Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Aquaporin-12B

Gene

AQP12B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.By similarity

GO - Molecular functioni

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Aquaporin-12B
Short name:
AQP-12B
Gene namesi
Name:AQP12B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000185176.12
HGNCiHGNC:6096 AQP12B
neXtProtiNX_A6NM10

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei100 – 126Helical; Name=3Sequence analysisAdd BLAST27
Transmembranei146 – 166Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei179 – 199Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei216 – 236Helical; Name=6Sequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000185176
PharmGKBiPA29902

Polymorphism and mutation databases

BioMutaiAQP12B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003288261 – 295Aquaporin-12BAdd BLAST295

Proteomic databases

PRIDEiA6NM10

Expressioni

Gene expression databases

BgeeiENSG00000185176
CleanExiHS_AQP12B
ExpressionAtlasiA6NM10 baseline and differential
GenevisibleiA6NM10 HS

Organism-specific databases

HPAiHPA042216

Interactioni

Protein-protein interaction databases

BioGridi575779, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliA6NM10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi87 – 89NPA 13
Motifi200 – 202NPA 23

Domaini

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJA3 Eukaryota
ENOG4111GCP LUCA
GeneTreeiENSGT00530000063816
HOGENOMiHOG000034023
HOVERGENiHBG050557
InParanoidiA6NM10
KOiK09871
OMAiACCLEMR
OrthoDBiEOG091G0JBQ
PhylomeDBiA6NM10
TreeFamiTF320251

Family and domain databases

Gene3Di1.20.1080.10, 1 hit
InterProiView protein in InterPro
IPR023271 Aquaporin-like
IPR016697 Aquaporin_11/12
IPR023265 Aquaporin_12
IPR000425 MIP
PANTHERiPTHR21191:SF8 PTHR21191:SF8, 1 hit
PfamiView protein in Pfam
PF00230 MIP, 1 hit
PIRSFiPIRSF017529 Aquaporin_11/12, 1 hit
PRINTSiPR02025 AQUAPORIN12
PR00783 MINTRINSICP
SUPFAMiSSF81338 SSF81338, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6NM10-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGLNVSLSF FFATFTLCEA ARRASKALLP VGAYEVFARE AMRTLVELGP
60 70 80 90 100
WAGDFGPDLL LTLLFLLFLA HGVTLDGASA NPTVSLQEFL MAEESLPGTL
110 120 130 140 150
LKLAAQGLGM QAACTLTRLC WAWELSDLHL LQSLMAQSCS SALRTSVPHG
160 170 180 190 200
ALVEAACAFC FHLTLLHLRH SPPAYSGPAV ALLVTVTAYT AGPFTSAFFN
210 220 230 240 250
PALAASVTFA CSGHTLLEYV QVYWLGPLTG MVLAVLLHQG RLPHLFQRNL
260 270 280 290
FYGQKNKYRA PRGKPAPASG DTQTPAKGSS VREPGRSGVE GPHSS
Length:295
Mass (Da):31,475
Last modified:July 24, 2007 - v1
Checksum:i0C7CFB4B04541C94
GO
Isoform 2 (identifier: A6NM10-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     41-41: A → AVGAVQLGACFLE

Note: No experimental confirmation available.
Show »
Length:307
Mass (Da):32,664
Checksum:iFA1AE3E9D0060372
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03280041A → AVGAVQLGACFLE in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011298 Genomic DNA No translation available.
BC139748 mRNA Translation: AAI39749.1
CCDSiCCDS46560.1 [A6NM10-2]
RefSeqiNP_001095937.1, NM_001102467.1 [A6NM10-2]
UniGeneiHs.437167

Genome annotation databases

EnsembliENST00000407834; ENSP00000384894; ENSG00000185176 [A6NM10-2]
ENST00000621682; ENSP00000481577; ENSG00000185176 [A6NM10-1]
GeneIDi653437
KEGGihsa:653437
UCSCiuc010fzj.4 human [A6NM10-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAQ12B_HUMAN
AccessioniPrimary (citable) accession number: A6NM10
Secondary accession number(s): A4QPB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 24, 2007
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health