A6NM62 (LRC53_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leucine-rich repeat-containing protein 53

Gene names

Name:

LRRC53

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1247 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Contains 7 LRR (leucine-rich) repeats. Contains 1 LRRCT domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Leucine-rich repeat Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1247	1247	Leucine-rich repeat-containing protein 53		PRO_0000317367
Regions
	Transmembrane	294 – 314	21	Helical; Potential
	Repeat	34 – 55	22	LRR 1
	Repeat	58 – 79	22	LRR 2
	Repeat	82 – 102	21	LRR 3
	Repeat	108 – 129	22	LRR 4
	Repeat	132 – 153	22	LRR 5
	Repeat	158 – 179	22	LRR 6
	Repeat	182 – 203	22	LRR 7
	Domain	214 – 271	58	LRRCT

Sequences

	Sequence		Length	Mass (Da)
	A6NM62 [UniParc]. Last modified July 22, 2008. Version 2. Checksum: A22DDB8BB3BEA9B3	FASTA	1,247	140,742
	10 20 30 40 50 60 MLRLVAACPE SCVVCTKDVT LCHQLTYIVA APMTTRVLII TDGYLSSIES TNLSLLFNLA 70 80 90 100 110 120 LLSLSRNGIE DVQEDALHGL TMLRTLLLEH NQISSSSLTD HTFSKLHSLQ VLVLSNNALR 130 140 150 160 170 180 TLRGSWFRNT SGLTRLQLDG NQITNLTDSS FGGTNLHSLR YLDLSNNFIS YIGKDAFRPL 190 200 210 220 230 240 PQLQEVDLSR NRLAHMPDVF TPLKQLILLS LDKNQWSCTC DLHPLARFLR NYIKSSAHTL 250 260 270 280 290 300 RNAKDLNCQP STAAVAAAQS VLRLSETNCD SKAPNFTLVL KDRSPLLPGP DVALLTVLGF 310 320 330 340 350 360 AGAVGLTCLG LVVFNWKLHQ GKANEHTSEN LCCRTFDEPL CAHEARNYHT KGYCNCHLTQ 370 380 390 400 410 420 ENEIKVMSTV GSRKEMPLLQ ENSHQATSAS ESATLDGSFR NLKKKDRGVG STLFCQDGRL 430 440 450 460 470 480 LHSECSEPPG NMRAFNEAGL LTTYNPRKVQ KLWNLEPGEV QPQTLQHHII RTEDISSDIF 490 500 510 520 530 540 RRRYATPASA LAGESLEKRL TNESWQPPIE KEDNGLHPHR QRHFITSSSS KPCEPEEHYV 550 560 570 580 590 600 QKIVQKNRSK YDDPCGLLKQ SKPRYFQPNN SLICKYVPCE QFEDYMKEKK PNRRQHSKPE 610 620 630 640 650 660 KEQIQINSAI EKFLMSEDNI DLSGLSTKTK KAYSPKRVIF HDPDLVEINR SMMSPKISTP 670 680 690 700 710 720 WKRQKNQSNQ LTKLDVKKFS NTGERNKGEK WFTNSWVLKR KRTPQSDLKG KIKGQNLKLN 730 740 750 760 770 780 LHPFRKVRVH PEKSLSSLPK QCKQVLLPPK KLSKTSETEA KINTVCSADF LQQSESSNYV 790 800 810 820 830 840 RLTSKRLPLK HDSKQTPYYQ RNTKRAPLLS ANNLRVVNQS SIESSCYSAG HIPDGNTSKL 850 860 870 880 890 900 PQPTPTDAEH RHSHSQFSTE QMEDATQLES KVLSYLATTW ENTGSDVLPF QHSRRATDQG 910 920 930 940 950 960 TTESTEHMGQ NVSKTSELNQ FSLSPRNQTQ LLDAHKTDSY NKEYTLDQNE ALQHREQNSS 970 980 990 1000 1010 1020 HAQLENKEKT LMTKPQISHQ IVENCIMDKE ENDVEKKLSK TETYDSSLIP QTQSKNNLSF 1030 1040 1050 1060 1070 1080 MKTNSIPYQN RIELPKDIST SPVSSQAVWH LTNSSEKGID STNALPRNDG TEALEIKIVG 1090 1100 1110 1120 1130 1140 KEEKNMLDES KTDSSMLTQI SQMTLKGITK ERQQTWENGT SEKYILHDAS SAEETITAKD 1150 1160 1170 1180 1190 1200 LSITSSHETQ NRILCSEVDP EVNSNVHNFR EVQNIQPDKD SAHKEGAMTV ETHEALSFLP 1210 1220 1230 1240 GLKDSFEAEN EVFLVPSRIN EAENSAPKPV LYPPSAEYAT TSPLETE

References

[1]

"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC105271 Genomic DNA. No translation available.
IPI	IPI00252944.
3D structure databases
ProteinModelPortal	A6NM62.
ModBase	Search...
PTM databases
PhosphoSite	A6NM62.
Proteomic databases
PaxDb	A6NM62.
PRIDE	A6NM62.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000294635; ENSP00000294635; ENSG00000162621.
Organism-specific databases
GeneCards	GC01M074935.
HGNC	HGNC:25255. LRRC53.
HPA	HPA054062.
neXtProt	NX_A6NM62.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146774.
HOGENOM	HOG000113373.
InParanoid	A6NM62.
OrthoDB	EOG44XJFZ.
Gene expression databases
ArrayExpress	A6NM62.
Bgee	A6NM62.
Genevestigator	A6NM62.
Family and domain databases
InterPro	IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. [Graphical view]
SMART	SM00369. LRR_TYP. 3 hits. [Graphical view]
PROSITE	PS51450. LRR. 7 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LRC53_HUMAN

Accession

Primary (citable) accession number: A6NM62

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	July 22, 2008
Last modified:	May 1, 2013
This is version 44 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.