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A6NMT0 (DBX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein DBX1
Alternative name(s):
Developing brain homeobox protein 1
Gene names
Name:DBX1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the H2.0 homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

transcription regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Homeobox protein DBX1
PRO_0000302843

Regions

DNA binding181 – 24060Homeobox
Compositional bias276 – 2805Poly-Glu
Compositional bias329 – 33911Poly-Glu

Sequences

Sequence LengthMass (Da)Tools
A6NMT0 [UniParc].

Last modified September 11, 2007. Version 2.
Checksum: E5C4EB73331E7B69

FASTA34337,283
        10         20         30         40         50         60 
MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP PAYLPRSVPT 

        70         80         90        100        110        120 
ASMSPPRQGA PTALTDTGAS DLGSPGPGSR RGGSPPTAFS PASETTFLKF GVNAILSSGP 

       130        140        150        160        170        180 
RTETSPALLQ SVPPKTFAFP YFEGSFQPFI RSSYFPASSS VVPIPGTFSW PLAARGKPRR 

       190        200        210        220        230        240 
GMLRRAVFSD VQRKALEKMF QKQKYISKPD RKKLAAKLGL KDSQVKIWFQ NRRMKWRNSK 

       250        260        270        280        290        300 
ERELLSSGGC REQTLPTKLN PHPDLSDVGQ KGPGNEEEEE GPGSPSHRLA YHASSDPQHL 

       310        320        330        340 
RDPRLPGPLP PSPAHSSSPG KPSDFSDSEE EEEGEEQEEI TVS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC068860 Genomic DNA. No translation available.
RefSeqNP_001025036.2. NM_001029865.2.
UniGeneHs.558604.

3D structure databases

ProteinModelPortalA6NMT0.
SMRA6NMT0. Positions 188-239.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000227256.

PTM databases

PhosphoSiteA6NMT0.

Proteomic databases

PRIDEA6NMT0.

Protocols and materials databases

DNASU120237.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000524983; ENSP00000436881; ENSG00000109851.
GeneID120237.
KEGGhsa:120237.
UCSCuc021qey.1. human.

Organism-specific databases

CTD120237.
GeneCardsGC11M020177.
HGNCHGNC:33185. DBX1.
HPAHPA039802.
neXtProtNX_A6NMT0.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG005454.
OrthoDBEOG7SXW4H.
PhylomeDBA6NMT0.

Gene expression databases

BgeeA6NMT0.
CleanExHS_DBX1.
GenevestigatorA6NMT0.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiDBX1.
GenomeRNAi120237.
NextBio80553.
PROA6NMT0.

Entry information

Entry nameDBX1_HUMAN
AccessionPrimary (citable) accession number: A6NMT0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: April 16, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM