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Protein

Putative COBW domain-containing protein 7

Gene

CBWD7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi55 – 584ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative COBW domain-containing protein 7
Alternative name(s):
Putative cobalamin synthase W domain-containing protein 7
Gene namesi
Name:CBWD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:31977. CBWD7.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145149368.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247Putative COBW domain-containing protein 7PRO_0000344630Add
BLAST

Proteomic databases

PRIDEiA6NM15.

PTM databases

PhosphoSiteiA6NM15.

Expressioni

Gene expression databases

BgeeiA6NM15.
ExpressionAtlasiA6NM15. baseline.
GenevestigatoriA6NM15.

Organism-specific databases

HPAiHPA042759.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000366608.

Structurei

3D structure databases

ProteinModelPortaliA6NM15.
SMRiA6NM15. Positions 14-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 229104CobW C-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the CobW family.Curated
Contains 1 cobW C-terminal domain.Curated

Phylogenomic databases

HOGENOMiHOG000182211.
HOVERGENiHBG056297.
InParanoidiA6NM15.

Family and domain databases

Gene3Di3.30.1220.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011629. Cbl_biosynth_CobW-like_C.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
[Graphical view]
SMARTiSM00833. CobW_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.

Sequencei

Sequence statusi: Complete.

A6NM15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFWVDAELGS DIYLDGIITI VDSKYGLKHL TEEKPDGLIN EATRQVALAD
60 70 80 90 100
IILINKTDLV PEEDVKKLRT TIRSINGLGQ ILETQRSRVD LSNVLDLHAF
110 120 130 140 150
DSLSGISLQK KLQHVPGTQP HLDQSIVTIT FEVPGNAKEE HLNMFIQNLL
160 170 180 190 200
WEKNVRNKDN HCMEVIRLKG LVSIKDKSQQ VIVQGVHELY DLEETPVSWK
210 220 230 240
DDTERTNRLV LIGRNLDKDI LKQLFIATVT ETEKQWTTHF KEDQVCT
Length:247
Mass (Da):28,232
Last modified:July 21, 2008 - v3
Checksum:i9961C0AF449D0F87
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129778 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000377391; ENSP00000366608; ENSG00000215126.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129778 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliA6NM15.
SMRiA6NM15. Positions 14-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000366608.

PTM databases

PhosphoSiteiA6NM15.

Proteomic databases

PRIDEiA6NM15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377391; ENSP00000366608; ENSG00000215126.

Organism-specific databases

GeneCardsiGC09P042945.
HGNCiHGNC:31977. CBWD7.
HPAiHPA042759.
neXtProtiNX_A6NM15.
PharmGKBiPA145149368.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000182211.
HOVERGENiHBG056297.
InParanoidiA6NM15.

Miscellaneous databases

NextBioi21547831.

Gene expression databases

BgeeiA6NM15.
ExpressionAtlasiA6NM15. baseline.
GenevestigatoriA6NM15.

Family and domain databases

Gene3Di3.30.1220.10. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR011629. Cbl_biosynth_CobW-like_C.
IPR003495. CobW/HypB/UreG_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02492. cobW. 1 hit.
PF07683. CobW_C. 1 hit.
[Graphical view]
SMARTiSM00833. CobW_C. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90002. SSF90002. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCBWD7_HUMAN
AccessioniPrimary (citable) accession number: A6NM15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 2008
Last sequence update: July 21, 2008
Last modified: January 6, 2015
This is version 54 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.