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Protein

Protein FAM170B

Gene

FAM170B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in fertilization through the acrosome reaction.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM170BCurated
Alternative name(s):
Acrosome-related protein1 Publication
Gene namesi
Name:FAM170BImported
Synonyms:C10orf73Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:19736. FAM170B.

Subcellular locationi

GO - Cellular componenti

  • acrosomal vesicle Source: UniProtKB
  • outer acrosomal membrane Source: UniProtKB

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162387168.

Polymorphism and mutation databases

BioMutaiFAM170B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003104941 – 283Protein FAM170BAdd BLAST283

Proteomic databases

PaxDbiA6NMN3.
PRIDEiA6NMN3.
TopDownProteomicsiA6NMN3.

PTM databases

iPTMnetiA6NMN3.
PhosphoSitePlusiA6NMN3.

Expressioni

Tissue specificityi

Exclusively expressed in adult testis.1 Publication

Gene expression databases

BgeeiENSG00000172538.
CleanExiHS_FAM170B.
GenevisibleiA6NMN3. HS.

Organism-specific databases

HPAiHPA043899.
HPA050610.

Interactioni

Subunit structurei

Interacts with GOPC.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000308292.

Structurei

3D structure databases

ProteinModelPortaliA6NMN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM170 family.Curated

Phylogenomic databases

eggNOGiENOG410IZBZ. Eukaryota.
ENOG411181D. LUCA.
GeneTreeiENSGT00530000063963.
HOGENOMiHOG000112445.
HOVERGENiHBG082564.
InParanoidiA6NMN3.
OMAiEYQSYSQ.
OrthoDBiEOG091G0GNZ.
PhylomeDBiA6NMN3.
TreeFamiTF337124.

Family and domain databases

InterProiView protein in InterPro
IPR033377. FAM170B.
PANTHERiPTHR33517:SF7. PTHR33517:SF7. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NMN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKCYFTDHRG EQSPTDGTTL SLTSPESTEE SVEVFWPGTI QREGSSPRPG
60 70 80 90 100
PAIPREEGLY FAARDRGMRD WSSSPSSESS EYQSYSQYQS CCSCMCDEDN
110 120 130 140 150
AAPQSVCAFY THVQTVRGVA VAWETEAGFE PVTRKPRIHE AQFIKRQRWN
160 170 180 190 200
GSSFEMASNT DMRWDLEACK SNCSPEPEDI DLLECCLQEL REPPDWLVTT
210 220 230 240 250
NYGVRCVACC RVLPSLDALL EHAQHGIREG FSCQIFFEEM LERRRAQGQA
260 270 280
HDQQLEEEQS PSDNSECSRP QGEVLSAQQQ EKQ
Length:283
Mass (Da):32,092
Last modified:July 24, 2007 - v1
Checksum:i4DEE3A62AF7BE9DF
GO

Sequence cautioni

The sequence AAH29839 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAH47597 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84S → F in AAH29839 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03706269R → L. Corresponds to variant dbSNP:rs17773851Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084727 Genomic DNA. No translation available.
BC029839 mRNA. Translation: AAH29839.1. Different initiation.
BC047597 mRNA. Translation: AAH47597.1. Different initiation.
CCDSiCCDS53536.1.
RefSeqiNP_001157956.1. NM_001164484.1.
UniGeneiHs.646291.

Genome annotation databases

EnsembliENST00000311787; ENSP00000308292; ENSG00000172538.
GeneIDi170370.
KEGGihsa:170370.
UCSCiuc001jhj.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF170B_HUMAN
AccessioniPrimary (citable) accession number: A6NMN3
Secondary accession number(s): Q86WY6, Q8N6K8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: June 7, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families