ID   F170B_HUMAN             Reviewed;         283 AA.
AC   A6NMN3; Q86WY6; Q8N6K8;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   24-JAN-2024, entry version 92.
DE   RecName: Full=Protein FAM170B {ECO:0000305};
DE   AltName: Full=Acrosome-related protein {ECO:0000303|PubMed:26179146};
GN   Name=FAM170B {ECO:0000312|HGNC:HGNC:19736};
GN   Synonyms=C10orf73 {ECO:0000312|HGNC:HGNC:19736};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164054; DOI=10.1038/nature02462;
RA   Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA   Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA   Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA   Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA   Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA   Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA   Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA   Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA   Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA   Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA   Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA   Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA   McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA   Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA   Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA   Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA   Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA   Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA   Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA   Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA   Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 10.";
RL   Nature 429:375-381(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND INTERACTION WITH GOPC.
RX   PubMed=26179146; DOI=10.1002/mrd.22523;
RA   Li Y., Lin S., Luo M., Guo H., Chen J., Ma Q., Gu Y., Jiang Z., Gui Y.;
RT   "FAM170B, a novel acrosomal protein involved in fertilization in mice.";
RL   Mol. Reprod. Dev. 82:787-796(2015).
CC   -!- FUNCTION: Plays a role in fertilization through the acrosome reaction.
CC       {ECO:0000250|UniProtKB:E9PXT9}.
CC   -!- SUBUNIT: Interacts with GOPC. {ECO:0000269|PubMed:26179146}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC       {ECO:0000269|PubMed:26179146}. Cytoplasmic vesicle, secretory vesicle,
CC       acrosome outer membrane {ECO:0000250|UniProtKB:E9PXT9}.
CC   -!- TISSUE SPECIFICITY: Exclusively expressed in adult testis.
CC       {ECO:0000269|PubMed:26179146}.
CC   -!- SIMILARITY: Belongs to the FAM170 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH29839.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAH47597.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AC084727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC029839; AAH29839.1; ALT_INIT; mRNA.
DR   EMBL; BC047597; AAH47597.1; ALT_INIT; mRNA.
DR   CCDS; CCDS53536.1; -.
DR   RefSeq; NP_001157956.1; NM_001164484.1.
DR   AlphaFoldDB; A6NMN3; -.
DR   STRING; 9606.ENSP00000308292; -.
DR   iPTMnet; A6NMN3; -.
DR   PhosphoSitePlus; A6NMN3; -.
DR   BioMuta; FAM170B; -.
DR   MassIVE; A6NMN3; -.
DR   PaxDb; 9606-ENSP00000308292; -.
DR   PeptideAtlas; A6NMN3; -.
DR   TopDownProteomics; A6NMN3; -.
DR   Antibodypedia; 61247; 37 antibodies from 10 providers.
DR   DNASU; 170370; -.
DR   Ensembl; ENST00000311787.6; ENSP00000308292.6; ENSG00000172538.7.
DR   GeneID; 170370; -.
DR   KEGG; hsa:170370; -.
DR   MANE-Select; ENST00000311787.6; ENSP00000308292.6; NM_001164484.2; NP_001157956.1.
DR   UCSC; uc001jhj.4; human.
DR   AGR; HGNC:19736; -.
DR   CTD; 170370; -.
DR   GeneCards; FAM170B; -.
DR   HGNC; HGNC:19736; FAM170B.
DR   HPA; ENSG00000172538; Tissue enriched (testis).
DR   neXtProt; NX_A6NMN3; -.
DR   PharmGKB; PA162387168; -.
DR   VEuPathDB; HostDB:ENSG00000172538; -.
DR   eggNOG; ENOG502S6PC; Eukaryota.
DR   GeneTree; ENSGT00940000162512; -.
DR   HOGENOM; CLU_062038_1_0_1; -.
DR   InParanoid; A6NMN3; -.
DR   OMA; LYTHVQT; -.
DR   OrthoDB; 5221602at2759; -.
DR   PhylomeDB; A6NMN3; -.
DR   TreeFam; TF337124; -.
DR   PathwayCommons; A6NMN3; -.
DR   BioGRID-ORCS; 170370; 16 hits in 1148 CRISPR screens.
DR   GenomeRNAi; 170370; -.
DR   Pharos; A6NMN3; Tdark.
DR   PRO; PR:A6NMN3; -.
DR   Proteomes; UP000005640; Chromosome 10.
DR   RNAct; A6NMN3; Protein.
DR   Bgee; ENSG00000172538; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 15 other cell types or tissues.
DR   GO; GO:0001669; C:acrosomal vesicle; IDA:UniProtKB.
DR   GO; GO:0002081; C:outer acrosomal membrane; ISS:UniProtKB.
DR   GO; GO:0009566; P:fertilization; IBA:GO_Central.
DR   GO; GO:2000344; P:positive regulation of acrosome reaction; ISS:UniProtKB.
DR   GO; GO:0080154; P:regulation of fertilization; ISS:UniProtKB.
DR   InterPro; IPR040879; Spt46-like.
DR   PANTHER; PTHR33517:SF2; PROTEIN FAM170B; 1.
DR   PANTHER; PTHR33517; PROTEIN FAM170B-RELATED; 1.
DR   Pfam; PF17734; Spt46; 1.
DR   Genevisible; A6NMN3; HS.
PE   1: Evidence at protein level;
KW   Cytoplasmic vesicle; Membrane; Reference proteome.
FT   CHAIN           1..283
FT                   /note="Protein FAM170B"
FT                   /id="PRO_0000310494"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          246..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..283
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         69
FT                   /note="R -> L (in dbSNP:rs17773851)"
FT                   /id="VAR_037062"
FT   CONFLICT        84
FT                   /note="S -> F (in Ref. 2; AAH29839)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   283 AA;  32092 MW;  4DEE3A62AF7BE9DF CRC64;
     MKCYFTDHRG EQSPTDGTTL SLTSPESTEE SVEVFWPGTI QREGSSPRPG PAIPREEGLY
     FAARDRGMRD WSSSPSSESS EYQSYSQYQS CCSCMCDEDN AAPQSVCAFY THVQTVRGVA
     VAWETEAGFE PVTRKPRIHE AQFIKRQRWN GSSFEMASNT DMRWDLEACK SNCSPEPEDI
     DLLECCLQEL REPPDWLVTT NYGVRCVACC RVLPSLDALL EHAQHGIREG FSCQIFFEEM
     LERRRAQGQA HDQQLEEEQS PSDNSECSRP QGEVLSAQQQ EKQ
//