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Protein

Olfactory receptor 6C76

Gene

OR6C76

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6C76
Gene namesi
Name:OR6C76
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:31305. OR6C76.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini45 – 5713CytoplasmicSequence analysisAdd
BLAST
Transmembranei58 – 8023Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini81 – 9414ExtracellularSequence analysisAdd
BLAST
Transmembranei95 – 11521Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini116 – 14227CytoplasmicSequence analysisAdd
BLAST
Transmembranei143 – 16321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini164 – 19532ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini217 – 23822CytoplasmicSequence analysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini260 – 2678ExtracellularSequence analysis
Transmembranei268 – 28821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini289 – 31224CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134906466.

Polymorphism and mutation databases

BioMutaiOR6C76.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 6C76PRO_0000310868Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi94 ↔ 176PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NM76.
PRIDEiA6NM76.

PTM databases

iPTMnetiA6NM76.
PhosphoSiteiA6NM76.

Expressioni

Gene expression databases

CleanExiHS_OR6C76.

Organism-specific databases

HPAiCAB009960.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000328402.

Structurei

3D structure databases

ProteinModelPortaliA6NM76.
SMRiA6NM76. Positions 34-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJ6. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NM76.
KOiK04257.
OMAiKICYQLV.
OrthoDBiEOG091G0F9F.
PhylomeDBiA6NM76.
TreeFamiTF336833.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NM76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNRTSVTDF ILLGLTDNPQ LQVVIFSFLF LTYVLSVTGN LTIISLTLLD
60 70 80 90 100
SHLKTPMYFF LRNFSLEISF TSVCNPRFLI SILTGDKSIS YNACAAQLFF
110 120 130 140 150
FIFLGSTEFF LLASMSYDCY VAICKPLHYT TIMSDRICYQ LIISSWLAGF
160 170 180 190 200
LVIFPPLAMG LQLDFCDSNV IDHFTCDSAP LLQISCTDTS TLELMSFILA
210 220 230 240 250
LFTLISTLIL VILSYTYIIR TILRIPSAQQ RKKAFSTCSS HVIVVSISYG
260 270 280 290 300
SCIFMYVKTS AKEGVALTKG VAILNTSVAP MLNPFIYTLR NQQVKQAFKD
310
VLRKISHKKK KH
Length:312
Mass (Da):35,119
Last modified:July 24, 2007 - v1
Checksum:i7059BE886A31DAC7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125816 Genomic DNA. No translation available.
CCDSiCCDS31823.1.
RefSeqiNP_001005183.1. NM_001005183.1.
UniGeneiHs.553764.

Genome annotation databases

EnsembliENST00000328314; ENSP00000328402; ENSG00000185821.
GeneIDi390326.
KEGGihsa:390326.
UCSCiuc010spm.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC125816 Genomic DNA. No translation available.
CCDSiCCDS31823.1.
RefSeqiNP_001005183.1. NM_001005183.1.
UniGeneiHs.553764.

3D structure databases

ProteinModelPortaliA6NM76.
SMRiA6NM76. Positions 34-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000328402.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NM76.
PhosphoSiteiA6NM76.

Polymorphism and mutation databases

BioMutaiOR6C76.

Proteomic databases

PaxDbiA6NM76.
PRIDEiA6NM76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328314; ENSP00000328402; ENSG00000185821.
GeneIDi390326.
KEGGihsa:390326.
UCSCiuc010spm.2. human.

Organism-specific databases

CTDi390326.
GeneCardsiOR6C76.
HGNCiHGNC:31305. OR6C76.
HPAiCAB009960.
neXtProtiNX_A6NM76.
PharmGKBiPA134906466.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFJ6. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00760000118790.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiA6NM76.
KOiK04257.
OMAiKICYQLV.
OrthoDBiEOG091G0F9F.
PhylomeDBiA6NM76.
TreeFamiTF336833.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii390326.
PROiA6NM76.

Gene expression databases

CleanExiHS_OR6C76.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO6C76_HUMAN
AccessioniPrimary (citable) accession number: A6NM76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.