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Protein

DNA polymerase

Gene

POLA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

Cofactori

[4Fe-4S] clusterUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotation
Ligand4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:POLA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000101868.10
HGNCiHGNC:9173 POLA1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101868

PTM / Processingi

Proteomic databases

EPDiA6NMQ1
MaxQBiA6NMQ1
PeptideAtlasiA6NMQ1
PRIDEiA6NMQ1

Expressioni

Gene expression databases

BgeeiENSG00000101868
ExpressionAtlasiA6NMQ1 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA6NMQ1
SMRiA6NMQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 102DNA_pol_alpha_NInterPro annotationAdd BLAST62
Domaini377 – 716DNA_pol_B_exo1InterPro annotationAdd BLAST340
Domaini774 – 1233DNA_pol_BInterPro annotationAdd BLAST460
Domaini1272 – 1461zf-DNA_PolInterPro annotationAdd BLAST190

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Keywords - Domaini

Zinc-fingerUniRule annotation

Phylogenomic databases

eggNOGiKOG0970 Eukaryota
COG0417 LUCA
GeneTreeiENSGT00550000074891
HOGENOMiHOG000163524
HOVERGENiHBG080008
OMAiPKDCIFP
OrthoDBiEOG091G00RR
PhylomeDBiA6NMQ1

Family and domain databases

Gene3Di1.10.3200.20, 1 hit
3.30.420.10, 1 hit
3.90.1600.10, 1 hit
InterProiView protein in InterPro
IPR006172 DNA-dir_DNA_pol_B
IPR017964 DNA-dir_DNA_pol_B_CS
IPR006133 DNA-dir_DNA_pol_B_exonuc
IPR006134 DNA-dir_DNA_pol_B_multi_dom
IPR024647 DNA_pol_a_cat_su_N
IPR023211 DNA_pol_palm_dom_sf
IPR038256 Pol_alpha_znc_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR015088 Znf_DNA-dir_DNA_pol_B_alpha
PfamiView protein in Pfam
PF12254 DNA_pol_alpha_N, 1 hit
PF00136 DNA_pol_B, 1 hit
PF03104 DNA_pol_B_exo1, 1 hit
PF08996 zf-DNA_Pol, 1 hit
PRINTSiPR00106 DNAPOLB
SMARTiView protein in SMART
SM00486 POLBc, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
PROSITEiView protein in PROSITE
PS00116 DNA_POLYMERASE_B, 1 hit

Sequencei

Sequence statusi: Complete.

A6NMQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPVHGDDCE IGASALSDSG SFVSSRARRE KKSKKGRQEA LERLKKAKAG
60 70 80 90 100
EKYKYEVEDF TGVYEEVDEE QYSKLVQARQ DDDWIVDDDG IGYVEDGREI
110 120 130 140 150
FDDDLEDDAL DADEKGKDGK ARNKDKRNVK KLAVTKPNNI KSMFIACAGK
160 170 180 190 200
KTADKAVDLS KDGLLGDILQ DLNTETPQIT PPPVMILKKK RSIGASPNPF
210 220 230 240 250
SVHTATAVPS GKIASPVSRK EPPLTPVPLK RAEFAGDDVQ VESTEEEQES
260 270 280 290 300
GAMEFEDGDF DEPMEVEEVD LEPMAAKAWD KESEPAEEVK QEADSGKGTV
310 320 330 340 350
SYLGSFLPDV SCWDIDQEGD SSFSVQEVQV DSSHLPLVKG ADEEQVFHFY
360 370 380 390 400
WLDAYEDQYN QPGVVFLFGK VWIESAETHV SCCVMVKNIE RTLYFLPREM
410 420 430 440 450
KIDLNTGKET GTPISMKDVY EEFDEKIATK YKIMKFKSKP VEKNYAFEIP
460 470 480 490 500
DVPEKSEYLE VKYSAEMPQL PQDLKGETFS HVFGTNTSSL ELFLMNRKIK
510 520 530 540 550
GPCWLEVKSP QLLNQPVSWC KVEAMALKPD LVNVIKDVSP PPLVVMAFSM
560 570 580 590 600
KTMQNAKNHQ NEIIAMAALV HHSFALDKAA PKPPFQSHFC VVSKPKDCIF
610 620 630 640 650
PYAFKEVIEK KNVKVEVAAT ERTLLGFFLA KVHKIDPDII VGHNIYGFEL
660 670 680 690 700
EVLLQRINVC KAPHWSKIGR LKRSNMPKLG GRSGFGERNA TCGRMICDVE
710 720 730 740 750
ISAKELIRCK SYHLSELVQQ ILKTERVVIP MENIQNMYSE SSQLLYLLEH
760 770 780 790 800
TWKDAKFILQ IMCELNVLPL ALQITNIAGN IMSRTLMGGR SERNEFLLLH
810 820 830 840 850
AFYENNYIVP DKQIFRKPQQ KLGDEDEEID GDTNKYKKGR KKAAYAGGLV
860 870 880 890 900
LDPKVGFYDK FILLLDFNSL YPSIIQEFNI CFTTVQRVAS EAQKVTEDGE
910 920 930 940 950
QEQIPELPDP SLEMGILPRE IRKLVERRKQ VKQLMKQQDL NPDLILQYDI
960 970 980 990 1000
RQKALKLTAN SMYGCLGFSY SRFYAKPLAA LVTYKGREIL MHTKEMVQKM
1010 1020 1030 1040 1050
NLEVIYGDTD SIMINTNSTN LEEVFKLGNK VKSEVNKLYK LLEIDIDGVF
1060 1070 1080 1090 1100
KSLLLLKKKK YAALVVEPTS DGNYVTKQEL KGLDIVRRDW CDLAKDTGNF
1110 1120 1130 1140 1150
VIGQILSDQS RDTIVENIQK RLIEIGENVL NGSVPVSQFE INKALTKDPQ
1160 1170 1180 1190 1200
DYPDKKSLPH VHVALWINSQ GGRKVKAGDT VSYVICQDGS NLTASQRAYA
1210 1220 1230 1240 1250
PEQLQKQDNL TIDTQYYLAQ QIHPVVARIC EPIDGIDAVL IATWLGLDPT
1260 1270 1280 1290 1300
QFRVHHYHKD EENDALLGGP AQLTDEEKYR DCERFKCPCP TCGTENIYDN
1310 1320 1330 1340 1350
VFDGSGTDME PSLYRCSNID CKASPLTFTV QLSNKLIMDI RRFIKKYYDG
1360 1370 1380 1390 1400
WLICEEPTCR NRTRHLPLQF SRTGPLCPAC MKATLQPEYS DKSLYTQLCF
1410 1420 1430 1440 1450
YRYIFDAECA LEKLTTDHEK DKLKKQFFTP KVLQDYRKLK NTAEQFLSRS
1460
GYSEVNLSKL FAGCAVKS
Length:1,468
Mass (Da):166,457
Last modified:July 24, 2007 - v1
Checksum:i9CC2AB5AB76E8746
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002504 Genomic DNA No translation available.
AC004655 Genomic DNA No translation available.
AC079375 Genomic DNA No translation available.
AC135280 Genomic DNA No translation available.
KF459032 Genomic DNA No translation available.
KF459037 Genomic DNA No translation available.
RefSeqiNP_001317289.1, NM_001330360.1
UniGeneiHs.567319

Genome annotation databases

EnsembliENST00000379068; ENSP00000368358; ENSG00000101868
GeneIDi5422
UCSCiuc064yjy.1 human

Similar proteinsi

Entry informationi

Entry nameiA6NMQ1_HUMAN
AccessioniPrimary (citable) accession number: A6NMQ1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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