A6NMT0 (DBX1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein DBX1

Alternative name(s):
Developing brain homeobox protein 1

Gene names

Name:

DBX1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the H2.0 homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro transcription regulatory region sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Homeobox protein DBX1		PRO_0000302843
Regions
	DNA binding	181 – 240	60	Homeobox
	Compositional bias	276 – 280	5	Poly-Glu
	Compositional bias	329 – 339	11	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	A6NMT0 [UniParc]. Last modified September 11, 2007. Version 2. Checksum: E5C4EB73331E7B69	FASTA	343	37,283
	10 20 30 40 50 60 MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP PAYLPRSVPT 70 80 90 100 110 120 ASMSPPRQGA PTALTDTGAS DLGSPGPGSR RGGSPPTAFS PASETTFLKF GVNAILSSGP 130 140 150 160 170 180 RTETSPALLQ SVPPKTFAFP YFEGSFQPFI RSSYFPASSS VVPIPGTFSW PLAARGKPRR 190 200 210 220 230 240 GMLRRAVFSD VQRKALEKMF QKQKYISKPD RKKLAAKLGL KDSQVKIWFQ NRRMKWRNSK 250 260 270 280 290 300 ERELLSSGGC REQTLPTKLN PHPDLSDVGQ KGPGNEEEEE GPGSPSHRLA YHASSDPQHL 310 320 330 340 RDPRLPGPLP PSPAHSSSPG KPSDFSDSEE EEEGEEQEEI TVS

References

[1]

"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC068860 Genomic DNA. No translation available.
IPI	IPI00027329.
RefSeq	NP_001025036.2. NM_001029865.2.
UniGene	Hs.558604.
3D structure databases
ProteinModelPortal	A6NMT0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000227256.
PTM databases
PhosphoSite	A6NMT0.
Proteomic databases
PRIDE	A6NMT0.
Protocols and materials databases
DNASU	120237.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000524983; ENSP00000436881; ENSG00000109851.
GeneID	120237.
KEGG	hsa:120237.
UCSC	uc021qey.1. human.
Organism-specific databases
CTD	120237.
GeneCards	GC11M020177.
HGNC	HGNC:33185. DBX1.
HPA	HPA039802.
neXtProt	NX_A6NMT0.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG005454.
PhylomeDB	A6NMT0.
Gene expression databases
ArrayExpress	A6NMT0.
Bgee	A6NMT0.
CleanEx	HS_DBX1.
Genevestigator	A6NMT0.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR000047. HTH_motif. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX. PR00031. HTHREPRESSR.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	120237.
NextBio	80553.

Entry information

Entry name

DBX1_HUMAN

Accession

Primary (citable) accession number: A6NMT0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	September 11, 2007
Last modified:	May 1, 2013
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.