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Protein

Zinc finger protein 92 homolog

Gene

ZFP92

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 174C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri180 – 202C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri208 – 230C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri236 – 258C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri264 – 286C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri292 – 314C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 92 homolog
Short name:
Zfp-92
Gene namesi
Name:ZFP92
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000189420.8
HGNCiHGNC:12865 ZFP92
neXtProtiNX_A6NM28

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000189420
PharmGKBiPA37454

Polymorphism and mutation databases

BioMutaiZFP92

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003288071 – 416Zinc finger protein 92 homologAdd BLAST416

Proteomic databases

EPDiA6NM28
MaxQBiA6NM28
PaxDbiA6NM28
PRIDEiA6NM28

PTM databases

iPTMnetiA6NM28
PhosphoSitePlusiA6NM28

Expressioni

Gene expression databases

BgeeiENSG00000189420
CleanExiHS_ZFP92
GenevisibleiA6NM28 HS

Organism-specific databases

HPAiHPA003030

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000462054

Structurei

3D structure databases

ProteinModelPortaliA6NM28
SMRiA6NM28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri152 – 174C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri180 – 202C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri208 – 230C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri236 – 258C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri264 – 286C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri292 – 314C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri320 – 342C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri348 – 370C2H2-type 8PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144166
HOVERGENiHBG018163
InParanoidiA6NM28
KOiK09228
OMAiCAKAFKG
OrthoDBiEOG091G02KC
PhylomeDBiA6NM28
TreeFamiTF337732

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 8 hits
PS50157 ZINC_FINGER_C2H2_2, 8 hits

Sequencei

Sequence statusi: Complete.

A6NM28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAILLTTRP KVPVSFEDVS VYFTKTEWKL LDLRQKVLYK RVMLENYSHL
60 70 80 90 100
VSLGFSFSKP HLISQLERGE GPWVADIPRT WATAGLHIGD RTQSKTSTST
110 120 130 140 150
QKHSGRQLPG ADPQGGKEGQ AARSSVLQRG AQGLGQSSAA GPQGPKGAEK
160 170 180 190 200
RYLCQQCGKA FSRSSNLIKH RIIHSGEKPY ACPECGKLFR RSFALLEHQR
210 220 230 240 250
IHSGEKPYAC PECSKTFTRS SNLIKHQVIH SGERPFACGD CGKLFRRSFA
260 270 280 290 300
LLEHARVHSG ERPYACPECG KAFSRSSNLI EHQRTHRGEK PYACGQCAKA
310 320 330 340 350
FKGVSQLIHH QRSHSGERPF ACRECGKAFR GRSGLSQHRR VHSGEKPYEC
360 370 380 390 400
SDCGKAFGRR ANLFKHQAVH GARRPAKAET ARRLAGPGST GPGSAVAATS
410
PPRPSTAARP SRPSRR
Length:416
Mass (Da):45,791
Last modified:April 8, 2008 - v3
Checksum:iBC5C71E88267EC4C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti273 – 276FSRS → LSQR in DR731275 (Ref. 2) Curated4
Sequence conflicti281E → D in DR731275 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82695 Genomic DNA No translation available.
DR731275 mRNA No translation available.
CCDSiCCDS59177.1
RefSeqiNP_001129745.1, NM_001136273.1
XP_005274709.1, XM_005274652.3
XP_011529417.1, XM_011531115.2
UniGeneiHs.534554
Hs.552181

Genome annotation databases

EnsembliENST00000338647; ENSP00000462054; ENSG00000189420
GeneIDi139735
KEGGihsa:139735
UCSCiuc011myo.3 human

Similar proteinsi

Entry informationi

Entry nameiZFP92_HUMAN
AccessioniPrimary (citable) accession number: A6NM28
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: April 8, 2008
Last modified: May 23, 2018
This is version 92 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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