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Protein

Putative T-complex protein 1 subunit theta-like 1

Gene

CCT8L1P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative T-complex protein 1 subunit theta-like 1
Gene namesi
Name:CCT8L1P
Synonyms:CCT8L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:32153. CCT8L1P.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003473381 – 557Putative T-complex protein 1 subunit theta-like 1Add BLAST557

Proteomic databases

PaxDbiA6NM43.
PRIDEiA6NM43.

Expressioni

Gene expression databases

CleanExiHS_CCT8L1.

Organism-specific databases

HPAiHPA039268.
HPA041336.
HPA045440.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000353048.

Structurei

3D structure databases

ProteinModelPortaliA6NM43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0362. Eukaryota.
ENOG410XPXR. LUCA.
HOVERGENiHBG098338.
InParanoidiA6NM43.
PhylomeDBiA6NM43.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NM43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSTVPSALE LPQRLALNPR ESPRSPEEEE PHLLSSLAAV QTLANVIRPC
60 70 80 90 100
YGPHGRQKFL VTMKGETVCT GCATAILRAL ELEHPAAWLL REAAQTQAEN
110 120 130 140 150
SGDGTAFVVL LTEALLEQAE QLLKFGLPRP QLREAYATAT AEVLATLPSL
160 170 180 190 200
AIQSLGPLED PSWALHSVMN THTLPPMNHL TKLVAHACWA IKELDGSFKP
210 220 230 240 250
ERVGVCTLHG GTLEDSCLLQ GLAISGKLCG QMAAVLSGAR VALFACPFGP
260 270 280 290 300
AHPNAPATAC LSSPADLAQF SKGSDQLLEK QVGQLAAAGI NVAVVLGEVD
310 320 330 340 350
EETLTLADKY GIVVIQARSR MEIIYLSEVL DTPLLPRLLP PQRPGKCQRV
360 370 380 390 400
YRQELGDGLA VVFEWECTGT PALTVVLRGA TTQGLRSAEQ AVYHSIDAYF
410 420 430 440 450
QPCQDPRLIP GAGATEMALA KMLSDKGSRL EGPNGPAFLA FARALKYLPK
460 470 480 490 500
TLAENAGLAV SDVVAEMSGV HQGGNLLMGV GAEGIINVAQ EGVWDTLIVK
510 520 530 540 550
AQGFRAVAEV VLQLVTVDEI VVAKKSPTHQ QIWNPDSKKT KKRPPPVEKK

KILGMNN
Length:557
Mass (Da):59,514
Last modified:July 24, 2007 - v1
Checksum:i536C5CED92C7F708
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046039217C → S.Corresponds to variant rs6969304dbSNPEnsembl.1
Natural variantiVAR_046040308D → N.Corresponds to variant rs12672139dbSNPEnsembl.1
Natural variantiVAR_046041395S → G.Corresponds to variant rs6953943dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005631 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW53969.1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005631 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW53969.1.

3D structure databases

ProteinModelPortaliA6NM43.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000353048.

Proteomic databases

PaxDbiA6NM43.
PRIDEiA6NM43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiCCT8L1P.
HGNCiHGNC:32153. CCT8L1P.
HPAiHPA039268.
HPA041336.
HPA045440.
neXtProtiNX_A6NM43.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0362. Eukaryota.
ENOG410XPXR. LUCA.
HOVERGENiHBG098338.
InParanoidiA6NM43.
PhylomeDBiA6NM43.

Gene expression databases

CleanExiHS_CCT8L1.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR017998. Chaperone_TCP-1.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTCPQL_HUMAN
AccessioniPrimary (citable) accession number: A6NM43
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: July 24, 2007
Last modified: October 5, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.