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Protein

Eukaryotic translation initiation factor 4E type 1B

Gene

EIF4E1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structure.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis, Translation regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E type 1B
Gene namesi
Name:EIF4E1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:33179. EIF4E1B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162384974.

Polymorphism and mutation databases

BioMutaiEIF4E1B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 242242Eukaryotic translation initiation factor 4E type 1BPRO_0000342513Add
BLAST

Proteomic databases

EPDiA6NMX2.
PaxDbiA6NMX2.
PeptideAtlasiA6NMX2.
PRIDEiA6NMX2.

PTM databases

iPTMnetiA6NMX2.
PhosphoSiteiA6NMX2.

Expressioni

Gene expression databases

BgeeiA6NMX2.
CleanExiHS_EIF4E1B.
ExpressionAtlasiA6NMX2. baseline and differential.

Organism-specific databases

HPAiHPA045045.

Interactioni

Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E AND EIF4G (By similarity).By similarity

Protein-protein interaction databases

STRINGi9606.ENSP00000323714.

Structurei

3D structure databases

ProteinModelPortaliA6NMX2.
SMRiA6NMX2. Positions 20-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 654EIF4EBP1/2/3 bindingBy similarity
Regioni81 – 8227-methylguanosine-containing mRNA cap bindingBy similarity
Regioni98 – 1025EIF4EBP1/2/3 bindingBy similarity
Regioni127 – 12827-methylguanosine-containing mRNA cap bindingBy similarity
Regioni157 – 1648EIF4EBP1/2/3 bindingBy similarity
Regioni182 – 18767-methylguanosine-containing mRNA cap bindingBy similarity
Regioni230 – 23237-methylguanosine-containing mRNA cap bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1670. Eukaryota.
COG5053. LUCA.
GeneTreeiENSGT00520000055549.
HOGENOMiHOG000186751.
HOVERGENiHBG006130.
InParanoidiA6NMX2.
KOiK03259.
OMAiNDENTAP.
PhylomeDBiA6NMX2.
TreeFamiTF101526.

Family and domain databases

Gene3Di3.30.760.10. 1 hit.
InterProiIPR023398. TIF_eIF4e-like.
IPR001040. TIF_eIF_4E.
IPR019770. TIF_eIF_4E_CS.
[Graphical view]
PANTHERiPTHR11960. PTHR11960. 1 hit.
PfamiPF01652. IF4E. 1 hit.
[Graphical view]
SUPFAMiSSF55418. SSF55418. 1 hit.
PROSITEiPS00813. IF4E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NMX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAVEVSEAE GGIREWEEEE KEEEAAERTP TGEKSPNSPR TLLSLRGKAR
60 70 80 90 100
TGGPMEVKLE LHPLQNRWAL WFFKNDRSRA WQDNLHLVTK VDTVEDFWAL
110 120 130 140 150
YSHIQLASKL SSGCDYALFK DGIQPMWEDS RNKRGGRWLV SLAKQQRHIE
160 170 180 190 200
LDRLWLETLL CLIGESFEEH SREVCGAVVN IRTKGDKIAV WTREAENQAG
210 220 230 240
VLHVGRVYKE RLGLSPKTII GYQAHADTAT KSNSLAKNKF VV
Length:242
Mass (Da):27,596
Last modified:July 1, 2008 - v3
Checksum:iC441D5F0A082339D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti227 – 2271D → Y.
Corresponds to variant rs13163938 [ dbSNP | Ensembl ].
VAR_044209

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091934 Genomic DNA. No translation available.
CCDSiCCDS47345.1.
RefSeqiNP_001092878.1. NM_001099408.1.
XP_011532801.1. XM_011534499.1.
UniGeneiHs.448362.

Genome annotation databases

EnsembliENST00000318682; ENSP00000323714; ENSG00000175766.
ENST00000504597; ENSP00000427633; ENSG00000175766.
GeneIDi253314.
KEGGihsa:253314.
UCSCiuc010jkf.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

eIF4E/4E-BP-Family Member Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091934 Genomic DNA. No translation available.
CCDSiCCDS47345.1.
RefSeqiNP_001092878.1. NM_001099408.1.
XP_011532801.1. XM_011534499.1.
UniGeneiHs.448362.

3D structure databases

ProteinModelPortaliA6NMX2.
SMRiA6NMX2. Positions 20-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323714.

PTM databases

iPTMnetiA6NMX2.
PhosphoSiteiA6NMX2.

Polymorphism and mutation databases

BioMutaiEIF4E1B.

Proteomic databases

EPDiA6NMX2.
PaxDbiA6NMX2.
PeptideAtlasiA6NMX2.
PRIDEiA6NMX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318682; ENSP00000323714; ENSG00000175766.
ENST00000504597; ENSP00000427633; ENSG00000175766.
GeneIDi253314.
KEGGihsa:253314.
UCSCiuc010jkf.1. human.

Organism-specific databases

CTDi253314.
GeneCardsiEIF4E1B.
HGNCiHGNC:33179. EIF4E1B.
HPAiHPA045045.
neXtProtiNX_A6NMX2.
PharmGKBiPA162384974.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1670. Eukaryota.
COG5053. LUCA.
GeneTreeiENSGT00520000055549.
HOGENOMiHOG000186751.
HOVERGENiHBG006130.
InParanoidiA6NMX2.
KOiK03259.
OMAiNDENTAP.
PhylomeDBiA6NMX2.
TreeFamiTF101526.

Miscellaneous databases

GenomeRNAii253314.
PROiA6NMX2.

Gene expression databases

BgeeiA6NMX2.
CleanExiHS_EIF4E1B.
ExpressionAtlasiA6NMX2. baseline and differential.

Family and domain databases

Gene3Di3.30.760.10. 1 hit.
InterProiIPR023398. TIF_eIF4e-like.
IPR001040. TIF_eIF_4E.
IPR019770. TIF_eIF_4E_CS.
[Graphical view]
PANTHERiPTHR11960. PTHR11960. 1 hit.
PfamiPF01652. IF4E. 1 hit.
[Graphical view]
SUPFAMiSSF55418. SSF55418. 1 hit.
PROSITEiPS00813. IF4E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Phylogenetic analysis of eIF4E-family members."
    Joshi B., Lee K., Maeder D.L., Jagus R.
    BMC Evol. Biol. 5:48-48(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiI4E1B_HUMAN
AccessioniPrimary (citable) accession number: A6NMX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: July 1, 2008
Last modified: July 6, 2016
This is version 72 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.