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Protein

Olfactory receptor 2AG2

Gene

OR2AG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2AG2
Gene namesi
Name:OR2AG2
Synonyms:OR2AG2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15143. OR2AG2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini52 – 565CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 9720ExtracellularSequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 20545ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini227 – 24418CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini266 – 2716ExtracellularSequence Analysis
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31624CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Olfactory receptor 2AG2PRO_0000312343Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NM03.
PRIDEiA6NM03.

PTM databases

PhosphoSiteiA6NM03.

Expressioni

Gene expression databases

BgeeiA6NM03.
CleanExiHS_OR2AG2.
GenevestigatoriA6NM03.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342697.

Structurei

3D structure databases

ProteinModelPortaliA6NM03.
SMRiA6NM03. Positions 20-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41022.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiA6NM03.
KOiK04257.
OMAiCVSWEIR.
OrthoDBiEOG72G17Q.
PhylomeDBiA6NM03.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NM03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRNSTLGS GFILVGILND SGSPELLYAT FTILYMLALT SNGLLLLAIT
60 70 80 90 100
IEARLHMPMY LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ
110 120 130 140 150
MFLALTMGSA EDLLLAFMAY DRYVAICHPL KYMTLMSPRV CWIMVATSWI
160 170 180 190 200
LASLIAIGHT MYTMHLPFCV SWEIRHLLCE IPPLLKLACA DTSRYELIIY
210 220 230 240 250
VTGVTFLLLP ISAIVASYTL VLFTVLRMPS NEGRKKALVT CSSHLIVVGM
260 270 280 290 300
FYGAATFMYV LPSSFHSPKQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA
310
LRRVLGKYIL LAHSTL
Length:316
Mass (Da):35,270
Last modified:July 24, 2007 - v1
Checksum:i0B2E3D549FEB7FF1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281Y → C.
Corresponds to variant rs7102536 [ dbSNP | Ensembl ].
VAR_037497
Natural varianti54 – 541R → P.
Corresponds to variant rs10839616 [ dbSNP | Ensembl ].
VAR_037498
Natural varianti87 – 871R → L.
Corresponds to variant rs11828782 [ dbSNP | Ensembl ].
VAR_037499
Natural varianti299 – 2991R → G.
Corresponds to variant rs7924459 [ dbSNP | Ensembl ].
VAR_037500

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091564 Genomic DNA. No translation available.
CCDSiCCDS31413.1.
RefSeqiNP_001004490.1. NM_001004490.1.
UniGeneiHs.534614.

Genome annotation databases

EnsembliENST00000338569; ENSP00000342697; ENSG00000188124.
GeneIDi338755.
KEGGihsa:338755.
UCSCiuc001meq.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091564 Genomic DNA. No translation available.
CCDSiCCDS31413.1.
RefSeqiNP_001004490.1. NM_001004490.1.
UniGeneiHs.534614.

3D structure databases

ProteinModelPortaliA6NM03.
SMRiA6NM03. Positions 20-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342697.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiA6NM03.

Proteomic databases

PaxDbiA6NM03.
PRIDEiA6NM03.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338569; ENSP00000342697; ENSG00000188124.
GeneIDi338755.
KEGGihsa:338755.
UCSCiuc001meq.1. human.

Organism-specific databases

CTDi338755.
GeneCardsiGC11M006790.
HGNCiHGNC:15143. OR2AG2.
neXtProtiNX_A6NM03.
PharmGKBiPA32127.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41022.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiA6NM03.
KOiK04257.
OMAiCVSWEIR.
OrthoDBiEOG72G17Q.
PhylomeDBiA6NM03.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii338755.
NextBioi97133.
PROiA6NM03.

Gene expression databases

BgeeiA6NM03.
CleanExiHS_OR2AG2.
GenevestigatoriA6NM03.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiO2AG2_HUMAN
AccessioniPrimary (citable) accession number: A6NM03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 24, 2007
Last modified: April 1, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.