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Protein

Leucine-rich repeat-containing protein 37A

Gene

LRRC37A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 37A
Gene namesi
Name:LRRC37A
Synonyms:LRRC37A1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:29069. LRRC37A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 1582ExtracellularSequence analysisAdd BLAST1547
Transmembranei1583 – 1603HelicalSequence analysisAdd BLAST21
Topological domaini1604 – 1700CytoplasmicSequence analysisAdd BLAST97

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9884.
OpenTargetsiENSG00000176681.

Polymorphism and mutation databases

BioMutaiLRRC37A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000033707936 – 1700Leucine-rich repeat-containing protein 37AAdd BLAST1665

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1079N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA6NMS7.
PRIDEiA6NMS7.

PTM databases

iPTMnetiA6NMS7.
PhosphoSitePlusiA6NMS7.

Expressioni

Gene expression databases

BgeeiENSG00000176681.
CleanExiHS_LRRC37A.
ExpressionAtlasiA6NMS7. baseline and differential.
GenevisibleiA6NMS7. HS.

Organism-specific databases

HPAiHPA042121.
HPA042701.
HPA043056.
HPA045090.
HPA049080.

Interactioni

Protein-protein interaction databases

IntActiA6NMS7. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliA6NMS7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati866 – 887LRR 1Add BLAST22
Repeati890 – 911LRR 2Add BLAST22
Repeati914 – 935LRR 3Add BLAST22
Repeati938 – 959LRR 4Add BLAST22
Repeati965 – 986LRR 5Add BLAST22

Sequence similaritiesi

Belongs to the LRRC37A family.Curated
Contains 5 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJNR. Eukaryota.
ENOG410YV94. LUCA.
GeneTreeiENSGT00530000063282.
HOGENOMiHOG000113269.
HOVERGENiHBG100009.
InParanoidiA6NMS7.
OMAiVILMEAP.
OrthoDBiEOG091G006W.
PhylomeDBiA6NMS7.
TreeFamiTF341959.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032754. LRRC37_N.
IPR015753. LRRC37A/B-like.
IPR029423. LRRC37AB_C.
[Graphical view]
PANTHERiPTHR23045. PTHR23045. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
PF15779. LRRC37. 7 hits.
PF14914. LRRC37AB_C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NMS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAQCPALV CVMSRLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT
60 70 80 90 100
SNPLGPPESW SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ
110 120 130 140 150
ESTENLVPFL DTWDSAGEQP LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL
160 170 180 190 200
KKDPAQRWSL AEIIGITRQL STPQSQKQTL QNEYSSTDTP YPGSLPPELR
210 220 230 240 250
VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ EAPAQLPQLL
260 270 280 290 300
EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
310 320 330 340 350
PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP
360 370 380 390 400
MEHELSISEQ QQPVQPSESP REVESSPTQQ ETPGQPPEHH EVTVSPPGHH
410 420 430 440 450
QTHHLASPSV SVKPPDVQLT IAAEPSAEVG TSLVHQEATT RLSGSGNDVE
460 470 480 490 500
PPAIQHGGPP LLPESSEEAG PLAVQQETSF QSPEPINNEN PSPTQQEAAA
510 520 530 540 550
EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT QATVQPLDLG
560 570 580 590 600
FTITPESKTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
610 620 630 640 650
PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ
660 670 680 690 700
VQTQHSHLTR ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL
710 720 730 740 750
PPSDKGQAQH SHLTQATVQP LDLELTITTK PTTEVKPSPT TEETSTQPPD
760 770 780 790 800
LGLAIIPEPT TETGHSTALE KTTAPRPDRV QTLHRSLTEV TGPPTELEPA
810 820 830 840 850
QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM LSCIDLNPEQ
860 870 880 890 900
RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
910 920 930 940 950
LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT
960 970 980 990 1000
ELSFGTFQAW HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV
1010 1020 1030 1040 1050
PLTTLKNILM MTVELEKLIL PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC
1060 1070 1080 1090 1100
LTNTTHCPEE ASVGNPEGAF MKVLQARKNY TSTELIVEPE EPSDSSGINL
1110 1120 1130 1140 1150
SGFGSEQLDT NDESDFISTL SYILPYFSAV NLDVKSLLLP FIKLPTTGNS
1160 1170 1180 1190 1200
LAKIQTVGQN RQRVKRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENA
1210 1220 1230 1240 1250
AEEKRLTSPA PREVEQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP
1260 1270 1280 1290 1300
FSKGTPSTSS PAKALPQVRD RSKDLTHAIS ILESAKARVT NTKTSKPIVH
1310 1320 1330 1340 1350
ARKKYRFHKT RSHVTHRTTK VKKSPKVRKK SYLSRLMLAN RLPFSAAKSL
1360 1370 1380 1390 1400
INSPSQGAFS SLGDLSPQEN PFLEVSALSE HFIEKNNTKH TTARNAFEEN
1410 1420 1430 1440 1450
DFMENTNMPE GTISENTNYN HPPEADSAGT AFNLGPTVKQ TETKWEYNNV
1460 1470 1480 1490 1500
GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSLIPNNNV RRLIAHVIRT
1510 1520 1530 1540 1550
LKMDCSGAHV QVTCAKLISR TGHLMKLLSG QQEVKASKIE WDTDQWKIEN
1560 1570 1580 1590 1600
YINESTEAQS EQKEKSLELK KEVPGYGYTD KLILALIVTG ILTILIILFC
1610 1620 1630 1640 1650
LIVICCHRRS LQEDEEGFSR GIFRFLPWRG CSSRRESQDG LSSFGQPLWF
1660 1670 1680 1690 1700
KDLYKPLSAT RINNHAWKLH KKSSNEDKIL NRDPGDSEAP TEEEESEALP
Length:1,700
Mass (Da):188,258
Last modified:May 31, 2011 - v3
Checksum:iF5DBA6389568D792
GO

Sequence cautioni

The sequence CAH18088 differs from that shown. Reason: Frameshift at positions 8 and 177.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58E → D in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti58E → D in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti349P → S in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti349P → S in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti370P → S in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti370P → S in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti377P → L in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti377P → L in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti406A → D in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti406A → D in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti440T → A in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti440T → A in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti552T → I in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti558K → M in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti558K → M in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti630P → A in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti630P → A in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti776R → H in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti776R → H in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti785R → Q in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti785R → Q in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti1255T → A in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti1255T → A in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti1288R → G in CAH18088 (PubMed:17974005).Curated1
Sequence conflicti1384E → G in AAH40501 (PubMed:15489334).Curated1
Sequence conflicti1693E → G in AAH40501 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749232 mRNA. Translation: CAH18088.1. Frameshift.
AC005829 Genomic DNA. No translation available.
AC139026 Genomic DNA. No translation available.
BC040501 mRNA. Translation: AAH40501.2.
CCDSiCCDS11504.2.
RefSeqiNP_055649.4. NM_014834.4.
UniGeneiHs.579108.
Hs.744157.
Hs.744758.

Genome annotation databases

EnsembliENST00000320254; ENSP00000326324; ENSG00000176681.
GeneIDi9884.
KEGGihsa:9884.
UCSCiuc002ikg.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR749232 mRNA. Translation: CAH18088.1. Frameshift.
AC005829 Genomic DNA. No translation available.
AC139026 Genomic DNA. No translation available.
BC040501 mRNA. Translation: AAH40501.2.
CCDSiCCDS11504.2.
RefSeqiNP_055649.4. NM_014834.4.
UniGeneiHs.579108.
Hs.744157.
Hs.744758.

3D structure databases

ProteinModelPortaliA6NMS7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA6NMS7. 1 interactor.

PTM databases

iPTMnetiA6NMS7.
PhosphoSitePlusiA6NMS7.

Polymorphism and mutation databases

BioMutaiLRRC37A.

Proteomic databases

PaxDbiA6NMS7.
PRIDEiA6NMS7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320254; ENSP00000326324; ENSG00000176681.
GeneIDi9884.
KEGGihsa:9884.
UCSCiuc002ikg.3. human.

Organism-specific databases

CTDi9884.
DisGeNETi9884.
GeneCardsiLRRC37A.
H-InvDBHIX0013912.
HIX0027330.
HIX0039350.
HIX0173525.
HIX0173724.
HIX0174144.
HIX0174145.
HIX0174159.
HIX0202473.
HGNCiHGNC:29069. LRRC37A.
HPAiHPA042121.
HPA042701.
HPA043056.
HPA045090.
HPA049080.
MIMi616555. gene.
neXtProtiNX_A6NMS7.
OpenTargetsiENSG00000176681.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJNR. Eukaryota.
ENOG410YV94. LUCA.
GeneTreeiENSGT00530000063282.
HOGENOMiHOG000113269.
HOVERGENiHBG100009.
InParanoidiA6NMS7.
OMAiVILMEAP.
OrthoDBiEOG091G006W.
PhylomeDBiA6NMS7.
TreeFamiTF341959.

Miscellaneous databases

GeneWikiiLRRC37A.
GenomeRNAii9884.
PROiA6NMS7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000176681.
CleanExiHS_LRRC37A.
ExpressionAtlasiA6NMS7. baseline and differential.
GenevisibleiA6NMS7. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032754. LRRC37_N.
IPR015753. LRRC37A/B-like.
IPR029423. LRRC37AB_C.
[Graphical view]
PANTHERiPTHR23045. PTHR23045. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
PF15779. LRRC37. 7 hits.
PF14914. LRRC37AB_C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiL37A1_HUMAN
AccessioniPrimary (citable) accession number: A6NMS7
Secondary accession number(s): Q68DY2, Q8IWC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 31, 2011
Last modified: November 2, 2016
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.