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A6NM45 (CLD24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative claudin-24
Gene names
Name:CLDN24
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.

Subcellular location

Cell junctiontight junction By similarity. Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the claudin family.

Caution

Could be the product of a pseudogene.

Ontologies

Keywords
   Cellular componentCell junction
Cell membrane
Membrane
Tight junction
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

tight junction

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Putative claudin-24
PRO_0000320201

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Potential
Topological domain32 – 8150Extracellular Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 11715Cytoplasmic Potential
Transmembrane118 – 13821Helical; Potential
Topological domain139 – 16123Extracellular Potential
Transmembrane162 – 18221Helical; Potential
Topological domain183 – 22038Cytoplasmic Potential

Natural variations

Natural variant181L → F.
Corresponds to variant rs7688467 [ dbSNP | Ensembl ].
VAR_055660

Sequences

Sequence LengthMass (Da)Tools
A6NM45 [UniParc].

Last modified June 26, 2013. Version 2.
Checksum: 57AE200093A81845

FASTA22024,421
        10         20         30         40         50         60 
MALIFRTAMQ SVGLLLSLLG WILSIITTYL PHWKNLNLDL NEMENWTMGL WQTCVIQEEV 

        70         80         90        100        110        120 
GMQCKDFDSF LALPAELRVS RILMFLSNGL GFLGLLVSGF GLDCLRIGES QRDLKRRLLI 

       130        140        150        160        170        180 
LGGILSWASG ITALVPVSWV AHKTVQEFWD ENVPDFVPRW EFGEALFLGW FAGLSLLLGG 

       190        200        210        220 
CLLNCAACSS HAPLALGHYA VAQMQTQCPY LEDGTADPQV 

« Hide

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC093844 Genomic DNA. No translation available.
CCDSCCDS54824.1.
RefSeqNP_001172078.1. NM_001185149.1.
UniGeneHs.727475.

3D structure databases

ProteinModelPortalA6NM45.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000333484.

Proteomic databases

PRIDEA6NM45.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000541814; ENSP00000438400; ENSG00000185758.
GeneID100132463.
KEGGhsa:100132463.

Organism-specific databases

CTD100132463.
GeneCardsGC04M184242.
HGNCHGNC:37200. CLDN24.
neXtProtNX_A6NM45.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40943.
HOGENOMHOG000220937.
HOVERGENHBG104065.
InParanoidA6NM45.
KOK06087.
OMAYAVAQMQ.
PhylomeDBA6NM45.
TreeFamTF331936.

Gene expression databases

BgeeA6NM45.
GenevestigatorA6NM45.

Family and domain databases

InterProIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERPTHR12002. PTHR12002. 1 hit.
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01077. CLAUDIN.
PROSITEPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi100132463.
NextBio20773913.

Entry information

Entry nameCLD24_HUMAN
AccessionPrimary (citable) accession number: A6NM45
Secondary accession number(s): F5H040
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 26, 2013
Last modified: July 9, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM