A6NM15 (CBWD7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative COBW domain-containing protein 7

Alternative name(s):
Putative cobalamin synthase W domain-containing protein 7

Gene names

Name:

CBWD7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	247 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Sequence similarities	Belongs to the CobW family. Contains 1 cobW C-terminal domain.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 247	247	Putative COBW domain-containing protein 7		PRO_0000344630
Regions
	Domain	126 – 229	104	CobW C-terminal
	Nucleotide binding	55 – 58	4	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A6NM15 [UniParc]. Last modified July 22, 2008. Version 3. Checksum: 9961C0AF449D0F87	FASTA	247	28,232
	10 20 30 40 50 60 MFWVDAELGS DIYLDGIITI VDSKYGLKHL TEEKPDGLIN EATRQVALAD IILINKTDLV 70 80 90 100 110 120 PEEDVKKLRT TIRSINGLGQ ILETQRSRVD LSNVLDLHAF DSLSGISLQK KLQHVPGTQP 130 140 150 160 170 180 HLDQSIVTIT FEVPGNAKEE HLNMFIQNLL WEKNVRNKDN HCMEVIRLKG LVSIKDKSQQ 190 200 210 220 230 240 VIVQGVHELY DLEETPVSWK DDTERTNRLV LIGRNLDKDI LKQLFIATVT ETEKQWTTHF KEDQVCT

References

[1]

"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC129778 Genomic DNA. No translation available.
IPI	IPI00887061.
3D structure databases
ProteinModelPortal	A6NM15.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000366608.
PTM databases
PhosphoSite	A6NM15.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377391; ENSP00000366608; ENSG00000215126.
Organism-specific databases
GeneCards	GC09P042658.
HGNC	HGNC:31977. CBWD7.
neXtProt	NX_A6NM15.
PharmGKB	PA145149368.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000182211.
HOVERGEN	HBG056297.
InParanoid	A6NM15.
Gene expression databases
ArrayExpress	A6NM15.
Bgee	A6NM15.
Genevestigator	A6NM15.
Family and domain databases
Gene3D	3.30.1220.10. 1 hit.
InterPro	IPR011629. Cbl_biosynth_CobW-like_C. IPR003495. CobW/HypB/UreG_dom. [Graphical view]
Pfam	PF02492. cobW. 1 hit. PF07683. CobW_C. 1 hit. [Graphical view]
SMART	SM00833. CobW_C. 1 hit. [Graphical view]
SUPFAM	SSF90002. Cbl_biosynth_CobW-like_C. 1 hit.
ProtoNet	Search...
Other
NextBio	21547831.

Entry information

Entry name

CBWD7_HUMAN

Accession

Primary (citable) accession number: A6NM15

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	July 22, 2008
Last modified:	May 1, 2013
This is version 45 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.