A6NM10 (AQ12B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aquaporin-12B
Short name=AQP-12B

Gene names

Name:

AQP12B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Aquaporins facilitate the transport of water and small neutral solutes across cell membranes By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Domain	Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
Sequence similarities	Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily. [View classification]

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A6NM10-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A6NM10-2)

The sequence of this isoform differs from the canonical sequence as follows:
     41-41: A → AVGAVQLGACFLE

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 295	295	Aquaporin-12B		PRO_0000328826
Regions
	Transmembrane	1 – 21	21	Helical; Name=1; Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Transmembrane	100 – 126	27	Helical; Name=3; Potential
	Transmembrane	146 – 166	21	Helical; Name=4; Potential
	Transmembrane	179 – 199	21	Helical; Name=5; Potential
	Transmembrane	216 – 236	21	Helical; Name=6; Potential
	Motif	87 – 89	3	NPA 1
	Motif	200 – 202	3	NPA 2
Natural variations
	Alternative sequence	41	1	A → AVGAVQLGACFLE in isoform 2.		VSP_032800

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 0C7CFB4B04541C94	FASTA	295	31,475
	10 20 30 40 50 60 MAGLNVSLSF FFATFTLCEA ARRASKALLP VGAYEVFARE AMRTLVELGP WAGDFGPDLL 70 80 90 100 110 120 LTLLFLLFLA HGVTLDGASA NPTVSLQEFL MAEESLPGTL LKLAAQGLGM QAACTLTRLC 130 140 150 160 170 180 WAWELSDLHL LQSLMAQSCS SALRTSVPHG ALVEAACAFC FHLTLLHLRH SPPAYSGPAV 190 200 210 220 230 240 ALLVTVTAYT AGPFTSAFFN PALAASVTFA CSGHTLLEYV QVYWLGPLTG MVLAVLLHQG 250 260 270 280 290 RLPHLFQRNL FYGQKNKYRA PRGKPAPASG DTQTPAKGSS VREPGRSGVE GPHSS
	Isoform 2 [UniParc]. Checksum: FA1AE3E9D0060372	FASTA	307	32,664
	10 20 30 40 50 60 MAGLNVSLSF FFATFTLCEA ARRASKALLP VGAYEVFARE AVGAVQLGAC FLEMRTLVEL 70 80 90 100 110 120 GPWAGDFGPD LLLTLLFLLF LAHGVTLDGA SANPTVSLQE FLMAEESLPG TLLKLAAQGL 130 140 150 160 170 180 GMQAACTLTR LCWAWELSDL HLLQSLMAQS CSSALRTSVP HGALVEAACA FCFHLTLLHL 190 200 210 220 230 240 RHSPPAYSGP AVALLVTVTA YTAGPFTSAF FNPALAASVT FACSGHTLLE YVQVYWLGPL 250 260 270 280 290 300 TGMVLAVLLH QGRLPHLFQR NLFYGQKNKY RAPRGKPAPA SGDTQTPAKG SSVREPGRSG VEGPHSS

References

[1]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC011298 Genomic DNA. No translation available. BC139748 mRNA. Translation: AAI39749.1.
IPI	IPI00856090. IPI00889507.
RefSeq	NP_001095937.1. NM_001102467.1.
UniGene	Hs.437167.
3D structure databases
ProteinModelPortal	A6NM10.
SMR	A6NM10. Positions 68-240.
ModBase	Search...
Proteomic databases
PaxDb	A6NM10.
PRIDE	A6NM10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000407834; ENSP00000384894; ENSG00000185176.
GeneID	653437.
KEGG	hsa:653437.
UCSC	uc010fzj.3. human.
Organism-specific databases
CTD	653437.
GeneCards	GC02M241615.
HGNC	HGNC:6096. AQP12B.
neXtProt	NX_A6NM10.
PharmGKB	PA29902.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46671.
HOGENOM	HOG000034023.
HOVERGEN	HBG050557.
KO	K09871.
OMA	LEHIIVY.
PhylomeDB	A6NM10.
Gene expression databases
ArrayExpress	A6NM10.
Bgee	A6NM10.
CleanEx	HS_AQP12B.
Genevestigator	A6NM10.
Family and domain databases
Gene3D	1.20.1080.10. 1 hit.
InterPro	IPR023271. Aquaporin-like. IPR016697. Aquaporin_11/12. IPR023265. Aquaporin_12. IPR000425. MIP. [Graphical view]
PANTHER	PTHR21191:SF8. PTHR21191:SF8. 1 hit.
Pfam	PF00230. MIP. 1 hit. [Graphical view]
PIRSF	PIRSF017529. Aquaporin_11/12. 1 hit.
PRINTS	PR02025. AQUAPORIN12. PR00783. MINTRINSICP.
SUPFAM	SSF81338. MIP. 1 hit.
PROSITE	PS00221. MIP. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	653437.
NextBio	123241.

Entry information

Entry name

AQ12B_HUMAN

Accession

Primary (citable) accession number: A6NM10
Secondary accession number(s): A4QPB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	July 24, 2007
Last modified:	May 1, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.