Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 5K4

Gene

OR5K4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5K4
Gene namesi
Name:OR5K4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000196098.2.
HGNCiHGNC:31291. OR5K4.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 97ExtracellularSequence analysisAdd BLAST22
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 139CytoplasmicSequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 205ExtracellularSequence analysisAdd BLAST45
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 240CytoplasmicSequence analysisAdd BLAST14
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 268ExtracellularSequence analysis7
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 321CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134945625.

Polymorphism and mutation databases

BioMutaiOR5K4.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121771 – 321Olfactory receptor 5K4Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NMS3.
PRIDEiA6NMS3.

Expressioni

Gene expression databases

BgeeiENSG00000196098.
CleanExiHS_OR5K4.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347003.

Structurei

3D structure databases

ProteinModelPortaliA6NMS3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9MS. Eukaryota.
ENOG41116R8. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NMS3.
KOiK04257.
OMAiMYIRPFE.
OrthoDBiEOG091G0AZH.
PhylomeDBiA6NMS3.
TreeFamiTF352737.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NMS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARENHSLAA EFILIGFTNY PELKTLLFVV FSAIYLVTMV GNLGLVALIY
60 70 80 90 100
VERRLLTPMY IFLGNLALMD SCCSCAVTPK MLENFFSEDR IISLYECMAQ
110 120 130 140 150
FYFLCLAETT DCFLLATMAY DRYVAICHPL QYHTMMSKTL CIRMTTGAFK
160 170 180 190 200
AGNLHSMIHV GLLLRLTFCR SNKIHHFFCD ILPLYRLSCT DPSINELMIY
210 220 230 240 250
IFSIPIQIFT IATVLISYLC ILLTVFKMKS KEGRGKAFST CASHFLSVSI
260 270 280 290 300
FYICLLMYIG PSEEGDKDTP VAIFYAIVIP LLNPFIYSLR NKEVINVLKK
310 320
IMRNYNILKQ TCSIANLFLI Y
Length:321
Mass (Da):36,711
Last modified:July 24, 2007 - v1
Checksum:i2EA0BD84E895978A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_037448206I → V. Corresponds to variant dbSNP:rs9822460Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC108730 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79864.1.
CCDSiCCDS33802.1.
RefSeqiNP_001005517.1. NM_001005517.1.
UniGeneiHs.554710.

Genome annotation databases

EnsembliENST00000354924; ENSP00000347003; ENSG00000196098.
GeneIDi403278.
KEGGihsa:403278.
UCSCiuc011bgv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR5K4_HUMAN
AccessioniPrimary (citable) accession number: A6NMS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 24, 2007
Last modified: September 27, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families