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Protein

Putative claudin-24

Gene

CLDN24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31647-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative claudin-24
Gene namesi
Name:CLDN24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:37200. CLDN24.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicSequence analysis10
Transmembranei11 – 31HelicalSequence analysisAdd BLAST21
Topological domaini32 – 81ExtracellularSequence analysisAdd BLAST50
Transmembranei82 – 102HelicalSequence analysisAdd BLAST21
Topological domaini103 – 117CytoplasmicSequence analysisAdd BLAST15
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 161ExtracellularSequence analysisAdd BLAST23
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 220CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185758.

Polymorphism and mutation databases

BioMutaiCLDN24.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003202011 – 220Putative claudin-24Add BLAST220

Proteomic databases

PaxDbiA6NM45.
PRIDEiA6NM45.

Expressioni

Gene expression databases

BgeeiENSG00000185758.
ExpressionAtlasiA6NM45. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000438400.

Structurei

3D structure databases

ProteinModelPortaliA6NM45.
SMRiA6NM45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410INS5. Eukaryota.
ENOG4111QE3. LUCA.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG104065.
InParanoidiA6NM45.
KOiK06087.
OMAiCPYLEDG.
OrthoDBiEOG091G0QQ0.
PhylomeDBiA6NM45.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NM45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALIFRTAMQ SVGLLLSLLG WILSIITTYL PHWKNLNLDL NEMENWTMGL
60 70 80 90 100
WQTCVIQEEV GMQCKDFDSF LALPAELRVS RILMFLSNGL GFLGLLVSGF
110 120 130 140 150
GLDCLRIGES QRDLKRRLLI LGGILSWASG ITALVPVSWV AHKTVQEFWD
160 170 180 190 200
ENVPDFVPRW EFGEALFLGW FAGLSLLLGG CLLNCAACSS HAPLALGHYA
210 220
VAQMQTQCPY LEDGTADPQV
Length:220
Mass (Da):24,421
Last modified:June 26, 2013 - v2
Checksum:i57AE200093A81845
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05566018L → F.Corresponds to variant rs7688467dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093844 Genomic DNA. No translation available.
CCDSiCCDS54824.1.
RefSeqiNP_001172078.1. NM_001185149.1.
UniGeneiHs.727475.

Genome annotation databases

EnsembliENST00000541814; ENSP00000438400; ENSG00000185758.
GeneIDi100132463.
KEGGihsa:100132463.
UCSCiuc021xva.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093844 Genomic DNA. No translation available.
CCDSiCCDS54824.1.
RefSeqiNP_001172078.1. NM_001185149.1.
UniGeneiHs.727475.

3D structure databases

ProteinModelPortaliA6NM45.
SMRiA6NM45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000438400.

Polymorphism and mutation databases

BioMutaiCLDN24.

Proteomic databases

PaxDbiA6NM45.
PRIDEiA6NM45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000541814; ENSP00000438400; ENSG00000185758.
GeneIDi100132463.
KEGGihsa:100132463.
UCSCiuc021xva.1. human.

Organism-specific databases

CTDi100132463.
GeneCardsiCLDN24.
HGNCiHGNC:37200. CLDN24.
neXtProtiNX_A6NM45.
OpenTargetsiENSG00000185758.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INS5. Eukaryota.
ENOG4111QE3. LUCA.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG104065.
InParanoidiA6NM45.
KOiK06087.
OMAiCPYLEDG.
OrthoDBiEOG091G0QQ0.
PhylomeDBiA6NM45.
TreeFamiTF331936.

Enzyme and pathway databases

BioCyciZFISH:G66-31647-MONOMER.

Miscellaneous databases

GenomeRNAii100132463.

Gene expression databases

BgeeiENSG00000185758.
ExpressionAtlasiA6NM45. baseline and differential.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLD24_HUMAN
AccessioniPrimary (citable) accession number: A6NM45
Secondary accession number(s): F5H040
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 26, 2013
Last modified: November 2, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.