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Protein

Homeobox protein DBX1

Gene

DBX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi181 – 24060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. regulation of transcription from RNA polymerase II promoter Source: Ensembl
  2. ventral spinal cord interneuron specification Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DBX1
Alternative name(s):
Developing brain homeobox protein 1
Gene namesi
Name:DBX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:33185. DBX1.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Homeobox protein DBX1PRO_0000302843Add
BLAST

Proteomic databases

PRIDEiA6NMT0.

PTM databases

PhosphoSiteiA6NMT0.

Expressioni

Gene expression databases

BgeeiA6NMT0.
CleanExiHS_DBX1.
GenevestigatoriA6NMT0.

Organism-specific databases

HPAiHPA039802.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000227256.

Structurei

3D structure databases

ProteinModelPortaliA6NMT0.
SMRiA6NMT0. Positions 188-239.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi276 – 2805Poly-Glu
Compositional biasi329 – 33911Poly-GluAdd
BLAST

Sequence similaritiesi

Belongs to the H2.0 homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00780000121911.
HOVERGENiHBG005454.
InParanoidiA6NMT0.
OrthoDBiEOG7SXW4H.
PhylomeDBiA6NMT0.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NMT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP
60 70 80 90 100
PAYLPRSVPT ASMSPPRQGA PTALTDTGAS DLGSPGPGSR RGGSPPTAFS
110 120 130 140 150
PASETTFLKF GVNAILSSGP RTETSPALLQ SVPPKTFAFP YFEGSFQPFI
160 170 180 190 200
RSSYFPASSS VVPIPGTFSW PLAARGKPRR GMLRRAVFSD VQRKALEKMF
210 220 230 240 250
QKQKYISKPD RKKLAAKLGL KDSQVKIWFQ NRRMKWRNSK ERELLSSGGC
260 270 280 290 300
REQTLPTKLN PHPDLSDVGQ KGPGNEEEEE GPGSPSHRLA YHASSDPQHL
310 320 330 340
RDPRLPGPLP PSPAHSSSPG KPSDFSDSEE EEEGEEQEEI TVS
Length:343
Mass (Da):37,283
Last modified:September 11, 2007 - v2
Checksum:iE5C4EB73331E7B69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068860 Genomic DNA. No translation available.
RefSeqiNP_001025036.2. NM_001029865.2.
UniGeneiHs.558604.

Genome annotation databases

EnsembliENST00000524983; ENSP00000436881; ENSG00000109851.
GeneIDi120237.
KEGGihsa:120237.
UCSCiuc021qey.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068860 Genomic DNA. No translation available.
RefSeqiNP_001025036.2. NM_001029865.2.
UniGeneiHs.558604.

3D structure databases

ProteinModelPortaliA6NMT0.
SMRiA6NMT0. Positions 188-239.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000227256.

PTM databases

PhosphoSiteiA6NMT0.

Proteomic databases

PRIDEiA6NMT0.

Protocols and materials databases

DNASUi120237.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000524983; ENSP00000436881; ENSG00000109851.
GeneIDi120237.
KEGGihsa:120237.
UCSCiuc021qey.1. human.

Organism-specific databases

CTDi120237.
GeneCardsiGC11M020177.
HGNCiHGNC:33185. DBX1.
HPAiHPA039802.
neXtProtiNX_A6NMT0.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00780000121911.
HOVERGENiHBG005454.
InParanoidiA6NMT0.
OrthoDBiEOG7SXW4H.
PhylomeDBiA6NMT0.

Miscellaneous databases

GeneWikiiDBX1.
GenomeRNAii120237.
NextBioi80553.
PROiA6NMT0.

Gene expression databases

BgeeiA6NMT0.
CleanExiHS_DBX1.
GenevestigatoriA6NMT0.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDBX1_HUMAN
AccessioniPrimary (citable) accession number: A6NMT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: February 4, 2015
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.