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A6NM03

- O2AG2_HUMAN

UniProt

A6NM03 - O2AG2_HUMAN

Protein

Olfactory receptor 2AG2

Gene

OR2AG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2AG2
    Gene namesi
    Name:OR2AG2
    Synonyms:OR2AG2P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15143. OR2AG2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32127.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 316316Olfactory receptor 2AG2PRO_0000312343Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiA6NM03.
    PRIDEiA6NM03.

    PTM databases

    PhosphoSiteiA6NM03.

    Expressioni

    Gene expression databases

    BgeeiA6NM03.
    CleanExiHS_OR2AG2.
    GenevestigatoriA6NM03.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000342697.

    Structurei

    3D structure databases

    ProteinModelPortaliA6NM03.
    SMRiA6NM03. Positions 20-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 565CytoplasmicSequence Analysis
    Topological domaini78 – 9720ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 20545ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 24418CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini266 – 2716ExtracellularSequence Analysis
    Topological domaini293 – 31624CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41022.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiA6NM03.
    KOiK04257.
    OMAiCVSWEIR.
    OrthoDBiEOG72G17Q.
    PhylomeDBiA6NM03.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NM03-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELRNSTLGS GFILVGILND SGSPELLYAT FTILYMLALT SNGLLLLAIT    50
    IEARLHMPMY LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ 100
    MFLALTMGSA EDLLLAFMAY DRYVAICHPL KYMTLMSPRV CWIMVATSWI 150
    LASLIAIGHT MYTMHLPFCV SWEIRHLLCE IPPLLKLACA DTSRYELIIY 200
    VTGVTFLLLP ISAIVASYTL VLFTVLRMPS NEGRKKALVT CSSHLIVVGM 250
    FYGAATFMYV LPSSFHSPKQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA 300
    LRRVLGKYIL LAHSTL 316
    Length:316
    Mass (Da):35,270
    Last modified:July 24, 2007 - v1
    Checksum:i0B2E3D549FEB7FF1
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti28 – 281Y → C.
    Corresponds to variant rs7102536 [ dbSNP | Ensembl ].
    VAR_037497
    Natural varianti54 – 541R → P.
    Corresponds to variant rs10839616 [ dbSNP | Ensembl ].
    VAR_037498
    Natural varianti87 – 871R → L.
    Corresponds to variant rs11828782 [ dbSNP | Ensembl ].
    VAR_037499
    Natural varianti299 – 2991R → G.
    Corresponds to variant rs7924459 [ dbSNP | Ensembl ].
    VAR_037500

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC091564 Genomic DNA. No translation available.
    CCDSiCCDS31413.1.
    RefSeqiNP_001004490.1. NM_001004490.1.
    UniGeneiHs.534614.

    Genome annotation databases

    EnsembliENST00000338569; ENSP00000342697; ENSG00000188124.
    GeneIDi338755.
    KEGGihsa:338755.
    UCSCiuc001meq.1. human.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC091564 Genomic DNA. No translation available.
    CCDSi CCDS31413.1.
    RefSeqi NP_001004490.1. NM_001004490.1.
    UniGenei Hs.534614.

    3D structure databases

    ProteinModelPortali A6NM03.
    SMRi A6NM03. Positions 20-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000342697.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei A6NM03.

    Proteomic databases

    PaxDbi A6NM03.
    PRIDEi A6NM03.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338569 ; ENSP00000342697 ; ENSG00000188124 .
    GeneIDi 338755.
    KEGGi hsa:338755.
    UCSCi uc001meq.1. human.

    Organism-specific databases

    CTDi 338755.
    GeneCardsi GC11M006790.
    HGNCi HGNC:15143. OR2AG2.
    neXtProti NX_A6NM03.
    PharmGKBi PA32127.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41022.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi A6NM03.
    KOi K04257.
    OMAi CVSWEIR.
    OrthoDBi EOG72G17Q.
    PhylomeDBi A6NM03.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GenomeRNAii 338755.
    NextBioi 97133.
    PROi A6NM03.

    Gene expression databases

    Bgeei A6NM03.
    CleanExi HS_OR2AG2.
    Genevestigatori A6NM03.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiO2AG2_HUMAN
    AccessioniPrimary (citable) accession number: A6NM03
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3