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Protein

Double homeobox protein A

Gene

DUXA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Putative transcription factor.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi15 – 7460Homeobox 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi101 – 16060Homeobox 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Double homeobox protein A
Gene namesi
Name:DUXA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:32179. DUXA.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671924.

Polymorphism and mutation databases

BioMutaiDUXA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 204204Double homeobox protein APRO_0000311327Add
BLAST

Proteomic databases

PaxDbiA6NLW8.
PRIDEiA6NLW8.

PTM databases

iPTMnetiA6NLW8.
PhosphoSiteiA6NLW8.

Expressioni

Gene expression databases

CleanExiHS_DUXA.

Organism-specific databases

HPAiHPA059358.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000452398.

Structurei

3D structure databases

ProteinModelPortaliA6NLW8.
SMRiA6NLW8. Positions 16-69, 102-156.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paired homeobox family.Curated
Contains 2 homeobox DNA-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
GeneTreeiENSGT00610000085975.
HOGENOMiHOG000112297.
InParanoidiA6NLW8.
OMAiRCRTTYS.
OrthoDBiEOG091G0K3P.
PhylomeDBiA6NLW8.
TreeFamiTF340750.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 2 hits.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50071. HOMEOBOX_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NLW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEDTYSHKM VKTNHRRCRT KFTEEQLKIL INTFNQKPYP GYATKQKLAL
60 70 80 90 100
EINTEESRIQ IWFQNRRARH GFQKRPEAET LESSQSQGQD QPGVEFQSRE
110 120 130 140 150
ARRCRTTYSA SQLHTLIKAF MKNPYPGIDS REELAKEIGV PESRVQIWFQ
160 170 180 190 200
NRRSRLLLQR KREPVASLEQ EEQGKIPEGL QGAEDTQNGT NFTSDSHFSG

ARTW
Length:204
Mass (Da):23,817
Last modified:July 24, 2007 - v1
Checksum:i56A0906E62A3BB56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025588 Genomic DNA. No translation available.
CCDSiCCDS33126.1.
RefSeqiNP_001012747.1. NM_001012729.1.
UniGeneiHs.585857.

Genome annotation databases

EnsembliENST00000554048; ENSP00000452398; ENSG00000258873.
GeneIDi503835.
KEGGihsa:503835.
UCSCiuc002qoa.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025588 Genomic DNA. No translation available.
CCDSiCCDS33126.1.
RefSeqiNP_001012747.1. NM_001012729.1.
UniGeneiHs.585857.

3D structure databases

ProteinModelPortaliA6NLW8.
SMRiA6NLW8. Positions 16-69, 102-156.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000452398.

PTM databases

iPTMnetiA6NLW8.
PhosphoSiteiA6NLW8.

Polymorphism and mutation databases

BioMutaiDUXA.

Proteomic databases

PaxDbiA6NLW8.
PRIDEiA6NLW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000554048; ENSP00000452398; ENSG00000258873.
GeneIDi503835.
KEGGihsa:503835.
UCSCiuc002qoa.2. human.

Organism-specific databases

CTDi503835.
GeneCardsiDUXA.
H-InvDBHIX0016200.
HGNCiHGNC:32179. DUXA.
HPAiHPA059358.
MIMi611168. gene.
neXtProtiNX_A6NLW8.
PharmGKBiPA142671924.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
GeneTreeiENSGT00610000085975.
HOGENOMiHOG000112297.
InParanoidiA6NLW8.
OMAiRCRTTYS.
OrthoDBiEOG091G0K3P.
PhylomeDBiA6NLW8.
TreeFamiTF340750.

Miscellaneous databases

GenomeRNAii503835.
PROiA6NLW8.
SOURCEiSearch...

Gene expression databases

CleanExiHS_DUXA.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 2 hits.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50071. HOMEOBOX_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUXA_HUMAN
AccessioniPrimary (citable) accession number: A6NLW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.