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A6NLU0

- RFPLA_HUMAN

UniProt

A6NLU0 - RFPLA_HUMAN

Protein

Ret finger protein-like 4A

Gene

RFPL4A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 3 (15 Jun 2010)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri11 – 5343RING-type; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ret finger protein-like 4A
    Alternative name(s):
    RING finger protein 210
    Gene namesi
    Name:RFPL4A
    Synonyms:RFPL4, RNF210
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:16449. RFPL4A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162401186.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 287287Ret finger protein-like 4APRO_0000300811Add
    BLAST

    Proteomic databases

    MaxQBiA6NLU0.
    PaxDbiA6NLU0.
    PRIDEiA6NLU0.

    PTM databases

    PhosphoSiteiA6NLU0.

    Expressioni

    Gene expression databases

    BgeeiA6NLU0.
    CleanExiHS_RFPL4A.
    GenevestigatoriA6NLU0.

    Organism-specific databases

    HPAiHPA046368.

    Interactioni

    Protein-protein interaction databases

    BioGridi131211. 2 interactions.
    STRINGi9606.ENSP00000345151.

    Structurei

    Secondary structure

    1
    287
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni102 – 1043
    Beta strandi109 – 1113
    Beta strandi115 – 1206
    Beta strandi135 – 1373
    Beta strandi139 – 1435
    Beta strandi146 – 15611
    Beta strandi161 – 1699
    Turni182 – 1854
    Beta strandi186 – 1927
    Turni193 – 1953
    Beta strandi196 – 1994
    Beta strandi201 – 2033
    Beta strandi205 – 2073
    Beta strandi215 – 2217
    Turni222 – 2254
    Beta strandi226 – 2316
    Turni232 – 2343
    Beta strandi237 – 2415
    Beta strandi250 – 2578
    Beta strandi259 – 2624
    Beta strandi267 – 2693

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2FBEX-ray2.52A/B/C/D94-287[»]
    ProteinModelPortaliA6NLU0.
    SMRiA6NLU0. Positions 4-285.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiA6NLU0.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini78 – 276199B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri11 – 5343RING-type; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG313937.
    HOGENOMiHOG000230861.
    HOVERGENiHBG061854.
    InParanoidiA6NLU0.
    OMAiICKESIN.
    OrthoDBiEOG7CVPZS.
    PhylomeDBiA6NLU0.
    TreeFamiTF317532.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR022723. RDM_domain_RFPL.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF13765. PRY. 1 hit.
    PF11002. RDM. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A6NLU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEHFKQIIR CPVCLKDLEE AVQLKCGYAC CLQCLNSLQK EPDGEGLLCR    50
    FCSVVSQKDD IKPKYKLRAL VSIIKELEPK LKSVLTMNPR MRKFQVDMTF 100
    DVDTANNYLI ISEDLRSFRS GDLSQNRKEQ AERFDTALCV LGTPRFTSGR 150
    HYWEVDVGTS QVWDVGVCKE SVNRQGKIVL SSEHGFLTVG CREGKVFAAS 200
    TVPMTPLWVS PQLHRVGIFL DVGMRSIAFY NVSDGCHIYT FIEIPVCEPW 250
    RPFFAHKRGS QDDQSILSIC SVINPSAASA PVSSEGK 287
    Length:287
    Mass (Da):32,238
    Last modified:June 15, 2010 - v3
    Checksum:i53B423A78E3F3E41
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008749 Genomic DNA. No translation available.
    CCDSiCCDS46201.1.
    RefSeqiNP_001138486.1. NM_001145014.1.
    UniGeneiHs.631553.

    Genome annotation databases

    EnsembliENST00000434937; ENSP00000392936; ENSG00000223638.
    GeneIDi342931.
    KEGGihsa:342931.
    UCSCiuc010yge.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008749 Genomic DNA. No translation available.
    CCDSi CCDS46201.1.
    RefSeqi NP_001138486.1. NM_001145014.1.
    UniGenei Hs.631553.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2FBE X-ray 2.52 A/B/C/D 94-287 [» ]
    ProteinModelPortali A6NLU0.
    SMRi A6NLU0. Positions 4-285.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131211. 2 interactions.
    STRINGi 9606.ENSP00000345151.

    PTM databases

    PhosphoSitei A6NLU0.

    Proteomic databases

    MaxQBi A6NLU0.
    PaxDbi A6NLU0.
    PRIDEi A6NLU0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000434937 ; ENSP00000392936 ; ENSG00000223638 .
    GeneIDi 342931.
    KEGGi hsa:342931.
    UCSCi uc010yge.2. human.

    Organism-specific databases

    CTDi 342931.
    GeneCardsi GC19P056270.
    HGNCi HGNC:16449. RFPL4A.
    HPAi HPA046368.
    MIMi 612601. gene.
    neXtProti NX_A6NLU0.
    PharmGKBi PA162401186.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG313937.
    HOGENOMi HOG000230861.
    HOVERGENi HBG061854.
    InParanoidi A6NLU0.
    OMAi ICKESIN.
    OrthoDBi EOG7CVPZS.
    PhylomeDBi A6NLU0.
    TreeFami TF317532.

    Miscellaneous databases

    EvolutionaryTracei A6NLU0.
    GenomeRNAii 342931.
    NextBioi 98405.
    PROi A6NLU0.
    SOURCEi Search...

    Gene expression databases

    Bgeei A6NLU0.
    CleanExi HS_RFPL4A.
    Genevestigatori A6NLU0.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR006574. PRY.
    IPR022723. RDM_domain_RFPL.
    IPR018355. SPla/RYanodine_receptor_subgr.
    IPR003877. SPRY_rcpt.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF13765. PRY. 1 hit.
    PF11002. RDM. 1 hit.
    PF00622. SPRY. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00589. PRY. 1 hit.
    SM00184. RING. 1 hit.
    SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Structure of the PRYSPRY-domain: implications for autoinflammatory diseases."
      Gruetter C., Briand C., Capitani G., Mittl P.R.E., Papin S., Tschopp J., Gruetter M.G.
      FEBS Lett. 580:99-106(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) OF 94-287.

    Entry informationi

    Entry nameiRFPLA_HUMAN
    AccessioniPrimary (citable) accession number: A6NLU0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 63 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3