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Protein
Submitted name:

WD repeat domain phosphoinositide-interacting protein 4

Gene

WDR45

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiA6NM71.

Names & Taxonomyi

Protein namesi
Submitted name:
WD repeat domain phosphoinositide-interacting protein 4Imported
Gene namesi
Name:WDR45Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:28912. WDR45.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei179 – 19921HelicalSequence analysisAdd
BLAST
Transmembranei211 – 23121HelicalSequence analysisAdd
BLAST
Transmembranei237 – 25620HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

MaxQBiA6NM71.
PaxDbiA6NM71.
PeptideAtlasiA6NM71.

Expressioni

Gene expression databases

BgeeiENSG00000196998.
ExpressionAtlasiA6NM71. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000365536.

Structurei

3D structure databases

ProteinModelPortaliA6NM71.
SMRiA6NM71. Positions 7-37, 44-172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2111. Eukaryota.
KOG4050. Eukaryota.
ENOG4110P10. LUCA.
GeneTreeiENSGT00730000110940.
OMAiLIMVHAS.
OrthoDBiEOG091G0EJZ.
TreeFamiTF314859.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR004895. Prenylated_rab_accept_PRA1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR032910. WIPI4.
[Graphical view]
PANTHERiPTHR11227:SF29. PTHR11227:SF29. 1 hit.
PfamiPF03208. PRA1. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NM71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQQPLRGVT SLRFNQDQSC FCCAMETGVR IYNVEPLMEK GHLGLCDLCP
60 70 80 90 100
SLEKQLLVFP GHKCGSLQLV DLASTKPGTS SAPFTINAHQ SDIACVSLNQ
110 120 130 140 150
PGTVVASASQ KGTLIRLFDT QSKEKLVELR RGTDPATLYC INFSHDSSFL
160 170 180 190 200
CASSDKGTVH IFALKDTRLN RRSAYVRPLH TLLSALVVAV ALGVLVWAAE
210 220 230 240 250
TRAAVRRCRR SHPAACLAAV LAVGLLVLWV AGGACTFLFS IAGPVLLILV
260 270 280 290
HASLRLRNLK NKIENKIESI GLKRTPMGLL LEALGQEQEA GS
Length:292
Mass (Da):31,519
Last modified:July 13, 2010 - v3
Checksum:i0A0D0F547FC400CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC231657 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000376358; ENSP00000365536; ENSG00000196998.
UCSCiuc033ecv.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC231657 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA6NM71.
SMRiA6NM71. Positions 7-37, 44-172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000365536.

Proteomic databases

MaxQBiA6NM71.
PaxDbiA6NM71.
PeptideAtlasiA6NM71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376358; ENSP00000365536; ENSG00000196998.
UCSCiuc033ecv.2. human.

Organism-specific databases

HGNCiHGNC:28912. WDR45.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2111. Eukaryota.
KOG4050. Eukaryota.
ENOG4110P10. LUCA.
GeneTreeiENSGT00730000110940.
OMAiLIMVHAS.
OrthoDBiEOG091G0EJZ.
TreeFamiTF314859.

Enzyme and pathway databases

SignaLinkiA6NM71.

Gene expression databases

BgeeiENSG00000196998.
ExpressionAtlasiA6NM71. baseline and differential.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR004895. Prenylated_rab_accept_PRA1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR032910. WIPI4.
[Graphical view]
PANTHERiPTHR11227:SF29. PTHR11227:SF29. 1 hit.
PfamiPF03208. PRA1. 1 hit.
PF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA6NM71_HUMAN
AccessioniPrimary (citable) accession number: A6NM71
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 13, 2010
Last modified: September 7, 2016
This is version 76 of the entry and version 3 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.