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A6NM45

- CLD24_HUMAN

UniProt

A6NM45 - CLD24_HUMAN

Protein

Putative claudin-24

Gene

CLDN24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 2 (26 Jun 2013)
      Previous versions | rss
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    Functioni

    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative claudin-24
    Gene namesi
    Name:CLDN24
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:37200. CLDN24.

    Subcellular locationi

    Cell junctiontight junction By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. tight junction Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Putative claudin-24PRO_0000320201Add
    BLAST

    Proteomic databases

    PRIDEiA6NM45.

    Expressioni

    Gene expression databases

    BgeeiA6NM45.
    GenevestigatoriA6NM45.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000333484.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NM45.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini32 – 8150ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 11715CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini139 – 16123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini183 – 22038CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the claudin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40943.
    HOGENOMiHOG000220937.
    HOVERGENiHBG104065.
    InParanoidiA6NM45.
    KOiK06087.
    OMAiYAVAQMQ.
    PhylomeDBiA6NM45.
    TreeFamiTF331936.

    Family and domain databases

    InterProiIPR006187. Claudin.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PANTHERiPTHR12002. PTHR12002. 1 hit.
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01077. CLAUDIN.
    PROSITEiPS01346. CLAUDIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NM45-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALIFRTAMQ SVGLLLSLLG WILSIITTYL PHWKNLNLDL NEMENWTMGL    50
    WQTCVIQEEV GMQCKDFDSF LALPAELRVS RILMFLSNGL GFLGLLVSGF 100
    GLDCLRIGES QRDLKRRLLI LGGILSWASG ITALVPVSWV AHKTVQEFWD 150
    ENVPDFVPRW EFGEALFLGW FAGLSLLLGG CLLNCAACSS HAPLALGHYA 200
    VAQMQTQCPY LEDGTADPQV 220
    Length:220
    Mass (Da):24,421
    Last modified:June 26, 2013 - v2
    Checksum:i57AE200093A81845
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181L → F.
    Corresponds to variant rs7688467 [ dbSNP | Ensembl ].
    VAR_055660

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093844 Genomic DNA. No translation available.
    CCDSiCCDS54824.1.
    RefSeqiNP_001172078.1. NM_001185149.1.
    UniGeneiHs.727475.

    Genome annotation databases

    EnsembliENST00000541814; ENSP00000438400; ENSG00000185758.
    GeneIDi100132463.
    KEGGihsa:100132463.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC093844 Genomic DNA. No translation available.
    CCDSi CCDS54824.1.
    RefSeqi NP_001172078.1. NM_001185149.1.
    UniGenei Hs.727475.

    3D structure databases

    ProteinModelPortali A6NM45.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000333484.

    Proteomic databases

    PRIDEi A6NM45.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000541814 ; ENSP00000438400 ; ENSG00000185758 .
    GeneIDi 100132463.
    KEGGi hsa:100132463.

    Organism-specific databases

    CTDi 100132463.
    GeneCardsi GC04M184242.
    HGNCi HGNC:37200. CLDN24.
    neXtProti NX_A6NM45.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40943.
    HOGENOMi HOG000220937.
    HOVERGENi HBG104065.
    InParanoidi A6NM45.
    KOi K06087.
    OMAi YAVAQMQ.
    PhylomeDBi A6NM45.
    TreeFami TF331936.

    Miscellaneous databases

    GenomeRNAii 100132463.
    NextBioi 20773913.

    Gene expression databases

    Bgeei A6NM45.
    Genevestigatori A6NM45.

    Family and domain databases

    InterProi IPR006187. Claudin.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    PANTHERi PTHR12002. PTHR12002. 1 hit.
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01077. CLAUDIN.
    PROSITEi PS01346. CLAUDIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCLD24_HUMAN
    AccessioniPrimary (citable) accession number: A6NM45
    Secondary accession number(s): F5H040
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: June 26, 2013
    Last modified: October 1, 2014
    This is version 58 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3