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Protein

Double homeobox protein A

Gene

DUXA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Putative transcription factor.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi15 – 74Homeobox 1PROSITE-ProRule annotationAdd BLAST60
DNA bindingi101 – 160Homeobox 2PROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Double homeobox protein A
Gene namesi
Name:DUXA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000258873.2.
HGNCiHGNC:32179. DUXA.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000258873.
PharmGKBiPA142671924.

Polymorphism and mutation databases

BioMutaiDUXA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113271 – 204Double homeobox protein AAdd BLAST204

Proteomic databases

PaxDbiA6NLW8.
PRIDEiA6NLW8.

PTM databases

iPTMnetiA6NLW8.
PhosphoSitePlusiA6NLW8.

Expressioni

Gene expression databases

BgeeiENSG00000258873.
CleanExiHS_DUXA.

Organism-specific databases

HPAiHPA059358.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000452398.

Structurei

3D structure databases

ProteinModelPortaliA6NLW8.
SMRiA6NLW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
GeneTreeiENSGT00610000085975.
HOGENOMiHOG000112297.
InParanoidiA6NLW8.
OMAiRCRTTYS.
OrthoDBiEOG091G0K3P.
PhylomeDBiA6NLW8.
TreeFamiTF340750.

Family and domain databases

CDDicd00086. homeodomain. 2 hits.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF00046. Homeobox. 2 hits.
PRINTSiPR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 2 hits.
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiView protein in PROSITE
PS50071. HOMEOBOX_2. 2 hits.

Sequencei

Sequence statusi: Complete.

A6NLW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDTYSHKM VKTNHRRCRT KFTEEQLKIL INTFNQKPYP GYATKQKLAL
60 70 80 90 100
EINTEESRIQ IWFQNRRARH GFQKRPEAET LESSQSQGQD QPGVEFQSRE
110 120 130 140 150
ARRCRTTYSA SQLHTLIKAF MKNPYPGIDS REELAKEIGV PESRVQIWFQ
160 170 180 190 200
NRRSRLLLQR KREPVASLEQ EEQGKIPEGL QGAEDTQNGT NFTSDSHFSG

ARTW
Length:204
Mass (Da):23,817
Last modified:July 24, 2007 - v1
Checksum:i56A0906E62A3BB56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025588 Genomic DNA. No translation available.
CCDSiCCDS33126.1.
RefSeqiNP_001012747.1. NM_001012729.1.
UniGeneiHs.585857.

Genome annotation databases

EnsembliENST00000554048; ENSP00000452398; ENSG00000258873.
GeneIDi503835.
KEGGihsa:503835.
UCSCiuc002qoa.2. human.

Similar proteinsi

Entry informationi

Entry nameiDUXA_HUMAN
AccessioniPrimary (citable) accession number: A6NLW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: September 27, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families