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A6NLU0 (RFPLA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ret finger protein-like 4A
Alternative name(s):
RING finger protein 210
Gene names
Name:RFPL4A
Synonyms:RFPL4, RNF210
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 B30.2/SPRY domain.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   DomainZinc-finger
   LigandMetal-binding
Zinc
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Ret finger protein-like 4A
PRO_0000300811

Regions

Domain78 – 276199B30.2/SPRY
Zinc finger11 – 5343RING-type; degenerate

Secondary structure

..................................... 287
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
A6NLU0 [UniParc].

Last modified June 15, 2010. Version 3.
Checksum: 53B423A78E3F3E41

FASTA28732,238
        10         20         30         40         50         60 
MAEHFKQIIR CPVCLKDLEE AVQLKCGYAC CLQCLNSLQK EPDGEGLLCR FCSVVSQKDD 

        70         80         90        100        110        120 
IKPKYKLRAL VSIIKELEPK LKSVLTMNPR MRKFQVDMTF DVDTANNYLI ISEDLRSFRS 

       130        140        150        160        170        180 
GDLSQNRKEQ AERFDTALCV LGTPRFTSGR HYWEVDVGTS QVWDVGVCKE SVNRQGKIVL 

       190        200        210        220        230        240 
SSEHGFLTVG CREGKVFAAS TVPMTPLWVS PQLHRVGIFL DVGMRSIAFY NVSDGCHIYT 

       250        260        270        280 
FIEIPVCEPW RPFFAHKRGS QDDQSILSIC SVINPSAASA PVSSEGK 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Structure of the PRYSPRY-domain: implications for autoinflammatory diseases."
Gruetter C., Briand C., Capitani G., Mittl P.R.E., Papin S., Tschopp J., Gruetter M.G.
FEBS Lett. 580:99-106(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) OF 94-287.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC008749 Genomic DNA. No translation available.
CCDSCCDS46201.1.
RefSeqNP_001138486.1. NM_001145014.1.
UniGeneHs.631553.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2FBEX-ray2.52A/B/C/D94-287[»]
ProteinModelPortalA6NLU0.
SMRA6NLU0. Positions 4-285.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131211. 2 interactions.
STRING9606.ENSP00000345151.

PTM databases

PhosphoSiteA6NLU0.

Proteomic databases

MaxQBA6NLU0.
PaxDbA6NLU0.
PRIDEA6NLU0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000434937; ENSP00000392936; ENSG00000223638.
GeneID342931.
KEGGhsa:342931.
UCSCuc010yge.2. human.

Organism-specific databases

CTD342931.
GeneCardsGC19P056270.
HGNCHGNC:16449. RFPL4A.
HPAHPA046368.
MIM612601. gene.
neXtProtNX_A6NLU0.
PharmGKBPA162401186.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG313937.
HOGENOMHOG000230861.
HOVERGENHBG061854.
InParanoidA6NLU0.
OMAICKESIN.
OrthoDBEOG7CVPZS.
PhylomeDBA6NLU0.
TreeFamTF317532.

Gene expression databases

BgeeA6NLU0.
CleanExHS_RFPL4A.
GenevestigatorA6NLU0.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR006574. PRY.
IPR022723. RDM_domain_RFPL.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamPF13765. PRY. 1 hit.
PF11002. RDM. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00589. PRY. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceA6NLU0.
GenomeRNAi342931.
NextBio98405.
PROA6NLU0.
SOURCESearch...

Entry information

Entry nameRFPLA_HUMAN
AccessionPrimary (citable) accession number: A6NLU0
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 15, 2010
Last modified: July 9, 2014
This is version 62 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM