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A6NM10 (AQ12B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aquaporin-12B

Short name=AQP-12B
Gene names
Name:AQP12B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Aquaporins facilitate the transport of water and small neutral solutes across cell membranes By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similarities

Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily. [View classification]

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainRepeat
Transmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontransporter activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: A6NM10-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: A6NM10-2)

The sequence of this isoform differs from the canonical sequence as follows:
     41-41: A → AVGAVQLGACFLE
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 295295Aquaporin-12B
PRO_0000328826

Regions

Transmembrane1 – 2121Helical; Name=1; Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Transmembrane100 – 12627Helical; Name=3; Potential
Transmembrane146 – 16621Helical; Name=4; Potential
Transmembrane179 – 19921Helical; Name=5; Potential
Transmembrane216 – 23621Helical; Name=6; Potential
Motif87 – 893NPA 1
Motif200 – 2023NPA 2

Natural variations

Alternative sequence411A → AVGAVQLGACFLE in isoform 2.
VSP_032800

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 0C7CFB4B04541C94

FASTA29531,475
        10         20         30         40         50         60 
MAGLNVSLSF FFATFTLCEA ARRASKALLP VGAYEVFARE AMRTLVELGP WAGDFGPDLL 

        70         80         90        100        110        120 
LTLLFLLFLA HGVTLDGASA NPTVSLQEFL MAEESLPGTL LKLAAQGLGM QAACTLTRLC 

       130        140        150        160        170        180 
WAWELSDLHL LQSLMAQSCS SALRTSVPHG ALVEAACAFC FHLTLLHLRH SPPAYSGPAV 

       190        200        210        220        230        240 
ALLVTVTAYT AGPFTSAFFN PALAASVTFA CSGHTLLEYV QVYWLGPLTG MVLAVLLHQG 

       250        260        270        280        290 
RLPHLFQRNL FYGQKNKYRA PRGKPAPASG DTQTPAKGSS VREPGRSGVE GPHSS 

« Hide

Isoform 2 [UniParc].

Checksum: FA1AE3E9D0060372
Show »

FASTA30732,664

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC011298 Genomic DNA. No translation available.
BC139748 mRNA. Translation: AAI39749.1.
CCDSCCDS46560.1. [A6NM10-2]
RefSeqNP_001095937.1. NM_001102467.1. [A6NM10-2]
UniGeneHs.437167.

3D structure databases

ProteinModelPortalA6NM10.
SMRA6NM10. Positions 62-240.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000384894.

Proteomic databases

PaxDbA6NM10.
PRIDEA6NM10.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000407834; ENSP00000384894; ENSG00000185176. [A6NM10-2]
GeneID653437.
KEGGhsa:653437.
UCSCuc010fzj.3. human. [A6NM10-2]

Organism-specific databases

CTD653437.
GeneCardsGC02M241615.
HGNCHGNC:6096. AQP12B.
neXtProtNX_A6NM10.
PharmGKBPA29902.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46671.
HOGENOMHOG000034023.
HOVERGENHBG050557.
KOK09871.
OMAACCLEMR.
PhylomeDBA6NM10.
TreeFamTF320251.

Gene expression databases

BgeeA6NM10.
CleanExHS_AQP12B.
GenevestigatorA6NM10.

Family and domain databases

Gene3D1.20.1080.10. 1 hit.
InterProIPR023271. Aquaporin-like.
IPR016697. Aquaporin_11/12.
IPR023265. Aquaporin_12.
IPR000425. MIP.
[Graphical view]
PANTHERPTHR21191:SF8. PTHR21191:SF8. 1 hit.
PfamPF00230. MIP. 1 hit.
[Graphical view]
PIRSFPIRSF017529. Aquaporin_11/12. 1 hit.
PRINTSPR02025. AQUAPORIN12.
PR00783. MINTRINSICP.
SUPFAMSSF81338. SSF81338. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi653437.
NextBio123241.
PROA6NM10.

Entry information

Entry nameAQ12B_HUMAN
AccessionPrimary (citable) accession number: A6NM10
Secondary accession number(s): A4QPB9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 24, 2007
Last modified: July 9, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM