466Annexin 2
    Add
    BLAST
    Repeati193 – 25967Annexin 3
    Add
    BLAST
    Repeati269 – 33466Annexin 4
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni2 – 2423S100A10-binding site Reviewed prediction
    Add
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid By similarity.

    Sequence similaritiesi

    Belongs to the annexin family.
    Contains 4 annexin repeats.

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    HOVERGENiHBG061815.
    InParanoidiA6NMY6.
    PhylomeDBiA6NMY6.

    Family and domain databases

    Gene3Di1.10.220.10. 4 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002389. AnnexinII.
    [Graphical view]
    PANTHERiPTHR10502:SF18. PTHR10502:SF18. 1 hit.
    PfamiPF00191. Annexin. 4 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR00198. ANNEXINII.
    SMARTiSM00335. ANX. 4 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A6NMY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTVHEILCK LSLEGDHSTP PSAYGSVKAY TNFDAERDAL NIETAIKTKG    50
    VDEVTIVNIV TNRDNAQRQD IVFSYQRRTK KELASALKSA LSGHLETVIL 100
    GLLKTPAQYD ASELKASMKG LGTDEDSLIE IICSRTNQEL QEINRVYKEM 150
    YKTDLEKDII SDTSGDFRKL MVALAKGRRA EDGSVIDYEL IDQDAQDLYD 200
    AGVKRKGTDV PKWISIMTER SVPHLQKVFD RYKSYSPYDM LESIRKEVKG 250
    DLENAFLNLV QRIQNKPLYF ADQLYDSMKG KGTRDKVLIR IMVSRSEVDM 300
    LKIRSEFKRK YGKSLYYYIQ QDTKGDYQKA LLYLCGGDD 339
    Length:339
    Mass (Da):38,659
    Last modified:January 15, 2008 - v2
    Checksum:i6A05AB3E19392A15
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti72 – 721V → S in M62898. 1 Publication
    Sequence conflicti338 – 3381D → A in M62898. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62898 mRNA. No translation available.
    AL139008 Genomic DNA. No translation available.
    UniGeneiHs.534301.

    Genome annotation databases

    UCSCiuc010mjx.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M62898 mRNA. No translation available.
    AL139008 Genomic DNA. No translation available.
    UniGenei Hs.534301.

    3D structure databases

    ProteinModelPortali A6NMY6.
    SMRi A6NMY6. Positions 2-339.
    ModBasei Search...

    Protein-protein interaction databases

    IntActi A6NMY6. 5 interactions.

    Proteomic databases

    MaxQBi A6NMY6.
    PRIDEi A6NMY6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc010mjx.3. human.

    Organism-specific databases

    GeneCardsi GC09P033780.
    HGNCi HGNC:539. ANXA2P2.
    HPAi CAB004311.
    neXtProti NX_A6NMY6.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG061815.
    InParanoidi A6NMY6.
    PhylomeDBi A6NMY6.

    Gene expression databases

    Genevestigatori A6NMY6.

    Family and domain databases

    Gene3Di 1.10.220.10. 4 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002389. AnnexinII.
    [Graphical view ]
    PANTHERi PTHR10502:SF18. PTHR10502:SF18. 1 hit.
    Pfami PF00191. Annexin. 4 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR00198. ANNEXINII.
    SMARTi SM00335. ANX. 4 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Characterization of the human lipocortin-2-encoding multigene family: its structure suggests the existence of a short amino acid unit undergoing duplication."
      Spano F., Raugei G., Palla E., Colella C., Melli M.
      Gene 95:243-251(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiAXA2L_HUMAN
    AccessioniPrimary (citable) accession number: A6NMY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: January 15, 2008
    Last modified: May 14, 2014
    This is version 57 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis By similarity.

    Caution

    Could be the product of a pseudogene. The existence of a transcript at this locus is supported by only one sequence submission (1 Publication).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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