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Protein

Transmembrane protein 212

Gene

TMEM212

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32153-MONOMER.

Protein family/group databases

TCDBi1.A.37.7.1. the cd20 ca(2+) channel (cd20) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 212
Gene namesi
Name:TMEM212
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:34295. TMEM212.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Transmembranei44 – 64HelicalSequence analysisAdd BLAST21
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Transmembranei99 – 119HelicalSequence analysisAdd BLAST21
Transmembranei148 – 168HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186329.
PharmGKBiPA162406475.

Polymorphism and mutation databases

BioMutaiTMEM212.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003412071 – 194Transmembrane protein 212Add BLAST194

Proteomic databases

PaxDbiA6NML5.
PRIDEiA6NML5.

Expressioni

Gene expression databases

BgeeiENSG00000186329.
CleanExiHS_TMEM212.
ExpressionAtlasiA6NML5. baseline and differential.
GenevisibleiA6NML5. HS.

Organism-specific databases

HPAiHPA053134.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334072.

Structurei

3D structure databases

ProteinModelPortaliA6NML5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWY4. Eukaryota.
ENOG410YJC5. LUCA.
GeneTreeiENSGT00390000016029.
HOGENOMiHOG000154625.
HOVERGENiHBG095589.
InParanoidiA6NML5.
OMAiWFTGWSV.
OrthoDBiEOG091G0OD0.
PhylomeDBiA6NML5.
TreeFamiTF337661.

Family and domain databases

InterProiIPR030417. MS4A.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NML5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGLYQAAGR ILVTLGILSV CSGVIAFFPV FSYKPWFTGW SVRIACPIWN
60 70 80 90 100
GALAITTGVL LLLAYREWTQ RYLGEATFTF VILSIMGCPL HFAIALESAL
110 120 130 140 150
LGPYCFYSFS GIAGTNYLGY AVTFPYPYAK FPLACVDPPH YEEYHLTLQA
160 170 180 190
LDLCLSFTLL CTSLTVFIKL SARLIQNGHI NMQLPAGNPN PFSP
Length:194
Mass (Da):21,425
Last modified:January 15, 2008 - v2
Checksum:i940FF9F9630714AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026825 mRNA. No translation available.
AC055714 Genomic DNA. No translation available.
CCDSiCCDS46958.1.
RefSeqiNP_001157908.1. NM_001164436.1.
XP_011511119.1. XM_011512817.1.
UniGeneiHs.642307.

Genome annotation databases

EnsembliENST00000334567; ENSP00000334072; ENSG00000186329.
ENST00000619900; ENSP00000484106; ENSG00000186329.
GeneIDi389177.
KEGGihsa:389177.
UCSCiuc003fhw.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026825 mRNA. No translation available.
AC055714 Genomic DNA. No translation available.
CCDSiCCDS46958.1.
RefSeqiNP_001157908.1. NM_001164436.1.
XP_011511119.1. XM_011512817.1.
UniGeneiHs.642307.

3D structure databases

ProteinModelPortaliA6NML5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334072.

Protein family/group databases

TCDBi1.A.37.7.1. the cd20 ca(2+) channel (cd20) family.

Polymorphism and mutation databases

BioMutaiTMEM212.

Proteomic databases

PaxDbiA6NML5.
PRIDEiA6NML5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334567; ENSP00000334072; ENSG00000186329.
ENST00000619900; ENSP00000484106; ENSG00000186329.
GeneIDi389177.
KEGGihsa:389177.
UCSCiuc003fhw.2. human.

Organism-specific databases

CTDi389177.
GeneCardsiTMEM212.
HGNCiHGNC:34295. TMEM212.
HPAiHPA053134.
neXtProtiNX_A6NML5.
OpenTargetsiENSG00000186329.
PharmGKBiPA162406475.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWY4. Eukaryota.
ENOG410YJC5. LUCA.
GeneTreeiENSGT00390000016029.
HOGENOMiHOG000154625.
HOVERGENiHBG095589.
InParanoidiA6NML5.
OMAiWFTGWSV.
OrthoDBiEOG091G0OD0.
PhylomeDBiA6NML5.
TreeFamiTF337661.

Enzyme and pathway databases

BioCyciZFISH:G66-32153-MONOMER.

Miscellaneous databases

GenomeRNAii389177.
PROiA6NML5.

Gene expression databases

BgeeiENSG00000186329.
CleanExiHS_TMEM212.
ExpressionAtlasiA6NML5. baseline and differential.
GenevisibleiA6NML5. HS.

Family and domain databases

InterProiIPR030417. MS4A.
[Graphical view]
PANTHERiPTHR23320. PTHR23320. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTM212_HUMAN
AccessioniPrimary (citable) accession number: A6NML5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.