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Protein

Ret finger protein-like 4A

Gene

RFPL4A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 53RING-type; degeneratePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31701-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ret finger protein-like 4A
Alternative name(s):
RING finger protein 210
Gene namesi
Name:RFPL4A
Synonyms:RFPL4, RNF210
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16449. RFPL4A.

Pathology & Biotechi

Organism-specific databases

DisGeNETi342931.
OpenTargetsiENSG00000223638.
PharmGKBiPA162401186.

Polymorphism and mutation databases

BioMutaiRFPL4A.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003008111 – 287Ret finger protein-like 4AAdd BLAST287

Proteomic databases

MaxQBiA6NLU0.
PaxDbiA6NLU0.
PRIDEiA6NLU0.

PTM databases

iPTMnetiA6NLU0.
PhosphoSitePlusiA6NLU0.

Expressioni

Gene expression databases

BgeeiENSG00000223638.
CleanExiHS_RFPL4A.

Organism-specific databases

HPAiHPA046368.

Interactioni

Protein-protein interaction databases

BioGridi131211. 3 interactors.
STRINGi9606.ENSP00000392936.

Structurei

Secondary structure

1287
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni102 – 104Combined sources3
Beta strandi109 – 111Combined sources3
Beta strandi115 – 120Combined sources6
Beta strandi135 – 137Combined sources3
Beta strandi139 – 143Combined sources5
Beta strandi146 – 156Combined sources11
Beta strandi161 – 169Combined sources9
Turni182 – 185Combined sources4
Beta strandi186 – 192Combined sources7
Turni193 – 195Combined sources3
Beta strandi196 – 199Combined sources4
Beta strandi201 – 203Combined sources3
Beta strandi205 – 207Combined sources3
Beta strandi215 – 221Combined sources7
Turni222 – 225Combined sources4
Beta strandi226 – 231Combined sources6
Turni232 – 234Combined sources3
Beta strandi237 – 241Combined sources5
Beta strandi250 – 257Combined sources8
Beta strandi259 – 262Combined sources4
Beta strandi267 – 269Combined sources3
Helixi275 – 278Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FBEX-ray2.52A/B/C/D94-287[»]
ProteinModelPortaliA6NLU0.
SMRiA6NLU0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA6NLU0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 276B30.2/SPRYPROSITE-ProRule annotationAdd BLAST199

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri11 – 53RING-type; degeneratePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118993.
HOGENOMiHOG000230861.
HOVERGENiHBG061854.
InParanoidiA6NLU0.
OMAiQTFLSIC.
OrthoDBiEOG091G0G5I.
PhylomeDBiA6NLU0.
TreeFamiTF317532.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR022723. RDM_domain_RFPL.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF11002. RDM. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NLU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEHFKQIIR CPVCLKDLEE AVQLKCGYAC CLQCLNSLQK EPDGEGLLCR
60 70 80 90 100
FCSVVSQKDD IKPKYKLRAL VSIIKELEPK LKSVLTMNPR MRKFQVDMTF
110 120 130 140 150
DVDTANNYLI ISEDLRSFRS GDLSQNRKEQ AERFDTALCV LGTPRFTSGR
160 170 180 190 200
HYWEVDVGTS QVWDVGVCKE SVNRQGKIVL SSEHGFLTVG CREGKVFAAS
210 220 230 240 250
TVPMTPLWVS PQLHRVGIFL DVGMRSIAFY NVSDGCHIYT FIEIPVCEPW
260 270 280
RPFFAHKRGS QDDQSILSIC SVINPSAASA PVSSEGK
Length:287
Mass (Da):32,238
Last modified:June 15, 2010 - v3
Checksum:i53B423A78E3F3E41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008749 Genomic DNA. No translation available.
CCDSiCCDS46201.1.
RefSeqiNP_001138486.1. NM_001145014.1.
UniGeneiHs.631553.

Genome annotation databases

EnsembliENST00000434937; ENSP00000392936; ENSG00000223638.
GeneIDi342931.
KEGGihsa:342931.
UCSCiuc010yge.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008749 Genomic DNA. No translation available.
CCDSiCCDS46201.1.
RefSeqiNP_001138486.1. NM_001145014.1.
UniGeneiHs.631553.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FBEX-ray2.52A/B/C/D94-287[»]
ProteinModelPortaliA6NLU0.
SMRiA6NLU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131211. 3 interactors.
STRINGi9606.ENSP00000392936.

PTM databases

iPTMnetiA6NLU0.
PhosphoSitePlusiA6NLU0.

Polymorphism and mutation databases

BioMutaiRFPL4A.

Proteomic databases

MaxQBiA6NLU0.
PaxDbiA6NLU0.
PRIDEiA6NLU0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434937; ENSP00000392936; ENSG00000223638.
GeneIDi342931.
KEGGihsa:342931.
UCSCiuc010yge.3. human.

Organism-specific databases

CTDi342931.
DisGeNETi342931.
GeneCardsiRFPL4A.
HGNCiHGNC:16449. RFPL4A.
HPAiHPA046368.
MIMi612601. gene.
neXtProtiNX_A6NLU0.
OpenTargetsiENSG00000223638.
PharmGKBiPA162401186.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00760000118993.
HOGENOMiHOG000230861.
HOVERGENiHBG061854.
InParanoidiA6NLU0.
OMAiQTFLSIC.
OrthoDBiEOG091G0G5I.
PhylomeDBiA6NLU0.
TreeFamiTF317532.

Enzyme and pathway databases

BioCyciZFISH:G66-31701-MONOMER.

Miscellaneous databases

EvolutionaryTraceiA6NLU0.
GenomeRNAii342931.
PROiA6NLU0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000223638.
CleanExiHS_RFPL4A.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR022723. RDM_domain_RFPL.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF11002. RDM. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRFPLA_HUMAN
AccessioniPrimary (citable) accession number: A6NLU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 15, 2010
Last modified: November 2, 2016
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.