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A6NM45

- CLD24_HUMAN

UniProt

A6NM45 - CLD24_HUMAN

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Protein

Putative claudin-24

Gene

CLDN24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative claudin-24
Gene namesi
Name:CLDN24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:37200. CLDN24.

Subcellular locationi

Cell junctiontight junction By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. tight junction Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Putative claudin-24PRO_0000320201Add
BLAST

Proteomic databases

PRIDEiA6NM45.

Expressioni

Gene expression databases

BgeeiA6NM45.
ExpressionAtlasiA6NM45. baseline.
GenevestigatoriA6NM45.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333484.

Structurei

3D structure databases

ProteinModelPortaliA6NM45.
SMRiA6NM45. Positions 50-189.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Topological domaini32 – 8150ExtracellularSequence AnalysisAdd
BLAST
Topological domaini103 – 11715CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini139 – 16123ExtracellularSequence AnalysisAdd
BLAST
Topological domaini183 – 22038CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40943.
GeneTreeiENSGT00760000119222.
HOGENOMiHOG000220937.
HOVERGENiHBG104065.
InParanoidiA6NM45.
KOiK06087.
OMAiYAVAQMQ.
PhylomeDBiA6NM45.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NM45 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALIFRTAMQ SVGLLLSLLG WILSIITTYL PHWKNLNLDL NEMENWTMGL
60 70 80 90 100
WQTCVIQEEV GMQCKDFDSF LALPAELRVS RILMFLSNGL GFLGLLVSGF
110 120 130 140 150
GLDCLRIGES QRDLKRRLLI LGGILSWASG ITALVPVSWV AHKTVQEFWD
160 170 180 190 200
ENVPDFVPRW EFGEALFLGW FAGLSLLLGG CLLNCAACSS HAPLALGHYA
210 220
VAQMQTQCPY LEDGTADPQV
Length:220
Mass (Da):24,421
Last modified:June 26, 2013 - v2
Checksum:i57AE200093A81845
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181L → F.
Corresponds to variant rs7688467 [ dbSNP | Ensembl ].
VAR_055660

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC093844 Genomic DNA. No translation available.
CCDSiCCDS54824.1.
RefSeqiNP_001172078.1. NM_001185149.1.
UniGeneiHs.727475.

Genome annotation databases

EnsembliENST00000541814; ENSP00000438400; ENSG00000185758.
GeneIDi100132463.
KEGGihsa:100132463.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC093844 Genomic DNA. No translation available.
CCDSi CCDS54824.1.
RefSeqi NP_001172078.1. NM_001185149.1.
UniGenei Hs.727475.

3D structure databases

ProteinModelPortali A6NM45.
SMRi A6NM45. Positions 50-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000333484.

Proteomic databases

PRIDEi A6NM45.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000541814 ; ENSP00000438400 ; ENSG00000185758 .
GeneIDi 100132463.
KEGGi hsa:100132463.

Organism-specific databases

CTDi 100132463.
GeneCardsi GC04M184242.
HGNCi HGNC:37200. CLDN24.
neXtProti NX_A6NM45.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40943.
GeneTreei ENSGT00760000119222.
HOGENOMi HOG000220937.
HOVERGENi HBG104065.
InParanoidi A6NM45.
KOi K06087.
OMAi YAVAQMQ.
PhylomeDBi A6NM45.
TreeFami TF331936.

Miscellaneous databases

GenomeRNAii 100132463.
NextBioi 20773913.

Gene expression databases

Bgeei A6NM45.
ExpressionAtlasi A6NM45. baseline.
Genevestigatori A6NM45.

Family and domain databases

InterProi IPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view ]
PANTHERi PTHR12002. PTHR12002. 1 hit.
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01077. CLAUDIN.
PROSITEi PS01346. CLAUDIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCLD24_HUMAN
AccessioniPrimary (citable) accession number: A6NM45
Secondary accession number(s): F5H040
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 26, 2013
Last modified: October 29, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3