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Protein

PRA1 family protein

Gene

WDR45

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

SignaLinkiA6NM71

Names & Taxonomyi

Protein namesi
Recommended name:
PRA1 family proteinUniRule annotation
Gene namesi
Name:WDR45Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000196998.16
HGNCiHGNC:28912 WDR45

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei179 – 199HelicalUniRule annotationAdd BLAST21
Transmembranei211 – 231HelicalUniRule annotationAdd BLAST21
Transmembranei237 – 256HelicalUniRule annotationAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196998

PTM / Processingi

Proteomic databases

EPDiA6NM71
MaxQBiA6NM71
PaxDbiA6NM71
PeptideAtlasiA6NM71
PRIDEiA6NM71

Expressioni

Gene expression databases

BgeeiENSG00000196998
ExpressionAtlasiA6NM71 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365536

Structurei

3D structure databases

ProteinModelPortaliA6NM71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili249 – 269Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the PRA1 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG2111 Eukaryota
KOG4050 Eukaryota
ENOG4110P10 LUCA
GeneTreeiENSGT00730000110940
OrthoDBiEOG091G0EJZ
TreeFamiTF314859

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR004895 Prenylated_rab_accept_PRA1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF03208 PRA1, 1 hit
PF00400 WD40, 1 hit
SMARTiView protein in SMART
SM00320 WD40, 3 hits
SUPFAMiSSF50978 SSF50978, 1 hit

Sequencei

Sequence statusi: Complete.

A6NM71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQQPLRGVT SLRFNQDQSC FCCAMETGVR IYNVEPLMEK GHLGLCDLCP
60 70 80 90 100
SLEKQLLVFP GHKCGSLQLV DLASTKPGTS SAPFTINAHQ SDIACVSLNQ
110 120 130 140 150
PGTVVASASQ KGTLIRLFDT QSKEKLVELR RGTDPATLYC INFSHDSSFL
160 170 180 190 200
CASSDKGTVH IFALKDTRLN RRSAYVRPLH TLLSALVVAV ALGVLVWAAE
210 220 230 240 250
TRAAVRRCRR SHPAACLAAV LAVGLLVLWV AGGACTFLFS IAGPVLLILV
260 270 280 290
HASLRLRNLK NKIENKIESI GLKRTPMGLL LEALGQEQEA GS
Length:292
Mass (Da):31,519
Last modified:July 13, 2010 - v3
Checksum:i0A0D0F547FC400CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC231657 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000376358; ENSP00000365536; ENSG00000196998
UCSCiuc033ecv.2 human

Similar proteinsi

Entry informationi

Entry nameiA6NM71_HUMAN
AccessioniPrimary (citable) accession number: A6NM71
Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 13, 2010
Last modified: March 28, 2018
This is version 90 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health