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Protein

Putative fidgetin-like protein 2

Gene

FIGNL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei395 – 3951ATP; via amide nitrogen and carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi435 – 4406ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fidgetin-like protein 2
Gene namesi
Name:FIGNL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:13287. FIGNL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388579.

Polymorphism and mutation databases

BioMutaiFIGNL2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 653653Putative fidgetin-like protein 2PRO_0000343702Add
BLAST

Proteomic databases

EPDiA6NMB9.
PRIDEiA6NMB9.

PTM databases

iPTMnetiA6NMB9.
PhosphoSiteiA6NMB9.

Expressioni

Gene expression databases

CleanExiHS_FIGNL2.

Structurei

3D structure databases

ProteinModelPortaliA6NMB9.
SMRiA6NMB9. Positions 365-652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi114 – 17057Gly-richAdd
BLAST
Compositional biasi180 – 25778Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

HOVERGENiHBG061204.
InParanoidiA6NMB9.
PhylomeDBiA6NMB9.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NMB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHWTPEHAQP LNQWPEQHLD VSSTTPSPAH KLELPPGGRQ RCHYAWAHDD
60 70 80 90 100
ISALTASNLL KRYAEKYSGV LDSPYERPAL GGYSDASFLN GAKGDPEPWP
110 120 130 140 150
GPEPPYPLAS LHEGLPGTKS GGGGGSGALG GSPVLAGNLP EPLYAGNACG
160 170 180 190 200
GPSAAPEYAA GYGGGYLAPG YCAQTGAALP PPPPAALLQP PPPPGYGPSA
210 220 230 240 250
PLYNYPAGGY AAQPGYGALP PPPGPPPAPY LTPGLPAPTP LPAPAPPTAY
260 270 280 290 300
GFPTAAPGAE SGLSLKRKAA DEGPEGRYRK YAYEPAKAPV ADGASYPAAD
310 320 330 340 350
NGECRGNGFR AKPPGAAEEA SGKYGGGVPL KVLGSPVYGP QLEPFEKFPE
360 370 380 390 400
RAPAPRGGFA VPSGETPKGV DPGALELVTS KMVDCGPPVQ WADVAGQGAL
410 420 430 440 450
KAALEEELVW PLLRPPAYPG SLRPPRTVLL FGPRGAGKAL LGRCLATQLG
460 470 480 490 500
ATLLRLRGAT LAAPGAAEGA RLLQAAFAAA RCRPPSVLLI SELEALLPAR
510 520 530 540 550
DDGAAAGGAL QVPLLACLDG GCGAGADGVL VVGTTSRPAA LDEATRRRFS
560 570 580 590 600
LRFYVALPDS PARGQILQRA LAQQGCALSE RELAALVQGT QGFSGGELGQ
610 620 630 640 650
LCQQAAAGAG LPGLQRPLSY KDLEAALAKV GPRASAKELD SFVEWDKMYG

SGH
Length:653
Mass (Da):66,603
Last modified:July 22, 2008 - v2
Checksum:iD84AD37DEFA9EB0C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti366 – 3661T → P.
Corresponds to variant rs303819 [ dbSNP | Ensembl ].
VAR_044425

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068987 Genomic DNA. No translation available.
RefSeqiNP_001013712.4. NM_001013690.4.
XP_005268927.1. XM_005268870.2.
XP_011536649.1. XM_011538347.1.
UniGeneiHs.648218.

Genome annotation databases

GeneIDi401720.
KEGGihsa:401720.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC068987 Genomic DNA. No translation available.
RefSeqiNP_001013712.4. NM_001013690.4.
XP_005268927.1. XM_005268870.2.
XP_011536649.1. XM_011538347.1.
UniGeneiHs.648218.

3D structure databases

ProteinModelPortaliA6NMB9.
SMRiA6NMB9. Positions 365-652.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiA6NMB9.
PhosphoSiteiA6NMB9.

Polymorphism and mutation databases

BioMutaiFIGNL2.

Proteomic databases

EPDiA6NMB9.
PRIDEiA6NMB9.

Protocols and materials databases

DNASUi401720.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi401720.
KEGGihsa:401720.

Organism-specific databases

CTDi401720.
GeneCardsiFIGNL2.
HGNCiHGNC:13287. FIGNL2.
neXtProtiNX_A6NMB9.
PharmGKBiPA162388579.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG061204.
InParanoidiA6NMB9.
PhylomeDBiA6NMB9.

Miscellaneous databases

GenomeRNAii401720.

Gene expression databases

CleanExiHS_FIGNL2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFIGL2_HUMAN
AccessioniPrimary (citable) accession number: A6NMB9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 6, 2016
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.