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Protein

Olfactory receptor 2AG2

Gene

OR2AG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32130-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2AG2
Gene namesi
Name:OR2AG2
Synonyms:OR2AG2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15143. OR2AG2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30ExtracellularSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 56CytoplasmicSequence analysis5
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 97ExtracellularSequence analysisAdd BLAST20
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 139CytoplasmicSequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 205ExtracellularSequence analysisAdd BLAST45
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 244CytoplasmicSequence analysisAdd BLAST18
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 271ExtracellularSequence analysis6
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 316CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188124.
PharmGKBiPA32127.

Polymorphism and mutation databases

BioMutaiOR2AG2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003123431 – 316Olfactory receptor 2AG2Add BLAST316

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NM03.
PRIDEiA6NM03.

PTM databases

iPTMnetiA6NM03.
PhosphoSitePlusiA6NM03.

Expressioni

Gene expression databases

CleanExiHS_OR2AG2.
ExpressionAtlasiA6NM03. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342697.

Structurei

3D structure databases

ProteinModelPortaliA6NM03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGT4. Eukaryota.
ENOG4111C5R. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiA6NM03.
KOiK04257.
OMAiCVSWEIR.
OrthoDBiEOG091G0FFK.
PhylomeDBiA6NM03.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NM03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRNSTLGS GFILVGILND SGSPELLYAT FTILYMLALT SNGLLLLAIT
60 70 80 90 100
IEARLHMPMY LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ
110 120 130 140 150
MFLALTMGSA EDLLLAFMAY DRYVAICHPL KYMTLMSPRV CWIMVATSWI
160 170 180 190 200
LASLIAIGHT MYTMHLPFCV SWEIRHLLCE IPPLLKLACA DTSRYELIIY
210 220 230 240 250
VTGVTFLLLP ISAIVASYTL VLFTVLRMPS NEGRKKALVT CSSHLIVVGM
260 270 280 290 300
FYGAATFMYV LPSSFHSPKQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA
310
LRRVLGKYIL LAHSTL
Length:316
Mass (Da):35,270
Last modified:July 24, 2007 - v1
Checksum:i0B2E3D549FEB7FF1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03749728Y → C.Corresponds to variant rs7102536dbSNPEnsembl.1
Natural variantiVAR_03749854R → P.Corresponds to variant rs10839616dbSNPEnsembl.1
Natural variantiVAR_03749987R → L.Corresponds to variant rs11828782dbSNPEnsembl.1
Natural variantiVAR_037500299R → G.Corresponds to variant rs7924459dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091564 Genomic DNA. No translation available.
CCDSiCCDS31413.1.
RefSeqiNP_001004490.1. NM_001004490.1.
UniGeneiHs.534614.

Genome annotation databases

EnsembliENST00000338569; ENSP00000342697; ENSG00000188124.
GeneIDi338755.
KEGGihsa:338755.
UCSCiuc001meq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC091564 Genomic DNA. No translation available.
CCDSiCCDS31413.1.
RefSeqiNP_001004490.1. NM_001004490.1.
UniGeneiHs.534614.

3D structure databases

ProteinModelPortaliA6NM03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342697.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiA6NM03.
PhosphoSitePlusiA6NM03.

Polymorphism and mutation databases

BioMutaiOR2AG2.

Proteomic databases

PaxDbiA6NM03.
PRIDEiA6NM03.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338569; ENSP00000342697; ENSG00000188124.
GeneIDi338755.
KEGGihsa:338755.
UCSCiuc001meq.2. human.

Organism-specific databases

CTDi338755.
GeneCardsiOR2AG2.
HGNCiHGNC:15143. OR2AG2.
neXtProtiNX_A6NM03.
OpenTargetsiENSG00000188124.
PharmGKBiPA32127.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGT4. Eukaryota.
ENOG4111C5R. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiA6NM03.
KOiK04257.
OMAiCVSWEIR.
OrthoDBiEOG091G0FFK.
PhylomeDBiA6NM03.
TreeFamiTF337295.

Enzyme and pathway databases

BioCyciZFISH:G66-32130-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii338755.
PROiA6NM03.

Gene expression databases

CleanExiHS_OR2AG2.
ExpressionAtlasiA6NM03. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO2AG2_HUMAN
AccessioniPrimary (citable) accession number: A6NM03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 24, 2007
Last modified: November 30, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.