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A6NMT0

- DBX1_HUMAN

UniProt

A6NMT0 - DBX1_HUMAN

Protein

Homeobox protein DBX1

Gene

DBX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 2 (11 Sep 2007)
      Previous versions | rss
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    Functioni

    Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi181 – 24060HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein DBX1
    Alternative name(s):
    Developing brain homeobox protein 1
    Gene namesi
    Name:DBX1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:33185. DBX1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Homeobox protein DBX1PRO_0000302843Add
    BLAST

    Proteomic databases

    PRIDEiA6NMT0.

    PTM databases

    PhosphoSiteiA6NMT0.

    Expressioni

    Gene expression databases

    BgeeiA6NMT0.
    CleanExiHS_DBX1.
    GenevestigatoriA6NMT0.

    Organism-specific databases

    HPAiHPA039802.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000227256.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NMT0.
    SMRiA6NMT0. Positions 188-239.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi276 – 2805Poly-Glu
    Compositional biasi329 – 33911Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Belongs to the H2.0 homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    HOVERGENiHBG005454.
    OrthoDBiEOG7SXW4H.
    PhylomeDBiA6NMT0.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NMT0-1 [UniParc]FASTAAdd to Basket

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    MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP    50
    PAYLPRSVPT ASMSPPRQGA PTALTDTGAS DLGSPGPGSR RGGSPPTAFS 100
    PASETTFLKF GVNAILSSGP RTETSPALLQ SVPPKTFAFP YFEGSFQPFI 150
    RSSYFPASSS VVPIPGTFSW PLAARGKPRR GMLRRAVFSD VQRKALEKMF 200
    QKQKYISKPD RKKLAAKLGL KDSQVKIWFQ NRRMKWRNSK ERELLSSGGC 250
    REQTLPTKLN PHPDLSDVGQ KGPGNEEEEE GPGSPSHRLA YHASSDPQHL 300
    RDPRLPGPLP PSPAHSSSPG KPSDFSDSEE EEEGEEQEEI TVS 343
    Length:343
    Mass (Da):37,283
    Last modified:September 11, 2007 - v2
    Checksum:iE5C4EB73331E7B69
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC068860 Genomic DNA. No translation available.
    RefSeqiNP_001025036.2. NM_001029865.2.
    UniGeneiHs.558604.

    Genome annotation databases

    EnsembliENST00000524983; ENSP00000436881; ENSG00000109851.
    GeneIDi120237.
    KEGGihsa:120237.
    UCSCiuc021qey.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC068860 Genomic DNA. No translation available.
    RefSeqi NP_001025036.2. NM_001029865.2.
    UniGenei Hs.558604.

    3D structure databases

    ProteinModelPortali A6NMT0.
    SMRi A6NMT0. Positions 188-239.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000227256.

    PTM databases

    PhosphoSitei A6NMT0.

    Proteomic databases

    PRIDEi A6NMT0.

    Protocols and materials databases

    DNASUi 120237.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000524983 ; ENSP00000436881 ; ENSG00000109851 .
    GeneIDi 120237.
    KEGGi hsa:120237.
    UCSCi uc021qey.1. human.

    Organism-specific databases

    CTDi 120237.
    GeneCardsi GC11M020177.
    HGNCi HGNC:33185. DBX1.
    HPAi HPA039802.
    neXtProti NX_A6NMT0.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG005454.
    OrthoDBi EOG7SXW4H.
    PhylomeDBi A6NMT0.

    Miscellaneous databases

    GeneWikii DBX1.
    GenomeRNAii 120237.
    NextBioi 80553.
    PROi A6NMT0.

    Gene expression databases

    Bgeei A6NMT0.
    CleanExi HS_DBX1.
    Genevestigatori A6NMT0.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDBX1_HUMAN
    AccessioniPrimary (citable) accession number: A6NMT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: September 11, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3