SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A6NMQ1

- A6NMQ1_HUMAN

UniProt

A6NMQ1 - A6NMQ1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
DNA polymerase
Gene
POLA1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. DNA-directed DNA polymerase activity Source: UniProtKB-KW
  3. nucleoside binding Source: InterPro
  4. nucleotide binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    DNA replicationUniRule annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
    Gene namesi
    Name:POLA1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:9173. POLA1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleus Source: HPA
    Complete GO annotation...

    PTM / Processingi

    Proteomic databases

    PRIDEiA6NMQ1.

    Expressioni

    Gene expression databases

    ArrayExpressiA6NMQ1.
    BgeeiA6NMQ1.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NMQ1.
    SMRiA6NMQ1. Positions 347-1246, 1275-1435.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA polymerase type-B family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000163524.
    HOVERGENiHBG080008.
    KOiK02320.
    OMAiEKYRDCE.
    OrthoDBiEOG7CNZDZ.
    PhylomeDBiA6NMQ1.

    Family and domain databases

    Gene3Di3.30.420.10. 1 hit.
    3.90.1600.10. 2 hits.
    InterProiIPR006172. DNA-dir_DNA_pol_B.
    IPR017964. DNA-dir_DNA_pol_B_CS.
    IPR006133. DNA-dir_DNA_pol_B_exonuc.
    IPR006134. DNA-dir_DNA_pol_B_multi_dom.
    IPR024647. DNA_pol_a_cat_su_N.
    IPR023211. DNA_pol_palm_dom.
    IPR012337. RNaseH-like_dom.
    IPR015088. Znf_DNA-dir_DNA_pol_B_alpha.
    [Graphical view]
    PfamiPF12254. DNA_pol_alpha_N. 1 hit.
    PF00136. DNA_pol_B. 1 hit.
    PF03104. DNA_pol_B_exo1. 1 hit.
    PF08996. zf-DNA_Pol. 1 hit.
    [Graphical view]
    PRINTSiPR00106. DNAPOLB.
    SMARTiSM00486. POLBc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53098. SSF53098. 1 hit.
    PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NMQ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPVHGDDCE IGASALSDSG SFVSSRARRE KKSKKGRQEA LERLKKAKAG     50
    EKYKYEVEDF TGVYEEVDEE QYSKLVQARQ DDDWIVDDDG IGYVEDGREI 100
    FDDDLEDDAL DADEKGKDGK ARNKDKRNVK KLAVTKPNNI KSMFIACAGK 150
    KTADKAVDLS KDGLLGDILQ DLNTETPQIT PPPVMILKKK RSIGASPNPF 200
    SVHTATAVPS GKIASPVSRK EPPLTPVPLK RAEFAGDDVQ VESTEEEQES 250
    GAMEFEDGDF DEPMEVEEVD LEPMAAKAWD KESEPAEEVK QEADSGKGTV 300
    SYLGSFLPDV SCWDIDQEGD SSFSVQEVQV DSSHLPLVKG ADEEQVFHFY 350
    WLDAYEDQYN QPGVVFLFGK VWIESAETHV SCCVMVKNIE RTLYFLPREM 400
    KIDLNTGKET GTPISMKDVY EEFDEKIATK YKIMKFKSKP VEKNYAFEIP 450
    DVPEKSEYLE VKYSAEMPQL PQDLKGETFS HVFGTNTSSL ELFLMNRKIK 500
    GPCWLEVKSP QLLNQPVSWC KVEAMALKPD LVNVIKDVSP PPLVVMAFSM 550
    KTMQNAKNHQ NEIIAMAALV HHSFALDKAA PKPPFQSHFC VVSKPKDCIF 600
    PYAFKEVIEK KNVKVEVAAT ERTLLGFFLA KVHKIDPDII VGHNIYGFEL 650
    EVLLQRINVC KAPHWSKIGR LKRSNMPKLG GRSGFGERNA TCGRMICDVE 700
    ISAKELIRCK SYHLSELVQQ ILKTERVVIP MENIQNMYSE SSQLLYLLEH 750
    TWKDAKFILQ IMCELNVLPL ALQITNIAGN IMSRTLMGGR SERNEFLLLH 800
    AFYENNYIVP DKQIFRKPQQ KLGDEDEEID GDTNKYKKGR KKAAYAGGLV 850
    LDPKVGFYDK FILLLDFNSL YPSIIQEFNI CFTTVQRVAS EAQKVTEDGE 900
    QEQIPELPDP SLEMGILPRE IRKLVERRKQ VKQLMKQQDL NPDLILQYDI 950
    RQKALKLTAN SMYGCLGFSY SRFYAKPLAA LVTYKGREIL MHTKEMVQKM 1000
    NLEVIYGDTD SIMINTNSTN LEEVFKLGNK VKSEVNKLYK LLEIDIDGVF 1050
    KSLLLLKKKK YAALVVEPTS DGNYVTKQEL KGLDIVRRDW CDLAKDTGNF 1100
    VIGQILSDQS RDTIVENIQK RLIEIGENVL NGSVPVSQFE INKALTKDPQ 1150
    DYPDKKSLPH VHVALWINSQ GGRKVKAGDT VSYVICQDGS NLTASQRAYA 1200
    PEQLQKQDNL TIDTQYYLAQ QIHPVVARIC EPIDGIDAVL IATWLGLDPT 1250
    QFRVHHYHKD EENDALLGGP AQLTDEEKYR DCERFKCPCP TCGTENIYDN 1300
    VFDGSGTDME PSLYRCSNID CKASPLTFTV QLSNKLIMDI RRFIKKYYDG 1350
    WLICEEPTCR NRTRHLPLQF SRTGPLCPAC MKATLQPEYS DKSLYTQLCF 1400
    YRYIFDAECA LEKLTTDHEK DKLKKQFFTP KVLQDYRKLK NTAEQFLSRS 1450
    GYSEVNLSKL FAGCAVKS 1468
    Length:1,468
    Mass (Da):166,457
    Last modified:July 24, 2007 - v1
    Checksum:i9CC2AB5AB76E8746
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002504 Genomic DNA. No translation available.
    AC004655 Genomic DNA. No translation available.
    AC079375 Genomic DNA. No translation available.
    AC135280 Genomic DNA. No translation available.
    RefSeqiXP_005274609.1. XM_005274552.1.
    UniGeneiHs.567319.

    Genome annotation databases

    EnsembliENST00000379068; ENSP00000368358; ENSG00000101868.
    GeneIDi5422.
    KEGGihsa:5422.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC002504 Genomic DNA. No translation available.
    AC004655 Genomic DNA. No translation available.
    AC079375 Genomic DNA. No translation available.
    AC135280 Genomic DNA. No translation available.
    RefSeqi XP_005274609.1. XM_005274552.1.
    UniGenei Hs.567319.

    3D structure databases

    ProteinModelPortali A6NMQ1.
    SMRi A6NMQ1. Positions 347-1246, 1275-1435.
    ModBasei Search...

    Proteomic databases

    PRIDEi A6NMQ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000379068 ; ENSP00000368358 ; ENSG00000101868 .
    GeneIDi 5422.
    KEGGi hsa:5422.

    Organism-specific databases

    CTDi 5422.
    HGNCi HGNC:9173. POLA1.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000163524.
    HOVERGENi HBG080008.
    KOi K02320.
    OMAi EKYRDCE.
    OrthoDBi EOG7CNZDZ.
    PhylomeDBi A6NMQ1.

    Miscellaneous databases

    ChiTaRSi POLA1. human.
    GenomeRNAii 5422.
    NextBioi 35462686.

    Gene expression databases

    ArrayExpressi A6NMQ1.
    Bgeei A6NMQ1.

    Family and domain databases

    Gene3Di 3.30.420.10. 1 hit.
    3.90.1600.10. 2 hits.
    InterProi IPR006172. DNA-dir_DNA_pol_B.
    IPR017964. DNA-dir_DNA_pol_B_CS.
    IPR006133. DNA-dir_DNA_pol_B_exonuc.
    IPR006134. DNA-dir_DNA_pol_B_multi_dom.
    IPR024647. DNA_pol_a_cat_su_N.
    IPR023211. DNA_pol_palm_dom.
    IPR012337. RNaseH-like_dom.
    IPR015088. Znf_DNA-dir_DNA_pol_B_alpha.
    [Graphical view ]
    Pfami PF12254. DNA_pol_alpha_N. 1 hit.
    PF00136. DNA_pol_B. 1 hit.
    PF03104. DNA_pol_B_exo1. 1 hit.
    PF08996. zf-DNA_Pol. 1 hit.
    [Graphical view ]
    PRINTSi PR00106. DNAPOLB.
    SMARTi SM00486. POLBc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53098. SSF53098. 1 hit.
    PROSITEi PS00116. DNA_POLYMERASE_B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    3. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. Ensembl
      Submitted (JUL-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiA6NMQ1_HUMAN
    AccessioniPrimary (citable) accession number: A6NMQ1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 24, 2007
    Last sequence update: July 24, 2007
    Last modified: September 3, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3

    Similar proteinsi