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A6NMQ1 (A6NMQ1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length1468 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). RuleBase RU000442

Sequence similarities

Belongs to the DNA polymerase type-B family. RuleBase RU000442

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000368358

Sequences

Sequence LengthMass (Da)Tools
A6NMQ1 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 9CC2AB5AB76E8746

FASTA1,468166,457
        10         20         30         40         50         60 
MAPVHGDDCE IGASALSDSG SFVSSRARRE KKSKKGRQEA LERLKKAKAG EKYKYEVEDF 

        70         80         90        100        110        120 
TGVYEEVDEE QYSKLVQARQ DDDWIVDDDG IGYVEDGREI FDDDLEDDAL DADEKGKDGK 

       130        140        150        160        170        180 
ARNKDKRNVK KLAVTKPNNI KSMFIACAGK KTADKAVDLS KDGLLGDILQ DLNTETPQIT 

       190        200        210        220        230        240 
PPPVMILKKK RSIGASPNPF SVHTATAVPS GKIASPVSRK EPPLTPVPLK RAEFAGDDVQ 

       250        260        270        280        290        300 
VESTEEEQES GAMEFEDGDF DEPMEVEEVD LEPMAAKAWD KESEPAEEVK QEADSGKGTV 

       310        320        330        340        350        360 
SYLGSFLPDV SCWDIDQEGD SSFSVQEVQV DSSHLPLVKG ADEEQVFHFY WLDAYEDQYN 

       370        380        390        400        410        420 
QPGVVFLFGK VWIESAETHV SCCVMVKNIE RTLYFLPREM KIDLNTGKET GTPISMKDVY 

       430        440        450        460        470        480 
EEFDEKIATK YKIMKFKSKP VEKNYAFEIP DVPEKSEYLE VKYSAEMPQL PQDLKGETFS 

       490        500        510        520        530        540 
HVFGTNTSSL ELFLMNRKIK GPCWLEVKSP QLLNQPVSWC KVEAMALKPD LVNVIKDVSP 

       550        560        570        580        590        600 
PPLVVMAFSM KTMQNAKNHQ NEIIAMAALV HHSFALDKAA PKPPFQSHFC VVSKPKDCIF 

       610        620        630        640        650        660 
PYAFKEVIEK KNVKVEVAAT ERTLLGFFLA KVHKIDPDII VGHNIYGFEL EVLLQRINVC 

       670        680        690        700        710        720 
KAPHWSKIGR LKRSNMPKLG GRSGFGERNA TCGRMICDVE ISAKELIRCK SYHLSELVQQ 

       730        740        750        760        770        780 
ILKTERVVIP MENIQNMYSE SSQLLYLLEH TWKDAKFILQ IMCELNVLPL ALQITNIAGN 

       790        800        810        820        830        840 
IMSRTLMGGR SERNEFLLLH AFYENNYIVP DKQIFRKPQQ KLGDEDEEID GDTNKYKKGR 

       850        860        870        880        890        900 
KKAAYAGGLV LDPKVGFYDK FILLLDFNSL YPSIIQEFNI CFTTVQRVAS EAQKVTEDGE 

       910        920        930        940        950        960 
QEQIPELPDP SLEMGILPRE IRKLVERRKQ VKQLMKQQDL NPDLILQYDI RQKALKLTAN 

       970        980        990       1000       1010       1020 
SMYGCLGFSY SRFYAKPLAA LVTYKGREIL MHTKEMVQKM NLEVIYGDTD SIMINTNSTN 

      1030       1040       1050       1060       1070       1080 
LEEVFKLGNK VKSEVNKLYK LLEIDIDGVF KSLLLLKKKK YAALVVEPTS DGNYVTKQEL 

      1090       1100       1110       1120       1130       1140 
KGLDIVRRDW CDLAKDTGNF VIGQILSDQS RDTIVENIQK RLIEIGENVL NGSVPVSQFE 

      1150       1160       1170       1180       1190       1200 
INKALTKDPQ DYPDKKSLPH VHVALWINSQ GGRKVKAGDT VSYVICQDGS NLTASQRAYA 

      1210       1220       1230       1240       1250       1260 
PEQLQKQDNL TIDTQYYLAQ QIHPVVARIC EPIDGIDAVL IATWLGLDPT QFRVHHYHKD 

      1270       1280       1290       1300       1310       1320 
EENDALLGGP AQLTDEEKYR DCERFKCPCP TCGTENIYDN VFDGSGTDME PSLYRCSNID 

      1330       1340       1350       1360       1370       1380 
CKASPLTFTV QLSNKLIMDI RRFIKKYYDG WLICEEPTCR NRTRHLPLQF SRTGPLCPAC 

      1390       1400       1410       1420       1430       1440 
MKATLQPEYS DKSLYTQLCF YRYIFDAECA LEKLTTDHEK DKLKKQFFTP KVLQDYRKLK 

      1450       1460 
NTAEQFLSRS GYSEVNLSKL FAGCAVKS 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC002504 Genomic DNA. No translation available.
AC004655 Genomic DNA. No translation available.
AC079375 Genomic DNA. No translation available.
AC135280 Genomic DNA. No translation available.
RefSeqXP_005274609.1. XM_005274552.1.
UniGeneHs.567319.

3D structure databases

ProteinModelPortalA6NMQ1.
SMRA6NMQ1. Positions 347-1246, 1275-1435.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEA6NMQ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000379068; ENSP00000368358; ENSG00000101868.
GeneID5422.
KEGGhsa:5422.

Organism-specific databases

CTD5422.
HGNCHGNC:9173. POLA1.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000163524.
HOVERGENHBG080008.
KOK02320.
OMAEKYRDCE.
OrthoDBEOG7CNZDZ.

Gene expression databases

ArrayExpressA6NMQ1.
BgeeA6NMQ1.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR004578. DNA-dir_DNA_pol_B_pol2.
IPR024647. DNA_pol_a_cat_su_N.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
IPR015088. Znf_DNA-dir_DNA_pol_B_alpha.
[Graphical view]
PfamPF12254. DNA_pol_alpha_N. 1 hit.
PF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
PF08996. zf-DNA_Pol. 1 hit.
[Graphical view]
PRINTSPR00106. DNAPOLB.
SMARTSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMSSF53098. SSF53098. 1 hit.
TIGRFAMsTIGR00592. pol2. 1 hit.
PROSITEPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPOLA1. human.
GenomeRNAi5422.
NextBio35462686.

Entry information

Entry nameA6NMQ1_HUMAN
AccessionPrimary (citable) accession number: A6NMQ1
Entry history
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.