A6NLU0 (RFPLA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ret finger protein-like 4A

Alternative name(s):
RING finger protein 210

Gene names

Name:	RFPL4A
Synonyms:	RFPL4, RNF210

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 287

287

Ret finger protein-like 4A

PRO_0000300811

Regions

Domain

78 – 276

199

B30.2/SPRY

Zinc finger

11 – 53

43

RING-type; degenerate

Secondary structure

1

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287

Helix Strand Turn

Details...

Turn

102 – 104

3

Beta strand

109 – 111

3

Beta strand

115 – 120

6

Beta strand

135 – 137

3

Beta strand

139 – 143

5

Beta strand

146 – 156

11

Beta strand

161 – 169

9

Turn

182 – 185

4

Beta strand

186 – 192

7

Turn

193 – 195

3

Beta strand

196 – 199

4

Beta strand

201 – 203

3

Beta strand

205 – 207

3

Beta strand

215 – 221

7

Turn

222 – 225

4

Beta strand

226 – 231

6

Turn

232 – 234

3

Beta strand

237 – 241

5

Beta strand

250 – 257

8

Beta strand

259 – 262

4

Beta strand

267 – 269

3

Sequences

	Sequence		Length	Mass (Da)
	A6NLU0 [UniParc]. Last modified June 15, 2010. Version 3. Checksum: 53B423A78E3F3E41	FASTA	287	32,238
	10 20 30 40 50 60 MAEHFKQIIR CPVCLKDLEE AVQLKCGYAC CLQCLNSLQK EPDGEGLLCR FCSVVSQKDD 70 80 90 100 110 120 IKPKYKLRAL VSIIKELEPK LKSVLTMNPR MRKFQVDMTF DVDTANNYLI ISEDLRSFRS 130 140 150 160 170 180 GDLSQNRKEQ AERFDTALCV LGTPRFTSGR HYWEVDVGTS QVWDVGVCKE SVNRQGKIVL 190 200 210 220 230 240 SSEHGFLTVG CREGKVFAAS TVPMTPLWVS PQLHRVGIFL DVGMRSIAFY NVSDGCHIYT 250 260 270 280 FIEIPVCEPW RPFFAHKRGS QDDQSILSIC SVINPSAASA PVSSEGK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Structure of the PRYSPRY-domain: implications for autoinflammatory diseases." Gruetter C., Briand C., Capitani G., Mittl P.R.E., Papin S., Tschopp J., Gruetter M.G. FEBS Lett. 580:99-106(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) OF 94-287.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AC008749 Genomic DNA. No translation available.

IPI

IPI00888946.

RefSeq

NP_001138486.1. NM_001145014.1.

UniGene

Hs.631553.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2FBE	X-ray	2.52	A/B/C/D	94-287	[»]

ProteinModelPortal

A6NLU0.

SMR

A6NLU0. Positions 56-285.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000345151.

PTM databases

PhosphoSite

A6NLU0.

Proteomic databases

PaxDb

A6NLU0.

PRIDE

A6NLU0.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000434937; ENSP00000392936; ENSG00000223638.

GeneID

342931.

KEGG

hsa:342931.

UCSC

uc010yge.2. human.

Organism-specific databases

CTD

342931.

GeneCards

GC19P056270.

HGNC

HGNC:16449. RFPL4A.

HPA

HPA046368.

MIM

612601. gene.

neXtProt

NX_A6NLU0.

PharmGKB

PA162401186.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG313937.

HOGENOM

HOG000230861.

HOVERGEN

HBG061854.

InParanoid

A6NLU0.

OMA

ICKESIN.

OrthoDB

EOG4NCMD7.

Gene expression databases

Bgee

A6NLU0.

CleanEx

HS_RFPL4A.

Genevestigator

A6NLU0.

Family and domain databases

Gene3D

3.30.40.10. 1 hit.

InterPro

IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR022723. RDM_domain_RFPL.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Pfam

PF11002. RDM. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]

PRINTS

PR01407. BUTYPHLNCDUF.

SMART

SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]

SUPFAM

SSF49899. ConA_like_lec_gl. 1 hit.

PROSITE

PS50188. B302_SPRY. 1 hit.
PS00518. ZF_RING_1. False negative.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

A6NLU0.

GenomeRNAi

342931.

NextBio

98405.

SOURCE

Search...

Entry information

Entry name

RFPLA_HUMAN

Accession

Primary (citable) accession number: A6NLU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	June 15, 2010
Last modified:	May 1, 2013
This is version 51 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.