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A6NLU0

- RFPLA_HUMAN

UniProt

A6NLU0 - RFPLA_HUMAN

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Protein

Ret finger protein-like 4A

Gene

RFPL4A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri11 – 5343RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ret finger protein-like 4A
Alternative name(s):
RING finger protein 210
Gene namesi
Name:RFPL4A
Synonyms:RFPL4, RNF210
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:16449. RFPL4A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162401186.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 287287Ret finger protein-like 4APRO_0000300811Add
BLAST

Proteomic databases

MaxQBiA6NLU0.
PaxDbiA6NLU0.
PRIDEiA6NLU0.

PTM databases

PhosphoSiteiA6NLU0.

Expressioni

Gene expression databases

BgeeiA6NLU0.
CleanExiHS_RFPL4A.
GenevestigatoriA6NLU0.

Organism-specific databases

HPAiHPA046368.

Interactioni

Protein-protein interaction databases

BioGridi131211. 4 interactions.
STRINGi9606.ENSP00000345151.

Structurei

Secondary structure

1
287
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni102 – 1043Combined sources
Beta strandi109 – 1113Combined sources
Beta strandi115 – 1206Combined sources
Beta strandi135 – 1373Combined sources
Beta strandi139 – 1435Combined sources
Beta strandi146 – 15611Combined sources
Beta strandi161 – 1699Combined sources
Turni182 – 1854Combined sources
Beta strandi186 – 1927Combined sources
Turni193 – 1953Combined sources
Beta strandi196 – 1994Combined sources
Beta strandi201 – 2033Combined sources
Beta strandi205 – 2073Combined sources
Beta strandi215 – 2217Combined sources
Turni222 – 2254Combined sources
Beta strandi226 – 2316Combined sources
Turni232 – 2343Combined sources
Beta strandi237 – 2415Combined sources
Beta strandi250 – 2578Combined sources
Beta strandi259 – 2624Combined sources
Beta strandi267 – 2693Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FBEX-ray2.52A/B/C/D94-287[»]
ProteinModelPortaliA6NLU0.
SMRiA6NLU0. Positions 56-285.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA6NLU0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini78 – 276199B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri11 – 5343RING-type; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG313937.
GeneTreeiENSGT00760000118993.
HOGENOMiHOG000230861.
HOVERGENiHBG061854.
InParanoidiA6NLU0.
OMAiICKESIN.
OrthoDBiEOG7CVPZS.
PhylomeDBiA6NLU0.
TreeFamiTF317532.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR022723. RDM_domain_RFPL.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF13765. PRY. 1 hit.
PF11002. RDM. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6NLU0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEHFKQIIR CPVCLKDLEE AVQLKCGYAC CLQCLNSLQK EPDGEGLLCR
60 70 80 90 100
FCSVVSQKDD IKPKYKLRAL VSIIKELEPK LKSVLTMNPR MRKFQVDMTF
110 120 130 140 150
DVDTANNYLI ISEDLRSFRS GDLSQNRKEQ AERFDTALCV LGTPRFTSGR
160 170 180 190 200
HYWEVDVGTS QVWDVGVCKE SVNRQGKIVL SSEHGFLTVG CREGKVFAAS
210 220 230 240 250
TVPMTPLWVS PQLHRVGIFL DVGMRSIAFY NVSDGCHIYT FIEIPVCEPW
260 270 280
RPFFAHKRGS QDDQSILSIC SVINPSAASA PVSSEGK
Length:287
Mass (Da):32,238
Last modified:June 15, 2010 - v3
Checksum:i53B423A78E3F3E41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008749 Genomic DNA. No translation available.
CCDSiCCDS46201.1.
RefSeqiNP_001138486.1. NM_001145014.1.
UniGeneiHs.631553.

Genome annotation databases

EnsembliENST00000434937; ENSP00000392936; ENSG00000223638.
GeneIDi342931.
KEGGihsa:342931.
UCSCiuc010yge.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008749 Genomic DNA. No translation available.
CCDSi CCDS46201.1.
RefSeqi NP_001138486.1. NM_001145014.1.
UniGenei Hs.631553.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2FBE X-ray 2.52 A/B/C/D 94-287 [» ]
ProteinModelPortali A6NLU0.
SMRi A6NLU0. Positions 56-285.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131211. 4 interactions.
STRINGi 9606.ENSP00000345151.

PTM databases

PhosphoSitei A6NLU0.

Proteomic databases

MaxQBi A6NLU0.
PaxDbi A6NLU0.
PRIDEi A6NLU0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000434937 ; ENSP00000392936 ; ENSG00000223638 .
GeneIDi 342931.
KEGGi hsa:342931.
UCSCi uc010yge.2. human.

Organism-specific databases

CTDi 342931.
GeneCardsi GC19P056270.
HGNCi HGNC:16449. RFPL4A.
HPAi HPA046368.
MIMi 612601. gene.
neXtProti NX_A6NLU0.
PharmGKBi PA162401186.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG313937.
GeneTreei ENSGT00760000118993.
HOGENOMi HOG000230861.
HOVERGENi HBG061854.
InParanoidi A6NLU0.
OMAi ICKESIN.
OrthoDBi EOG7CVPZS.
PhylomeDBi A6NLU0.
TreeFami TF317532.

Miscellaneous databases

EvolutionaryTracei A6NLU0.
GenomeRNAii 342931.
NextBioi 98405.
PROi A6NLU0.
SOURCEi Search...

Gene expression databases

Bgeei A6NLU0.
CleanExi HS_RFPL4A.
Genevestigatori A6NLU0.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR006574. PRY.
IPR022723. RDM_domain_RFPL.
IPR003877. SPRY_dom.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF13765. PRY. 1 hit.
PF11002. RDM. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view ]
PRINTSi PR01407. BUTYPHLNCDUF.
SMARTi SM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS50188. B302_SPRY. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Structure of the PRYSPRY-domain: implications for autoinflammatory diseases."
    Gruetter C., Briand C., Capitani G., Mittl P.R.E., Papin S., Tschopp J., Gruetter M.G.
    FEBS Lett. 580:99-106(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) OF 94-287.

Entry informationi

Entry nameiRFPLA_HUMAN
AccessioniPrimary (citable) accession number: A6NLU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 15, 2010
Last modified: October 29, 2014
This is version 64 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3