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Protein

Zinc finger protein 92 homolog

Gene

ZFP92

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri180 – 20223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri208 – 23023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri236 – 25823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri264 – 28623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri292 – 31423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri320 – 34223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri348 – 37023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 92 homolog
Short name:
Zfp-92
Gene namesi
Name:ZFP92
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:12865. ZFP92.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37454.

Polymorphism and mutation databases

BioMutaiZFP92.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Zinc finger protein 92 homologPRO_0000328807Add
BLAST

Proteomic databases

MaxQBiA6NM28.
PaxDbiA6NM28.
PeptideAtlasiA6NM28.
PRIDEiA6NM28.

PTM databases

iPTMnetiA6NM28.
PhosphoSiteiA6NM28.

Expressioni

Gene expression databases

BgeeiA6NM28.
CleanExiHS_ZFP92.
GenevisibleiA6NM28. HS.

Organism-specific databases

HPAiHPA003030.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000462054.

Structurei

3D structure databases

ProteinModelPortaliA6NM28.
SMRiA6NM28. Positions 14-62, 149-377.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 8572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 8 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri180 – 20223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri208 – 23023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri236 – 25823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri264 – 28623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri292 – 31423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri320 – 34223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri348 – 37023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129992.
HOVERGENiHBG018163.
InParanoidiA6NM28.
KOiK09228.
OMAiCAKAFKG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiA6NM28.
TreeFamiTF337732.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NM28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAILLTTRP KVPVSFEDVS VYFTKTEWKL LDLRQKVLYK RVMLENYSHL
60 70 80 90 100
VSLGFSFSKP HLISQLERGE GPWVADIPRT WATAGLHIGD RTQSKTSTST
110 120 130 140 150
QKHSGRQLPG ADPQGGKEGQ AARSSVLQRG AQGLGQSSAA GPQGPKGAEK
160 170 180 190 200
RYLCQQCGKA FSRSSNLIKH RIIHSGEKPY ACPECGKLFR RSFALLEHQR
210 220 230 240 250
IHSGEKPYAC PECSKTFTRS SNLIKHQVIH SGERPFACGD CGKLFRRSFA
260 270 280 290 300
LLEHARVHSG ERPYACPECG KAFSRSSNLI EHQRTHRGEK PYACGQCAKA
310 320 330 340 350
FKGVSQLIHH QRSHSGERPF ACRECGKAFR GRSGLSQHRR VHSGEKPYEC
360 370 380 390 400
SDCGKAFGRR ANLFKHQAVH GARRPAKAET ARRLAGPGST GPGSAVAATS
410
PPRPSTAARP SRPSRR
Length:416
Mass (Da):45,791
Last modified:April 8, 2008 - v3
Checksum:iBC5C71E88267EC4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti273 – 2764FSRS → LSQR in DR731275 (Ref. 2) Curated
Sequence conflicti281 – 2811E → D in DR731275 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82695 Genomic DNA. No translation available.
DR731275 mRNA. No translation available.
CCDSiCCDS59177.1.
RefSeqiNP_001129745.1. NM_001136273.1.
XP_005274709.1. XM_005274652.2.
XP_011529417.1. XM_011531115.1.
UniGeneiHs.534554.
Hs.552181.

Genome annotation databases

EnsembliENST00000338647; ENSP00000462054; ENSG00000189420.
GeneIDi139735.
KEGGihsa:139735.
UCSCiuc011myo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82695 Genomic DNA. No translation available.
DR731275 mRNA. No translation available.
CCDSiCCDS59177.1.
RefSeqiNP_001129745.1. NM_001136273.1.
XP_005274709.1. XM_005274652.2.
XP_011529417.1. XM_011531115.1.
UniGeneiHs.534554.
Hs.552181.

3D structure databases

ProteinModelPortaliA6NM28.
SMRiA6NM28. Positions 14-62, 149-377.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000462054.

PTM databases

iPTMnetiA6NM28.
PhosphoSiteiA6NM28.

Polymorphism and mutation databases

BioMutaiZFP92.

Proteomic databases

MaxQBiA6NM28.
PaxDbiA6NM28.
PeptideAtlasiA6NM28.
PRIDEiA6NM28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338647; ENSP00000462054; ENSG00000189420.
GeneIDi139735.
KEGGihsa:139735.
UCSCiuc011myo.3. human.

Organism-specific databases

CTDi139735.
GeneCardsiZFP92.
HGNCiHGNC:12865. ZFP92.
HPAiHPA003030.
neXtProtiNX_A6NM28.
PharmGKBiPA37454.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129992.
HOVERGENiHBG018163.
InParanoidiA6NM28.
KOiK09228.
OMAiCAKAFKG.
OrthoDBiEOG7KSX7Q.
PhylomeDBiA6NM28.
TreeFamiTF337732.

Miscellaneous databases

GenomeRNAii139735.
PROiA6NM28.

Gene expression databases

BgeeiA6NM28.
CleanExiHS_ZFP92.
GenevisibleiA6NM28. HS.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 8 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 8 hits.
PS50157. ZINC_FINGER_C2H2_2. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in human."
    Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 42-290.

Entry informationi

Entry nameiZFP92_HUMAN
AccessioniPrimary (citable) accession number: A6NM28
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: July 6, 2016
This is version 79 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.