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Protein

Olfactory receptor 5K4

Gene

OR5K4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5K4
Gene namesi
Name:OR5K4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:31291. OR5K4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9722ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13921CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 20545ExtracellularSequence analysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini227 – 24014CytoplasmicSequence analysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini262 – 2687ExtracellularSequence analysis
Transmembranei269 – 28921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini290 – 32132CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945625.

Polymorphism and mutation databases

BioMutaiOR5K4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 321321Olfactory receptor 5K4PRO_0000312177Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NMS3.
PRIDEiA6NMS3.

Expressioni

Gene expression databases

CleanExiHS_OR5K4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347003.

Structurei

3D structure databases

ProteinModelPortaliA6NMS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9MS. Eukaryota.
ENOG41116R8. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NMS3.
KOiK04257.
OMAiQTCSIAN.
OrthoDBiEOG7DFXCK.
PhylomeDBiA6NMS3.
TreeFamiTF352737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NMS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARENHSLAA EFILIGFTNY PELKTLLFVV FSAIYLVTMV GNLGLVALIY
60 70 80 90 100
VERRLLTPMY IFLGNLALMD SCCSCAVTPK MLENFFSEDR IISLYECMAQ
110 120 130 140 150
FYFLCLAETT DCFLLATMAY DRYVAICHPL QYHTMMSKTL CIRMTTGAFK
160 170 180 190 200
AGNLHSMIHV GLLLRLTFCR SNKIHHFFCD ILPLYRLSCT DPSINELMIY
210 220 230 240 250
IFSIPIQIFT IATVLISYLC ILLTVFKMKS KEGRGKAFST CASHFLSVSI
260 270 280 290 300
FYICLLMYIG PSEEGDKDTP VAIFYAIVIP LLNPFIYSLR NKEVINVLKK
310 320
IMRNYNILKQ TCSIANLFLI Y
Length:321
Mass (Da):36,711
Last modified:July 24, 2007 - v1
Checksum:i2EA0BD84E895978A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti206 – 2061I → V.
Corresponds to variant rs9822460 [ dbSNP | Ensembl ].
VAR_037448

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108730 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79864.1.
CCDSiCCDS33802.1.
RefSeqiNP_001005517.1. NM_001005517.1.
UniGeneiHs.554710.

Genome annotation databases

EnsembliENST00000354924; ENSP00000347003; ENSG00000196098.
GeneIDi403278.
KEGGihsa:403278.
UCSCiuc011bgv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108730 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79864.1.
CCDSiCCDS33802.1.
RefSeqiNP_001005517.1. NM_001005517.1.
UniGeneiHs.554710.

3D structure databases

ProteinModelPortaliA6NMS3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347003.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR5K4.

Proteomic databases

PaxDbiA6NMS3.
PRIDEiA6NMS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354924; ENSP00000347003; ENSG00000196098.
GeneIDi403278.
KEGGihsa:403278.
UCSCiuc011bgv.2. human.

Organism-specific databases

CTDi403278.
GeneCardsiOR5K4.
HGNCiHGNC:31291. OR5K4.
neXtProtiNX_A6NMS3.
PharmGKBiPA134945625.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9MS. Eukaryota.
ENOG41116R8. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NMS3.
KOiK04257.
OMAiQTCSIAN.
OrthoDBiEOG7DFXCK.
PhylomeDBiA6NMS3.
TreeFamiTF352737.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii403278.
NextBioi107713.
PROiA6NMS3.

Gene expression databases

CleanExiHS_OR5K4.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiOR5K4_HUMAN
AccessioniPrimary (citable) accession number: A6NMS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 24, 2007
Last modified: February 17, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.