A6NMQ1 (A6NMQ1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA polymerase RuleBase RU000442
EC=2.7.7.7 RuleBase RU000442

Gene names

Name:

POLA1 Ensembl ENSP00000368358

Organism

Homo sapiens (Human) [Reference proteome] Ensembl ENSP00000368358

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1468 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). RuleBase RU000442
Sequence similarities	Belongs to the DNA polymerase type-B family. RuleBase RU000442
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSP00000368358

Ontologies

Keywords
Biological process	DNA replication RuleBase RU000442
Ligand	DNA-binding RuleBase RU000442
Molecular function	DNA-directed DNA polymerase RuleBase RU000442 Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW nucleoside binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A6NMQ1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 9CC2AB5AB76E8746	FASTA	1,468	166,457
	10 20 30 40 50 60 MAPVHGDDCE IGASALSDSG SFVSSRARRE KKSKKGRQEA LERLKKAKAG EKYKYEVEDF 70 80 90 100 110 120 TGVYEEVDEE QYSKLVQARQ DDDWIVDDDG IGYVEDGREI FDDDLEDDAL DADEKGKDGK 130 140 150 160 170 180 ARNKDKRNVK KLAVTKPNNI KSMFIACAGK KTADKAVDLS KDGLLGDILQ DLNTETPQIT 190 200 210 220 230 240 PPPVMILKKK RSIGASPNPF SVHTATAVPS GKIASPVSRK EPPLTPVPLK RAEFAGDDVQ 250 260 270 280 290 300 VESTEEEQES GAMEFEDGDF DEPMEVEEVD LEPMAAKAWD KESEPAEEVK QEADSGKGTV 310 320 330 340 350 360 SYLGSFLPDV SCWDIDQEGD SSFSVQEVQV DSSHLPLVKG ADEEQVFHFY WLDAYEDQYN 370 380 390 400 410 420 QPGVVFLFGK VWIESAETHV SCCVMVKNIE RTLYFLPREM KIDLNTGKET GTPISMKDVY 430 440 450 460 470 480 EEFDEKIATK YKIMKFKSKP VEKNYAFEIP DVPEKSEYLE VKYSAEMPQL PQDLKGETFS 490 500 510 520 530 540 HVFGTNTSSL ELFLMNRKIK GPCWLEVKSP QLLNQPVSWC KVEAMALKPD LVNVIKDVSP 550 560 570 580 590 600 PPLVVMAFSM KTMQNAKNHQ NEIIAMAALV HHSFALDKAA PKPPFQSHFC VVSKPKDCIF 610 620 630 640 650 660 PYAFKEVIEK KNVKVEVAAT ERTLLGFFLA KVHKIDPDII VGHNIYGFEL EVLLQRINVC 670 680 690 700 710 720 KAPHWSKIGR LKRSNMPKLG GRSGFGERNA TCGRMICDVE ISAKELIRCK SYHLSELVQQ 730 740 750 760 770 780 ILKTERVVIP MENIQNMYSE SSQLLYLLEH TWKDAKFILQ IMCELNVLPL ALQITNIAGN 790 800 810 820 830 840 IMSRTLMGGR SERNEFLLLH AFYENNYIVP DKQIFRKPQQ KLGDEDEEID GDTNKYKKGR 850 860 870 880 890 900 KKAAYAGGLV LDPKVGFYDK FILLLDFNSL YPSIIQEFNI CFTTVQRVAS EAQKVTEDGE 910 920 930 940 950 960 QEQIPELPDP SLEMGILPRE IRKLVERRKQ VKQLMKQQDL NPDLILQYDI RQKALKLTAN 970 980 990 1000 1010 1020 SMYGCLGFSY SRFYAKPLAA LVTYKGREIL MHTKEMVQKM NLEVIYGDTD SIMINTNSTN 1030 1040 1050 1060 1070 1080 LEEVFKLGNK VKSEVNKLYK LLEIDIDGVF KSLLLLKKKK YAALVVEPTS DGNYVTKQEL 1090 1100 1110 1120 1130 1140 KGLDIVRRDW CDLAKDTGNF VIGQILSDQS RDTIVENIQK RLIEIGENVL NGSVPVSQFE 1150 1160 1170 1180 1190 1200 INKALTKDPQ DYPDKKSLPH VHVALWINSQ GGRKVKAGDT VSYVICQDGS NLTASQRAYA 1210 1220 1230 1240 1250 1260 PEQLQKQDNL TIDTQYYLAQ QIHPVVARIC EPIDGIDAVL IATWLGLDPT QFRVHHYHKD 1270 1280 1290 1300 1310 1320 EENDALLGGP AQLTDEEKYR DCERFKCPCP TCGTENIYDN VFDGSGTDME PSLYRCSNID 1330 1340 1350 1360 1370 1380 CKASPLTFTV QLSNKLIMDI RRFIKKYYDG WLICEEPTCR NRTRHLPLQF SRTGPLCPAC 1390 1400 1410 1420 1430 1440 MKATLQPEYS DKSLYTQLCF YRYIFDAECA LEKLTTDHEK DKLKKQFFTP KVLQDYRKLK 1450 1460 NTAEQFLSRS GYSEVNLSKL FAGCAVKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC002504 Genomic DNA. No translation available. AC004655 Genomic DNA. No translation available. AC079375 Genomic DNA. No translation available. AC135280 Genomic DNA. No translation available.
IPI	IPI00647655.
3D structure databases
ProteinModelPortal	A6NMQ1.
SMR	A6NMQ1. Positions 607-1229, 1275-1435.
ModBase	Search...
Protein-protein interaction databases
STRING	A6NMQ1.
Proteomic databases
PRIDE	A6NMQ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000379068; ENSP00000368358; ENSG00000101868.
Organism-specific databases
HGNC	HGNC:9173. POLA1.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000163524.
HOVERGEN	HBG080008.
OMA	GSGTDME.
OrthoDB	EOG43XV2M.
Gene expression databases
ArrayExpress	A6NMQ1.
Bgee	A6NMQ1.
Family and domain databases
Gene3D	3.90.1600.10. 2 hits.
InterPro	IPR006172. DNA-dir_DNA_pol_B. IPR017964. DNA-dir_DNA_pol_B_CS. IPR006133. DNA-dir_DNA_pol_B_exonuc. IPR006134. DNA-dir_DNA_pol_B_multi_dom. IPR004578. DNA-dir_DNA_pol_B_pol2. IPR024647. DNA_pol_a_cat_su_N. IPR023211. DNA_pol_palm_dom. IPR012337. RNaseH-like_dom. IPR015088. Znf_DNA-dir_DNA_pol_B_alpha. [Graphical view]
Pfam	PF12254. DNA_pol_alpha_N. 1 hit. PF00136. DNA_pol_B. 1 hit. PF03104. DNA_pol_B_exo1. 1 hit. PF08996. zf-DNA_Pol. 1 hit. [Graphical view]
PRINTS	PR00106. DNAPOLB.
SMART	SM00486. POLBc. 1 hit. [Graphical view]
SUPFAM	SSF53098. RNaseH_fold. 1 hit.
TIGRFAMs	TIGR00592. pol2. 1 hit.
PROSITE	PS00116. DNA_POLYMERASE_B. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	POLA1. human.
NextBio	35462686.

Entry information

Entry name

A6NMQ1_HUMAN

Accession

Primary (citable) accession number: A6NMQ1

Entry history

Integrated into UniProtKB/TrEMBL:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.