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A6NM03 (O2AG2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2AG2
Gene names
Name:OR2AG2
Synonyms:OR2AG2P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length316 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 316316Olfactory receptor 2AG2
PRO_0000312343

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5121Helical; Name=1; Potential
Topological domain52 – 565Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 9720Extracellular Potential
Transmembrane98 – 11821Helical; Name=3; Potential
Topological domain119 – 13921Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 20545Extracellular Potential
Transmembrane206 – 22621Helical; Name=5; Potential
Topological domain227 – 24418Cytoplasmic Potential
Transmembrane245 – 26521Helical; Name=6; Potential
Topological domain266 – 2716Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31624Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation191N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 179 By similarity

Natural variations

Natural variant281Y → C.
Corresponds to variant rs7102536 [ dbSNP | Ensembl ].
VAR_037497
Natural variant541R → P.
Corresponds to variant rs10839616 [ dbSNP | Ensembl ].
VAR_037498
Natural variant871R → L.
Corresponds to variant rs11828782 [ dbSNP | Ensembl ].
VAR_037499
Natural variant2991R → G.
Corresponds to variant rs7924459 [ dbSNP | Ensembl ].
VAR_037500

Sequences

Sequence LengthMass (Da)Tools
A6NM03 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 0B2E3D549FEB7FF1

FASTA31635,270
        10         20         30         40         50         60 
MELRNSTLGS GFILVGILND SGSPELLYAT FTILYMLALT SNGLLLLAIT IEARLHMPMY 

        70         80         90        100        110        120 
LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ MFLALTMGSA EDLLLAFMAY 

       130        140        150        160        170        180 
DRYVAICHPL KYMTLMSPRV CWIMVATSWI LASLIAIGHT MYTMHLPFCV SWEIRHLLCE 

       190        200        210        220        230        240 
IPPLLKLACA DTSRYELIIY VTGVTFLLLP ISAIVASYTL VLFTVLRMPS NEGRKKALVT 

       250        260        270        280        290        300 
CSSHLIVVGM FYGAATFMYV LPSSFHSPKQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA 

       310 
LRRVLGKYIL LAHSTL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC091564 Genomic DNA. No translation available.
RefSeqNP_001004490.1. NM_001004490.1.
UniGeneHs.534614.

3D structure databases

ProteinModelPortalA6NM03.
SMRA6NM03. Positions 20-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000342697.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteA6NM03.

Proteomic databases

PaxDbA6NM03.
PRIDEA6NM03.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000338569; ENSP00000342697; ENSG00000188124.
GeneID338755.
KEGGhsa:338755.
UCSCuc001meq.1. human.

Organism-specific databases

CTD338755.
GeneCardsGC11M006790.
HGNCHGNC:15143. OR2AG2.
neXtProtNX_A6NM03.
PharmGKBPA32127.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41022.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidA6NM03.
KOK04257.
OMACVSWEIR.
OrthoDBEOG72G17Q.
PhylomeDBA6NM03.
TreeFamTF337295.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeA6NM03.
CleanExHS_OR2AG2.
GenevestigatorA6NM03.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi338755.
NextBio97133.
PROA6NM03.

Entry information

Entry nameO2AG2_HUMAN
AccessionPrimary (citable) accession number: A6NM03
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries