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Protein

Homeobox protein DBX1

Gene

DBX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Could have a role in patterning the central nervous system during embryogenesis. Has a key role in regulating the distinct phenotypic features that distinguish two major classes of ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile, neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons, features that differentiate them from an adjacent set of V1 neurons (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi181 – 240HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein DBX1
Alternative name(s):
Developing brain homeobox protein 1
Gene namesi
Name:DBX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:33185. DBX1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi120237.
OpenTargetsiENSG00000109851.

Polymorphism and mutation databases

BioMutaiDBX1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003028431 – 343Homeobox protein DBX1Add BLAST343

Proteomic databases

PRIDEiA6NMT0.

PTM databases

iPTMnetiA6NMT0.
PhosphoSitePlusiA6NMT0.

Expressioni

Gene expression databases

BgeeiENSG00000109851.
CleanExiHS_DBX1.

Organism-specific databases

HPAiHPA039802.

Structurei

3D structure databases

ProteinModelPortaliA6NMT0.
SMRiA6NMT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 280Poly-Glu5
Compositional biasi329 – 339Poly-GluAdd BLAST11

Sequence similaritiesi

Belongs to the H2.0 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00890000139333.
HOVERGENiHBG005454.
InParanoidiA6NMT0.
OMAiMMFPSLI.
OrthoDBiEOG091G0MGV.
PhylomeDBiA6NMT0.

Family and domain databases

InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NMT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMFPGLLAPP AGYPSLLRPT PTLTLPQSLQ SAFSGHSSFL VEDLIRISRP
60 70 80 90 100
PAYLPRSVPT ASMSPPRQGA PTALTDTGAS DLGSPGPGSR RGGSPPTAFS
110 120 130 140 150
PASETTFLKF GVNAILSSGP RTETSPALLQ SVPPKTFAFP YFEGSFQPFI
160 170 180 190 200
RSSYFPASSS VVPIPGTFSW PLAARGKPRR GMLRRAVFSD VQRKALEKMF
210 220 230 240 250
QKQKYISKPD RKKLAAKLGL KDSQVKIWFQ NRRMKWRNSK ERELLSSGGC
260 270 280 290 300
REQTLPTKLN PHPDLSDVGQ KGPGNEEEEE GPGSPSHRLA YHASSDPQHL
310 320 330 340
RDPRLPGPLP PSPAHSSSPG KPSDFSDSEE EEEGEEQEEI TVS
Length:343
Mass (Da):37,283
Last modified:September 11, 2007 - v2
Checksum:iE5C4EB73331E7B69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068860 Genomic DNA. No translation available.
RefSeqiNP_001025036.2. NM_001029865.2.
UniGeneiHs.558604.

Genome annotation databases

EnsembliENST00000524983; ENSP00000436881; ENSG00000109851.
GeneIDi120237.
KEGGihsa:120237.
UCSCiuc021qey.2. human.

Similar proteinsi

Entry informationi

Entry nameiDBX1_HUMAN
AccessioniPrimary (citable) accession number: A6NMT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: August 30, 2017
This is version 77 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families