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Protein

Leucine-rich repeat-containing protein 37A2

Gene

LRRC37A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32904-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 37A2
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:32404. LRRC37A2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini36 – 1582ExtracellularSequence analysisAdd BLAST1547
Transmembranei1583 – 1603HelicalSequence analysisAdd BLAST21
Topological domaini1604 – 1700CytoplasmicSequence analysisAdd BLAST97

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000238083.
PharmGKBiPA162394530.

Polymorphism and mutation databases

BioMutaiLRRC37A2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 35Sequence analysisAdd BLAST35
ChainiPRO_000033708036 – 1700Leucine-rich repeat-containing protein 37A2Add BLAST1665

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1079N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiA6NM11.
PaxDbiA6NM11.
PRIDEiA6NM11.

PTM databases

iPTMnetiA6NM11.
PhosphoSitePlusiA6NM11.

Expressioni

Gene expression databases

BgeeiENSG00000238083.
CleanExiHS_LRRC37A2.
GenevisibleiA6NM11. HS.

Organism-specific databases

HPAiHPA042121.
HPA042701.
HPA043056.
HPA045090.
HPA049080.

Interactioni

Protein-protein interaction databases

IntActiA6NM11. 4 interactors.
STRINGi9606.ENSP00000333071.

Structurei

3D structure databases

ProteinModelPortaliA6NM11.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati137 – 160LRR 1Add BLAST24
Repeati230 – 253LRR 2Add BLAST24
Repeati267 – 290LRR 3Add BLAST24
Repeati864 – 887LRR 4Add BLAST24
Repeati888 – 911LRR 5Add BLAST24
Repeati912 – 935LRR 6Add BLAST24
Repeati937 – 959LRR 7Add BLAST23
Repeati963 – 987LRR 8Add BLAST25
Repeati1002 – 1027LRR 9Add BLAST26
Repeati1124 – 1146LRR 10Add BLAST23

Sequence similaritiesi

Belongs to the LRRC37A family.Curated
Contains 10 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJNR. Eukaryota.
ENOG410YV94. LUCA.
GeneTreeiENSGT00530000063282.
HOGENOMiHOG000113269.
HOVERGENiHBG100009.
InParanoidiA6NM11.
OMAiPENTINQ.
OrthoDBiEOG091G006W.
PhylomeDBiA6NM11.
TreeFamiTF341959.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032754. LRRC37_N.
IPR015753. LRRC37A/B-like.
IPR029423. LRRC37AB_C.
[Graphical view]
PANTHERiPTHR23045. PTHR23045. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
PF15779. LRRC37. 7 hits.
PF14914. LRRC37AB_C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NM11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAQCPALV CVMSRLRFWG PWPLLMWQLL WLLVKEAQPL EWVKDPLQLT
60 70 80 90 100
SNPLGPPDSW SSHSSHFPRE SPHAPTLPAD PWDFDHLGPS ASSEMPAPPQ
110 120 130 140 150
ESTENLVPFL DTWDSAGEQP LEPEQFLASQ QDLKDKLSPQ ERLPVSPKKL
160 170 180 190 200
KKDPAQRWSL AEIIGITRQL STPQSQKQTL QNEYSSTDTP YPGSLPPELR
210 220 230 240 250
VKSDEPPGPS EQVGPSQFHL EPETQNPETL EDIQSSSLQQ EAPAQLPQLL
260 270 280 290 300
EEEPSSMQQE APALPPESSM ESLTLPNHEV SVQPPGEDQA YYHLPNITVK
310 320 330 340 350
PADVEVTITS EPTNETESSQ AQQETPIQFP EEVEPSATQQ EAPIEPPVPP
360 370 380 390 400
MEHELSISEQ QQPVQPSESP REVESSPTQQ ETPGQPPEHH EVTVSPPGHH
410 420 430 440 450
QTHHLASPSV SVKPPDVQLT IAAEPSAEVG TSLVHQEATT RLSGSGNDVE
460 470 480 490 500
PPAIQHGGPP LLPESSEEAG PLAVQQETSF QSPEPINNEN PSPTQQEAAA
510 520 530 540 550
EHPQTAEEGE SSLTHQEAPA QTPEFPNVVV AQPPEHSHLT QATVQPLDLG
560 570 580 590 600
FTITPESKTE VELSPTMKET PTQPPKKVVP QLRVYQGVTN PTPGQDQAQH
610 620 630 640 650
PVSPSVTVQL LDLGLTITPE PTTEVGHSTP PKRTIVSPKH PEVTLPHPDQ
660 670 680 690 700
VQTQHSHLTR ATVQPLDLGF TITPKSMTEV EPSTALMTTA PPPGHPEVTL
710 720 730 740 750
PPSDKGQAQH SHLTQATVQP LDLELTITTK PTTEVKPSPT TEETSTQPPD
760 770 780 790 800
LGLAIIPEPT TETRHSTALE KTTAPRPDRV QTLHRSLTEV TGPPTELEPA
810 820 830 840 850
QDSLVQSESY TQNKALTAPE EHKASTSTNI CELCTCGDEM LSCIDLNPEQ
860 870 880 890 900
RLRQVPVPEP NTHNGTFTIL NFQGNYISYI DGNVWKAYSW TEKLILRENN
910 920 930 940 950
LTELHKDSFE GLLSLQYLDL SCNKIQSIER HTFEPLPFLK FINLSCNVIT
960 970 980 990 1000
ELSFGTFQAW HGMQFLHKLI LNHNPLTTVE DPYLFKLPAL KYLDMGTTLV
1010 1020 1030 1040 1050
PLTTLKNILM MTVELEKLIL PSHMACCLCQ FKNSIEAVCK TVKLHCNSAC
1060 1070 1080 1090 1100
LTNTTHCPEE ASVGNPEGAF MKVLQARKNY TSTELIVEPE EPSDSSGINL
1110 1120 1130 1140 1150
SGFGSEQLDT NDESDFISTL SYILPYFSAV NLDVKSLLLP FIKLPTTGNS
1160 1170 1180 1190 1200
LAKIQTVGQN RQRVKRVLMG PRSIQKRHFK EVGRQSIRRE QGAQASVENA
1210 1220 1230 1240 1250
AEEKRLGSPA PREVEQPHTQ QGPEKLAGNA VYTKPSFTQE HKAAVSVLKP
1260 1270 1280 1290 1300
FSKGAPSTSS PAKALPQVRD RWKDLTHAIS ILESAKARVT NTKTSKPIVH
1310 1320 1330 1340 1350
ARKKYRFHKT RSHVTHRTPK VKKSPKVRKK SYLSRLMLAN RLPFSAAKSL
1360 1370 1380 1390 1400
INSPSQGAFS SLGDLSPQEN PFLEVSAPSE HFIENNNTKH TTARNAFEEN
1410 1420 1430 1440 1450
DFMENTNMPE GTISENTNYN HPHEADSAGT AFNLGPTVKQ TETKWEYNNV
1460 1470 1480 1490 1500
GTDLSPEPKS FNYPLLSSPG DQFEIQLTQQ LQSLIPNNNV RRLIAHVIRT
1510 1520 1530 1540 1550
LKMDCSGAHV QVTCAKLISR TGHLMKLLSG QQEVKASKIE WDTDQWKIEN
1560 1570 1580 1590 1600
YINESTEAQS EQKEKSLELK KEVPGYGYTD KLILALIVTG ILTILIILFC
1610 1620 1630 1640 1650
LIVICCHRRS LQEDEEGFSR GIFRFLPWRG CSSRRESQDG LSSFGQPLWF
1660 1670 1680 1690 1700
KDMYKPLSAT RINNHAWKLH KKSSNEDKIL NRDPGDSEAP TEEEESEALP
Length:1,700
Mass (Da):188,393
Last modified:January 15, 2008 - v2
Checksum:iB80368373F772CDF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1508A → T in AAI44428 (PubMed:15489334).Curated1
Sequence conflicti1628W → R in AAI44428 (PubMed:15489334).Curated1
Sequence conflicti1686 – 1687Missing in AAI44428 (PubMed:15489334).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0707991141F → L.1 PublicationCorresponds to variant rs151267673dbSNPEnsembl.1
Natural variantiVAR_0708001281I → T.1 PublicationCorresponds to variant rs62073349dbSNPEnsembl.1
Natural variantiVAR_0708011385N → K.1 PublicationCorresponds to variant rs1969205dbSNPEnsembl.1
Natural variantiVAR_0708021423H → P.1 PublicationCorresponds to variant rs201103889dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138645 Genomic DNA. No translation available.
BC144427 mRNA. Translation: AAI44428.1.
CCDSiCCDS42353.1.
RefSeqiNP_001006608.2. NM_001006607.2.
UniGeneiHs.646568.
Hs.744157.
Hs.744758.

Genome annotation databases

EnsembliENST00000333412; ENSP00000333071; ENSG00000238083.
ENST00000576629; ENSP00000459551; ENSG00000238083.
GeneIDi474170.
KEGGihsa:474170.
UCSCiuc002ikn.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138645 Genomic DNA. No translation available.
BC144427 mRNA. Translation: AAI44428.1.
CCDSiCCDS42353.1.
RefSeqiNP_001006608.2. NM_001006607.2.
UniGeneiHs.646568.
Hs.744157.
Hs.744758.

3D structure databases

ProteinModelPortaliA6NM11.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA6NM11. 4 interactors.
STRINGi9606.ENSP00000333071.

PTM databases

iPTMnetiA6NM11.
PhosphoSitePlusiA6NM11.

Polymorphism and mutation databases

BioMutaiLRRC37A2.

Proteomic databases

EPDiA6NM11.
PaxDbiA6NM11.
PRIDEiA6NM11.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333412; ENSP00000333071; ENSG00000238083.
ENST00000576629; ENSP00000459551; ENSG00000238083.
GeneIDi474170.
KEGGihsa:474170.
UCSCiuc002ikn.2. human.

Organism-specific databases

CTDi474170.
GeneCardsiLRRC37A2.
HGNCiHGNC:32404. LRRC37A2.
HPAiHPA042121.
HPA042701.
HPA043056.
HPA045090.
HPA049080.
MIMi616556. gene.
neXtProtiNX_A6NM11.
OpenTargetsiENSG00000238083.
PharmGKBiPA162394530.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJNR. Eukaryota.
ENOG410YV94. LUCA.
GeneTreeiENSGT00530000063282.
HOGENOMiHOG000113269.
HOVERGENiHBG100009.
InParanoidiA6NM11.
OMAiPENTINQ.
OrthoDBiEOG091G006W.
PhylomeDBiA6NM11.
TreeFamiTF341959.

Enzyme and pathway databases

BioCyciZFISH:G66-32904-MONOMER.

Miscellaneous databases

ChiTaRSiLRRC37A2. human.
GenomeRNAii474170.
PROiA6NM11.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000238083.
CleanExiHS_LRRC37A2.
GenevisibleiA6NM11. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032754. LRRC37_N.
IPR015753. LRRC37A/B-like.
IPR029423. LRRC37AB_C.
[Graphical view]
PANTHERiPTHR23045. PTHR23045. 1 hit.
PfamiPF13855. LRR_8. 1 hit.
PF15779. LRRC37. 7 hits.
PF14914. LRRC37AB_C. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 4 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiL37A2_HUMAN
AccessioniPrimary (citable) accession number: A6NM11
Secondary accession number(s): B7ZMC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.