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A6NM03

- O2AG2_HUMAN

UniProt

A6NM03 - O2AG2_HUMAN

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Protein

Olfactory receptor 2AG2

Gene

OR2AG2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2AG2
Gene namesi
Name:OR2AG2
Synonyms:OR2AG2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15143. OR2AG2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Olfactory receptor 2AG2PRO_0000312343Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6NM03.
PRIDEiA6NM03.

PTM databases

PhosphoSiteiA6NM03.

Expressioni

Gene expression databases

BgeeiA6NM03.
CleanExiHS_OR2AG2.
GenevestigatoriA6NM03.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342697.

Structurei

3D structure databases

ProteinModelPortaliA6NM03.
SMRiA6NM03. Positions 20-296.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Topological domaini52 – 565CytoplasmicSequence Analysis
Topological domaini78 – 9720ExtracellularSequence AnalysisAdd
BLAST
Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini161 – 20545ExtracellularSequence AnalysisAdd
BLAST
Topological domaini227 – 24418CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini266 – 2716ExtracellularSequence Analysis
Topological domaini293 – 31624CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei245 – 26521Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41022.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiA6NM03.
KOiK04257.
OMAiCVSWEIR.
OrthoDBiEOG72G17Q.
PhylomeDBiA6NM03.
TreeFamiTF337295.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NM03 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELRNSTLGS GFILVGILND SGSPELLYAT FTILYMLALT SNGLLLLAIT
60 70 80 90 100
IEARLHMPMY LLLGQLSLMD LLFTSVVTPK ALADFLRREN TISFGGCALQ
110 120 130 140 150
MFLALTMGSA EDLLLAFMAY DRYVAICHPL KYMTLMSPRV CWIMVATSWI
160 170 180 190 200
LASLIAIGHT MYTMHLPFCV SWEIRHLLCE IPPLLKLACA DTSRYELIIY
210 220 230 240 250
VTGVTFLLLP ISAIVASYTL VLFTVLRMPS NEGRKKALVT CSSHLIVVGM
260 270 280 290 300
FYGAATFMYV LPSSFHSPKQ DNIISVFYTI VTPALNPLIY SLRNKEVMRA
310
LRRVLGKYIL LAHSTL
Length:316
Mass (Da):35,270
Last modified:July 24, 2007 - v1
Checksum:i0B2E3D549FEB7FF1
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti28 – 281Y → C.
Corresponds to variant rs7102536 [ dbSNP | Ensembl ].
VAR_037497
Natural varianti54 – 541R → P.
Corresponds to variant rs10839616 [ dbSNP | Ensembl ].
VAR_037498
Natural varianti87 – 871R → L.
Corresponds to variant rs11828782 [ dbSNP | Ensembl ].
VAR_037499
Natural varianti299 – 2991R → G.
Corresponds to variant rs7924459 [ dbSNP | Ensembl ].
VAR_037500

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC091564 Genomic DNA. No translation available.
CCDSiCCDS31413.1.
RefSeqiNP_001004490.1. NM_001004490.1.
UniGeneiHs.534614.

Genome annotation databases

EnsembliENST00000338569; ENSP00000342697; ENSG00000188124.
GeneIDi338755.
KEGGihsa:338755.
UCSCiuc001meq.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC091564 Genomic DNA. No translation available.
CCDSi CCDS31413.1.
RefSeqi NP_001004490.1. NM_001004490.1.
UniGenei Hs.534614.

3D structure databases

ProteinModelPortali A6NM03.
SMRi A6NM03. Positions 20-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000342697.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei A6NM03.

Proteomic databases

PaxDbi A6NM03.
PRIDEi A6NM03.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338569 ; ENSP00000342697 ; ENSG00000188124 .
GeneIDi 338755.
KEGGi hsa:338755.
UCSCi uc001meq.1. human.

Organism-specific databases

CTDi 338755.
GeneCardsi GC11M006790.
HGNCi HGNC:15143. OR2AG2.
neXtProti NX_A6NM03.
PharmGKBi PA32127.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41022.
GeneTreei ENSGT00760000118850.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi A6NM03.
KOi K04257.
OMAi CVSWEIR.
OrthoDBi EOG72G17Q.
PhylomeDBi A6NM03.
TreeFami TF337295.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii 338755.
NextBioi 97133.
PROi A6NM03.

Gene expression databases

Bgeei A6NM03.
CleanExi HS_OR2AG2.
Genevestigatori A6NM03.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiO2AG2_HUMAN
AccessioniPrimary (citable) accession number: A6NM03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3