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A6NM10

- AQ12B_HUMAN

UniProt

A6NM10 - AQ12B_HUMAN

Protein

Aquaporin-12B

Gene

AQP12B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.By similarity

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aquaporin-12B
    Short name:
    AQP-12B
    Gene namesi
    Name:AQP12B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:6096. AQP12B.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29902.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 295295Aquaporin-12BPRO_0000328826Add
    BLAST

    Proteomic databases

    PaxDbiA6NM10.
    PRIDEiA6NM10.

    Expressioni

    Gene expression databases

    BgeeiA6NM10.
    CleanExiHS_AQP12B.
    GenevestigatoriA6NM10.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000384894.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NM10.
    SMRiA6NM10. Positions 62-240.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12627Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei216 – 23621Helical; Name=6Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi87 – 893NPA 1
    Motifi200 – 2023NPA 2

    Domaini

    Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

    Sequence similaritiesi

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46671.
    HOGENOMiHOG000034023.
    HOVERGENiHBG050557.
    KOiK09871.
    OMAiACCLEMR.
    PhylomeDBiA6NM10.
    TreeFamiTF320251.

    Family and domain databases

    Gene3Di1.20.1080.10. 1 hit.
    InterProiIPR023271. Aquaporin-like.
    IPR016697. Aquaporin_11/12.
    IPR023265. Aquaporin_12.
    IPR000425. MIP.
    [Graphical view]
    PANTHERiPTHR21191:SF8. PTHR21191:SF8. 1 hit.
    PfamiPF00230. MIP. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017529. Aquaporin_11/12. 1 hit.
    PRINTSiPR02025. AQUAPORIN12.
    PR00783. MINTRINSICP.
    SUPFAMiSSF81338. SSF81338. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A6NM10-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAGLNVSLSF FFATFTLCEA ARRASKALLP VGAYEVFARE AMRTLVELGP    50
    WAGDFGPDLL LTLLFLLFLA HGVTLDGASA NPTVSLQEFL MAEESLPGTL 100
    LKLAAQGLGM QAACTLTRLC WAWELSDLHL LQSLMAQSCS SALRTSVPHG 150
    ALVEAACAFC FHLTLLHLRH SPPAYSGPAV ALLVTVTAYT AGPFTSAFFN 200
    PALAASVTFA CSGHTLLEYV QVYWLGPLTG MVLAVLLHQG RLPHLFQRNL 250
    FYGQKNKYRA PRGKPAPASG DTQTPAKGSS VREPGRSGVE GPHSS 295
    Length:295
    Mass (Da):31,475
    Last modified:July 24, 2007 - v1
    Checksum:i0C7CFB4B04541C94
    GO
    Isoform 2 (identifier: A6NM10-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         41-41: A → AVGAVQLGACFLE

    Note: No experimental confirmation available.

    Show »
    Length:307
    Mass (Da):32,664
    Checksum:iFA1AE3E9D0060372
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei41 – 411A → AVGAVQLGACFLE in isoform 2. 1 PublicationVSP_032800

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC011298 Genomic DNA. No translation available.
    BC139748 mRNA. Translation: AAI39749.1.
    CCDSiCCDS46560.1. [A6NM10-2]
    RefSeqiNP_001095937.1. NM_001102467.1. [A6NM10-2]
    UniGeneiHs.437167.

    Genome annotation databases

    EnsembliENST00000407834; ENSP00000384894; ENSG00000185176. [A6NM10-2]
    GeneIDi653437.
    KEGGihsa:653437.
    UCSCiuc010fzj.3. human. [A6NM10-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC011298 Genomic DNA. No translation available.
    BC139748 mRNA. Translation: AAI39749.1 .
    CCDSi CCDS46560.1. [A6NM10-2 ]
    RefSeqi NP_001095937.1. NM_001102467.1. [A6NM10-2 ]
    UniGenei Hs.437167.

    3D structure databases

    ProteinModelPortali A6NM10.
    SMRi A6NM10. Positions 62-240.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000384894.

    Proteomic databases

    PaxDbi A6NM10.
    PRIDEi A6NM10.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000407834 ; ENSP00000384894 ; ENSG00000185176 . [A6NM10-2 ]
    GeneIDi 653437.
    KEGGi hsa:653437.
    UCSCi uc010fzj.3. human. [A6NM10-2 ]

    Organism-specific databases

    CTDi 653437.
    GeneCardsi GC02M241615.
    HGNCi HGNC:6096. AQP12B.
    neXtProti NX_A6NM10.
    PharmGKBi PA29902.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46671.
    HOGENOMi HOG000034023.
    HOVERGENi HBG050557.
    KOi K09871.
    OMAi ACCLEMR.
    PhylomeDBi A6NM10.
    TreeFami TF320251.

    Miscellaneous databases

    GenomeRNAii 653437.
    NextBioi 123241.
    PROi A6NM10.

    Gene expression databases

    Bgeei A6NM10.
    CleanExi HS_AQP12B.
    Genevestigatori A6NM10.

    Family and domain databases

    Gene3Di 1.20.1080.10. 1 hit.
    InterProi IPR023271. Aquaporin-like.
    IPR016697. Aquaporin_11/12.
    IPR023265. Aquaporin_12.
    IPR000425. MIP.
    [Graphical view ]
    PANTHERi PTHR21191:SF8. PTHR21191:SF8. 1 hit.
    Pfami PF00230. MIP. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017529. Aquaporin_11/12. 1 hit.
    PRINTSi PR02025. AQUAPORIN12.
    PR00783. MINTRINSICP.
    SUPFAMi SSF81338. SSF81338. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiAQ12B_HUMAN
    AccessioniPrimary (citable) accession number: A6NM10
    Secondary accession number(s): A4QPB9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3