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Protein

Sialic acid-binding Ig-like lectin 16

Gene

SIGLEC16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Putative adhesion molecule that mediates sialic-acid dependent binding to cells.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201Sialic acidBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Enzyme and pathway databases

ReactomeiR-HSA-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid-binding Ig-like lectin 16
Short name:
Siglec-16
Alternative name(s):
Siglec-P16
Gene namesi
Name:SIGLEC16
Synonyms:SIGLECP16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:24851. SIGLEC16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 434418ExtracellularSequence analysisAdd
BLAST
Transmembranei435 – 45521HelicalSequence analysisAdd
BLAST
Topological domaini456 – 48126CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 481465Sialic acid-binding Ig-like lectin 16PRO_0000332258Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 174PROSITE-ProRule annotation
Disulfide bondi42 ↔ 102PROSITE-ProRule annotation
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence analysis
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence analysis
Disulfide bondi165 ↔ 216PROSITE-ProRule annotation
Disulfide bondi259 ↔ 306PROSITE-ProRule annotation
Glycosylationi338 – 3381N-linked (GlcNAc...)Sequence analysis
Glycosylationi347 – 3471N-linked (GlcNAc...)Sequence analysis
Disulfide bondi363 ↔ 408PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiA6NMB1.

Expressioni

Tissue specificityi

Expressed in bone marrow, fetal brain, fetal liver, lung and salivary gland. Detected in brain, macrophage, cancerous esophagus and lung at protein level.1 Publication

Gene expression databases

BgeeiA6NMB1.

Structurei

3D structure databases

ProteinModelPortaliA6NMB1.
SMRiA6NMB1. Positions 22-431.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 122104Ig-like V-typeAdd
BLAST
Domaini147 – 23286Ig-like C2-type 1Add
BLAST
Domaini238 – 32285Ig-like C2-type 2Add
BLAST
Domaini327 – 42498Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiA6NMB1.
PhylomeDBiA6NMB1.
TreeFamiTF332441.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NMB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLLPLLLPV LGAGSLNKDP SYSLQVQRQV PVPEGLCVIV SCNLSYPRDG
60 70 80 90 100
WDESTAAYGY WFKGRTSPKT GAPVATNNQS REVAMSTRDR FQLTGDPGKG
110 120 130 140 150
SCSLVIRDAQ REDEAWYFFR VERGSRVRHS FLSNAFFLKV TALTQKPDVY
160 170 180 190 200
IPETLEPGQP VTVICVFNWA FKKCPAPSFS WTGAALSPRR TRPSTSHFSV
210 220 230 240 250
LSFTPSPQDH DTDLTCHVDF SRKGVSAQRT VRLRVASLEL QGNVIYLEVQ
260 270 280 290 300
KGQFLRLLCA ADSQPPATLS WVLQDRVLSS SHPWGPRTLG LELPGVKAGD
310 320 330 340 350
SGRYTCRAEN RLGSQQRALD LSVQYPPENL RVMVSQANRT VLENLRNGTS
360 370 380 390 400
LRVLEGQSLR LVCVTHSSPP ARLSWTWGEQ TVGPSQPSDP GVLQLPRVQM
410 420 430 440 450
EHEGEFTCHA RHPLGSQRVS LSFSVHCKSG PMTGVVLVAV GEVAMKILLL
460 470 480
CLCLILLRVR SCRRKAARAA LGMEAADAVT D
Length:481
Mass (Da):52,992
Last modified:April 29, 2008 - v3
Checksum:i72C6D2D759F94BBC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011452 Genomic DNA. No translation available.
BC039008 mRNA. No translation available.
UniGeneiHs.568076.
Hs.738007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011452 Genomic DNA. No translation available.
BC039008 mRNA. No translation available.
UniGeneiHs.568076.
Hs.738007.

3D structure databases

ProteinModelPortaliA6NMB1.
SMRiA6NMB1. Positions 22-431.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiA6NMB1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiSIGLEC16.
H-InvDBHIX0040097.
HGNCiHGNC:24851. SIGLEC16.
neXtProtiNX_A6NMB1.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiA6NMB1.
PhylomeDBiA6NMB1.
TreeFamiTF332441.

Enzyme and pathway databases

ReactomeiR-HSA-2172127. DAP12 interactions.

Miscellaneous databases

PROiA6NMB1.

Gene expression databases

BgeeiA6NMB1.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 4 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia."
    Angata T., Kerr S.C., Greaves D.R., Varki N.M., Crocker P.R., Varki A.
    J. Biol. Chem. 277:24466-24474(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  4. "SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans."
    Cao H., Lakner U., de Bono B., Traherne J.A., Trowsdale J., Barrow A.D.
    Eur. J. Immunol. 38:2303-2315(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiSIG16_HUMAN
AccessioniPrimary (citable) accession number: A6NMB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: May 11, 2016
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

According to PubMed:18629938, the SIGLECP16 sequence, that was initially classified as a pseudogene, has a 4 bp deletion when compared with the sequence shown in this entry. This deletion is a polymorphism with a frequency of around 50% in the UK population. The frameshifted allele is non-functional whereas the sequence displayed here seems to be functional. The functional allele has been named SIGLEC16 in PubMed:18629938.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.