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Protein

V-set and transmembrane domain-containing protein 2B

Gene

VSTM2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32062-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
V-set and transmembrane domain-containing protein 2B
Gene namesi
Name:VSTM2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:33595. VSTM2B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 263ExtracellularSequence analysisAdd BLAST235
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285CytoplasmicSequence analysis1

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000187135.
PharmGKBiPA162408890.

Polymorphism and mutation databases

BioMutaiVSTM2B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000031994329 – 285V-set and transmembrane domain-containing protein 2BAdd BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 127PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiA6NLU5.
PRIDEiA6NLU5.

PTM databases

iPTMnetiA6NLU5.
PhosphoSitePlusiA6NLU5.

Expressioni

Gene expression databases

BgeeiENSG00000187135.
CleanExiHS_VSTM2B.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000335038.

Structurei

3D structure databases

ProteinModelPortaliA6NLU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 143Ig-like V-typeAdd BLAST115

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKGK. Eukaryota.
ENOG4111HPI. LUCA.
GeneTreeiENSGT00510000046940.
HOGENOMiHOG000253955.
HOVERGENiHBG052093.
InParanoidiA6NLU5.
OMAiGRSYTTD.
OrthoDBiEOG091G0ND0.
PhylomeDBiA6NLU5.
TreeFamiTF331739.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A6NLU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQRNRLGAL GYLPPLLLHA LLLFVADAAF TEVPKDVTVR EGDDIEMPCA
60 70 80 90 100
FRASGATSYS LEIQWWYLKE PPRELLHELA LSVPGARSKV TNKDATKIST
110 120 130 140 150
VRVQGNDISH RLRLSAVRLQ DEGVYECRVS DYSDDDTQEH KAQAMLRVLS
160 170 180 190 200
RFAPPNMQAA EAVSHIQSSG PRRHGPASAA NANNAGAASR TTSEPGRGDK
210 220 230 240 250
SPPPGSPPAA IDPAVPEAAA ASAAHTPTTT VAAAAAASSA SPPSGQAVLL
260 270 280
RQRHGSGTGR SYTTDPLLSL LLLALHKFLR LLLGH
Length:285
Mass (Da):30,297
Last modified:January 15, 2008 - v2
Checksum:iB21B2FF41E3DC320
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011474 Genomic DNA. No translation available.
CCDSiCCDS46034.1.
RefSeqiNP_001139811.1. NM_001146339.1.
XP_011525204.1. XM_011526902.2.
UniGeneiHs.451618.

Genome annotation databases

EnsembliENST00000335523; ENSP00000335038; ENSG00000187135.
GeneIDi342865.
KEGGihsa:342865.
UCSCiuc010xrl.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011474 Genomic DNA. No translation available.
CCDSiCCDS46034.1.
RefSeqiNP_001139811.1. NM_001146339.1.
XP_011525204.1. XM_011526902.2.
UniGeneiHs.451618.

3D structure databases

ProteinModelPortaliA6NLU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000335038.

PTM databases

iPTMnetiA6NLU5.
PhosphoSitePlusiA6NLU5.

Polymorphism and mutation databases

BioMutaiVSTM2B.

Proteomic databases

PaxDbiA6NLU5.
PRIDEiA6NLU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335523; ENSP00000335038; ENSG00000187135.
GeneIDi342865.
KEGGihsa:342865.
UCSCiuc010xrl.2. human.

Organism-specific databases

CTDi342865.
GeneCardsiVSTM2B.
HGNCiHGNC:33595. VSTM2B.
neXtProtiNX_A6NLU5.
OpenTargetsiENSG00000187135.
PharmGKBiPA162408890.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKGK. Eukaryota.
ENOG4111HPI. LUCA.
GeneTreeiENSGT00510000046940.
HOGENOMiHOG000253955.
HOVERGENiHBG052093.
InParanoidiA6NLU5.
OMAiGRSYTTD.
OrthoDBiEOG091G0ND0.
PhylomeDBiA6NLU5.
TreeFamiTF331739.

Enzyme and pathway databases

BioCyciZFISH:G66-32062-MONOMER.

Miscellaneous databases

GenomeRNAii342865.
PROiA6NLU5.

Gene expression databases

BgeeiENSG00000187135.
CleanExiHS_VSTM2B.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVTM2B_HUMAN
AccessioniPrimary (citable) accession number: A6NLU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.